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Primary pelvic exenteration: Our experience with 23 patients from a single institution

  • Authors:
    • Mihai Gheorghe
    • Alexandra Lavinia Cozlea
    • Szilard Leo Kiss
    • Mihai Stanca
    • Mihai Emil Căpîlna
    • Nicolae Bacalbașa
    • Andreea Anamaria Moldovan
  • View Affiliations / Copyright

    Affiliations: First Obstetrics and Gynecology Clinic, ‘George Emil Palade’ University of Medicine, Pharmacy, Science and Technology, 540136 Târgu Mureș, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020022 Bucharest, Romania, Department of Infectious Diseases, Brașov County Emergency Hospital, 500326 Brașov, Romania
    Copyright: © Gheorghe et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1060
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    Published online on: July 26, 2021
       https://doi.org/10.3892/etm.2021.10494
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Abstract

This study was designed with an aim to share our experience of primary pelvic exenterations. The study included 23 patients with different types of pelvic cancer enrolled at a single institution between November 2011 and July 2020. The patient mean age was 55 years (range, 43‑72 years) and the oncological indications included: Stage IVa cervical cancer (11 cases, 48.9%), stage IVa endometrial cancer (1 case, 4.3%), stage IVa vaginal cancer (6 cases, 26%), stage IIIb bladder cancer (3 cases, 13%), stage IIIc rectal cancer (1 case, 4.3%) and undifferentiated pelvic sarcoma (1 case, 4.3%). Total, anterior, and posterior pelvic exenterations were performed on 34.4, 56.5 and 13% of cases, respectively. Related to levator ani muscle, 13 (56.5%) pelvic exenterations were supralevatorian, 10 (43.5%) infralevatorian, and 5 (21.7%) were infralevatorian with vulvectomy. No major intraoperative complications occurred. Seven patients (30.5%) developed early complications, 4 of them (17.4%) required reoperation and 1 (4.3%) perioperative death caused by a pulmonary embolism was recorded. Only 1 patient experienced a late complication, a urostomy stenosis. Over a median follow‑up period of 35 months, 8 (34.8%) patients died. The median overall survival (OS) was 33 months (range, 1‑96 months). The 2‑year and 5‑year survival rates were 72 and 66%, respectively. Primary pelvic exenteration may be related with various postoperative complications, without high perioperative morality and with long‑term survival.
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Copy and paste a formatted citation
Spandidos Publications style
Gheorghe M, Cozlea AL, Kiss SL, Stanca M, Căpîlna ME, Bacalbașa N and Moldovan AA: Primary pelvic exenteration: Our experience with 23 patients from a single institution. Exp Ther Med 22: 1060, 2021.
APA
Gheorghe, M., Cozlea, A.L., Kiss, S.L., Stanca, M., Căpîlna, M.E., Bacalbașa, N., & Moldovan, A.A. (2021). Primary pelvic exenteration: Our experience with 23 patients from a single institution. Experimental and Therapeutic Medicine, 22, 1060. https://doi.org/10.3892/etm.2021.10494
MLA
Gheorghe, M., Cozlea, A. L., Kiss, S. L., Stanca, M., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Primary pelvic exenteration: Our experience with 23 patients from a single institution". Experimental and Therapeutic Medicine 22.4 (2021): 1060.
Chicago
Gheorghe, M., Cozlea, A. L., Kiss, S. L., Stanca, M., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Primary pelvic exenteration: Our experience with 23 patients from a single institution". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1060. https://doi.org/10.3892/etm.2021.10494
Copy and paste a formatted citation
x
Spandidos Publications style
Gheorghe M, Cozlea AL, Kiss SL, Stanca M, Căpîlna ME, Bacalbașa N and Moldovan AA: Primary pelvic exenteration: Our experience with 23 patients from a single institution. Exp Ther Med 22: 1060, 2021.
APA
Gheorghe, M., Cozlea, A.L., Kiss, S.L., Stanca, M., Căpîlna, M.E., Bacalbașa, N., & Moldovan, A.A. (2021). Primary pelvic exenteration: Our experience with 23 patients from a single institution. Experimental and Therapeutic Medicine, 22, 1060. https://doi.org/10.3892/etm.2021.10494
MLA
Gheorghe, M., Cozlea, A. L., Kiss, S. L., Stanca, M., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Primary pelvic exenteration: Our experience with 23 patients from a single institution". Experimental and Therapeutic Medicine 22.4 (2021): 1060.
Chicago
Gheorghe, M., Cozlea, A. L., Kiss, S. L., Stanca, M., Căpîlna, M. E., Bacalbașa, N., Moldovan, A. A."Primary pelvic exenteration: Our experience with 23 patients from a single institution". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1060. https://doi.org/10.3892/etm.2021.10494
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