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Molecular mechanisms in septic shock (Review)

  • Authors:
    • Gabriel Gorecki
    • Daniel Cochior
    • Cosmin Moldovan
    • Elena Rusu
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    Affiliations: Medicine Doctoral School, ‘Titu Maiorescu’ University of Bucharest, 040317 Bucharest, Romania, Faculty of Medicine, ‘Titu Maiorescu’ University of Bucharest, 031593 Bucharest, Romania
    Copyright: © Gorecki et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1161
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    Published online on: August 11, 2021
       https://doi.org/10.3892/etm.2021.10595
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Abstract

Sepsis is a clinical syndrome defined by the presence of infection and systemic inflammatory response to infection and results from a complex interaction between the host and infectious agents. It is characterized by the activation of multiple inflammatory pathways, with an increased risk of mortality. The incidence of sepsis has been on an ever‑increasing pathway in recent years. Sepsis can be induced by several clinical situations that predispose to its occurrence: malignant tumors, organ transplantation, AIDS, radiation therapy, burns, sores, polytrauma, diabetes mellitus, hepatic failure, renal failure, malnutrition, catheters or different invasive devices, and urinary catheters. The microorganisms involved in the pathogenesis of sepsis are Gram‑positive cocci (Staphylococci, Streptococci) and Gram‑negative bacilli (Klebsiella, Pseudomonas aeruginosa, E. coli), fungi (Candida), parasites, and viruses. Among mechanisms involved in septic shock production, two pathological phenomena appear: the profound decompensation of circulation and metabolic disturbances that evolve towards an irreversible state. The intimate mechanism of shock involves the activation of monocytes, macrophages and neutrophils by lipopolysaccharides of Gram‑negative bacteria. The microvascular bed is directly involved in the etiopathogenesis of disorders of acute inflammatory states associated with or without sepsis. A better comprehension of sepsis pathophysiology, especially the molecular mechanisms of septic shock, allows for new therapeutic perspectives.
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Copy and paste a formatted citation
Spandidos Publications style
Gorecki G, Cochior D, Moldovan C and Rusu E: Molecular mechanisms in septic shock (Review). Exp Ther Med 22: 1161, 2021.
APA
Gorecki, G., Cochior, D., Moldovan, C., & Rusu, E. (2021). Molecular mechanisms in septic shock (Review). Experimental and Therapeutic Medicine, 22, 1161. https://doi.org/10.3892/etm.2021.10595
MLA
Gorecki, G., Cochior, D., Moldovan, C., Rusu, E."Molecular mechanisms in septic shock (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1161.
Chicago
Gorecki, G., Cochior, D., Moldovan, C., Rusu, E."Molecular mechanisms in septic shock (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1161. https://doi.org/10.3892/etm.2021.10595
Copy and paste a formatted citation
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Spandidos Publications style
Gorecki G, Cochior D, Moldovan C and Rusu E: Molecular mechanisms in septic shock (Review). Exp Ther Med 22: 1161, 2021.
APA
Gorecki, G., Cochior, D., Moldovan, C., & Rusu, E. (2021). Molecular mechanisms in septic shock (Review). Experimental and Therapeutic Medicine, 22, 1161. https://doi.org/10.3892/etm.2021.10595
MLA
Gorecki, G., Cochior, D., Moldovan, C., Rusu, E."Molecular mechanisms in septic shock (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1161.
Chicago
Gorecki, G., Cochior, D., Moldovan, C., Rusu, E."Molecular mechanisms in septic shock (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1161. https://doi.org/10.3892/etm.2021.10595
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