Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review

Neuroendocrine neoplasia and bone (Review)

  • Authors:
    • Adina Ghemigian
    • Mara Carsote
    • Florica Sandru
    • Razvan-Cosmin Petca
    • Ana-Maria Oproiu
    • Aida Petca
    • Ana Valea
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Dermatology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Urology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Plastic and Reconstructive Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Endocrinology, ‘I. Hatieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania
  • Article Number: 1219
    |
    Published online on: August 26, 2021
       https://doi.org/10.3892/etm.2021.10653
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

This is a narrative review focusing on neuroendocrine neoplasia (NEN) and bone status, in terms of metastases and osteoporosis/fractures. One fifth of NEN have skeletal dissemination, this affinity being regulated by intrinsic tumor factors such as the C‑X‑C chemokine receptor 4 (CXCR4). Bone colonization impairs the patient quality of life, representing a surrogate of reduced survival. Patients with NEN without bone metastases may exhibit low bone mineral density, perhaps carcinoid‑related osteoporosis, yet not a standardized cause of osteoporosis. Case‑finding strategies to address bone health in NEN with a good prognosis are lacking. Contributors to fractures in NEN subjects may include: menopausal status and advanced age, different drugs, induced hypogonadism, malnutrition, malabsorption (due to intestinal resection, carcinoid syndrome), hypovitaminosis D, impaired glucose profile (due to excessive hormones such as glucagon, somatostatinoma or use of somatostatin analogues), various corticoid regimes, and high risk of fall due to sarcopenia. Pheocromocytoma/paraganglioma involve bone through malignant forms (bone is an elective site) and potential secondary osteoporosis due to excessive hormonal content and increased sympathetic activity which is a key player of bone microarchitecture/quality as reflected by low Trabecular Bone Score. Glucocorticoid osteoporosis is related to NEN‑associated ectopic Cushing syndrome. Currently, there are a lack of studies to emphasis that excessive gut‑derivate serotonin in NENs with carcinoid syndrome is a specific activator of bone loss thus a contributor to carcinoid‑related osteoporosis.
View Figures
View References

1 

Oberndorfer S: Karzinoide tumoren des dünndarms. In: Frankfurter Zeitschrift für Pathologie, pp426-429, 1907.

2 

Gill AJ: Why did they change that? Practical implications of the evolving classification of neuroendocrine tumours of the gastrointestinal tract. Histopathology. 78:162–170. 2021.PubMed/NCBI View Article : Google Scholar

3 

Guadagno E, D'Avella E, Cappabianca P, Colao A and Del Basso De Caro M: Ki67 in endocrine neoplasms: To count or not to count, this is the question! A systematic review from the English language literature. J Endocrinol Invest. 43:1429–1445. 2020.PubMed/NCBI View Article : Google Scholar

4 

Assarzadegan N and Montgomery E: What is new in the 2019 World Health Organization (WHO) classification of tumors of the digestive system: Review of selected updates on neuroendocrine neoplasms, appendiceal tumors, and molecular testing. Arch Pathol Lab Med. 145:664–677. 2021.PubMed/NCBI View Article : Google Scholar

5 

Zappalà G, McDonald PG and Cole SW: Tumor dormancy and the neuroendocrine system: An undisclosed connection? Cancer Metastasis Rev. 32:189–200. 2013.PubMed/NCBI View Article : Google Scholar

6 

Ramírez-Rentería C, Ferreira-Hermosillo A, Marrero-Rodríguez D, Taniguchi-Ponciano K, Melgar-Manzanilla V and Mercado M: An update on gastroenteropancreatic neuroendocrine neoplasms: From mysteries to paradigm shifts. Arch Med Res. 51:765–776. 2020.PubMed/NCBI View Article : Google Scholar

7 

Klöppel G and La Rosa S: Ki67 labeling index: Assessment and prognostic role in gastroenteropancreatic neuroendocrine neoplasms. Virchows Arch. 472:341–349. 2018.PubMed/NCBI View Article : Google Scholar

8 

Kim JY, Hong SM and Ro JY: Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol. 29:11–16. 2017.PubMed/NCBI View Article : Google Scholar

9 

Chauhan A, Yu Q, Ray N, Farooqui Z, Huang B, Durbin EB, Tucker T, Evers M, Arnold S and Anthony LB: Global burden of neuroendocrine tumors and changing incidence in Kentucky. Oncotarget. 9:19245–19254. 2018.PubMed/NCBI View Article : Google Scholar

10 

Sackstein PE, O'Neil DS, Neugut AI, Chabot J and Fojo T: Epidemiologic trends in neuroendocrine tumors: An examination of incidence rates and survival of specific patient subgroups over the past 20 years. Semin Oncol. 45:249–258. 2018.PubMed/NCBI View Article : Google Scholar

11 

Riihimäki M, Hemminki A, Sundquist K, Sundquist J and Hemminki K: The epidemiology of metastases in neuroendocrine tumors. Int J Cancer. 139:2679–2686. 2016.PubMed/NCBI View Article : Google Scholar

12 

Akimoto J, Fukuhara H, Suda T, Nagai K, Ichikawa M, Fukami S, Kohno M, Matsubayashi J and Nagao T: Clinicopathological analysis in patients with neuroendocrine tumors that metastasized to the brain. BMC Cancer. 16(36)2016.PubMed/NCBI View Article : Google Scholar

13 

Cives M, Quaresmini D, Rizzo FM, Felici C, D'Oronzo S, Simone V and Silvestris F: Osteotropism of neuroendocrine tumors: Role of the CXCL12/ CXCR4 pathway in promoting EMT in vitro. Oncotarget. 8:22534–22549. 2017.PubMed/NCBI View Article : Google Scholar

14 

Cives M, Pellè E, Rinzivillo M, Prosperi D, Tucci M, Silvestris F and Panzuto F: Bone metastases in neuroendocrine tumors: Molecular parhogenesis and implications in clinical practice. Neuroendocrinology. 111:207–216. 2021.PubMed/NCBI View Article : Google Scholar

15 

Harvey NC, McCloskey EV, Mitchell PJ, Dawson-Hughes B, Pierroz DD, Reginster JY, Rizzoli R, Cooper C and Kanis JA: Mind the (treatment) gap: A global perspective on current and future strategies for prevention of fragility fractures. Osteoporos Int. 28:1507–1529. 2017.PubMed/NCBI View Article : Google Scholar

16 

Liu J, Curtis EM, Cooper C and Harvey NC: State of the art in osteoporosis risk assessment and treatment. J Endocrinol Invest. 42:1149–1164. 2019.PubMed/NCBI View Article : Google Scholar

17 

Kanis JA, Svedbom A, Harvey N and McCloskey EV: The osteoporosis treatment gap. J Bone Miner Res. 29:1926–1928. 2014.PubMed/NCBI View Article : Google Scholar

18 

International Osteoporosis Foundation: https://www.osteoporosis.foundation/. Accessed April 1, 2021.

19 

Clynes MA, Harvey NC, Curtis EM, Fuggle NR, Dennison EM and Cooper C: The epidemiology of osteoporosis. Br Med Bull. 133:105–117. 2020.PubMed/NCBI View Article : Google Scholar

20 

Curtis EM, Woolford S, Holmes C, Cooper C and Harvey NC: General and specific considerations as to why osteoporosis-related care is often suboptimal. Curr Osteoporos Rep. 18:38–46. 2020.PubMed/NCBI View Article : Google Scholar

21 

Barton DW, Behrend CJ and Carmouche JJ: Rates of osteoporosis screening and treatment following vertebral fracture. Spine J. 19:411–417. 2019.PubMed/NCBI View Article : Google Scholar

22 

Söreskog E, Borgström F, Shepstone L, Clarke S, Cooper C, Harvey I, Harvey NC, Howe A, Johansson H, Marshall T, et al: Long-term cost-effectiveness of screening for fracture risk in a UK primary care setting: the SCOOP study. Osteoporos Int. 31:1499–1506. 2020.PubMed/NCBI View Article : Google Scholar

23 

Zamborsky R, Svec A, Kokavec M and Galbavy S: Bone metastases in neuroendocrine tumors. Bratisl Lek Listy. 118:529–534. 2017.PubMed/NCBI View Article : Google Scholar

24 

Koizumi M, Gokita T and Toda K: Impending atypical femoral fracture in patients with medullary thyroid cancer with skeletal metastasis treated with long-term bisphosphonate and denosumab. Clin Nucl Med. 42:463–464. 2017.PubMed/NCBI View Article : Google Scholar

25 

Carsote M, Valea A, Dumitru N, Terzea D, Petrova E, Albu S, Buruiana A and Ghemigian A: Metastases in daily endocrine practice. Arch Balk Med Union. 51:476–480. 2016.

26 

Rizzo FM, Vesely C, Childs A, Marafioti T, Khan MS, Mandair D, Cives M, Ensell L, Lowe H, Akarca AU, et al: Circulating tumour cells and their association with bone metastases in patients with neuroendocrine tumours. Br J Cancer. 120:294–300. 2019.PubMed/NCBI View Article : Google Scholar

27 

Zheng Z, Chen C, Jiang L, Zhou X, Dai X, Song Y and Li Y: Incidence and risk factors of gastrointestinal neuroendocrine neoplasm metastasis in liver, lung, bone, and brain: A population-based study. Cancer Med. 8:7288–7298. 2019.PubMed/NCBI View Article : Google Scholar

28 

Van Loon K, Zhang L, Keiser J, Carrasco C, Glass K, Ramirez MT, Bobiak S, Nakakura EK, Venook AP, Shah MH and Bergsland EK: Bone metastases and skeletal-related events from neuroendocrine tumors. Endocr Connect. 4:9–17. 2015.PubMed/NCBI View Article : Google Scholar

29 

Hori T, Yasuda T, Suzuki K, Kanamori M and Kimura T: Skeletal metastasis of carcinoid tumors: Two case reports and review of the literature. Oncol Lett. 3:1105–1108. 2012.PubMed/NCBI View Article : Google Scholar

30 

Trikalinos NA, Tan BR, Amin M, Liu J, Govindan R and Morgensztern D: Effect of metastatic site on survival in patients with neuroendocrine neoplasms (NENs). An analysis of SEER data from 2010 to 2014. BMC Endocr Disord. 20(44)2020.PubMed/NCBI View Article : Google Scholar

31 

Wang S and Zhang J, Liu S and Zhang J: The prognostic analysis of different metastatic patterns in pancreatic neuroendocrine tumors patients: A population based analysis. Medicine (Baltimore). 98(e17773)2019.PubMed/NCBI View Article : Google Scholar

32 

Deleval N, Pesque L, Dieudonné A, Viry F, Hentic O, Lebtahi R, Ruszniewski P and de Mestier L: Prognostic impact of bone metastases detected by 18F-DOPA PET in patients with metastatic midgut neuroendocrine tumors. Eur Radiol. 31:4166–4174. 2021.PubMed/NCBI View Article : Google Scholar

33 

Altieri B, Di Dato C, Modica R, Bottiglieri F, Di Sarno A, Pittaway JFH, Martini C, Faggiano A and Colao A: Bone metabolism and vitamin D implication in gastroenteropancreatic neuroendocrine tumors. Nutrients. 12(1021)2020.PubMed/NCBI View Article : Google Scholar

34 

Sen Gupta P, Grozinsky-Glasberg S, Drake WM, Akker SA, Perry L, Grossman AB and Druce MR: Are serotonin metabolite levels related to bone mineral density in patients with neuroendocrine tumours? Clin Endocrinol (Oxf). 80:246–252. 2014.PubMed/NCBI View Article : Google Scholar

35 

Jacobson A and Cunningham JL: Connective tissue growth factor in tumor pathogenesis. Fibrogenesis Tissue Repair. 5 (Suppl 1)(S8)2012.PubMed/NCBI View Article : Google Scholar

36 

Migut AE, Kaur H and Avritscher R: Neuroendocrine tumors: Imaging of treatment and follow-up. Radiol Clin North Am. 58:1161–1171. 2020.PubMed/NCBI View Article : Google Scholar

37 

Galgano SJ, Sharbidre K and Morgan DE: Multimodality imaging of neuroendocrine tumors. Radiol Clin North Am. 58:1147–1159. 2020.PubMed/NCBI View Article : Google Scholar

38 

Albu SE, Geleriu A, Carsote M, Mihai A, Vasiliu C and Poiana C: The vitamin D status in menopausal women. Arch Balk MedUnion. 50:275–277. 2015.

39 

Khashayar P, Meybodi HA, Amoabediny G and Larijani B: Biochemical markers of bone turnover and their role in osteoporosis diagnosis: A narrative review. Recent Pat Endocr Metab Immune Drug Discov. 9:79–89. 2015.PubMed/NCBI View Article : Google Scholar

40 

Centre for Metabolic Bone Diseases, University of Sheffield, UK: FRAX® Fracture Risk Assessment Tool: https://www.sheffield.ac.uk/FRAX/tool.aspx?country=9. Accessed April 1, 2021.

41 

Carsote M, Radu O, Dumitrascu A, Terzea D, Valea A and Ghemigian A: Bone and menopause: Threshold of intervention. Rom Med J. 63:233–236. 2016.

42 

Sandru F, Carsote M, Albu SE, Valea A, Petca A and Dumitrascu MC: Glucagonoma: From skin lesions to the neuroendocrine component (Review). Exp Ther Med. 20:3389–3393. 2020.PubMed/NCBI View Article : Google Scholar

43 

Byun J, Kim SH, Jeong HS, Rhee Y, Lee WJ and Kang CM: ACTH-producing neuroendocrine tumor of the pancreas: A case report and literature review. Ann Hepatobiliary Pancreat Surg. 21:61–65. 2017.PubMed/NCBI View Article : Google Scholar

44 

Sandru F, Carsote M, Dumitrascu MC, Albu SE and Valea A: Glucocorticoids and trabecular bone score. J Med Life. 13:449–453. 2020.PubMed/NCBI View Article : Google Scholar

45 

Kannivelu A, Loke KS, Kok TY, Osmany SY, Ali SZ, Suat-Jin L and Ng DC: The role of PET/CT in the evaluation of skeletal metastases. Semin Musculoskelet Radiol. 18:149–165. 2014.PubMed/NCBI View Article : Google Scholar

46 

Adkins J and Lu Y: Diffuse bone metastases in pancreatic neuroendocrine tumor shown on octreoscan. Clin Nucl Med. 44:257–258. 2019.PubMed/NCBI View Article : Google Scholar

47 

Gauthé M, Testart Dardel N, Ruiz Santiago F, Ohnona J, Nataf V, Montravers F and Talbot JN: Vertebral metastases from neuroendocrine tumours: How to avoid false positives on 68Ga-DOTA-TOC PET using CT pattern analysis? Eur Radiol. 28:3943–3952. 2018.PubMed/NCBI View Article : Google Scholar

48 

Lim KHJ, Raja H, D'Arienzo P, Barriuso J, McNamara MG, Hubner RA, Mansoor W, Valle JW and Lamarca A: Identification of areas for improvement in the management of bone metastases in patients with neuroendocrine neoplasms. Neuroendocrinology. 110:688–696. 2020.PubMed/NCBI View Article : Google Scholar

49 

Altieri B, Di Dato C, Martini C, Sciammarella C, Di Sarno A, Colao A and Faggiano A: NIKE Group. Bone metastases in neuroendocrine neoplasms: From pathogenesis to clinical management. Cancers (Basel). 11(1332)2019.PubMed/NCBI View Article : Google Scholar

50 

Alexandraki KI, Pizanias M, Uri I, Thomas D, Page T, Kolomodi D, Low CS, Adesanya O, Tsoli M, Gross DJ, et al: The prognosis and management of neuroendocrine neoplasms-related metastatic bone disease: Lessons from clinical practice. Endocrine. 64:690–701. 2019.PubMed/NCBI View Article : Google Scholar

51 

Zhang M, Zhao P, Shi X, Zhao A, Zhang L and Zhou L: Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: A large, retrospective single-centre study. BMC Endocr Disord. 17(39)2017.PubMed/NCBI View Article : Google Scholar

52 

Helbig G, Straczyńska-Niemiec A, Szewczyk I, Nowicka E, Bierzyńska-Macyszyn G and Kyrcz-Krzemień S: Unexpected cause of anemia: Metastasis of neuroendocrine tumor to the bone marrow. Pol Arch Med Wewn. 124:635–636. 2014.PubMed/NCBI

53 

Valea A, Carsote M, Ghervan C and Georgescu C: Glycemic profile in patients with acromegaly treated with somatostatin analogue. J Med Life. 8:82–86. 2015.PubMed/NCBI

54 

Lamarca A, Elliott E, Barriuso J, Backen A, McNamara MG, Hubner R and Valle JW: Chemotherapy for advanced non-pancreatic well-differentiated neuroendocrine tumours of the gastrointestinal tract, a systematic review and meta-analys: A lost cause? Cancer Treat Rev. 44:26–41. 2016.PubMed/NCBI View Article : Google Scholar

55 

Poiană C, Carşote M, Ardeleanu C, Terzea D, Avramescu ET, Neamţu MC and Miulescu RD: The value of the immunohistochemistry in a case of gastric neuroendocrine tumor and thyroid metastasis. Rom J Morphol Embryol. 52:187–192. 2011.PubMed/NCBI

56 

Watts NB: Postmenopausal osteoporosis: A clinical review. J Womens Health (Larchmt). 27:1093–1096. 2018.PubMed/NCBI View Article : Google Scholar

57 

Misiorowski W: Osteoporosis in men. Prz Menopauzalny. 16:70–73. 2017.PubMed/NCBI View Article : Google Scholar

58 

Cortellini A, Bozzetti F, Palumbo P, Brocco D, Di Marino P, Tinari N, De Tursi M, Agostinelli V, Patruno L, Valdesi C, et al: Weighing the role of skeletal muscle mass and muscle density in cancer patients receiving PD-1/PD-L1 checkpoint inhibitors: A multicenter real-life study. Sci Rep. 10(1456)2020.PubMed/NCBI View Article : Google Scholar

59 

Fernández-Sala X, Barceló-Vidal J, Tusquets I and Conde-Estévez D: Effectiveness and safety of a novel dexamethasone mouthwash formulation in managing stomatitis in cancer patients. Farm Hosp. 45:41–44. 2020.PubMed/NCBI View Article : Google Scholar

60 

Conteduca V, Oromendia C, Eng KW, Bareja R, Sigouros M, Molina A, Faltas BM, Sboner A, Mosquera JM, Elemento O, et al: Clinical features of neuroendocrine prostate cancer. Eur J Cancer. 121:7–18. 2019.PubMed/NCBI View Article : Google Scholar

61 

Clement DS, Tesselaar ME, van Leerdam ME, Srirajaskanthan R and Ramage JK: Nutritional and vitamin status in patients with neuroendocrine neoplasms. World J Gastroenterol. 25:1171–1184. 2019.PubMed/NCBI View Article : Google Scholar

62 

Kędzierska L, Madej-Michniewicz A, Marczuk N, Dołęgowska B, Starzyńska T and Błogowski W: Clinical significance of various growth factors in patients with different gastric neoplasms. Am J Transl Res. 12:118–129. 2020.PubMed/NCBI

63 

Ranade R and Basu S: Metabolic bone disease in the context of metastatic neuroendocrine tumor: Differentiation from skeletal metastasis, the molecular PET-CT imaging features, and exploring the possible etiopathologies including parathyroid adenoma (MEN1) and paraneoplastic humoral hypercalcemia of malignancy due to PTHrP hypersecretion. World J Nucl Med. 16:62–67. 2017.PubMed/NCBI View Article : Google Scholar

64 

Iliesiu A, Ungureanu IA, Petca A, Constantin MM, Petca RC, Sandru F, Constantin T and Dumitrascu MC: Paraganglioma presenting as a mesenteric cystic mass: A case report. Exp Ther Med. 20:2489–2492. 2020.PubMed/NCBI View Article : Google Scholar

65 

Valea A, Morar A, Ghemigian A, Petrova E, Tupea C, Popescu M, Dumitru N and Carsote M: Diagnosis of neurofibromatosis type 1-related pheocromocytoma after stroke and myocardical infarction. Rom Med J. 67:420–424. 2020.

66 

Aygun N and Uludag M: Pheochromocytoma and paraganglioma: From epidemiology to clinical findings. Sisli Etfal Hastan Tip Bul. 54:159–168. 2020.PubMed/NCBI View Article : Google Scholar

67 

Sandru F, Dumitrascu MC, Albu SE, Carsote M and Valea A: Osteoporosis and adrenal incidentaloma: To be or not to be? Rom J Med Pract. 14:381–384. 2019.

68 

Jimenez P, Tatsui C, Jessop A, Thosani S and Jimenez C: Treatment for malignant pheochromocytomas and paragangliomas: 5 Years of progress. Curr Oncol Rep. 19(83)2017.PubMed/NCBI View Article : Google Scholar

69 

Ilanchezhian M, Jha A, Pacak K and Del Rivero J: Emerging treatments for advanced/metastatic pheochromocytoma and paraganglioma. Curr Treat Options Oncol. 21(85)2020.PubMed/NCBI View Article : Google Scholar

70 

Rider AJ, Walsh A, Sollenberger EL, Dryden SC, DeAngelis KD, Weir AB III and Fowler BT: Orbital pheochromocytoma metastasis in 2 patients with known pheochromocytoma. Ophthalmic Plast Reconstr Surg. 35:e131–e134. 2019.PubMed/NCBI View Article : Google Scholar

71 

Rahpeyma A and Khajehahmadi S: Pheochromocytoma metastasing to the jaw: Review of the literature and new case. Indian J Surg Oncol. 11:433–437. 2020.PubMed/NCBI View Article : Google Scholar

72 

Fadiga L, Saraiva J, Paiva I and Carrilho F: Thoracic spine metastasis presenting 18 years after complete resection of a phaeochromocytoma. BMJ Case Rep. 12(e229621)2019.PubMed/NCBI View Article : Google Scholar

73 

Jang Khan NA, Ullah S, Siddiqui HU and Karim A: Spinal cord compression by metastatic thoracic spine paraganglioma. J Ayub Med Coll Abbottabad. 28:617–619. 2016.PubMed/NCBI

74 

Ayala-Ramirez M, Palmer JL, Hofmann MC, de la Cruz M, Moon BS, Waguespack SG, Habra MA and Jimenez C: Bone metastases and skeletal-related events in patients with malignant pheochromocytoma and sympathetic paraganglioma. J Clin Endocrinol Metab. 98:1492–1497. 2013.PubMed/NCBI View Article : Google Scholar

75 

Huang CT, Yang WC and Lin SF: Multiple endocrine neoplasia type 2A. Kaohsiung J Med Sci. 28:341–344. 2012.PubMed/NCBI View Article : Google Scholar

76 

Gravel G, Leboulleux S, Tselikas L, Fassio F, Berraf M, Berdelou A, Ba B, Hescot S, Hadoux J, Schlumberger M, et al: Prevention of serious skeletal-related events by interventional radiology techniques in patients with malignant paraganglioma and pheochromocytoma. Endocrine. 59:547–554. 2018.PubMed/NCBI View Article : Google Scholar

77 

Athimulam S and Bancos I: Evaluation of bone health in patients with adrenal tumors. Curr Opin Endocrinol Diabetes Obes. 26:125–132. 2019.PubMed/NCBI View Article : Google Scholar

78 

Kim BJ, Kwak MK, Kim JS, Lee SH and Koh JM: Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma. Bone. 116:1–7. 2018.PubMed/NCBI View Article : Google Scholar

79 

Yokomoto-Umakoshi M, Umakoshi H, Fukumoto T, Matsuda Y, Nagata H, Ogata M, Kawate H, Miyazawa T, Sakamoto R and Ogawa Y: Q-AND-A study group. Pheochromocytoma and paraganglioma: An emerging cause of secondary osteoporosis. Bone. 133(115221)2020.PubMed/NCBI View Article : Google Scholar

80 

Yokomoto-Umakoshi M, Umakoshi H, Sakamoto R, Fukumoto T, Ogata M, Nakano Y, Iwahashi N, Kaneko H, Mizoguchi N, Hattori A, et al: Role of deteriorated bone quality in the development of osteoporosis in pheochromocytoma and paraganglioma. Bone. 142(115607)2021.PubMed/NCBI View Article : Google Scholar

81 

Yokomoto-Umakoshi M, Umakoshi H, Ogata M, Fukumoto T, Matsuda Y, Miyazawa T, Sakamoto R and Ogawa Y: Q-AND-A study group. Coexistence of osteoporosis and atherosclerosis in pheochromocytoma: New insights into its long-term management. Osteoporos Int. 31:2151–2160. 2020.PubMed/NCBI View Article : Google Scholar

82 

Poiana C, Radoi V, Carsote M and Bilezikian JP: New clues that may link osteoporosis to the circulating lipid profile. Bone Res. 1:260–266. 2013.PubMed/NCBI View Article : Google Scholar

83 

Jackuliak P, Kužma M, Killinger Z and Payer J: Good long-term glycemic compensation is associated with better trabecular bone score in postmenopausal women with type 2 diabetes. Physiol Res. 68 (Suppl 2):S149–S156. 2019.PubMed/NCBI View Article : Google Scholar

84 

Webb SM and Valassi E: Morbidity of Cushing's syndrome and impact of treatment. Endocrinol Metab Clin North Am. 47:299–311. 2018.PubMed/NCBI View Article : Google Scholar

85 

Dumitrascu MC, Stanescu AMA, Bejan C, Sandru F, Toader DO, Radavoi DG, Cotirlet A, Judea Pusta CT and Diaconu CC: Obesity and its implications on stress urinary incontinence. Rev Chim. 70:3660–3662. 2019.

86 

Young J, Haissaguerre M, Viera-Pinto O, Chabre O, Baudin E and Tabarin A: Management of endocrine disease: Cushing's syndrome due to ectopic ACTH secretion: An expert operational opinion. Eur J Endocrinol. 182:R29–R58. 2020.PubMed/NCBI View Article : Google Scholar

87 

Grigoryan S, Avram AM and Turcu AF: Functional imaging in ectopic Cushing syndrome. Curr Opin Endocrinol Diabetes Obes. 27:146–154. 2020.PubMed/NCBI View Article : Google Scholar

88 

Kyriacou A, Stepien KM and Issa B: Urinary steroid metabolites in a case of florid ectopic Cushing's syndrome and clinical correlations. Hormones (Athens). 15:540–547. 2016.PubMed/NCBI View Article : Google Scholar

89 

Hayes AR and Grossman AB: The ectopic adrenocorticotropic hormone syndrome: Rarely easy, always challenging. Endocrinol Metab Clin North Am. 47:409–425. 2018.PubMed/NCBI View Article : Google Scholar

90 

Șandru F, Dumitrașcu MC, Albu SE, Carsote M and Valea A: Obesity and osteoporotic fractures. Rom J Mil Med. 123:166–171. 2020.

91 

Carsote M, Preda SA, Mitroi M, Camen A and Radu L: Serum osteocalcin, P1NP, alkaline phosphase, and crosslaps in humans: The relationship with body mass index. Rev Chim. 70:1615–1618. 2019.

92 

Broersen LHA, van Haalen FM, Kienitz T, Biermasz NR, Strasburger CJ, Dekkers OM and Pereira AM: Sex Differences in presentation but not in outcome for ACTH-dependent Cushing's syndrome. Front Endocrinol (Lausanne). 10(580)2019.

93 

Vinolas H, Grouthier V, Mehsen-Cetre N, Boisson A, Winzenrieth R, Schaeverbeke T, Mesguich C, Bordenave L and Tabarin A: Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score. Clin Endocrinol (Oxf). 89:148–154. 2018.PubMed/NCBI View Article : Google Scholar

94 

Valassi E, Santos A, Yaneva M, Tóth M, Strasburger CJ, Chanson P, Wass JA, Chabre O, Pfeifer M, Feelders RA, et al: The European registry on Cushing's syndrome: 2-Year experience. Baseline demographic and clinical characteristics. Eur J Endocrinol. 165:383–392. 2011.PubMed/NCBI View Article : Google Scholar

95 

Rashid F, Riccio SA, Munk PL, Malfair D and Heran MK: Vertebroplasty for vertebral compression fractures secondary to Cushing's syndrome induced by an ACTH-producing bronchial carcinoid tumour. Singapore Med J. 50:e147–e150. 2009.PubMed/NCBI

96 

Coe SG, Tan WW and Fox TP: Cushing's syndrome due to ectopic adrenocorticotropic hormone production secondary to hepatic carcinoid: Diagnosis, treatment, and improved quality of life. J Gen Intern Med. 23:875–878. 2008.PubMed/NCBI View Article : Google Scholar

97 

Neary NM, Lopez-Chavez A, Abel BS, Boyce AM, Schaub N, Kwong K, Stratakis CA, Moran CA, Giaccone G and Nieman LK: Neuroendocrine ACTH-producing tumor of the thymus-experience with 12 patients over 25 years. J Clin Endocrinol Metab. 97:2223–2230. 2012.PubMed/NCBI View Article : Google Scholar

98 

Gut P: Liver metastases in gastroenteropancreatic neuroendocrine tumours-treatment methods. Prz Gastroenterol. 15:207–214. 2020.PubMed/NCBI View Article : Google Scholar

99 

Carsote M, Petrova EN, Radu O, Goldstein A, Ghemigian A and Valea A: Serotonin: Beyond menopause: Rom J Med Pract (Pract Med). 11:270–272. 2016.

100 

Szajer J, Yung G, Russo R and Mansberg R: Adrenocorticotropic hormone-secreting neuroendocrine tumor of the rectum demonstrated on 68Ga-DOTATATE and 18F-FDG PET imaging. Clin Nucl Med. 42:773–775. 2017.PubMed/NCBI View Article : Google Scholar

101 

Angarita FA, Rodríguez JL, Meek E, Sánchez JO, Tawil M and Torregrosa L: Locally-advanced primary neuroendocrine carcinoma of the breast: Case report and review of the literature. World J Surg Oncol. 11(128)2013.PubMed/NCBI View Article : Google Scholar

102 

Banerjee SS and Eyden B: Divergent differentiation in malignant melanomas: A review. Histopathology. 52:119–129. 2008.PubMed/NCBI View Article : Google Scholar

103 

Poiană C, Neamţu MC, Avramescu ET, Carşote M, Trifănescu R, Terzea D, Neamţu OM and Dănciulescu Miulescu R: The dedifferentiation of neuroendocrine tumor metastases: Myth or reality? Rom J Morphol Embryol. 54:201–203. 2013.PubMed/NCBI

104 

Dumas M, Laly P, Gottlieb J, Vercellino L, Paycha F, Bagot M, Baroudjian B, Madelaine I, Basset-Seguin N, Eftekhari P, et al: Osteopenia and fractures associated with long-term therapy with MEK inhibitors. Melanoma Res. 28:641–644. 2018.PubMed/NCBI View Article : Google Scholar

105 

Lee YK, Lee EG, Kim HY, Lee Y, Lee SM, Suh DC, Yoo JI and Lee S: Osteoporotic fractures of the spine, hip, and other locations after adjuvant endocrine therapy with aromatase inhibitors in breast cancer patients: A meta-analysis. J Korean Med Sci. 35(e403)2020.PubMed/NCBI View Article : Google Scholar

106 

Li Y and Simonds WF: Endocrine neoplasms in familial syndromes of hyperparathyroidism. Endocr Relat Cancer. 23:R229–R247. 2016.PubMed/NCBI View Article : Google Scholar

107 

Miulescu R, Balaban DV, Sandru F and Jinga M: Cutaneous manifestations in pancreatic diseases-A review. J Clin Med. 9(2611)2020.PubMed/NCBI View Article : Google Scholar

108 

Slouma M, Abbes M, Dhahri R, Litaiem N, Gueddiche N, Mansouri N, Msekni I, Gharsallah I, Metoui L and Louzir B: Multiple endocrine neoplasia type 1 revealed by a hip pathologic fracture. Clin Rheumatol. 40:775–782. 2021.PubMed/NCBI View Article : Google Scholar

109 

Herath M, Parameswaran V, Thompson M, Williams M and Burgess J: Paediatric and young adult manifestations and outcomes of multiple endocrine neoplasia type 1. Clin Endocrinol (Oxf). 91:633–638. 2019.PubMed/NCBI View Article : Google Scholar

110 

Mele C, Mencarelli M, Caputo M, Mai S, Pagano L, Aimaretti G, Scacchi M, Falchetti A and Marzullo P: Phenotypes associated with MEN1 syndrome: A focus on genotype-phenotype correlations. Front Endocrinol (Lausanne). 11(591501)2020.PubMed/NCBI View Article : Google Scholar

111 

Sandru F, Carsote M, Valea A, Albu SE, Petca RC and Dumitrascu MC: Somatostatinoma: Beyond neurofibromatosis type 1 (review). Exp Ther Med. 20:3383–3388. 2020.PubMed/NCBI View Article : Google Scholar

112 

Shah S and George KJ: The association of spinal deformity with dural ectasia in neurofibromatosis type 1. Br J Neurosurgery. 33:620–623. 2019.PubMed/NCBI View Article : Google Scholar

113 

Prudhomme L, Delleci C, Trimouille A, Chateil JF, Prodhomme O, Goizet C and Van Gils J: Severe thoracic and spinal bone abnormalities in neurofibromatosis type 1. Eur J Med Genet. 63(103815)2020.PubMed/NCBI View Article : Google Scholar

114 

Eads JR, Reidy-Lagunes D, Soares HP, Chan JA, Anthony LB, Halfdanarson TR, Naraev BG, Wolin EM, Halperin DM, Li D, et al: Differential diagnosis of diarrhea in patients with neuroendocrine tumors. Pancreas. 49:1123–1130. 2020.PubMed/NCBI View Article : Google Scholar

115 

Michalowska M, Znorko B, Kaminski T, Oksztulska-Kolanek E and Pawlak D: New insights into tryptophan and its metabolites in the regulation of bone metabolism. J Physiol Pharmacol. 66:779–791. 2015.PubMed/NCBI

116 

Al Saedi A, Sharma S, Summers MA, Nurgali K and Duque G: The multiple faces of tryptophan in bone biology. Exp Gerontol. 129(110778)2020.PubMed/NCBI View Article : Google Scholar

117 

Khanassov V, Hu J, Reeves D and van Marwijk H: Selective serotonin reuptake inhibitor and selective serotonin and norepinephrine reuptake inhibitor use and risk of fractures in adults: A systematic review and meta-analysis. Int J Geriatr Psychiatry. 33:1688–1708. 2018.PubMed/NCBI View Article : Google Scholar

118 

Banskota S, Ghia JE and Khan WI: Serotonin in the gut: Blessing or a curse. Biochimie. 161:56–64. 2019.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ghemigian A, Carsote M, Sandru F, Petca R, Oproiu A, Petca A and Valea A: Neuroendocrine neoplasia and bone (Review). Exp Ther Med 22: 1219, 2021.
APA
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., & Valea, A. (2021). Neuroendocrine neoplasia and bone (Review). Experimental and Therapeutic Medicine, 22, 1219. https://doi.org/10.3892/etm.2021.10653
MLA
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., Valea, A."Neuroendocrine neoplasia and bone (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1219.
Chicago
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., Valea, A."Neuroendocrine neoplasia and bone (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1219. https://doi.org/10.3892/etm.2021.10653
Copy and paste a formatted citation
x
Spandidos Publications style
Ghemigian A, Carsote M, Sandru F, Petca R, Oproiu A, Petca A and Valea A: Neuroendocrine neoplasia and bone (Review). Exp Ther Med 22: 1219, 2021.
APA
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., & Valea, A. (2021). Neuroendocrine neoplasia and bone (Review). Experimental and Therapeutic Medicine, 22, 1219. https://doi.org/10.3892/etm.2021.10653
MLA
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., Valea, A."Neuroendocrine neoplasia and bone (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1219.
Chicago
Ghemigian, A., Carsote, M., Sandru, F., Petca, R., Oproiu, A., Petca, A., Valea, A."Neuroendocrine neoplasia and bone (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1219. https://doi.org/10.3892/etm.2021.10653
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team