Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases

Wang,Yangkun; Shen,Lan; Yun,Tian; Zhu,Chaoya; Wang,Ping; Wang,Sunan

doi:10.3892/etm.2021.10380

Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases

Authors:
- Yangkun Wang
- Lan Shen
- Tian Yun
- Chaoya Zhu
- Ping Wang
- Sunan Wang
View Affiliations

Affiliations: Department of Pathology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518110, P.R. China, Department of Pathology, The 989 Hospital of The Joint Logistic Support Force of The Chinese People's Liberation Army, Luoyang, Henan 471031, P.R. China, Department of Pathology, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Clinical Laboratory, BGI Genomics‑Shenzhen, Shenzhen, Guangdong 518083, P.R. China, School of Electronic and Communication Engineering, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, P.R. China
Published online on: July 1, 2021 https://doi.org/10.3892/etm.2021.10380
Article Number: 948
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast‑fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis‑ or scar‑like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory‑cell infiltration backgrounds. The immunophenotype was vimentin‑ and smooth muscle actin‑positive with pan‑cytokeratin, desmin and calponin expression and CD34‑positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion‑like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor‑like lesions.

View Figures

View References

1	Odze RD, Lam AK, Ochiai A and Washington MK: WHO classification of tumours of the digestive system. Lyon: International Agency for Research on Cancer, 2019.
2	Theilen TM, Soerensen J, Bochennek K, Becker M, Schwabe D, Rolle U, Klingebiel T and Lehrnbecher T: Crizotinib in ALK⁺ inflammatory myofibroblastic tumors-Current experience and future perspectives. Pediatr Blood Cancer. 65(65)2018.PubMed/NCBI View Article : Google Scholar
3	Raggio B and Chheda N: Inflammatory myofibroblastic tumor of the epiglottis excised with a carbon dioxide laser: Case report and literature review. Ear Nose Throat J. 97:E31–E33. 2018.PubMed/NCBI View Article : Google Scholar
4	Yutaka Y, Sato T, Matsushita K, Aiba H, Muranishi Y, Sakaguchi Y, Sugiura T, Okada M, Nakamura T and Date H: Pulmonary inflammatory myofibroblastic tumor in children: A case report and brief review of literature. Semin Thorac Cardiovasc Surg. 30:230–237. 2018.
5	Kube S, Vokuhl C, Dantonello T, Scheer M, Hallmen E, Feuchtgruber S, Escherich G, Niggli F, Kuehnle I, von Kalle T, et al: Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe. Pediatr Blood Cancer. 65(e27012)2018.PubMed/NCBI View Article : Google Scholar
6	Hu J and Chen TB: Inflammatory myofibroblastic tumor of the paranasal sinus: Three cases report. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 31:722–724. 2017.PubMed/NCBI View Article : Google Scholar : (In Chinese).
7	Sagar AES, Jimenez CA and Shannon VR: Clinical and Histopathologic correlates and management strategies for inflammatory myofibroblastic tumor of the lung. A case series and review of the literature. Med Oncol. 35(102)2018.PubMed/NCBI View Article : Google Scholar
8	Hayashi M, Kawakubo H, Mayanagi S, Nakamura R, Suda K, Wada N and Kitagawa Y: Gastric inflammatory myofibroblastic tumor treated with combined laparoscopic and endoscopic gastric wedge resection: A case report. World J Surg Oncol. 16(161)2018.PubMed/NCBI View Article : Google Scholar
9	Jadhav M, Harvi R, Patil R and Kittur S: Inflammatory myofibroblastic tumor of the stomach presenting as an Exophytic Mass-A diagnostic dilemma. Turk Patoloji Derg. 35:151–156. 2017.PubMed/NCBI View Article : Google Scholar
10	Wang Y: Gastric Cancer Pathology [M]//Chunfang Gao, Yangkun Wang. Digestive System Oncology. 1st Edition, Beijing, People's Military Medical Press, pp296-404, 2012.
11	Strianese D, Tranfa F, Finelli M, Iuliano A, Staibano S and Mariniello G: Inflammatory myofibroblastic tumor of the orbit: A clinico-pathological study of 25 cases. Saudi J Ophthalmol. 32:33–39. 2018.PubMed/NCBI View Article : Google Scholar
12	Lee JE, Choi SY, Lee HK, Yi BH, Lee MH, Lee S, Lee SJ, Lee J and Jeong WK: Computed tomographic features of inflammatory myofibroblastic tumour of the stomach in adult patients: An analysis of five multicentre cases with literature review. J Med Imaging Radiat Oncol. 62:769–776. 2018.PubMed/NCBI View Article : Google Scholar
13	Shi H, Wei L, Sun L and Guo A: Primary gastric inflammatory myofibroblastic tumor: A clinicopathologic and immunohistochemical study of 5 cases. Pathol Res Pract. 206:287–291. 2010.PubMed/NCBI View Article : Google Scholar
14	Cheng B, Yang C, Liu Z, Liu L and Zhou L: Primary gastric inflammatory myofibroblastic tumor: A case report. Medicine (Baltimore). 97(e13423)2018.PubMed/NCBI View Article : Google Scholar
15	Pettinato G, Manivel JC, De Rosa N and Dehner LP: Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol. 94:538–546. 1990.PubMed/NCBI View Article : Google Scholar
16	Coindre JM: Histologic classification of soft tissue tumors (WHO, 1994). Ann Pathol. 14:426–427. 1994.PubMed/NCBI(In French).
17	Lemale J, Boudjemaa S, Parmentier B, Ducou Le Pointe H, Coulomb A and Dainese L: A pseudotumoral lesion revealing Meckel's diverticulum. Arch Pediatr. 23:1157–1160. 2016.PubMed/NCBI View Article : Google Scholar : (In French).
18	Rao N, Iwenofu H, Tang B, Woyach J and Liebner DA: Inflammatory myofibroblastic tumor driven by novel NUMA1-ALK fusion responds to ALK inhibition. J Natl Compr Canc Netw. 16:115–121. 2018.PubMed/NCBI View Article : Google Scholar
19	Fan J, Yang M, Huang B, Wang Z, Luo D, Zhang J, Zhang P, Shi H, Li Y and Nie X: ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation: A case report. Diagn Pathol. 15(8)2020.PubMed/NCBI View Article : Google Scholar
20	Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM and Hornick JL: Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of infammatory myofibroblatic tumor with nuclear membrane or perinuclear ALK. Am J Surg Pathol. 35:135–144. 2011.PubMed/NCBI View Article : Google Scholar
21	Koh J, Lee KL, Lee MS, Ahn HS and Chang MS: Gastric inverted hyperplastic polyp with inflammatory myofibroblastic tumor-like stroma, mimicking GI stromal tumor. Gastrointest Endosc. 89:433–435. 2019.PubMed/NCBI View Article : Google Scholar
22	Klingbeil KD, Balaban A, Fertig RM, Gamret AC, Gong Y, Torres C and Satahoo SS: Inflammatory fibroid polyp of the gastric antrum presenting as hypovolemic shock: Case report and literature review. Intractable Rare Dis Res. 6:304–309. 2017.PubMed/NCBI View Article : Google Scholar
23	Lacka DE and Nasierowska-Guttmejer A: Fibromatosis-immunohistochemical evaluation, differential diagnosis from gastrointestinal tumors, and other mesenchymal tumours. Prz Gastroenterol. 14:79–85. 2019.PubMed/NCBI View Article : Google Scholar
24	Rowe SP and Fishman EK: Cinematic rendering of neurofibromatosis type I gastrointestinal stromal tumors. Radiology. 291(298)2019.PubMed/NCBI View Article : Google Scholar
25	Wang YK, Jiang B, Yang YC, Wang SN, Li YY, Meng NL, Yuan XT, Jiang RD and Li ZG: Gastric aggressive fibromatosis: Report of a case and review of the literature. Int J Clin Exp Pathol. 12:372–377. 2019.PubMed/NCBI
26	Voth E, Serio S, Gross J, Singh A, Dietz N and Nandipati K: Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation. J Surg Case Rep. 2018(rjy307)2018.PubMed/NCBI View Article : Google Scholar
27	Olsen G, Beal EW, Pfeil S and Dillhoff M: Primary gastric synovial sarcoma mimicking a gastrointestinal stromal tumor (GIST): Gastric synovial sarcoma. J Gastrointest Surg. 22:1450–1451. 2018.PubMed/NCBI View Article : Google Scholar