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Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study

  • Authors:
    • Caterina Maria Grillo
    • Luigi Maiolino
    • Agnese Maria Chiara Rapisarda
    • Giuseppe Caruso
    • Gaia Palermo
    • Salvatore Caruso
  • View Affiliations / Copyright

    Affiliations: Department of Medical and Surgical Sciences and Advanced Technologies ‘G. Ingrassia’, ENT Section, University of Catania, I-95124 Catania, Italy, Department of General Surgery and Medical Surgical Specialties, Gynecological Clinic, Research Group for Sexology, University of Catania, I-95124 Catania, Italy, Department BIOMETEC, University of Catania, I-95124 Catania, Italy
    Copyright: © Grillo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1103
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    Published online on: August 2, 2021
       https://doi.org/10.3892/etm.2021.10537
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Abstract

The present study aimed to evaluate the effects of 2 mg drospirenone (DRSP) and 1 mg 17β‑estradiol (E2) hormone therapy (HT) in combination with rehabilitation therapy for postmenopausal women with Meniere's disease (MD). The combined drug hormone treatment was denoted as DRSP/E2. A total of 65 postmenopausal female patients with MD and severe distress were enrolled in the present prospective study. A total of 31 women comprised the study group (group A), undergoing HT and rehabilitation therapy, whereas 34 women who opted for rehabilitation therapy alone comprised the control group (group B). Vestibular function and distress associated with MD were assessed by stabilometry and the Dizziness Handicap Inventory (DHI) questionnaire, respectively. The data were collected at baseline and during the 3‑ and 6‑month follow‑up visits. The areas of the stabilometric ellipses exhibited a higher reduction in group A compared with group B with regard to the baseline values at both follow‑up assessments (P<0.001). At baseline, both groups exhibited severe self‑perceived discomfort, with similar DHI scores of 72.3±3.7 (group A) and 70.6±3.9 (group B; P=0.07). At the 3‑month follow‑up, both groups underwent a gradual improvement, which was significantly higher in group A (47.5±3.7) compared with in group B (64.2±3.3; P<0.001). At the 6‑month follow‑up, the DHI scores were improved in group A (43.4±3.4) compared with in group B (58.5±3.1; P<0.001). Therefore, DRSP/E2 HT was effective in reducing the fluid overload, which is characteristic of MD. The findings of the present study demonstrated that integrated therapy based on the administration of DRSP/E2 HT and rehabilitation may be more effective compared with rehabilitation alone for the management of postmenopausal exacerbation of MD.
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Copy and paste a formatted citation
Spandidos Publications style
Grillo CM, Maiolino L, Rapisarda AM, Caruso G, Palermo G and Caruso S: Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study. Exp Ther Med 22: 1103, 2021.
APA
Grillo, C.M., Maiolino, L., Rapisarda, A.M., Caruso, G., Palermo, G., & Caruso, S. (2021). Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study. Experimental and Therapeutic Medicine, 22, 1103. https://doi.org/10.3892/etm.2021.10537
MLA
Grillo, C. M., Maiolino, L., Rapisarda, A. M., Caruso, G., Palermo, G., Caruso, S."Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study". Experimental and Therapeutic Medicine 22.4 (2021): 1103.
Chicago
Grillo, C. M., Maiolino, L., Rapisarda, A. M., Caruso, G., Palermo, G., Caruso, S."Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1103. https://doi.org/10.3892/etm.2021.10537
Copy and paste a formatted citation
x
Spandidos Publications style
Grillo CM, Maiolino L, Rapisarda AM, Caruso G, Palermo G and Caruso S: Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study. Exp Ther Med 22: 1103, 2021.
APA
Grillo, C.M., Maiolino, L., Rapisarda, A.M., Caruso, G., Palermo, G., & Caruso, S. (2021). Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study. Experimental and Therapeutic Medicine, 22, 1103. https://doi.org/10.3892/etm.2021.10537
MLA
Grillo, C. M., Maiolino, L., Rapisarda, A. M., Caruso, G., Palermo, G., Caruso, S."Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study". Experimental and Therapeutic Medicine 22.4 (2021): 1103.
Chicago
Grillo, C. M., Maiolino, L., Rapisarda, A. M., Caruso, G., Palermo, G., Caruso, S."Effects of hormone therapy containing 2 mg drospirenone and 1 mg 17β‑estradiol on postmenopausal exacerbation of Meniere's disease: Preliminary study". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1103. https://doi.org/10.3892/etm.2021.10537
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