Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases

  • Authors:
    • Yangkun Wang
    • Lan Shen
    • Tian Yun
    • Chaoya Zhu
    • Ping Wang
    • Sunan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518110, P.R. China, Department of Pathology, The 989 Hospital of The Joint Logistic Support Force of The Chinese People's Liberation Army, Luoyang, Henan 471031, P.R. China, Department of Pathology, The Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China, Clinical Laboratory, BGI Genomics‑Shenzhen, Shenzhen, Guangdong 518083, P.R. China, School of Electronic and Communication Engineering, Shenzhen Polytechnic, Shenzhen, Guangdong 518055, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 948
    |
    Published online on: July 1, 2021
       https://doi.org/10.3892/etm.2021.10380
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study reported on the histomorphological observations and immunohistochemical features of five cases of gastric inflammatory myofibroblastic tumor (IMT). Loosely arranged fat fusiform myofibroblast‑fibroblasts and diffusely or patchily distributed inflammatory cells, which formed a diverse morphological structure, were observed. In the mucous vascular structure, mucoid or collagenous areas, fibromatosis‑ or scar‑like lesions were generally <10 mm in size and both had diffuse or patchy plasma cells, lymphocytes and other inflammatory‑cell infiltration backgrounds. The immunophenotype was vimentin‑ and smooth muscle actin‑positive with pan‑cytokeratin, desmin and calponin expression and CD34‑positive foci; furthermore, three cases were positive for anaplastic lymphoma kinase expression. Gastric IMT is rare, with unique histopathological changes and corrosion‑like invasion of the smooth muscle of the stomach wall, blood vessels, nerves and adipose tissue. It should be differentiated from a variety of spindle cell tumor types and tumor‑like lesions.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Odze RD, Lam AK, Ochiai A and Washington MK: WHO classification of tumours of the digestive system. Lyon: International Agency for Research on Cancer, 2019.

2 

Theilen TM, Soerensen J, Bochennek K, Becker M, Schwabe D, Rolle U, Klingebiel T and Lehrnbecher T: Crizotinib in ALK+ inflammatory myofibroblastic tumors-Current experience and future perspectives. Pediatr Blood Cancer. 65(65)2018.PubMed/NCBI View Article : Google Scholar

3 

Raggio B and Chheda N: Inflammatory myofibroblastic tumor of the epiglottis excised with a carbon dioxide laser: Case report and literature review. Ear Nose Throat J. 97:E31–E33. 2018.PubMed/NCBI View Article : Google Scholar

4 

Yutaka Y, Sato T, Matsushita K, Aiba H, Muranishi Y, Sakaguchi Y, Sugiura T, Okada M, Nakamura T and Date H: Pulmonary inflammatory myofibroblastic tumor in children: A case report and brief review of literature. Semin Thorac Cardiovasc Surg. 30:230–237. 2018.

5 

Kube S, Vokuhl C, Dantonello T, Scheer M, Hallmen E, Feuchtgruber S, Escherich G, Niggli F, Kuehnle I, von Kalle T, et al: Inflammatory myofibroblastic tumors-A retrospective analysis of the Cooperative Weichteilsarkom Studiengruppe. Pediatr Blood Cancer. 65(e27012)2018.PubMed/NCBI View Article : Google Scholar

6 

Hu J and Chen TB: Inflammatory myofibroblastic tumor of the paranasal sinus: Three cases report. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 31:722–724. 2017.PubMed/NCBI View Article : Google Scholar : (In Chinese).

7 

Sagar AES, Jimenez CA and Shannon VR: Clinical and Histopathologic correlates and management strategies for inflammatory myofibroblastic tumor of the lung. A case series and review of the literature. Med Oncol. 35(102)2018.PubMed/NCBI View Article : Google Scholar

8 

Hayashi M, Kawakubo H, Mayanagi S, Nakamura R, Suda K, Wada N and Kitagawa Y: Gastric inflammatory myofibroblastic tumor treated with combined laparoscopic and endoscopic gastric wedge resection: A case report. World J Surg Oncol. 16(161)2018.PubMed/NCBI View Article : Google Scholar

9 

Jadhav M, Harvi R, Patil R and Kittur S: Inflammatory myofibroblastic tumor of the stomach presenting as an Exophytic Mass-A diagnostic dilemma. Turk Patoloji Derg. 35:151–156. 2017.PubMed/NCBI View Article : Google Scholar

10 

Wang Y: Gastric Cancer Pathology [M]//Chunfang Gao, Yangkun Wang. Digestive System Oncology. 1st Edition, Beijing, People's Military Medical Press, pp296-404, 2012.

11 

Strianese D, Tranfa F, Finelli M, Iuliano A, Staibano S and Mariniello G: Inflammatory myofibroblastic tumor of the orbit: A clinico-pathological study of 25 cases. Saudi J Ophthalmol. 32:33–39. 2018.PubMed/NCBI View Article : Google Scholar

12 

Lee JE, Choi SY, Lee HK, Yi BH, Lee MH, Lee S, Lee SJ, Lee J and Jeong WK: Computed tomographic features of inflammatory myofibroblastic tumour of the stomach in adult patients: An analysis of five multicentre cases with literature review. J Med Imaging Radiat Oncol. 62:769–776. 2018.PubMed/NCBI View Article : Google Scholar

13 

Shi H, Wei L, Sun L and Guo A: Primary gastric inflammatory myofibroblastic tumor: A clinicopathologic and immunohistochemical study of 5 cases. Pathol Res Pract. 206:287–291. 2010.PubMed/NCBI View Article : Google Scholar

14 

Cheng B, Yang C, Liu Z, Liu L and Zhou L: Primary gastric inflammatory myofibroblastic tumor: A case report. Medicine (Baltimore). 97(e13423)2018.PubMed/NCBI View Article : Google Scholar

15 

Pettinato G, Manivel JC, De Rosa N and Dehner LP: Inflammatory myofibroblastic tumor (plasma cell granuloma). Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations. Am J Clin Pathol. 94:538–546. 1990.PubMed/NCBI View Article : Google Scholar

16 

Coindre JM: Histologic classification of soft tissue tumors (WHO, 1994). Ann Pathol. 14:426–427. 1994.PubMed/NCBI(In French).

17 

Lemale J, Boudjemaa S, Parmentier B, Ducou Le Pointe H, Coulomb A and Dainese L: A pseudotumoral lesion revealing Meckel's diverticulum. Arch Pediatr. 23:1157–1160. 2016.PubMed/NCBI View Article : Google Scholar : (In French).

18 

Rao N, Iwenofu H, Tang B, Woyach J and Liebner DA: Inflammatory myofibroblastic tumor driven by novel NUMA1-ALK fusion responds to ALK inhibition. J Natl Compr Canc Netw. 16:115–121. 2018.PubMed/NCBI View Article : Google Scholar

19 

Fan J, Yang M, Huang B, Wang Z, Luo D, Zhang J, Zhang P, Shi H, Li Y and Nie X: ALK expressed in a gastrointestinal stromal tumor harboring PDGFRA p. D842V mutation: A case report. Diagn Pathol. 15(8)2020.PubMed/NCBI View Article : Google Scholar

20 

Mariño-Enríquez A, Wang WL, Roy A, Lopez-Terrada D, Lazar AJ, Fletcher CD, Coffin CM and Hornick JL: Epithelioid inflammatory myofibroblastic sarcoma: An aggressive intra-abdominal variant of infammatory myofibroblatic tumor with nuclear membrane or perinuclear ALK. Am J Surg Pathol. 35:135–144. 2011.PubMed/NCBI View Article : Google Scholar

21 

Koh J, Lee KL, Lee MS, Ahn HS and Chang MS: Gastric inverted hyperplastic polyp with inflammatory myofibroblastic tumor-like stroma, mimicking GI stromal tumor. Gastrointest Endosc. 89:433–435. 2019.PubMed/NCBI View Article : Google Scholar

22 

Klingbeil KD, Balaban A, Fertig RM, Gamret AC, Gong Y, Torres C and Satahoo SS: Inflammatory fibroid polyp of the gastric antrum presenting as hypovolemic shock: Case report and literature review. Intractable Rare Dis Res. 6:304–309. 2017.PubMed/NCBI View Article : Google Scholar

23 

Lacka DE and Nasierowska-Guttmejer A: Fibromatosis-immunohistochemical evaluation, differential diagnosis from gastrointestinal tumors, and other mesenchymal tumours. Prz Gastroenterol. 14:79–85. 2019.PubMed/NCBI View Article : Google Scholar

24 

Rowe SP and Fishman EK: Cinematic rendering of neurofibromatosis type I gastrointestinal stromal tumors. Radiology. 291(298)2019.PubMed/NCBI View Article : Google Scholar

25 

Wang YK, Jiang B, Yang YC, Wang SN, Li YY, Meng NL, Yuan XT, Jiang RD and Li ZG: Gastric aggressive fibromatosis: Report of a case and review of the literature. Int J Clin Exp Pathol. 12:372–377. 2019.PubMed/NCBI

26 

Voth E, Serio S, Gross J, Singh A, Dietz N and Nandipati K: Solitary fibrous tumor of the stomach with high-grade sarcomatous dedifferentiation. J Surg Case Rep. 2018(rjy307)2018.PubMed/NCBI View Article : Google Scholar

27 

Olsen G, Beal EW, Pfeil S and Dillhoff M: Primary gastric synovial sarcoma mimicking a gastrointestinal stromal tumor (GIST): Gastric synovial sarcoma. J Gastrointest Surg. 22:1450–1451. 2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Shen L, Yun T, Zhu C, Wang P and Wang S: Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases. Exp Ther Med 22: 948, 2021.
APA
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., & Wang, S. (2021). Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases. Experimental and Therapeutic Medicine, 22, 948. https://doi.org/10.3892/etm.2021.10380
MLA
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., Wang, S."Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases". Experimental and Therapeutic Medicine 22.3 (2021): 948.
Chicago
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., Wang, S."Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases". Experimental and Therapeutic Medicine 22, no. 3 (2021): 948. https://doi.org/10.3892/etm.2021.10380
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Shen L, Yun T, Zhu C, Wang P and Wang S: Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases. Exp Ther Med 22: 948, 2021.
APA
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., & Wang, S. (2021). Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases. Experimental and Therapeutic Medicine, 22, 948. https://doi.org/10.3892/etm.2021.10380
MLA
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., Wang, S."Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases". Experimental and Therapeutic Medicine 22.3 (2021): 948.
Chicago
Wang, Y., Shen, L., Yun, T., Zhu, C., Wang, P., Wang, S."Clinicopathological features of gastric inflammatory myofibroblastic tumor: Report of five cases". Experimental and Therapeutic Medicine 22, no. 3 (2021): 948. https://doi.org/10.3892/etm.2021.10380
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team