Open Access

Evaluation of animal models of Crohn's disease with anal fistula (Review)

  • Authors:
    • Shuangshuang Lu
    • Keyuan Zhu
    • Yongxin Guo
    • Enjing Wang
    • Jin Huang
  • View Affiliations

  • Published online on: July 8, 2021     https://doi.org/10.3892/etm.2021.10406
  • Article Number: 974
  • Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Anal fistula is a common and serious complication of Crohn's disease (CD). A sufficiently suitable animal model that may be used to simulate this disease is yet to be established. The aim of the present review was to summarize the different characteristics and experimental methods of commonly used animal models of CD with anal fistula. Electronic databases were searched for studies reporting on the use of this type of animal model. A total of 234 related articles were retrieved, of which six articles met the inclusion criteria; these were used as references for the present review article. The characteristics of the animal models, the advantages and disadvantages of the modeling methods and the similarities with patients with CD and anal fistula were summarized and analyzed. The evidence suggests that a sufficiently suitable animal preclinical model requires to be established.
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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lu S, Zhu K, Guo Y, Wang E and Huang J: Evaluation of animal models of Crohn's disease with anal fistula (Review). Exp Ther Med 22: 974, 2021
APA
Lu, S., Zhu, K., Guo, Y., Wang, E., & Huang, J. (2021). Evaluation of animal models of Crohn's disease with anal fistula (Review). Experimental and Therapeutic Medicine, 22, 974. https://doi.org/10.3892/etm.2021.10406
MLA
Lu, S., Zhu, K., Guo, Y., Wang, E., Huang, J."Evaluation of animal models of Crohn's disease with anal fistula (Review)". Experimental and Therapeutic Medicine 22.3 (2021): 974.
Chicago
Lu, S., Zhu, K., Guo, Y., Wang, E., Huang, J."Evaluation of animal models of Crohn's disease with anal fistula (Review)". Experimental and Therapeutic Medicine 22, no. 3 (2021): 974. https://doi.org/10.3892/etm.2021.10406