Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plant‑based diet (vegan) adults

  • Authors:
    • Corina-Aurelia Zugravu
    • Adriana Macri
    • Nastasia Belc
    • Roxana Bohiltea
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  • Published online on: July 14, 2021     https://doi.org/10.3892/etm.2021.10425
  • Article Number: 993
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Abstract

Plant‑based nutrition has become extremely popular in the contemporary era. Its positive effects are sustained by many studies, but one of its risks is that it is almost completely devoid of vitamin B12. In the present study, we analyzed the effects of two types of vitamin B12 supplements, cyancobalamin and methylcobalamin on the level of active serum vitamin (holotranscobalamin) in a group of Romanian individuals (n=42) following a (vegan) plant‑based diet. The results revealed that cyancobalamin gives better results in maintaining B12, as quantified by the holotranscobalamin value (median=150 pcg/l) when compared with methylcobalamin (median=78.5 pcg/l). The frequency of administration, regardless of the quantity in one dose, is another important factor in maintaining the holotranscobalamin level within suitable limits. More frequent intakes give more optimal results. Vegans trying to supplement with alternative products (algae, kombucha, other fermented products), had the lowest levels of holotranscobalamin, always bellow the recommended level of 35 pcg/l (median=29 pcg/l). Vegans must be educated on B12 supplementation, about the pharmaceutical forms on the market and their performances and on choosing the optimal plan in order to avoid the onset of B12 deficiency.

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September-2021
Volume 22 Issue 3

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zugravu C, Macri A, Belc N and Bohiltea R: Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plant‑based diet (vegan) adults. Exp Ther Med 22: 993, 2021
APA
Zugravu, C., Macri, A., Belc, N., & Bohiltea, R. (2021). Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plant‑based diet (vegan) adults. Experimental and Therapeutic Medicine, 22, 993. https://doi.org/10.3892/etm.2021.10425
MLA
Zugravu, C., Macri, A., Belc, N., Bohiltea, R."Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plant‑based diet (vegan) adults". Experimental and Therapeutic Medicine 22.3 (2021): 993.
Chicago
Zugravu, C., Macri, A., Belc, N., Bohiltea, R."Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plant‑based diet (vegan) adults". Experimental and Therapeutic Medicine 22, no. 3 (2021): 993. https://doi.org/10.3892/etm.2021.10425