Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Gain of TPPP as a predictor of progression in patients with bladder cancer

  • Authors:
    • Ying-Hsu Chang
    • Po-Hung Lin
    • Chin-Chang Chen
    • Wen-Hui Weng
    • Kai-Jie Yu
    • Chung-Yi Liu
    • Chin-Hsuan Hsieh
    • Tzu-Hsuan Chang
    • I-Hung Shao
    • Hung-Cheng Kan
    • Cheng-Keng Chuang
    • See-Tong Pang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, New Taipei Municipal Tucheng Hospital, Chang Gung Memorial Hospital, New Taipei City 236017, Taiwan, R.O.C., Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan 33305, Taiwan, R.O.C., Department of Chemical Engineering and Biotechnology and Graduate Institute of Biochemical and Biomedical Engineering, National Taipei University of Technology, Taipei 10608, Taiwan, R.O.C.
  • Article Number: 1204
    |
    Published online on: August 24, 2021
       https://doi.org/10.3892/etm.2021.10638
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study investigated the role of tubulin polymerization promoting protein (TPPP) in the regulation of bladder cancer (BC) cell proliferation and migration, in addition to the association between TPPP gene copy number amplification and clinicopathological characteristics of BC. TPPP gene amplification was measured in human BC epithelial cells and samples obtained from 52 patients with BC via fluorescence in situ hybridization. TPPP gain was defined as mean TPPP copy number >2.2 per nucleus (cutoff). The neutrophil‑to‑lymphocyte ratio (NLR) was also obtained from the preoperative data of the patients. For in vitro assays, BC cell lines were transfected with either TPPP small interfering RNAs or scrambled control, following which cell proliferation and migration were determined using Cell Counting Kit‑8 and Transwell migration assays, respectively. The percentage of cells with TPPP copy number amplification in the four BC epithelial cell lines (MGH‑U1, ‑U1R, ‑U3, ‑U4) examined (86.0‑100.0%) was found to be higher compared with that in the normal human uroepithelial cell lines (3.0 and 9.0%). Patients were divided into one‑ (1.9%), two‑ (55.8%), three‑ (7.7%), four‑ (26.9%) and five‑copy (7.7%) types. Results calculated using Fisher's exact test indicated that the gain of TPPP in patients with BC associated significantly with age (P<0.05), advanced histological grade (P<0.001), tumor stage (P<0.05), histological type (P<0.001) and NLR (P<0.05). In MGH‑U1R and MGH‑U4 cells, cell proliferation and migration were revealed to be significantly lower following TPPP knockdown compared with those in cells transfected with the scrambled control. In conclusion, findings from the present study suggest that TPPP is important for cell proliferation, cell migration and BC progression, such that TPPP copy number assessment would be advised for preoperative urine cytology for urothelial neoplasia diagnosis.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2019. CA Cancer J Clin. 69:7–34. 2019.PubMed/NCBI View Article : Google Scholar

2 

Polo A, Crispo A, Cerino P, Falzone L, Candido S, Giudice A, De Petro G, Ciliberto G, Montella M, Budillon A and Costantini S: Environment and bladder cancer: Molecular analysis by interaction networks. Oncotarget. 8:65240–65252. 2017.PubMed/NCBI View Article : Google Scholar

3 

Goebell PJ and Knowles MA: Bladder cancer or bladder cancers? Genetically distinct malignant conditions of the urothelium. Urol Oncol. 28:409–428. 2010.PubMed/NCBI View Article : Google Scholar

4 

Sanguedolce F, Bufo P, Carrieri G and Cormio L: Predictive markers in bladder cancer: Do we have molecular markers ready for clinical use? Crit Rev Clin Lab Sci. 51:291–304. 2014.PubMed/NCBI View Article : Google Scholar

5 

Hernández S, López-Knowles E, Lloreta J, Kogevinas M, Amorós A, Tardón A, Carrato A, Serra C, Malats N and Real FX: Prospective study of FGFR3 mutations as a prognostic factor in nonmuscle invasive urothelial bladder carcinomas. J Clin Oncol. 24:3664–3671. 2006.PubMed/NCBI View Article : Google Scholar

6 

Lamy A, Gobet F, Laurent M, Blanchard F, Varin C, Moulin C, Andreou A, Frebourg T and Pfister C: Molecular profiling of bladder tumors based on the detection of FGFR3 and TP53 mutations. J Urol. 176:2686–2689. 2006.PubMed/NCBI View Article : Google Scholar

7 

Lopez-Knowles E, Hernández S, Kogevinas M, Lloreta J, Amorós A, Tardón A, Carrato A, Kishore S, Serra C, Malats N, et al: The p53 pathway and outcome among patients with T1G3 bladder tumors. Clin Cancer Res. 12:6029–6036. 2006.PubMed/NCBI View Article : Google Scholar

8 

Dominguez G, Carballido J, Silva J, Silva JM, García JM, Menéndez J, Provencio M, España P and Bonilla F: p14ARF promoter hypermethylation in plasma DNA as an indicator of disease recurrence in bladder cancer patients. Clin Cancer Res. 8:980–985. 2002.PubMed/NCBI

9 

Brown FM: Urine cytology. It is still the gold standard for screening? Urol Clin North Am. 27:25–37. 2000.PubMed/NCBI View Article : Google Scholar

10 

Chuang KL, Chuang HC, Ng KF, Chang YH, Wu CT, Chuang CK, Liao SK and Pang ST: Urinary fluorescence in situ hybridization assay for detecting urothelial carcinoma in Taiwanese patients. BJU Int. 105:1413–1416. 2010.PubMed/NCBI View Article : Google Scholar

11 

Mischinger J, Guttenberg LP, Hennenlotter J, Gakis G, Aufderklamm S, Rausch S, Neumann E, Bedke J, Kruck S, Schwentner C, et al: Comparison of different concepts for interpretation of chromosomal aberrations in urothelial cells detected by fluorescence in situ hybridization. J Cancer Res Clin Oncol. 143:677–685. 2017.PubMed/NCBI View Article : Google Scholar

12 

Molitor M, Junker K, Eltze E, Toma M, Denzinger S, Siegert S, Knuechel R and Gaisa NT: Comparison of structural genetics of non-schistosoma-associated squamous cell carcinoma of the urinary bladder. Int J Clin Exp Pathol. 8:8143–8158. 2015.PubMed/NCBI

13 

Moktefi A, Pouessel D, Liu J, Sirab N, Maille P, Soyeux P, Bergman CC, Auriault ML, Vordos D, Taille A, et al: Reappraisal of HER2 status in the spectrum of advanced urothelial carcinoma: A need of guidelines for treatment eligibility. Mod Pathol. 31:1270–1281. 2018.PubMed/NCBI View Article : Google Scholar

14 

Lengauer C, Kinzler KW and Vogelstein B: Genetic instabilities in human cancers. Nature. 396:643–649. 1998.PubMed/NCBI View Article : Google Scholar

15 

Hanahan D and Weinberg RA: The hallmarks of cancer. Cell. 100:57–70. 2000.PubMed/NCBI View Article : Google Scholar

16 

Wu CF, Pang ST, Shee JJ, Chang PL, Chuang CK, Chen CS, Liao SK and Weng WH: Identification of genetic alterations in upper urinary tract urothelial carcinoma in end-stage renal disease patients. Genes Chromosomes Cancer. 49:928–934. 2010.PubMed/NCBI View Article : Google Scholar

17 

Yamamoto Y, Chochi Y, Matsuyama H, Eguchi S, Kawauchi S, Furuya T, Oga A, Kang JJ, Naito K and Sasaki K: Gain of 5p15.33 is associated with progression of bladder cancer. Oncology. 72:132–138. 2007.PubMed/NCBI View Article : Google Scholar

18 

Kang JU, Koo SH, Kwon KC, Park JW and Kim JM: Gain at chromosomal region 5p15.33, containing TERT, is the most frequent genetic event in early stages of non-small cell lung cancer. Cancer Genet Cytogenetics. 182:1–11. 2008.PubMed/NCBI View Article : Google Scholar

19 

Takahashi M, Tomizawa K, Fujita SC, Sato K, Uchida T and Imahori K: A brain-specific protein p25 is localized and associated with oligodendrocytes, neuropil, and fiber-like structures of the CA3 hippocampal region in the rat brain. J Neurochem. 60:228–235. 1993.PubMed/NCBI View Article : Google Scholar

20 

Kovács GG, László L, Kovács J, Jensen PH, Lindersson E, Botond G, Molnár T, Perczel A, Hudecz F, Mezo G, et al: Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies. Neurobiol Dis. 17:155–162. 2004.PubMed/NCBI View Article : Google Scholar

21 

Hlavanda E, Kovacs J, Olah J, Orosz F, Medzihradszky KF and Ovadi J: Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations. Biochemistry. 41:8657–8664. 2002.PubMed/NCBI View Article : Google Scholar

22 

Acevedo K, Li R, Soo P, Suryadinata R, Sarcevic B, Valova VA, Graham ME, Robinson PJ and Bernard O: The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules. Exp Cell Res. 313:4091–4106. 2007.PubMed/NCBI View Article : Google Scholar

23 

Hlavanda E, Klement E, Kókai E, Kovács J, Vincze O, Tökési N, Orosz F, Medzihradszky KF, Dombrádi V and Ovádi J: Phosphorylation blocks the activity of tubulin polymerization-promoting protein (TPPP): Identification of sites targeted by different kinases. J Biol Chem. 282:29531–29539. 2007.PubMed/NCBI View Article : Google Scholar

24 

Tirian L, Hlavanda E, Oláh J, Horváth I, Orosz F, Szabó B, Kovács J, Szabad J and Ovádi J: TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation. Proc Natl Acad Sci USA. 100:13976–13981. 2003.PubMed/NCBI View Article : Google Scholar

25 

Zotter A, Bodor A, Olah J, Hlavanda E, Orosz F, Perczel A and Ovádi J: Disordered TPPP/p25 binds GTP and displays Mg2+-dependent GTPase activity. FEBS Lett. 585:803–808. 2011.PubMed/NCBI View Article : Google Scholar

26 

Inokawa Y, Sonohara F, Kanda M, Hayashi M, Nishikawa Y, Sugimoto H, Kodera Y and Nomoto S: Correlation between poor prognosis and lower TPPP gene expression in hepatocellular carcinoma. Anticancer Res. 36:4639–4645. 2016.PubMed/NCBI View Article : Google Scholar

27 

Edge SB and Edge SB: AJCC Cancer Staging Manual, 8th edition. Springer, 2017.

28 

Chuang CK, Pang ST, Chuang TJ and Liao SK: Profiling of matrix metalloproteinases and tissue inhibitors of metalloproteinases proteins in bladder urothelial carcinoma. Oncol Lett. 1:691–695. 2010.PubMed/NCBI View Article : Google Scholar

29 

Kato T, Ishikawa K and Nemoto R: Morphologic characterization of two established cell lines, T24 and MGH-U1, derived from human bladder carcinoma (author's transl). Nihon Hinyokika Gakkai Zasshi. 69(40)1978.PubMed/NCBI View Article : Google Scholar : (In Japanese).

30 

Floyd JW, Lin CW and Prout GR Jr: Multi-drug resistance of a doxorubicin-resistant bladder cancer cell line. J Urol. 144:169–171. 1990.PubMed/NCBI View Article : Google Scholar

31 

Lin CW, Lin JC and Prout GR: Establishment and characterization of four human bladder tumor cell lines and sublines with different degrees of malignancy. Cancer Res. 45:5070–5079. 1985.PubMed/NCBI

32 

Weng WH, Chen YT, Yu KJ, Chang YH, Chuang CK and Pang ST: Genetic alterations of HER genes in chromophobe renal cell carcinoma. Oncol Lett. 11:2111–2116. 2016.PubMed/NCBI View Article : Google Scholar

33 

Dogan S, Becker JC, Rekhtman N, Tang LH, Nafa K, Ladanyi M and Klimstra DS: Use of touch imprint cytology as a simple method to enrich tumor cells for molecular analysis. Cancer Cytopathol. 121:354–360. 2013.PubMed/NCBI View Article : Google Scholar

34 

Ozyalvacli ME, Ozyalvacli G, Kocaaslan R, Cecen K, Uyeturk U, Kemahlı E and Gucuk A: Neutrophil-lymphocyte ratio as a predictor of recurrence and progression in patients with high-grade pT1 bladder cancer. Can Urol Assoc J. 9:E126–E131. 2015.PubMed/NCBI View Article : Google Scholar

35 

Sarosdy MF, Kahn PR, Ziffer MD, Love WR, Barkin J, Abara EO, Jansz K, Bridge JA, Johansson SL, Persons DL and Gibson JS: Use of a multitarget fluorescence in situ hybridization assay to diagnose bladder cancer in patients with hematuria. J Urology. 176:44–47. 2006.PubMed/NCBI View Article : Google Scholar

36 

Pan A, Zhou Y, Mu K, Liu Y, Sun F, Li P and Li L: Detection of gene copy number alterations in DCIS and invasive breast cancer by QM-FISH. Am J Transl Res. 8:4994–5004. 2016.PubMed/NCBI

37 

Silva MP, Barros-Silva JD, Vieira J, Lisboa S, Torres L, Correia C, Vieira-Coimbra M, Martins AT, Jerónimo C, Henrique R, et al: NCOA2 is a candidate target gene of 8q gain associated with clinically aggressive prostate cancer. Genes Chromosomes Cancer. 55:365–374. 2016.PubMed/NCBI View Article : Google Scholar

38 

Colotta F, Allavena P, Sica A, Garlanda C and Mantovani A: Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability. Carcinogenesis. 30:1073–1081. 2009.PubMed/NCBI View Article : Google Scholar

39 

Mantovani A, Allavena P, Sica A and Balkwill F: Cancer-related inflammation. Nature. 454:436–444. 2008.PubMed/NCBI View Article : Google Scholar

40 

Azab B, Bhatt VR, Phookan J, Murukutla S, Kohn N, Terjanian T and Widmann WD: Usefulness of the neutrophil-to-lymphocyte ratio in predicting short- and long-term mortality in breast cancer patients. Ann Surg Oncol. 19:217–224. 2012.PubMed/NCBI View Article : Google Scholar

41 

Halazun KJ, Hardy MA, Rana AA, Woodland DC IV, Luyten EJ, Mahadev S, Witkowski P, Siegel AB, Brown RS Jr and Emond JC: Negative impact of neutrophil-lymphocyte ratio on outcome after liver transplantation for hepatocellular carcinoma. Ann Surg. 250:141–151. 2009.PubMed/NCBI View Article : Google Scholar

42 

Jung MR, Park YK, Jeong O, Seon JW, Ryu SY, Kim DY and Kim YJ: Elevated preoperative neutrophil to lymphocyte ratio predicts poor survival following resection in late stage gastric cancer. J Surg Oncol. 104:504–510. 2011.PubMed/NCBI View Article : Google Scholar

43 

Cho H, Hur HW, Kim SW, Kim SH, Kim JH, Kim YT and Lee K: Pre-treatment neutrophil to lymphocyte ratio is elevated in epithelial ovarian cancer and predicts survival after treatment. Cancer Immunol Iimmunother. 58:15–23. 2009.PubMed/NCBI View Article : Google Scholar

44 

Eble JN SG, Epstein JI and Sesterhenn IAD (eds): World health organization classification of tumors. Tumors of the urinary system and genital male organs. IARC Press, Lyon., 2004.

45 

Polesel J, Bosetti C, di Maso M, Montella M, Libra M, Garbeglio A, Zucchetto A, Turati F, Talamini R, La Vecchia C and Serraino D: Duration and intensity of tobacco smoking and the risk of papillary and non-papillary transitional cell carcinoma of the bladder. Cancer Causes Control. 25:1151–1158. 2014.PubMed/NCBI View Article : Google Scholar

46 

Schroeder A, Heller DA, Winslow MM, Dahlman JE, Pratt GW, Langer R, Jacks T and Anderson DG: Treating metastatic cancer with nanotechnology. Nat Rev Cancer. 12:39–50. 2011.PubMed/NCBI View Article : Google Scholar

47 

Kaverina I and Straube A: Regulation of cell migration by dynamic microtubules. In: Seminars in cell & developmental biology Elsevier, pp968-974, 2011.

48 

Jordan MA and Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer. 4:253–265. 2004.PubMed/NCBI View Article : Google Scholar

49 

Schofield AV, Steel R and Bernard O: Rho-associated coiled-coil kinase (ROCK) protein controls microtubule dynamics in a novel signaling pathway that regulates cell migration. J Biol Chemistry. 287:43620–43629. 2012.PubMed/NCBI View Article : Google Scholar

50 

Schofield AV, Gamell C, Suryadinata R, Sarcevic B and Bernard O: Tubulin polymerization promoting protein 1 (Tppp1) phosphorylation by Rho-associated coiled-coil kinase (rock) and cyclin-dependent kinase 1 (Cdk1) inhibits microtubule dynamics to increase cell proliferation. J Biol Chem. 288:7907–7917. 2013.PubMed/NCBI View Article : Google Scholar

51 

Gamell C, Schofield AV, Suryadinata R, Sarcevic B and Bernard O: LIMK2 mediates resistance to chemotherapeutic drugs in neuroblastoma cells through regulation of drug-induced cell cycle arrest. PLoS One. 8(e72850)2013.PubMed/NCBI View Article : Google Scholar

52 

Chen Q, Yang C, Chen L, Zhang JJ, Ge WL, Yuan H, Meng LD, Huang XM, Shen P, Miao Y and Jiang KR: YY1 targets tubulin polymerisation-promoting protein to inhibit migration, invasion and angiogenesis in pancreatic cancer via p38/MAPK and PI3K/AKT pathways. Br J Cancer. 121:912–921. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chang Y, Lin P, Chen C, Weng W, Yu K, Liu C, Hsieh C, Chang T, Shao I, Kan H, Kan H, et al: Gain of TPPP as a predictor of progression in patients with bladder cancer. Exp Ther Med 22: 1204, 2021.
APA
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C. ... Pang, S. (2021). Gain of TPPP as a predictor of progression in patients with bladder cancer. Experimental and Therapeutic Medicine, 22, 1204. https://doi.org/10.3892/etm.2021.10638
MLA
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C., Hsieh, C., Chang, T., Shao, I., Kan, H., Chuang, C., Pang, S."Gain of TPPP as a predictor of progression in patients with bladder cancer". Experimental and Therapeutic Medicine 22.5 (2021): 1204.
Chicago
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C., Hsieh, C., Chang, T., Shao, I., Kan, H., Chuang, C., Pang, S."Gain of TPPP as a predictor of progression in patients with bladder cancer". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1204. https://doi.org/10.3892/etm.2021.10638
Copy and paste a formatted citation
x
Spandidos Publications style
Chang Y, Lin P, Chen C, Weng W, Yu K, Liu C, Hsieh C, Chang T, Shao I, Kan H, Kan H, et al: Gain of TPPP as a predictor of progression in patients with bladder cancer. Exp Ther Med 22: 1204, 2021.
APA
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C. ... Pang, S. (2021). Gain of TPPP as a predictor of progression in patients with bladder cancer. Experimental and Therapeutic Medicine, 22, 1204. https://doi.org/10.3892/etm.2021.10638
MLA
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C., Hsieh, C., Chang, T., Shao, I., Kan, H., Chuang, C., Pang, S."Gain of TPPP as a predictor of progression in patients with bladder cancer". Experimental and Therapeutic Medicine 22.5 (2021): 1204.
Chicago
Chang, Y., Lin, P., Chen, C., Weng, W., Yu, K., Liu, C., Hsieh, C., Chang, T., Shao, I., Kan, H., Chuang, C., Pang, S."Gain of TPPP as a predictor of progression in patients with bladder cancer". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1204. https://doi.org/10.3892/etm.2021.10638
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team