Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2021 Volume 22 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review)

  • Authors:
    • Xiuhua Yang
    • Tao Meng
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1178
    |
    Published online on: August 13, 2021
       https://doi.org/10.3892/etm.2021.10612
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Recurrent pregnancy loss (RPL), pre‑eclampsia (PE), fetal growth restriction (FGR), and preterm delivery are examples of ‘great obstetrical syndromes’ (GOS). Placental dysfunction is the most common pathogenesis of GOS. In human pregnancies, the effects of uterine natural killer cells involve angiogenesis, promoting the remodeling of uterine spiral artery, and improving the invasion of trophoblast cells. The uNK cells supply killer immunoglobulin‑like receptors (KIRs), which come into contact with human leukocyte antigen‑C (HLA‑C) ligands expressed by extravillous trophoblast cells (EVTs). Numerous studies have investigated the association between GOS and KIR/HLA‑C combination. However, the outcomes have not been conclusive. The present review aimed to reveal the association between GOS and KIR/HLA‑C combination to screen out high‑risk pregnancies, strengthen the treatment of pregnancy complications, and reduce the frequency of adverse maternal and fetal outcomes. It has been reported that a female with a KIR AA genotype and a neonate with a paternal HLA‑C2 molecule is more prone to develop GOS and have a small fetus since less cytokines were secreted by uNK cells. Conversely, the combination of KIR BB haplotype (including the activating KIR2DS1) and HLA‑C2 can induce the production of cytokines and increase trophoblast invasion, leading to the birth of a large fetus. KIR/HLA‑C combinations may be applicable in selecting third‑party gametes or surrogates. Detection of maternal KIR genes and HLA‑C molecules from the couple could serve as useful markers for predicting and diagnosing GOS.
View Figures

Figure 1

View References

1 

Lopes MRU, Danowski A, Funke A, Rego J, Levy R and Andrade DCO: Update on antiphospholipid antibody syndrome. Rev Assoc Med Bras. 63:994–999. 2017.PubMed/NCBI View Article : Google Scholar

2 

Egeland GM, Skurtveit S, Staff AC, Eide GE, Daltveit AK, Klungsøyr K, Trogstad L, Magnus PM, Brantsæter AL and Haugen M: Pregnancy-related risk factors are associated with a significant burden of treated hypertension within 10 years of delivery: Findings from a population-based norwegian cohort. J Am Heart Assoc. 7(e008318)2018.PubMed/NCBI View Article : Google Scholar

3 

Brosens I, Pijnenborg R, Vercruysse L and Romero R: The ‘Great Obstetrical Syndromes’ are associated with disorders of deep placentation. Am J Obstet Gynecol. 204:193–201. 2011.PubMed/NCBI View Article : Google Scholar

4 

Vince GS, Starkey PM, Jackson MC, Sargent IL and Redman CW: Flow cytometric characterisation of cell populations in human pregnancy decidua and isolation of decidual macrophages. J Immunol Methods. 132:181–189. 1990.PubMed/NCBI View Article : Google Scholar

5 

Abrahams VM, Straszewski-Chavez SL, Guller S and Mor G: First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Mol Hum Reprod. 10:55–63. 2004.PubMed/NCBI View Article : Google Scholar

6 

Moffett-King A: Natural killer cells and pregnancy. Nat Rev Immunol. 2:656–663. 2002.PubMed/NCBI View Article : Google Scholar

7 

Yang X, Gilman-Sachs A and Kwak-Kim J: Ovarian and endometrial immunity during the ovarian cycle. J Reprod Immunol. 133:7–14. 2019.PubMed/NCBI View Article : Google Scholar

8 

Colucci F: The role of KIR and HLA interactions in pregnancy complications. Immunogenetics. 69:557–565. 2017.PubMed/NCBI View Article : Google Scholar

9 

Moffett A and Colucci F: Uterine NK cells: Active regulators at the maternal-fetal interface. J Clin Invest. 124:1872–1879. 2014.PubMed/NCBI View Article : Google Scholar

10 

Xiong S, Sharkey AM, Kennedy PR, Gardner L, Farrell LE, Chazara O, Bauer J, Hiby SE, Colucci F and Moffett A: Maternal uterine NK cell-activating receptor KIR2DS1 enhances placentation. J Clin Invest. 123:4264–4272. 2013.PubMed/NCBI View Article : Google Scholar

11 

Bulmer JN, Innes BA, Levey J, Robson SC and Lash GE: The role of vascular smooth muscle cell apoptosis and migration during uterine spiral artery remodeling in normal human pregnancy. FASEB J. 26:2975–2985. 2012.PubMed/NCBI View Article : Google Scholar

12 

Li C, Houser BL, Nicotra ML and Strominger JL: HLA-G homodimer-induced cytokine secretion through HLA-G receptors on human decidual macrophages and natural killer cells. Proc Natl Acad Sci USA. 106:5767–5772. 2009.PubMed/NCBI View Article : Google Scholar

13 

Hanna J, Goldman-Wohl D, Hamani Y, Avraham I, Greenfield C, Natanson-Yaron S, Prus D, Cohen-Daniel L, Arnon TI, Manaster I, et al: Decidual NK cells regulate key developmental processes at the human fetal-maternal interface. Nat Med. 12:1065–1074. 2006.PubMed/NCBI View Article : Google Scholar

14 

Hiby SE, Apps R, Sharkey AM, Farrell LE, Gardner L, Mulder A, Claas FH, Walker JJ, Redman CW, Morgan L, et al: Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2. J Clin Invest. 120:4102–4110. 2010.PubMed/NCBI View Article : Google Scholar

15 

Hiby SE, Regan L, Lo W, Farrell L, Carrington M and Moffett A: Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage. Hum Reprod. 23:972–976. 2008.PubMed/NCBI View Article : Google Scholar

16 

Ozturk OG, Sahin G, Karacor ED and Kucukgoz U: Evaluation of KIR genes in recurrent miscarriage. J Assist Reprod Genet. 29:933–938. 2012.PubMed/NCBI View Article : Google Scholar

17 

Nowak I, Malinowski A, Tchorzewski H, Barcz E, Wilczynski JR, Banasik M, Grybos M, Kurpisz M, Luszczek W, Majorczyk E, et al: HLA-C C1C2 heterozygosity may protect women bearing the killer immunoglobulin-like receptor AA genotype from spontaneous abortion. J Reprod Immunol. 88:32–37. 2011.PubMed/NCBI View Article : Google Scholar

18 

Faridi RM and Agrawal S: Killer immunoglobulin-like receptors (KIRs) and HLA-C allorecognition patterns implicative of dominant activation of natural killer cells contribute to recurrent miscarriages. Hum Reprod. 26:491–497. 2011.PubMed/NCBI View Article : Google Scholar

19 

Witt CS, Goodridge J, Gerbase-Delima MG, Daher S and Christiansen FT: Maternal KIR repertoire is not associated with recurrent spontaneous abortion. Hum Reprod. 19:2653–2657. 2004.PubMed/NCBI View Article : Google Scholar

20 

Hiby SE, Walker JJ, O'Shaughnessy KM, Redman CW, Carrington M, Trowsdale J and Moffett A: Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. J Exp Med. 200:957–965. 2004.PubMed/NCBI View Article : Google Scholar

21 

Nakimuli A, Chazara O, Hiby SE, Farrell L, Tukwasibwe S, Jayaraman J, Traherne JA, Trowsdale J, Colucci F, Lougee E, et al: A KIR B centromeric region present in Africans but not Europeans protects pregnant women from pre-eclampsia. Proc Natl Acad Sci USA. 112:845–850. 2015.PubMed/NCBI View Article : Google Scholar

22 

Sánchez-Rodríguez EN, Nava-Salazar S, Mendoza-Rodríguez CA, Moran C, Romero-Arauz JF, Ortega E, Granados J, Cervantes-Peredo A and Cerbón M: Persistence of decidual NK cells and KIR genotypes in healthy pregnant and preeclamptic women: A case-control study in the third trimester of gestation. Reprod Biol Endocrinol. 9(8)2011.PubMed/NCBI View Article : Google Scholar

23 

Yang X, Yang Y, Yuan Y, Liu L and Meng T: The roles of uterine natural killer (NK) cells and KIR/HLA-C combination in the development of preeclampsia: A systematic review. Biomed Res Int. 2020(4808072)2020.PubMed/NCBI View Article : Google Scholar

24 

Alecsandru D, Barrio A, Garrido N, Aparicio P, Pellicer A, Moffett A and García-Velasco JA: Parental human leukocyte antigen-C allotypes are predictive of live birth rate and risk of poor placentation in assisted reproductive treatment. Fertil Steril. 114:809–817. 2020.PubMed/NCBI View Article : Google Scholar

25 

Faridi RM, Das V, Tripthi G, Talwar S, Parveen F and Agrawal S: Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages. Hum Reprod. 24:1758–1764. 2009.PubMed/NCBI View Article : Google Scholar

26 

Yang X, Yang E, Wang WJ, He Q, Jubiz G, Katukurundage D, Dambaeva S, Beaman K and Kwak-Kim J: Decreased HLA-C1 alleles in couples of KIR2DL2 positive women with recurrent pregnancy loss. J Reprod Immunol. 142(103186)2020.PubMed/NCBI View Article : Google Scholar

27 

Sacks G: Enough! Stop the arguments and get on with the science of natural killer cell testing. Hum Reprod. 30:1526–1531. 2015.PubMed/NCBI View Article : Google Scholar

28 

Yagel S: The developmental role of natural killer cells at the fetal-maternal interface. Am J Obstet Gynecol. 201:344–350. 2009.PubMed/NCBI View Article : Google Scholar

29 

Abbas Y, Oefner CM, Polacheck WJ, Gardner L, Farrell L, Sharkey A, Kamm R, Moffett A and Oyen ML: A microfluidics assay to study invasion of human placental trophoblast cells. J R Soc Interface. 14(20170131)2017.PubMed/NCBI View Article : Google Scholar

30 

Kennedy PR, Chazara O, Gardner L, Ivarsson MA, Farrell LE, Xiong S, Hiby SE, Colucci F, Sharkey AM and Moffett A: Activating KIR2DS4 is expressed by uterine NK cells and contributes to successful pregnancy. J Immunol. 197:4292–4300. 2016.PubMed/NCBI View Article : Google Scholar

31 

Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z and Wei H: Natural killer cells promote fetal development through the secretion of growth-promoting factors. Immunity. 47:1100–1113.e6. 2017.PubMed/NCBI View Article : Google Scholar

32 

Lash GE, Schiessl B, Kirkley M, Innes BA, Cooper A, Searle RF, Robson SC and Bulmer JN: Expression of angiogenic growth factors by uterine natural killer cells during early pregnancy. J Leukoc Biol. 80:572–580. 2006.PubMed/NCBI View Article : Google Scholar

33 

Parham P and Moffett A: Variable NK cell receptors and their MHC class I ligands in immunity, reproduction and human evolution. Nat Rev Immunol. 13:133–144. 2013.PubMed/NCBI View Article : Google Scholar

34 

Lanier LL: NK cell recognition. Annu Rev Immunol. 23:225–274. 2005.PubMed/NCBI View Article : Google Scholar

35 

Shiroishi M, Tsumoto K, Amano K, Shirakihara Y, Colonna M, Braud VM, Allan DS, Makadzange A, Rowland-Jones S, Willcox B, et al: Human inhibitory receptors Ig-like transcript 2 (ILT2) and ILT4 compete with CD8 for MHC class I binding and bind preferentially to HLA-G. Proc Natl Acad Sci USA. 100:8856–8861. 2003.PubMed/NCBI View Article : Google Scholar

36 

King A, Hiby SE, Gardner L, Joseph S, Bowen JM, Verma S, Burrows TD and Loke YW: Recognition of trophoblast HLA class I molecules by decidual NK cell receptors-a review. Placenta. 21 (Suppl A):S81–S85. 2000.PubMed/NCBI View Article : Google Scholar

37 

Apps R, Murphy SP, Fernando R, Gardner L, Ahad T and Moffett A: Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology. 127:26–39. 2009.PubMed/NCBI View Article : Google Scholar

38 

Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song YJ, Yang L, French AR, Sunwoo JB, Lemieux S, Hansen TH and Yokoyama WM: Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature. 436:709–713. 2005.PubMed/NCBI View Article : Google Scholar

39 

Anfossi N, André P, Guia S, Falk CS, Roetynck S, Stewart CA, Breso V, Frassati C, Reviron D, Middleton D, et al: Human NK cell education by inhibitory receptors for MHC class I. Immunity. 25:331–342. 2006.PubMed/NCBI View Article : Google Scholar

40 

Yu J, Heller G, Chewning J, Kim S, Yokoyama WM and Hsu KC: Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. J Immunol. 179:5977–5989. 2007.PubMed/NCBI View Article : Google Scholar

41 

Fauriat C, Ivarsson MA, Ljunggren HG, Malmberg KJ and Michaëlsson J: Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. Blood. 115:1166–1174. 2010.PubMed/NCBI View Article : Google Scholar

42 

Moffett A and Colucci F: Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction. Immunol Rev. 267:283–297. 2015.PubMed/NCBI View Article : Google Scholar

43 

Koopman LA, Kopcow HD, Rybalov B, Boyson JE, Orange JS, Schatz F, Masch R, Lockwood CJ, Schachter AD, Park PJ and Strominger JL: Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med. 198:1201–1212. 2003.PubMed/NCBI View Article : Google Scholar

44 

Verma S, Hiby SE, Loke YW and King A: Human decidual natural killer cells express the receptor for and respond to the cytokine interleukin 15. Biol Reprod. 62:959–968. 2000.PubMed/NCBI View Article : Google Scholar

45 

Drake PM, Gunn MD, Charo IF, Tsou CL, Zhou Y, Huang L and Fisher SJ: Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. J Exp Med. 193:1199–1212. 2001.PubMed/NCBI View Article : Google Scholar

46 

Hanna J, Wald O, Goldman-Wohl D, Prus D, Markel G, Gazit R, Katz G, Haimov-Kochman R, Fujii N, Yagel S, et al: CXCL12 expression by invasive trophoblasts induces the specific migration of CD16-human natural killer cells. Blood. 102:1569–1577. 2003.PubMed/NCBI View Article : Google Scholar

47 

Hsu KC, Chida S, Geraghty DE and Dupont B: The killer cell immunoglobulin-like receptor (KIR) genomic region: Gene-order, haplotypes and allelic polymorphism. Immunol Rev. 190:40–52. 2002.PubMed/NCBI View Article : Google Scholar

48 

Alecsandru D and García-Velasco JA: Why natural killer cells are not enough: A further understanding of killer immunoglobulin-like receptor and human leukocyte antigen. Fertil Steril. 107:1273–1278. 2017.PubMed/NCBI View Article : Google Scholar

49 

Bashirova AA, Martin MP, McVicar DW and Carrington M: The killer immunoglobulin-like receptor gene cluster: Tuning the genome for defense. Annu Rev Genomics Hum Genet. 7:277–300. 2006.PubMed/NCBI View Article : Google Scholar

50 

Robinson J, Halliwell JA, McWilliam H, Lopez R and Marsh SG: IPD-the immuno polymorphism database. Nucleic Acids Res. 41(Database issue):D1234–D1240. 2013.PubMed/NCBI View Article : Google Scholar

51 

Gonzalez-Galarza FF, Christmas S, Middleton D and Jones AR: Allele frequency net: A database and online repository for immune gene frequencies in worldwide populations. Nucleic Acids Res. 39(Database issue):D913–D919. 2011.PubMed/NCBI View Article : Google Scholar

52 

Winter CC, Gumperz JE, Parham P, Long EO and Wagtmann N: Direct binding and functional transfer of NK cell inhibitory receptors reveal novel patterns of HLA-C allotype recognition. J Immunol. 161:571–577. 1998.PubMed/NCBI

53 

Morin SJ, Treff NR, Tao X, Scott RT III, Franasiak JM, Juneau CR, Maguire M and Scott RT: Combination of uterine natural killer cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences the risk of pregnancy loss: A retrospective cohort analysis of direct embryo genotyping data from euploid transfers. Fertil Steril. 107:677–683.e2. 2017.PubMed/NCBI View Article : Google Scholar

54 

Male V, Hughes T, McClory S, Colucci F, Caligiuri MA and Moffett A: Immature NK cells, capable of producing IL-22, are present in human uterine mucosa. J Immunol. 185:3913–3918. 2010.PubMed/NCBI View Article : Google Scholar

55 

Male V, Sharkey A, Masters L, Kennedy PR, Farrell LE and Moffett A: The effect of pregnancy on the uterine NK cell KIR repertoire. Eur J Immunol. 41:3017–3027. 2011.PubMed/NCBI View Article : Google Scholar

56 

Hilton HG and Parham P: Missing or altered self: Human NK cell receptors that recognize HLA-C. Immunogenetics. 69:567–579. 2017.PubMed/NCBI View Article : Google Scholar

57 

Hong Y, Wang X, Lu P, Song Y and Lin Q: Killer immunoglobulin-like receptor repertoire on uterine natural killer cell subsets in women with recurrent spontaneous abortions. Eur J Obstet Gynecol Reprod Biol. 140:218–223. 2008.PubMed/NCBI View Article : Google Scholar

58 

Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss. Fertil Steril. 89(1603)2008.PubMed/NCBI View Article : Google Scholar

59 

Varla-Leftherioti M, Spyropoulou-Vlachou M, Niokou D, Keramitsoglou T, Darlamitsou A, Tsekoura C, Papadimitropoulos M, Lepage V, Balafoutas C and Stavropoulos-Giokas C: Natural killer (NK) cell receptors' repertoire in couples with recurrent spontaneous abortions. Am J Reprod Immunol. 49:183–191. 2003.PubMed/NCBI View Article : Google Scholar

60 

Flores AC, Marcos CY, Paladino N, Arruvito L, Williams F, Middleton D and Fainboim L: KIR receptors and HLA-C in the maintenance of pregnancy. Tissue Antigens. 69 (Suppl 1):S112–S113. 2007.PubMed/NCBI View Article : Google Scholar

61 

Wang S, Zhao YR, Jiao YL, Wang LC, Li JF, Cui B, Xu CY, Shi YH and Chen ZJ: Increased activating killer immunoglobulin-like receptor genes and decreased specific HLA-C alleles in couples with recurrent spontaneous abortion. Biochem Biophys Res Commun. 360:696–701. 2007.PubMed/NCBI View Article : Google Scholar

62 

Vargas RG, Bompeixe EP, Franca PP, Marques de Moraes M and da Graca Bicalho M: Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage. Am J Reprod Immunol. 62:34–43. 2009.PubMed/NCBI View Article : Google Scholar

63 

Wang S, Li YP, Ding B, Zhao YR, Chen ZJ, Xu CY, Fu YB and Wang XT: Recurrent miscarriage is associated with a decline of decidual natural killer cells expressing killer cell immunoglobulin-like receptors specific for human leukocyte antigen C. J Obstet Gynaecol Res. 40:1288–1295. 2014.PubMed/NCBI View Article : Google Scholar

64 

Dambaeva SV, Lee DH, Sung N, Chen CY, Bao S, Gilman-Sachs A, Kwak-Kim J and Beaman KD: Recurrent pregnancy loss in women with killer cell immunoglobulin-like receptor KIR2DS1 is associated with an increased HLA-C2 allelic frequency. Am J Reprod Immunol. 75:94–103. 2016.PubMed/NCBI View Article : Google Scholar

65 

Elbaşı MO, Tulunay A, Karagözoğlu H, Kahraman S and Ekşioğlu-Demiralp E: Maternal killer-cell immunoglobulin-like receptors and paternal human leukocyte antigen ligands in recurrent pregnancy loss cases in Turkey. Clin Exp Reprod Med. 47:122–129. 2020.PubMed/NCBI View Article : Google Scholar

66 

Alecsandru D, Garrido N, Vicario JL, Barrio A, Aparicio P, Requena A and García-Velasco JA: Maternal KIR haplotype influences live birth rate after double embryo transfer in IVF cycles in patients with recurrent miscarriages and implantation failure. Hum Reprod. 29:2637–2643. 2014.PubMed/NCBI View Article : Google Scholar

67 

Varla-Leftherioti M, Spyropoulou-Vlachou M, Keramitsoglou T, Papadimitropoulos M, Tsekoura C, Graphou O, Papadopoulou C, Gerondi M and Stavropoulos-Giokas C: Lack of the appropriate natural killer cell inhibitory receptors in women with spontaneous abortion. Hum Immunol. 66:65–71. 2005.PubMed/NCBI View Article : Google Scholar

68 

Clark DA, Chaouat G, Wong K, Gorczynski RM and Kinsky R: Tolerance mechanisms in pregnancy: A reappraisal of the role of class I paternal MHC antigens. Am J Reprod Immunol. 63:93–103. 2010.PubMed/NCBI View Article : Google Scholar

69 

Nowak I, Malinowski A, Tchorzewski H, Barcz E, Wilczynski JR, Grybos M, Kurpisz M, Luszczek W, Banasik M, Reszczynska-Slezak D, et al: Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion. J Appl Genet. 50:391–398. 2009.PubMed/NCBI View Article : Google Scholar

70 

Yamada H, Shimada S, Kato EH, Morikawa M, Iwabuchi K, Kishi R, Onoé K and Minakami H: Decrease in a specific killer cell immunoglobulin-like receptor on peripheral natural killer cells in women with recurrent spontaneous abortion of unexplained etiology. Am J Reprod Immunol. 51:241–247. 2004.PubMed/NCBI View Article : Google Scholar

71 

Varla-Leftherioti M: The significance of the women's repertoire of natural killer cell receptors in the maintenance of pregnancy. Chem Immunol Allergy. 89:84–95. 2005.PubMed/NCBI View Article : Google Scholar

72 

Ntrivalas EI, Bowser CR, Kwak-Kim J, Beaman KD and Gilman-Sachs A: Expression of killer immunoglobulin-like receptors on peripheral blood NK cell subsets of women with recurrent spontaneous abortions or implantation failures. Am J Reprod Immunol. 53:215–221. 2005.PubMed/NCBI View Article : Google Scholar

73 

Akbari S, Shahsavar F, Karami R, Yari F, Anbari K and Ahmadi SAY: Recurrent spontaneous abortion (RSA) and maternal KIR genes: A comprehensive meta-analysis. JBRA Assist Reprod. 24:197–213. 2020.PubMed/NCBI View Article : Google Scholar

74 

Hiby SE, Apps R, Chazara O, Farrell LE, Magnus P, Trogstad L, Gjessing HK, Carrington M and Moffett A: Maternal KIR in combination with paternal HLA-C2 regulate human birth weight. J Immunol. 192:5069–5073. 2014.PubMed/NCBI View Article : Google Scholar

75 

Yang X and Meng T: MiR-215-5p decreases migration and invasion of trophoblast cells through regulating CDC6 in preeclampsia. Cell Biochem Funct. 38:472–479. 2020.PubMed/NCBI View Article : Google Scholar

76 

Kelemu T, Erlandsson L, Seifu D, Hansson E, Abebe M, Teklu S, Girma S, Traherne JA, Moffett A and Hansson SR: Polymorphism in killer cell immunoglobulin-like receptors and human leukocyte antigen-c and predisposition to preeclampsia in Ethiopian pregnant women population. J Reprod Immunol. 141(103169)2020.PubMed/NCBI View Article : Google Scholar

77 

Huhn O, Chazara O, Ivarsson MA, Retière C, Venkatesan TC, Norman PJ, Hilton HG, Jayaraman J, Traherne JA, Trowsdale J, et al: High-resolution genetic and phenotypic analysis of KIR2DL1 alleles and their association with pre-eclampsia. J Immunol. 201:2593–2601. 2018.PubMed/NCBI View Article : Google Scholar

78 

Saito S, Takeda Y, Sakai M, Nakabayahi M and Hayakawa S: The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men. J Reprod Immunol. 70:93–98. 2006.PubMed/NCBI View Article : Google Scholar

79 

Long W, Shi Z, Fan S, Liu L, Lu Y, Guo X, Rong C, Cui X and Ding H: Association of maternal KIR and fetal HLA-C genes with the risk of preeclampsia in the Chinese Han population. Placenta. 36:433–437. 2015.PubMed/NCBI View Article : Google Scholar

80 

Gentle NL, Loubser S, Paximadis M, Puren A and Tiemessen CT: Killer-cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) class I genetic diversity in four South African populations. Hum Immunol. 78:503–509. 2017.PubMed/NCBI View Article : Google Scholar

81 

Higuma-Myojo S, Sasaki Y, Miyazaki S, Sakai M, Siozaki A, Miwa N and Saito S: Cytokine profile of natural killer cells in early human pregnancy. Am J Reprod Immunol. 54:21–29. 2005.PubMed/NCBI View Article : Google Scholar

82 

Nakimuli A, Chazara O, Byamugisha J, Elliott AM, Kaleebu P, Mirembe F and Moffett A: Pregnancy, parturition and preeclampsia in women of African ancestry. Am J Obstet Gynecol. 210:510–520.e1. 2014.PubMed/NCBI View Article : Google Scholar

83 

Wallace AE, Whitley GS, Thilaganathan B and Cartwright JE: Decidual natural killer cell receptor expression is altered in pregnancies with impaired vascular remodeling and a higher risk of pre-eclampsia. J Leukoc Biol. 97:79–86. 2015.PubMed/NCBI View Article : Google Scholar

84 

Larsen TG, Hackmon R, Geraghty DE and Hviid TVF: Fetal human leukocyte antigen-C and maternal killer-cell immunoglobulin-like receptors in cases of severe preeclampsia. Placenta. 75:27–33. 2019.PubMed/NCBI View Article : Google Scholar

85 

Moffett A, Hiby SE and Sharkey AM: The role of the maternal immune system in the regulation of human birthweight. Philos Trans R Soc Lond B Biol Sci. 370(20140071)2015.PubMed/NCBI View Article : Google Scholar

86 

Clark MM, Chazara O, Sobel EM, Gjessing HK, Magnus P, Moffett A and Sinsheimer JS: Human birth weight and reproductive immunology: Testing for interactions between maternal and offspring KIR and HLA-C genes. Hum Hered. 81:181–193. 2016.PubMed/NCBI View Article : Google Scholar

87 

Hilton HG, Vago L, Older Aguilar AM, Moesta AK, Graef T, Abi-Rached L, Norman PJ, Guethlein LA, Fleischhauer K and Parham P: Mutation at positively selected positions in the binding site for HLA-C shows that KIR2DL1 is a more refined but less adaptable NK cell receptor than KIR2DL3. J Immunol. 189:1418–1430. 2012.PubMed/NCBI View Article : Google Scholar

88 

Madeja Z, Yadi H, Apps R, Boulenouar S, Roper SJ, Gardner L, Moffett A, Colucci F and Hemberger M: Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth. Proc Natl Acad Sci USA. 108:4012–4017. 2011.PubMed/NCBI View Article : Google Scholar

89 

Kieckbusch J, Gaynor LM, Moffett A and Colucci F: MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling. Nat Commun. 5(3359)2014.PubMed/NCBI View Article : Google Scholar

90 

Skjaerven R, Vatten LJ, Wilcox AJ, Rønning T, Irgens LM and Lie RT: Recurrence of pre-eclampsia across generations: Exploring fetal and maternal genetic components in a population based cohort. BMJ. 331(877)2005.PubMed/NCBI View Article : Google Scholar

91 

Hiby SE, Ashrafian-Bonab M, Farrell L, Single RM, Balloux F, Carrington M, Moffett A and Ebrahimi Z: Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations. Immunogenetics. 62:65–73. 2010.PubMed/NCBI View Article : Google Scholar

92 

Vukcevic D, Traherne JA, Næss S, Ellinghaus E, Kamatani Y, Dilthey A, Lathrop M, Karlsen TH, Franke A, Moffatt M, et al: Imputation of KIR types from SNP variation data. Am J Hum Genet. 97:593–607. 2015.PubMed/NCBI View Article : Google Scholar

93 

Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M, Meyer KB, Park JE, Stephenson E, Polański K, Goncalves A, et al: Single-cell reconstruction of the early maternal-fetal interface in humans. Nature. 563:347–353. 2018.PubMed/NCBI View Article : Google Scholar

94 

Moffett A, Chazara O, Colucci F and Johnson MH: Variation of maternal KIR and fetal HLA-C genes in reproductive failure: Too early for clinical intervention. Reprod Biomed Online. 33:763–769. 2016.PubMed/NCBI View Article : Google Scholar

95 

Chaouat G: Reconsidering the Medawar paradigm placental viviparity existed for eons, even in vertebrates; without a ‘problem’: Why are Tregs important for preeclampsia in great apes? J Reprod Immunol. 114:48–57. 2016.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang X and Meng T: Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review). Exp Ther Med 22: 1178, 2021.
APA
Yang, X., & Meng, T. (2021). Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review). Experimental and Therapeutic Medicine, 22, 1178. https://doi.org/10.3892/etm.2021.10612
MLA
Yang, X., Meng, T."Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1178.
Chicago
Yang, X., Meng, T."Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1178. https://doi.org/10.3892/etm.2021.10612
Copy and paste a formatted citation
x
Spandidos Publications style
Yang X and Meng T: Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review). Exp Ther Med 22: 1178, 2021.
APA
Yang, X., & Meng, T. (2021). Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review). Experimental and Therapeutic Medicine, 22, 1178. https://doi.org/10.3892/etm.2021.10612
MLA
Yang, X., Meng, T."Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review)". Experimental and Therapeutic Medicine 22.4 (2021): 1178.
Chicago
Yang, X., Meng, T."Killer‑cell immunoglobulin‑like receptor/human leukocyte antigen‑C combination and ‘great obstetrical syndromes’ (Review)". Experimental and Therapeutic Medicine 22, no. 4 (2021): 1178. https://doi.org/10.3892/etm.2021.10612
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team