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IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media

  • Authors:
    • Roxana Serban
    • Cristiana Filip
    • Luminita Mihaela Radulescu
    • Minerva Codruta Badescu
    • Magda Mariana Badescu
    • Bogdan Mihail Diaconescu
    • Mihail Dan Cobzeanu
    • Bogdan Mihail Cobzeanu
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Clinical Rehabilitation Hospital, 700656 Iasi, Romania, Department of Internal Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Physiopathology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Occupational Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Department of Otorhinolaryngology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
    Copyright: © Serban et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1226
    |
    Published online on: August 27, 2021
       https://doi.org/10.3892/etm.2021.10660
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Abstract

Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL‑1α), interleukin 6 (IL‑6) and interleukin 8 (IL‑8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL‑6 and IL‑8 had the highest value in patients with CSOM and IL‑1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.
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Copy and paste a formatted citation
Spandidos Publications style
Serban R, Filip C, Radulescu LM, Badescu MC, Badescu MM, Diaconescu BM, Cobzeanu MD and Cobzeanu BM: IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media. Exp Ther Med 22: 1226, 2021.
APA
Serban, R., Filip, C., Radulescu, L.M., Badescu, M.C., Badescu, M.M., Diaconescu, B.M. ... Cobzeanu, B.M. (2021). IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media. Experimental and Therapeutic Medicine, 22, 1226. https://doi.org/10.3892/etm.2021.10660
MLA
Serban, R., Filip, C., Radulescu, L. M., Badescu, M. C., Badescu, M. M., Diaconescu, B. M., Cobzeanu, M. D., Cobzeanu, B. M."IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media". Experimental and Therapeutic Medicine 22.5 (2021): 1226.
Chicago
Serban, R., Filip, C., Radulescu, L. M., Badescu, M. C., Badescu, M. M., Diaconescu, B. M., Cobzeanu, M. D., Cobzeanu, B. M."IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1226. https://doi.org/10.3892/etm.2021.10660
Copy and paste a formatted citation
x
Spandidos Publications style
Serban R, Filip C, Radulescu LM, Badescu MC, Badescu MM, Diaconescu BM, Cobzeanu MD and Cobzeanu BM: IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media. Exp Ther Med 22: 1226, 2021.
APA
Serban, R., Filip, C., Radulescu, L.M., Badescu, M.C., Badescu, M.M., Diaconescu, B.M. ... Cobzeanu, B.M. (2021). IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media. Experimental and Therapeutic Medicine, 22, 1226. https://doi.org/10.3892/etm.2021.10660
MLA
Serban, R., Filip, C., Radulescu, L. M., Badescu, M. C., Badescu, M. M., Diaconescu, B. M., Cobzeanu, M. D., Cobzeanu, B. M."IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media". Experimental and Therapeutic Medicine 22.5 (2021): 1226.
Chicago
Serban, R., Filip, C., Radulescu, L. M., Badescu, M. C., Badescu, M. M., Diaconescu, B. M., Cobzeanu, M. D., Cobzeanu, B. M."IL‑1α, IL‑6 and IL‑8 serum values in patients with chronic suppurative otitis media". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1226. https://doi.org/10.3892/etm.2021.10660
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