Open Access

Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)

  • Authors:
    • Zhidi Lin
    • Feizhou Lu
    • Xiaosheng Ma
    • Xinlei Xia
    • Fei Zou
    • Jianyuan Jiang
  • View Affiliations

  • Published online on: August 26, 2021     https://doi.org/10.3892/etm.2021.10655
  • Article Number: 1221
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lower back pain (LBP) is an extremely common symptom and is recognized as a leading contributor to disability and disease burden globally. Intervertebral disc degeneration (IDD) represents a major cause of LBP. However, the molecular mechanisms involved in the pathogenesis of IDD remain unclear, and currently available treatments, including conservative and surgical options, fail to effectively delay, stop or reverse the progression of IDD. Circular RNAs (circRNAs) are a newly discovered group of covalently closed, single‑stranded and endogenous non‑coding RNAs. A growing body of research has revealed that a number of circRNAs are widely and aberrantly expressed in IDD tissues. Furthermore, they play important roles in the pathogenesis of IDD, including proliferation, apoptosis, senescence, mitophagy, inflammation and extracellular matrix metabolism, mainly by acting as sponges for microRNAs. The present review aims to summarize the current understanding on the mechanisms of circRNA‑mediated regulation in IDD.
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November-2021
Volume 22 Issue 5

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Lin Z, Lu F, Ma X, Xia X, Zou F and Jiang J: Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review). Exp Ther Med 22: 1221, 2021
APA
Lin, Z., Lu, F., Ma, X., Xia, X., Zou, F., & Jiang, J. (2021). Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review). Experimental and Therapeutic Medicine, 22, 1221. https://doi.org/10.3892/etm.2021.10655
MLA
Lin, Z., Lu, F., Ma, X., Xia, X., Zou, F., Jiang, J."Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1221.
Chicago
Lin, Z., Lu, F., Ma, X., Xia, X., Zou, F., Jiang, J."Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1221. https://doi.org/10.3892/etm.2021.10655