Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway

  • Authors:
    • Lan Zhan
    • Xiangxiu Wang
    • Yanjing Zhang
    • Guonian Zhu
    • Yu Ding
    • Xuemei Chen
    • Wei Jiang
    • Sisi Wu
  • View Affiliations / Copyright

    Affiliations: Core Facilities, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Zhan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1082
    |
    Published online on: July 29, 2021
       https://doi.org/10.3892/etm.2021.10516
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Doxorubicin (DOX) stimulates the generation of reactive oxygen species, thereby impairing mitochondrial functions. Angiotensin‑converting enzyme inhibitors (ACEIs) have been identified to exhibit protective effects on cardiovascular diseases. The present study aimed to test the hypothesis that an ACEI benazepril hydrochloride (HCl) may protect against DOX‑induced cardiotoxicity. The DOX injury model was established using rat embryonic cardiac myoblast cells (H9c2 cell line) treated with DOX in vitro. H9c2 cells were treated with benazepril‑HCl, DOX or a mixture of DOX and benazepril‑HCl to measure the activities of myocardial enzymes including lactate dehydrogenase (LDH), superoxide dismutase, catalase and glutathione peroxidase, in addition to the concentration of malondialdehyde in the culture medium. Cells without any treatment were used as a control. DOX treatment increased the levels of activity of myocardial enzymes in H9c2 cells compared with those in the untreated control cells. Additionally, co‑treatment with benazepril‑HCl significantly reduced the levels of apoptosis occurring due to DOX‑mediated cellular damage. The mechanistic experiment revealed that pretreatment with benazepril‑HCl counteracted the DOX‑induced oxidative stress and suppressed the activation of apoptosis via the PI3K/Akt signaling pathway. By contrast, an Akt inhibitor (MK2206) inhibited the protective effects of benazepril‑HCl against DOX‑induced H9c2 cell injury, as revealed by increased LDH release in H9c2 cells. These results suggested that benazepril‑HCl may potentially be administered as an adjuvant for DOX in long‑term clinical use.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rosen MR, Myerburg RJ, Francis DP, Cole GD and Marbán E: Translating stem cell research to cardiac disease therapies: Pitfalls and prospects for improvement. J Am Coll Cardiol. 64:922–937. 2014.PubMed/NCBI View Article : Google Scholar

2 

Khouri MG, Klein MR, Velazquez EJ and Jones LW: Current and emerging modalities for detection of cardiotoxicity in cardio-oncology. Future Cardiol. 11:471–484. 2015.PubMed/NCBI View Article : Google Scholar

3 

Angsutararux P, Luanpitpong S and Issaragrisil S: Chemotherapy-induced cardiotoxicity: Overview of the roles of oxidative stress. Oxid Med Cell Longev. 2015(795602)2015.PubMed/NCBI View Article : Google Scholar

4 

Ma ZG, Kong CY, Wu HM, Song P, Zhang X, Yuan YP, Deng W and Tang QZ: Toll-like receptor 5 deficiency diminishes doxorubicin-induced acute cardiotoxicity in mice. Theranostics. 10:11013–11025. 2020.PubMed/NCBI View Article : Google Scholar

5 

Cappetta D, De Angelis A, Sapio L, Prezioso L, Illiano M, Quaini F, Rossi F, Berrino L, Naviglio S and Urbanek K: Oxidative stress and cellular response to doxorubicin: A common factor in the complex milieu of anthracycline cardiotoxicity. Oxid Med Cell Longev. 2017(1521020)2017.PubMed/NCBI View Article : Google Scholar

6 

Nithipongvanitch R, Ittarat W, Cole MP, Tangpong J, Clair DK and Oberley TD: Mitochondrial and nuclear p53 localization in cardiomyocytes: Redox modulation by doxorubicin (Adriamycin)? Antioxid Redox Signal. 9:1001–1008. 2007.PubMed/NCBI View Article : Google Scholar

7 

Phaniendra A, Jestadi DB and Periyasamy L: Free radicals: Properties, sources, targets, and their implication in various diseases. Indian J Clin Biochem. 30:11–26. 2015.PubMed/NCBI View Article : Google Scholar

8 

Murabito A, Hirsch E and Ghigo A: Mechanisms of anthracycline-induced cardiotoxicity: Is mitochondrial dysfunction the answer? Front Cardiovasc Med. 7(35)2020.PubMed/NCBI View Article : Google Scholar

9 

Wallace KB, Sardão VA and Oliveira PJ: Mitochondrial determinants of doxorubicin-induced cardiomyopathy. Circ Res. 126:926–941. 2020.PubMed/NCBI View Article : Google Scholar

10 

Fu X, Kong L, Tang M, Zhang J, Zhou X, Li G, Wang H and Fu F: Protective effect of ocotillol against doxorubicin-induced acute and chronic cardiac injury. Mol Med Rep. 9:360–364. 2014.PubMed/NCBI View Article : Google Scholar

11 

Wang H, Yu P, Gou H, Zhang J, Zhu M, Wang ZH, Tian JW, Jiang YT and Fu FH: Cardioprotective effects of 20 (S)-ginsenoside Rh2 against doxorubicin-induced cardiotoxicity in vitro and in vivo. Evid Based Complement Alternat Med. 2012(506214)2012.PubMed/NCBI View Article : Google Scholar

12 

Nazmi AS, Ahmad SJ, Pillai KK, Akhtar M, Ahmad A and Najmi AK: Protective effects of Bombyx mori, quercetin and benazepril against doxorubicin induced cardiotoxicity and nephrotoxicity. J Saudi Chem Soc. 20 (Suppl 1):S573–S578. 2016.

13 

Ganatra S, Nohria A, Shah S, Groarke JD, Sharma A, Venesy D, Patten R, Gunturu K, Zarwan C, Neilan TG, et al: Upfront dexrazoxane for the reduction of anthracycline-induced cardiotoxicity in adults with preexisting cardiomyopathy and cancer: A consecutive case series. Cardiooncology. 5(1)2019.PubMed/NCBI View Article : Google Scholar

14 

Sacco G, Bigioni M, Evangelista S, Goso C, Manzini S and Maggi CA: Cardioprotective effects of zofenopril, a new angiotensin-converting enzyme inhibitor, on doxorubicin-induced cardiotoxicity in the rat. Eur J Pharmacol. 414:71–78. 2001.PubMed/NCBI View Article : Google Scholar

15 

Guglin M, Munster P, Fink A and Krischer J: Lisinopril or Coreg CR in reducing cardiotoxicity in women with breast cancer receiving trastuzumab: A rationale and design of a randomized clinical trial. Am Heart J. 188:87–92. 2017.PubMed/NCBI View Article : Google Scholar

16 

Spallarossa P, Guerrini M, Arboscello E and Sicbaldi V: Enalapril and carvedilol for preventing chemotherapy-induced left ventricular systolic dysfunction. J Am Coll Cardiol. 62:2451–2452. 2013.PubMed/NCBI View Article : Google Scholar

17 

Choi HS, Park ES, Kang HJ, Shin HY, Noh CI, Yun YS, Ahn HS and Choi JY: Dexrazoxane for preventing anthracycline cardiotoxicity in children with solid tumors. J Korean Med Sci. 25:1336–1342. 2010.PubMed/NCBI View Article : Google Scholar

18 

Octavia Y, Tocchetti CG, Gabrielson KL, Janssens S, Crijns HJ and Moens AL: Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 52:1213–1225. 2012.PubMed/NCBI View Article : Google Scholar

19 

Zablocki D and Sadoshima J: Angiotensin II and oxidative stress in the failing heart. Antioxid Redox Signal. 19:1095–1109. 2013.PubMed/NCBI View Article : Google Scholar

20 

King JN, Font A, Rousselot JF, Ash RA, Bonfanti U, Brovida C, Crowe ID, Lanore D, Pechereau D, Seewald W and Strehlau G: Effects of benazepril on survival of dogs with chronic kidney disease: A multicenter, randomized, blinded, placebo-controlled clinical trial. J Vet Intern Med. 31:1113–1122. 2017.PubMed/NCBI View Article : Google Scholar

21 

Chan KK, Buch A, Glazer RD, John VA and Barr WH: Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers. Pharm Res. 11:432–437. 1994.PubMed/NCBI View Article : Google Scholar

22 

Muñoz-Durango N, Fuentes CA, Castillo AE, González-Gómez LM, Vecchiola A, Fardella CE and Kalergis A: Role of the renin-angiotensin-aldosterone system beyond blood pressure regulation: Molecular and cellular mechanisms involved in end-organ damage during arterial hypertension. Int J Mol Sci. 17(797)2016.PubMed/NCBI View Article : Google Scholar

23 

Parving HH: Diabetic nephropathy. Prevention and treatment. Kidney Int. 60:2041–2055. 2001.PubMed/NCBI View Article : Google Scholar

24 

Yim HE and Yoo KH: Renin-angiotensin system-considerations for hypertension and kidney. Electrolyte Blood Press. 6:42–50. 2008.PubMed/NCBI View Article : Google Scholar

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

26 

Wang Z, Wang J, Xie R, Xie R, Liu R and Lu Y: Mitochondria-derived reactive oxygen species play an important role in doxorubicin-induced platelet apoptosis. Int J Mol Sci. 16:11087–11100. 2015.PubMed/NCBI View Article : Google Scholar

27 

Kuyumcu F and Aycan A: Evaluation of oxidative stress levels and antioxidant enzyme activities in burst fractures. Med Sci Monit. 24:225–234. 2018.PubMed/NCBI View Article : Google Scholar

28 

Ma ZG, Yuan YP, Xu SC, Wei WY, Xu CR, Zhang X, Wu QQ, Liao HH, Ni J and Tang QZ: CTRP3 attenuates cardiac dysfunction, inflammation, oxidative stress and cell death in diabetic cardiomyopathy in rats. Diabetologia. 60:1126–1137. 2017.PubMed/NCBI View Article : Google Scholar

29 

Kumari H, Huang WH and Chan MWY: Review on the role of epigenetic modifications in doxorubicin-induced cardiotoxicity. Front Cardiovasc Med. 7(56)2020.PubMed/NCBI View Article : Google Scholar

30 

Munger MA: Use of angiotensin receptor blockers in cardiovascular protection: Current evidence and future directions. P T. 36:22–40. 2011.PubMed/NCBI

31 

Haybar H, Shahrabi S, Deris Zayeri Z and Pezeshki S: Strategies to increase cardioprotection through cardioprotective chemokines in chemotherapy-induced cardiotoxicity. Int J Cardiol. 269:276–282. 2018.PubMed/NCBI View Article : Google Scholar

32 

Yakubova A, Thorrez L, Svetlichnyy D, Zwarts L, Vulsteke V, Laenen G, Oosterlinck W, Moreau Y, Dehaspe L, Van Houdt J, et al: ACE-inhibition induces a cardioprotective transcriptional response in the metabolic syndrome heart. Sci Rep. 8(16169)2018.PubMed/NCBI View Article : Google Scholar

33 

Gujral DM, Lloyd G and Bhattacharyya S: Effect of prophylactic betablocker or ACE inhibitor on cardiac dysfunction and heart failure during anthracycline chemotherapy ± trastuzumab. Breast. 37:64–71. 2018.PubMed/NCBI View Article : Google Scholar

34 

Steele JL, Henik RA and Stepien RL: Effects of angiotensin-converting enzyme inhibition on plasma aldosterone concentration, plasma renin activity, and blood pressure in spontaneously hypertensive cats with chronic renal disease. Vet Ther. 3:157–166. 2002.PubMed/NCBI

35 

Wan W, Jiang X, Li X, Zhang C and Yi X: Silencing of angiotensin-converting enzyme by RNA interference prevents H9c2 cardiomyocytes from apoptosis induced by anoxia/reoxygenation through regulation of the intracellular renin-angiotensin system. Int J Mol Med. 32:1380–1386. 2013.PubMed/NCBI View Article : Google Scholar

36 

Li YW, Li YM, Hon Y, Wan QL, He RL, Wang ZZ and Zhao CH: AT1 receptor modulator attenuates the hypercholesterolemia-induced impairment of the myocardial ischemic post-conditioning benefits. Korean Circ J. 47:182–192. 2017.PubMed/NCBI View Article : Google Scholar

37 

Nie P, Meng F, Zhang J, Wei X and Shen C: Astragaloside IV exerts a myocardial protective effect against cardiac hypertrophy in rats, partially via activating the Nrf2/HO-1 signaling pathway. Oxid Med Cell Longev. 2019(4625912)2019.PubMed/NCBI View Article : Google Scholar

38 

Maron BA and Leopold JA: Aldosterone receptor antagonists: Effective but often forgotten. Circulation. 121:934–939. 2010.PubMed/NCBI View Article : Google Scholar

39 

Gorini S, De Angelis A, Berrino L, Malara N, Rosano G and Ferraro E: Chemotherapeutic drugs and mitochondrial dysfunction: Focus on doxorubicin, trastuzumab, and sunitinib. Oxid Med Cell Longev. 2018(7582730)2018.PubMed/NCBI View Article : Google Scholar

40 

Jing S, Sun G, Cui X, Meng X, Qin M and Sun X: Myricitrin protects against doxorubicin-induced cardiotoxicity by counteracting oxidative stress and inhibiting mitochondrial apoptosis via ERK/P53 pathway. Evid Based Complement Alternat Medi. 2016(6093783)2016.PubMed/NCBI View Article : Google Scholar

41 

Varga ZV, Ferdinandy P, Liaudet L and Pacher P: Drug-induced mitochondrial dysfunction and cardiotoxicity. Am J Physiol Heart Circ Physiol. 309:H1453–H1467. 2015.PubMed/NCBI View Article : Google Scholar

42 

Mantawy EM, El-Bakly WM, Esmat A, Badr AM and EI-Demerdash E: Chrysin alleviates acute doxorubicin cardiotoxicity in rats via suppression of oxidative stress, inflammation and apoptosis. Eur J Pharmacol. 728:107–118. 2014.PubMed/NCBI View Article : Google Scholar

43 

Kurutas EB: The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: Current state. Nutr J. 15(71)2016.PubMed/NCBI View Article : Google Scholar

44 

Wu YZ, Zhang L, Wu ZX, Shan TT and Xiong C: Berberine ameliorates doxorubicin-induced cardiotoxicity via a SIRT1/p66Shc-mediated pathway. Oxid Med Cell Longev. 2019(2150394)2019.PubMed/NCBI View Article : Google Scholar

45 

Malik ZA, Singh M and Sharma PL: Neuroprotective effect of momordica charantia in global cerebral ischemia and reperfusion induced neuronal damage in diabetic mice. J Ethnopharmacol. 133:729–734. 2011.PubMed/NCBI View Article : Google Scholar

46 

Jiang M, Li J, Peng Q, Liu Y, Liu W, Luo C, Peng J, Li J, Yung KK and Mo Z: Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation. J Neuroinflammation. 11(167)2014.PubMed/NCBI View Article : Google Scholar

47 

Singal PK, Li T, Kumar D, Danelisen I and Iliskovic N: Adriamycin-induced heart failure: Mechanism and modulation. Mol Cell Biochem. 207:77–86. 2000.PubMed/NCBI View Article : Google Scholar

48 

Taniyama Y and Walsh K: Elevated myocardial Akt signaling ameliorates doxorubicin-induced congestive heart failure and promotes heart growth. J Mol Cell Cardiol. 34:1241–1247. 2002.PubMed/NCBI View Article : Google Scholar

49 

Timolati F, Ott D, Pentassuglia L, Giraud MN, Perriard JC, Suter TM and Zuppinger C: Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol. 41:845–854. 2006.PubMed/NCBI View Article : Google Scholar

50 

Lai HC, Liu TJ, Ting CT, Sharma PM and Wang PH: Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI3 kinase/Akt pathway. Mol Cell Endocrinol. 205:99–106. 2003.PubMed/NCBI View Article : Google Scholar

51 

Watkins SJ, Borthwick GM and Arthur HM: The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro. In Vitro Cell Dev Biol Anim. 47:125–131. 2001.PubMed/NCBI View Article : Google Scholar

52 

Branco AF, Pereira SP, Susana G, Gusev O, Rizvanov AA and Olivira PJ: Gene expression profiling of H9c2 myoblast differentiation towards a cardiac-like phenotype. PLoS One. 10(e0129303)2015.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhan L, Wang X, Zhang Y, Zhu G, Ding Y, Chen X, Jiang W and Wu S: Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway. Exp Ther Med 22: 1082, 2021.
APA
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X. ... Wu, S. (2021). Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway. Experimental and Therapeutic Medicine, 22, 1082. https://doi.org/10.3892/etm.2021.10516
MLA
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X., Jiang, W., Wu, S."Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway". Experimental and Therapeutic Medicine 22.4 (2021): 1082.
Chicago
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X., Jiang, W., Wu, S."Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1082. https://doi.org/10.3892/etm.2021.10516
Copy and paste a formatted citation
x
Spandidos Publications style
Zhan L, Wang X, Zhang Y, Zhu G, Ding Y, Chen X, Jiang W and Wu S: Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway. Exp Ther Med 22: 1082, 2021.
APA
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X. ... Wu, S. (2021). Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway. Experimental and Therapeutic Medicine, 22, 1082. https://doi.org/10.3892/etm.2021.10516
MLA
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X., Jiang, W., Wu, S."Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway". Experimental and Therapeutic Medicine 22.4 (2021): 1082.
Chicago
Zhan, L., Wang, X., Zhang, Y., Zhu, G., Ding, Y., Chen, X., Jiang, W., Wu, S."Benazepril hydrochloride protects against doxorubicin cardiotoxicity by regulating the PI3K/Akt pathway". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1082. https://doi.org/10.3892/etm.2021.10516
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team