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Review

Current research developments of patient‑derived tumour xenograft models (Review)

  • Authors:
    • Zhenyu Yin
    • Ewetse Paul Maswikiti
    • Qian Liu
    • Yuping Bai
    • Xiaomei Li
    • Wenbo Qi
    • Le Liu
    • Yanling Ma
    • Hao Chen
  • View Affiliations / Copyright

    Affiliations: The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730030, P.R. China, Department of Oncology, Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, P.R. China
  • Article Number: 1206
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    Published online on: August 24, 2021
       https://doi.org/10.3892/etm.2021.10640
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Abstract

Patient‑derived tumor xenograft (PDTX) models are established by transferring patient tumors into immunodeficient mice. In these murine models, the characteristics of the primary tumor are retained, including the microenvironment of tumor cell growth and histopathology. Due to this, it has become the most reliable in vivo human cancer model. However, the success rates differ by type of tumor, site of transplantation and tumor aggressiveness. Subcutaneous transplantation is a standard method for PDTX, and subrenal capsule transplantation improves the engraftment rate. Recently, PDTX models are frequently used in the fields of precision medicine, predictive biomarkers, evaluation of drug efficacy and preclinical research on tumor immunotherapeutic drugs. The aim of the present article was to review the establishment, clinical applications and limitations of the PDTX model in tumor research.
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Copy and paste a formatted citation
Spandidos Publications style
Yin Z, Maswikiti EP, Liu Q, Bai Y, Li X, Qi W, Liu L, Ma Y and Chen H: Current research developments of patient‑derived tumour xenograft models (Review). Exp Ther Med 22: 1206, 2021.
APA
Yin, Z., Maswikiti, E.P., Liu, Q., Bai, Y., Li, X., Qi, W. ... Chen, H. (2021). Current research developments of patient‑derived tumour xenograft models (Review). Experimental and Therapeutic Medicine, 22, 1206. https://doi.org/10.3892/etm.2021.10640
MLA
Yin, Z., Maswikiti, E. P., Liu, Q., Bai, Y., Li, X., Qi, W., Liu, L., Ma, Y., Chen, H."Current research developments of patient‑derived tumour xenograft models (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1206.
Chicago
Yin, Z., Maswikiti, E. P., Liu, Q., Bai, Y., Li, X., Qi, W., Liu, L., Ma, Y., Chen, H."Current research developments of patient‑derived tumour xenograft models (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1206. https://doi.org/10.3892/etm.2021.10640
Copy and paste a formatted citation
x
Spandidos Publications style
Yin Z, Maswikiti EP, Liu Q, Bai Y, Li X, Qi W, Liu L, Ma Y and Chen H: Current research developments of patient‑derived tumour xenograft models (Review). Exp Ther Med 22: 1206, 2021.
APA
Yin, Z., Maswikiti, E.P., Liu, Q., Bai, Y., Li, X., Qi, W. ... Chen, H. (2021). Current research developments of patient‑derived tumour xenograft models (Review). Experimental and Therapeutic Medicine, 22, 1206. https://doi.org/10.3892/etm.2021.10640
MLA
Yin, Z., Maswikiti, E. P., Liu, Q., Bai, Y., Li, X., Qi, W., Liu, L., Ma, Y., Chen, H."Current research developments of patient‑derived tumour xenograft models (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1206.
Chicago
Yin, Z., Maswikiti, E. P., Liu, Q., Bai, Y., Li, X., Qi, W., Liu, L., Ma, Y., Chen, H."Current research developments of patient‑derived tumour xenograft models (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1206. https://doi.org/10.3892/etm.2021.10640
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