Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 22 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis

  • Authors:
    • Koji Fukuda
    • Yasushi Miura
    • Toshihisa Maeda
    • Shinya Hayashi
    • Tomoyuki Matsumoto
    • Ryosuke Kuroda
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo 650‑0017, Japan
    Copyright: © Fukuda et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1000
    |
    Published online on: July 15, 2021
       https://doi.org/10.3892/etm.2021.10432
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that causes chronic inflammation in synovial tissues. Hyperplasia of synovial tissues leads to the formation of pannus that invades the joint cartilage and bone, resulting in joint destruction. Fas ligand (FasL), which is a member of the tumor necrosis factor superfamily, contributes to the pathogenesis of autoimmune diseases, including RA. The current study attempted to identify genes whose expressions in rheumatoid fibroblast‑like synoviocytes (RA‑FLS) were regulated by FasL, using cDNA microarray. A total of four individual lines of primary cultured RA‑FLS were incubated either with recombinant human FasL protein or PBS as an unstimulated control for 12 h. Gene expression was detected using a microarray assay. The results revealed the expression profiles of genes in RA‑FLS regulated by Fas and investigated the functions of the genes that were regulated. Among the genes in this profile, the mRNA expression changes of the following genes were indicated to be of note using RT‑qPCR: Dual specificity phosphatase 6, epiregulin, interleukin 11, angiopoietin‑like 7, protein inhibitor of activated STAT 2 and growth differentiation factor 5. These genes may affect the pathogenesis of RA by affecting apoptosis, proliferation, cytokine production, cytokine‑induced inflammation, intracellular signaling, angiogenesis, bone destruction and chondrogenesis. To the best of our knowledge, the current study is the first study to reveal the expression profile of genes in RA‑FLS regulated by FasL. The data demonstrated that FasL may regulate the expression of a number of key molecules in RA‑FLS, thus affecting RA pathogenesis. Further studies of the genes detected may improve the understanding of RA pathogenesis and provide novel treatment targets for RA.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Chou CT, Yang JS and Lee MR: Apoptosis in rheumatoid arthritis-expression of Fas, Fas-L, p53, and Bcl-2 in rheumatoid synovial tissues. J Pathol. 193:110–116. 2001.PubMed/NCBI View Article : Google Scholar

2 

Tak PP, Zvaifler NJ, Green DR and Firestein GS: Rheumatoid arthritis and p53: How oxidative stress might alter the course of inflammatory diseases. Immunol Today. 21:78–82. 2000.PubMed/NCBI View Article : Google Scholar

3 

Yamanishi Y, Boyle DL, Rosengren S, Green DR, Zvaifler NJ and Firestein GS: Regional analysis of p53 mutations in rheumatoid arthritis synovium. Proc Natl Acad Sci USA. 99:10025–10030. 2002.PubMed/NCBI View Article : Google Scholar

4 

Bustamante MF, Garcia-Carbonell R, Whisenant KD and Guma M: Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis. Arthritis Res Ther. 19(110)2017.PubMed/NCBI View Article : Google Scholar

5 

Baier A, Meineckel I, Gay S and Pap T: Apoptosis in rheumatoid arthritis. Curr Opin Rheumatol. 15:274–279. 2003.PubMed/NCBI View Article : Google Scholar

6 

Takami N, Osawa K, Miura Y, Komai K, Taniguchi M, Shiraishi M, Sato K, Iguchi T, Shiozawa K, Hashiramoto A and Shiozawa S: Hypermethylated promoter region of DR3, the death receptor 3 gene, in rheumatoid arthritis synovial cells. Arthritis Rheum. 54:779–787. 2006.PubMed/NCBI View Article : Google Scholar

7 

Peng SL: Fas (CD95)-related apoptosis and rheumatoid arthritis. Rheumatology (Oxford). 45:26–30. 2006.PubMed/NCBI View Article : Google Scholar

8 

Wakisaka S, Suzuki N, Takeba Y, Shimoyama Y, Nagafuchi H, Takeno M, Saito N, Yokoe T, Kaneko A, Asai T and Sakane T: Modulation by proinflammatory cytokines of Fas/Fas ligand-mediated apoptotic cell death of synovial cells in patients with rheumatoid arthritis (RA). Clin Exp Immunol. 114:119–128. 1998.PubMed/NCBI View Article : Google Scholar

9 

Croft M and Siegel RM: Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases. Nat Rev Rheumatol. 13:217–233. 2017.PubMed/NCBI View Article : Google Scholar

10 

Schedel J, Gay RE, Kuenzler P, Seemayer C, Simmen B, Michel BA and Gay S: FLICE-inhibitory protein expression in synovial fibroblasts and at sites of cartilage and bone erosion in rheumatoid arthritis. Arthritis Rheum. 46:1512–1518. 2002.PubMed/NCBI View Article : Google Scholar

11 

Kobayashi T, Okamoto K, Kobata T, Hasunuma T, Kato T, Hamada H and Nishioka K: Differential regulation of Fas-mediated apoptosis of rheumatoid synoviocytes by tumor necrosis factor alpha and basic fibroblast growth factor is associated with the expression of apoptosis-related molecules. Arthritis Rheum. 43:1106–1114. 2000.PubMed/NCBI View Article : Google Scholar

12 

Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH and Peter ME: Two CD95 (APO-1/Fas) signaling pathways. EMBO J. 17:1675–1687. 1998.PubMed/NCBI View Article : Google Scholar

13 

Audo R, Calmon-Hamaty F, Papon L, Combe B, Morel J and Hahne M: Distinct effects of soluble and membrane-bound fas ligand on fibroblast-like synoviocytes from rheumatoid arthritis patients. Arthritis Rheumatol. 66:3289–3299. 2014.PubMed/NCBI View Article : Google Scholar

14 

Guegan JP and Legembre P: Nonapoptotic functions of Fas/CD95 in the immune response. FEBS J. 285:809–827. 2018.PubMed/NCBI View Article : Google Scholar

15 

Shi G, Wu Y, Zhang J and Wu J: Death decoy receptor TR6/DcR3 inhibits T cell chemotaxis in vitro and in vivo. J Immunol. 171:3407–3414. 2003.PubMed/NCBI View Article : Google Scholar

16 

Pitti RM, Marsters SA, Lawrence DA, Roy M, Kischkel FC, Dowd P, Huang A, Donahue CJ, Sherwood SW, Baldwin DT, et al: Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer. Nature. 396:699–703. 1998.PubMed/NCBI View Article : Google Scholar

17 

Tsuji S, Hosotani R, Yonehara S, Masui T, Tulachan SS, Nakajima S, Kobayashi H, Koizumi M, Toyoda E, Ito D, et al: Endogenous decoy receptor 3 blocks the growth inhibition signals mediated by Fas ligand in human pancreatic adenocarcinoma. Int J Cancer. 106:17–25. 2003.PubMed/NCBI View Article : Google Scholar

18 

Yu KY, Kwon B, Ni J, Zhai Y, Ebner R and Kwon BS: A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 274:13733–13736. 1999.PubMed/NCBI View Article : Google Scholar

19 

Migone TS, Zhang J, Luo X, Zhuang L, Chen C, Hu B, Hong JS, Perry JW, Chen SF, Zhou JX, et al: TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 16:479–492. 2002.PubMed/NCBI View Article : Google Scholar

20 

Hayashi S, Miura Y, Nishiyama T, Mitani M, Tateishi K, Sakai Y, Hashiramoto A, Kurosaka M, Shiozawa S and Doita M: Decoy receptor 3 expressed in rheumatoid synovial fibroblasts protects the cells against Fas-induced apoptosis. Arthritis Rheum. 56:1067–1075. 2007.PubMed/NCBI View Article : Google Scholar

21 

Takahashi M, Miura Y, Hayashi S, Tateishi K, Fukuda K and Kurosaka M: DcR3-TL1A signalling inhibits cytokine-induced proliferation of rheumatoid synovial fibroblasts. Int J Mol Med. 28:423–427. 2011.PubMed/NCBI View Article : Google Scholar

22 

Fukuda K, Miura Y, Maeda T, Hayashi S and Kurosaka M: Interleukin12B is upregulated by decoy receptor 3 in rheumatoid synovial fibroblasts. Mol Med Rep. 13:3647–3652. 2016.PubMed/NCBI View Article : Google Scholar

23 

Fukuda K, Miura Y, Maeda T, Hayashi S and Kuroda R: Decoy receptor 3 down-regulates centrosomal protein 70 kDa specifically in rheumatoid synovial fibroblasts. Mod Rheumatol. 28:287–292. 2018.PubMed/NCBI View Article : Google Scholar

24 

Maeda T, Miura Y, Fukuda K, Hayashi S and Kurosaka M: Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts. Mol Med Rep. 12:5191–5196. 2015.PubMed/NCBI View Article : Google Scholar

25 

Fukuda K, Miura Y, Maeda T, Takahashi M, Hayashi S and Kurosaka M: Decoy receptor 3 regulates the expression of various genes in rheumatoid arthritis synovial fibroblasts. Int J Mol Med. 32:910–916. 2013.PubMed/NCBI View Article : Google Scholar

26 

Fukuda K, Miura Y, Maeda T, Hayashi S and Kuroda R: Expression profiling of genes in rheumatoid fibroblast-like synoviocytes regulated by tumor necrosis factor-like ligand 1A using cDNA microarray analysis. Biomed Rep. 1:1–5. 2019.PubMed/NCBI View Article : Google Scholar

27 

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31:315–324. 1988.PubMed/NCBI View Article : Google Scholar

28 

Chang Q, Peter ME and Grassi MA: Fas ligand-Fas signaling participates in light-induced apoptotic death in photoreceptor cells. Invest Ophthalmol Vis Sci. 53:3703–3716. 2012.PubMed/NCBI View Article : Google Scholar

29 

Nitobe J, Yamaguchi S, Okuyama M, Nozaki N, Sata M, Miyamoto T, Takeishi Y, Kubota I and Tomoike H: Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes. Cardiovasc Res. 57:119–128. 2003.PubMed/NCBI View Article : Google Scholar

30 

Thiel CT, Kraus C, Rauch A, Ekici AB, Rautenstrauss B and Reis A: A new quantitative PCR multiplex assay for rapid analysis of chromosome 17p11.2-12 duplications and deletions leading to HMSN/HNPP. Eur J Hum Genet. 11:170–178. 2003.PubMed/NCBI View Article : Google Scholar

31 

Choi YJ and Yun HK: Transcriptional profiles of Rhizobium vitis-inoculated and salicylic acid-treated ‘Tamnara’ grapevines based on microarray analysis. J Plant Biotechnol. 43:37–48. 2016.

32 

Chang YC, Chen TC, Lee CT, Yang CY, Wang HW, Wang CC and Hsieh SL: Epigenetic control of MHC class II expression in tumor-associated macrophages by decoy receptor 3. Blood. 111:5054–5063. 2008.PubMed/NCBI View Article : Google Scholar

33 

Espinosa I, Catasus L, Canet B, D'Angelo E, Munoz J and Prat J: Gene expression analysis identifies two groups of ovarian high-grade serous carcinomas with different prognosis. Mod Pathol. 24:846–854. 2011.PubMed/NCBI View Article : Google Scholar

34 

Khan J, Simon R, Bittner M, Chen Y, Leighton SB, Pohida T, Smith PD, Jiang Y, Gooden GC, Trent JM, et al: Gene expression profiling of alveolar rhabdomyosarcoma with cDNA microarrays. Cancer Res. 58:5009–5013. 1998.PubMed/NCBI

35 

Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF and Biddison WE: Analysis of gene expression in mutiple sclerosis lesions using cDNA microarrays. Ann Neurol. 46:425–428. 1999.PubMed/NCBI View Article : Google Scholar

36 

Li J, Yang S, Lu S, Zhao H, Feng J, Li W, Ma F, Ren Q, Liu B, Zhang L, et al: Differential gene expression profile associated with the abnormality of bone marrow mesenchymal stem cells in aplastic anemia. PLoS One. 7(e47764)2012.PubMed/NCBI View Article : Google Scholar

37 

van der Pouw Kraan TC, van Gaalen FA, Kasperkovitz PV, Verbeet NL, Smeets TJ, Kraan MC, Fero M, Tak PP, Huizinga TW, Pieterman E, et al: Rheumatoid arthritis is a heterogeneous disease: Evidence for differences in the activation of the STAT-1 pathway between rheumatoid tissues. Arthritis Rheum. 48:2132–2145. 2003.PubMed/NCBI View Article : Google Scholar

38 

Lee SK, Jeon EK, Kim YJ, Seo SH, Kim CD, Lim JS and Lee JH: A global gene expression analysis of the peripheral blood mononuclear cells reveals the gene expression signature in psoriasis. Ann Dermatol. 21:237–242. 2009.PubMed/NCBI View Article : Google Scholar

39 

Heller RA, Schena M, Chai A, Shalon D, Bedilion T, Gilmore J, Woolley DE and Davis RW: Discovery and analysis of inflammatory disease-related genes using cDNA microarrays. Proc Natl Acad Sci USA. 94:2150–2155. 1997.PubMed/NCBI View Article : Google Scholar

40 

Bertin S, Lozano-Ruiz B, Bachiller V, Garcia-Martinez I, Herdman S, Zapater P, Frances R, Such J, Lee J, Raz E and González-Navajas JM: Dual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice. Mucosal Immunol. 8:505–515. 2015.PubMed/NCBI View Article : Google Scholar

41 

Hsu SF, Lee YB, Lee YC, Chung AL, Apaya MK, Shyur LF, Cheng CF, Ho FM and Meng TC: Dual specificity phosphatase DUSP6 promotes endothelial inflammation through inducible expression of ICAM-1. FEBS J. 285:1593–1610. 2018.PubMed/NCBI View Article : Google Scholar

42 

Patel RD, Kim DJ, Peters JM and Perdew GH: The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicol Sci. 89:75–82. 2006.PubMed/NCBI View Article : Google Scholar

43 

Murakami M, Harada M, Kamimura D, Ogura H, Okuyama Y, Kumai N, Okuyama A, Singh R, Jiang JJ, Atsumi T, et al: Disease-association analysis of an inflammation-related feedback loop. Cell Rep. 3:946–959. 2013.PubMed/NCBI View Article : Google Scholar

44 

Harada M, Kamimura D, Arima Y, Kohsaka H, Nakatsuji Y, Nishida M, Atsumi T, Meng J, Bando H, Singh R, et al: Temporal expression of growth factors triggered by epiregulin regulates inflammation development. J Immunol. 194:1039–1046. 2015.PubMed/NCBI View Article : Google Scholar

45 

Lahoti TS, Hughes JM, Kusnadi A, John K, Zhu B, Murray IA, Gowda K, Peters JM, Amin SG and Perdew GH: Aryl hydrocarbon receptor antagonism attenuates growth factor expression, proliferation, and migration in fibroblast-like synoviocytes from patients with rheumatoid arthritis. J Pharmacol Exp Ther. 348:236–245. 2014.PubMed/NCBI View Article : Google Scholar

46 

Yin T, Taga T, Tsang ML, Yasukawa K, Kishimoto T and Yang YC: Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction. J Immunol. 151:2555–2561. 1993.PubMed/NCBI

47 

Trepicchio WL, Bozza M, Pedneault G and Dorner AJ: Recombinant human IL-11 attenuates the inflammatory response through down-regulation of proinflammatory cytokine release and nitric oxide production. J Immunol. 157:3627–3634. 1996.PubMed/NCBI

48 

Hermann JA, Hall MA, Maini RN, Feldmann M and Brennan FM: Important immunoregulatory role of interleukin-11 in the inflammatory process in rheumatoid arthritis. Arthritis Rheum. 41:1388–1397. 1998.PubMed/NCBI View Article : Google Scholar

49 

Elshabrawy HA, Volin MV, Essani AB, Chen Z, McInnes IB, Van Raemdonck K, Palasiewicz K, Arami S, Gonzalez M, Ashour HM, et al: IL-11 facilitates a novel connection between RA joint fibroblasts and endothelial cells. Angiogenesis. 21:215–228. 2018.PubMed/NCBI View Article : Google Scholar

50 

Murakami K, Kobayashi Y, Uehara S, Suzuki T, Koide M, Yamashita T, Nakamura M, Takahashi N, Kato H, Udagawa N and Nakamura Y: A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro. PLoS One. 12(e0181126)2017.PubMed/NCBI View Article : Google Scholar

51 

Parri M, Pietrovito L, Grandi A, Campagnoli S, De Camilli E, Bianchini F, Marchio S, Bussolino F, Jin B, Sarmientos P, et al: Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer. Angiogenesis. 17:881–896. 2014.PubMed/NCBI View Article : Google Scholar

52 

Qian T, Wang K, Cui J, He Y and Yang Z: Angiopoietin-Like Protein 7 promotes an inflammatory phenotype in RAW264.7 macrophages through the P38 MAPK signaling pathway. Inflammation. 39:974–985. 2016.PubMed/NCBI View Article : Google Scholar

53 

Lao M, Shi M, Zou Y, Huang M, Ye Y, Qiu Q, Xiao Y, Zeng S, Liang L, Yang X and Xu H: Protein inhibitor of activated STAT3 regulates migration, invasion, and activation of Fibroblast-like synoviocytes in rheumatoid arthritis. J Immunol. 196:596–606. 2016.PubMed/NCBI View Article : Google Scholar

54 

Muller S, Ledl A and Schmidt D: SUMO: A regulator of gene expression and genome integrity. Oncogene. 23:1998–2008. 2004.PubMed/NCBI View Article : Google Scholar

55 

Schmidt D and Muller S: PIAS/SUMO: New partners in transcriptional regulation. Cell Mol Life Sci. 60:2561–2574. 2003.PubMed/NCBI View Article : Google Scholar

56 

Wu Y, Guo Z, Wu H, Wang X, Yang L, Shi X, Du J, Tang B, Li W, Yang L and Zhang Y: SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. PLoS One. 7(e39606)2012.PubMed/NCBI View Article : Google Scholar

57 

Chowdhury D, Singh A, Gupta A, Tulsawani R, Meena RC and Chakrabarti A: p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells. Cell Stress Chaperones. 24:393–407. 2019.PubMed/NCBI View Article : Google Scholar

58 

Bobacz K, Gruber R, Soleiman A, Graninger WB, Luyten FP and Erlacher L: Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis. Osteoarthritis Cartilage. 10:394–401. 2002.PubMed/NCBI View Article : Google Scholar

59 

Hotten GC, Matsumoto T, Kimura M, Bechtold RF, Kron R, Ohara T, Tanaka H, Satoh Y, Okazaki M, Shirai T, et al: Recombinant human growth/differentiation factor 5 stimulates mesenchyme aggregation and chondrogenesis responsible for the skeletal development of limbs. Growth Factors. 13:65–74. 1996.PubMed/NCBI View Article : Google Scholar

60 

Liu FL, Lin LH, Sytwu HK and Chang DM: GDF-5 is suppressed by IL-1beta and enhances TGF-beta3-mediated chondrogenic differentiation in human rheumatoid fibroblast-like synoviocytes. Exp Mol Pathol. 88:163–170. 2010.PubMed/NCBI View Article : Google Scholar

61 

Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, Fujioka M, Sudo A, Uchida A, Yamamoto S, et al: A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet. 39:529–533. 2007.PubMed/NCBI View Article : Google Scholar

62 

Martinez A, Varade J, Lamas JR, Fernandez-Arquero M, Jover JA, de la Concha EG, Fernandez-Gutierrez B and Urcelay E: GDF5 Polymorphism associated with osteoarthritis: Risk for rheumatoid arthritis. Ann Rheum Dis. 67:1352–1353. 2008.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Fukuda K, Miura Y, Maeda T, Hayashi S, Matsumoto T and Kuroda R: Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis. Exp Ther Med 22: 1000, 2021.
APA
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., & Kuroda, R. (2021). Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis. Experimental and Therapeutic Medicine, 22, 1000. https://doi.org/10.3892/etm.2021.10432
MLA
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., Kuroda, R."Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis". Experimental and Therapeutic Medicine 22.3 (2021): 1000.
Chicago
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., Kuroda, R."Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1000. https://doi.org/10.3892/etm.2021.10432
Copy and paste a formatted citation
x
Spandidos Publications style
Fukuda K, Miura Y, Maeda T, Hayashi S, Matsumoto T and Kuroda R: Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis. Exp Ther Med 22: 1000, 2021.
APA
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., & Kuroda, R. (2021). Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis. Experimental and Therapeutic Medicine, 22, 1000. https://doi.org/10.3892/etm.2021.10432
MLA
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., Kuroda, R."Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis". Experimental and Therapeutic Medicine 22.3 (2021): 1000.
Chicago
Fukuda, K., Miura, Y., Maeda, T., Hayashi, S., Matsumoto, T., Kuroda, R."Expression profiling of genes in rheumatoid fibroblast‑like synoviocytes regulated by Fas ligand via cDNA microarray analysis". Experimental and Therapeutic Medicine 22, no. 3 (2021): 1000. https://doi.org/10.3892/etm.2021.10432
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team