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A multidisciplinary approach in the diagnostic challenge of GIST

  • Authors:
    • Mihai Ceausu
    • Bogdan Socea
    • Vladimir Paul Ciobotaru
    • Vlad Denis Constantin
    • Simona Enache
    • Valentin Enache
    • Alice Bancu
    • Laura Ileana Socea
    • Dragoș Șerban
    • Dragoș Predescu
    • Cătălin G. Smarandache
    • Zenaida Ceausu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Pathology Department, University Emergency Hospital, 050098 Bucharest, Romania, Pathology Department, ‘Victor Babeş’ Institute of Bucharest, 050096 Bucharest, Romania, Department of Organic Chemistry, Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania, Pathology Department, ‘Sf. Pantelimon’ Emergency Hospital, 021659 Bucharest, Romania
    Copyright: © Ceausu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1063
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    Published online on: July 27, 2021
       https://doi.org/10.3892/etm.2021.10497
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Abstract

Gastrointestinal stromal tumors (GISTs) are the most common malignant mesenchymal lesions of the gastrointestinal tract. They originate from the interstitial cells of Cajal and are characterized by overexpression of the tyrosine kinase receptor, protein product of c‑KIT gene (KIT). In this retrospective study, conducted over a period of 10 years, we retrieved from our database, a total number of 57 patients, admitted and operated in the surgical department of ‘Sf. Pantelimon’ Emergency Clinical Hospital, Bucharest, for digestive tumors, histopathologically confirmed as GISTs. More than half of the cases presented as surgical emergencies and the tumors found during the surgical procedures, which proved to be GISTs, were sometimes difficult to differentiate from other mesenchymal tumors, both for the clinician and the pathologist. The diagnosis of GIST relies mostly on pathology and immunohistochemistry, but also on clinical and imagistic data. The most common emergencies were digestive hemorrhage (associated with gastric location), followed by intestinal obstruction (especially for the ileal localization). The largest dimensions corresponded to gastric location. For selected indications (upper digestive sites), upper digestive endoscopy approaches 100% sensitivity. This study focuses on diagnosis of GISTs sustained by both clinical and imagistic methods, along with histopathology and immunohistochemistry techniques, according to the World Health Organization 2019 criteria. Even though the differential diagnosis of these tumors is challenging, an interdisciplinary cooperation with a multiple approach increases the odds of a correct positive diagnosis.
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Copy and paste a formatted citation
Spandidos Publications style
Ceausu M, Socea B, Ciobotaru VP, Constantin VD, Enache S, Enache V, Bancu A, Socea LI, Șerban D, Predescu D, Predescu D, et al: A multidisciplinary approach in the diagnostic challenge of GIST. Exp Ther Med 22: 1063, 2021.
APA
Ceausu, M., Socea, B., Ciobotaru, V.P., Constantin, V.D., Enache, S., Enache, V. ... Ceausu, Z. (2021). A multidisciplinary approach in the diagnostic challenge of GIST. Experimental and Therapeutic Medicine, 22, 1063. https://doi.org/10.3892/etm.2021.10497
MLA
Ceausu, M., Socea, B., Ciobotaru, V. P., Constantin, V. D., Enache, S., Enache, V., Bancu, A., Socea, L. I., Șerban, D., Predescu, D., Smarandache, C. G., Ceausu, Z."A multidisciplinary approach in the diagnostic challenge of GIST". Experimental and Therapeutic Medicine 22.4 (2021): 1063.
Chicago
Ceausu, M., Socea, B., Ciobotaru, V. P., Constantin, V. D., Enache, S., Enache, V., Bancu, A., Socea, L. I., Șerban, D., Predescu, D., Smarandache, C. G., Ceausu, Z."A multidisciplinary approach in the diagnostic challenge of GIST". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1063. https://doi.org/10.3892/etm.2021.10497
Copy and paste a formatted citation
x
Spandidos Publications style
Ceausu M, Socea B, Ciobotaru VP, Constantin VD, Enache S, Enache V, Bancu A, Socea LI, Șerban D, Predescu D, Predescu D, et al: A multidisciplinary approach in the diagnostic challenge of GIST. Exp Ther Med 22: 1063, 2021.
APA
Ceausu, M., Socea, B., Ciobotaru, V.P., Constantin, V.D., Enache, S., Enache, V. ... Ceausu, Z. (2021). A multidisciplinary approach in the diagnostic challenge of GIST. Experimental and Therapeutic Medicine, 22, 1063. https://doi.org/10.3892/etm.2021.10497
MLA
Ceausu, M., Socea, B., Ciobotaru, V. P., Constantin, V. D., Enache, S., Enache, V., Bancu, A., Socea, L. I., Șerban, D., Predescu, D., Smarandache, C. G., Ceausu, Z."A multidisciplinary approach in the diagnostic challenge of GIST". Experimental and Therapeutic Medicine 22.4 (2021): 1063.
Chicago
Ceausu, M., Socea, B., Ciobotaru, V. P., Constantin, V. D., Enache, S., Enache, V., Bancu, A., Socea, L. I., Șerban, D., Predescu, D., Smarandache, C. G., Ceausu, Z."A multidisciplinary approach in the diagnostic challenge of GIST". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1063. https://doi.org/10.3892/etm.2021.10497
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