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Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review)

  • Authors:
    • Ioana Rădulescu
    • Ana Miruna Drăgoi
    • Simona Corina Trifu
    • Mihai Bogdan Cristea
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    Affiliations: Faculty of Psychology and Educational Sciences, University of Bucharest, 050663 Bucharest, Romania, Department of Psychiatry, ‘Prof. Dr. Alex. Obregia’ Clinical Hospital of Psychiatry, 041914 Bucharest, Romania, Department of Clinical Neurosciences, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Morphological Sciences, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Copyright: © Rădulescu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1131
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    Published online on: August 5, 2021
       https://doi.org/10.3892/etm.2021.10565
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Abstract

In modern society, depression is one of the most common mental illness; however, its pathophysiology is not yet fully understood. A great body of evidence suggests that depression causes changes in neuroplasticity in specific regions of the brain which are correlated to symptom severity, negative emotional rumination as well as fear learning. Depression is correlated with atrophy of neurons in the cortical and limbic brain regions that control mood and emotion. Antidepressant therapy can exhibit effects on neuroplasticity and reverse the neuroanatomical changes found in depressed patients. The investigation of fast‑acting agents that reverse behavioral and neuronal deficiencies of chronic depression, especially the glutamate receptor antagonist NMDA ketamine, and the cellular mechanisms underlying the rapid antidepressant actions of ketamine and related agents are of real interest in current research. Actual medication such as serotonin (5‑HT) selective reuptake inhibitor (SSRI) antidepressants, require weeks to months of administration before a clear therapeutic response. The current review aimed to underline the negative effects of depression on neuroplasticity and present the current findings on the effects of antidepressant medication.
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Copy and paste a formatted citation
Spandidos Publications style
Rădulescu I, Drăgoi AM, Trifu SC and Cristea MB: Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review). Exp Ther Med 22: 1131, 2021.
APA
Rădulescu, I., Drăgoi, A.M., Trifu, S.C., & Cristea, M.B. (2021). Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review). Experimental and Therapeutic Medicine, 22, 1131. https://doi.org/10.3892/etm.2021.10565
MLA
Rădulescu, I., Drăgoi, A. M., Trifu, S. C., Cristea, M. B."Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1131.
Chicago
Rădulescu, I., Drăgoi, A. M., Trifu, S. C., Cristea, M. B."Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1131. https://doi.org/10.3892/etm.2021.10565
Copy and paste a formatted citation
x
Spandidos Publications style
Rădulescu I, Drăgoi AM, Trifu SC and Cristea MB: Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review). Exp Ther Med 22: 1131, 2021.
APA
Rădulescu, I., Drăgoi, A.M., Trifu, S.C., & Cristea, M.B. (2021). Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review). Experimental and Therapeutic Medicine, 22, 1131. https://doi.org/10.3892/etm.2021.10565
MLA
Rădulescu, I., Drăgoi, A. M., Trifu, S. C., Cristea, M. B."Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1131.
Chicago
Rădulescu, I., Drăgoi, A. M., Trifu, S. C., Cristea, M. B."Neuroplasticity and depression: Rewiring the brain's networks through pharmacological therapy (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1131. https://doi.org/10.3892/etm.2021.10565
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