Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 22 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway

  • Authors:
    • Wen-Hua Zhang
    • Yu Chen
    • Li-Mo Gao
    • Yan-Na Cao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Ophthalmology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China
  • Article Number: 1235
    |
    Published online on: August 31, 2021
       https://doi.org/10.3892/etm.2021.10669
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glaucoma is a disease involving impaired visual function accompanied by degeneration and necrosis of the optic nerve. Epigallocatechin‑3‑gallate (EGCG) exerts a neuroprotective effect against the degeneration of retinal ganglion cells. However, whether EGCG can relieve glaucoma and the possible mechanisms remain unclear. In order to determine the function of EGCG in glaucoma, an acute glaucoma rat model was established. Optic neuropathology was examined by haematoxylin‑eosin staining and immunofluorescence staining for class III‑β tubulin. The levels of inflammation‑associated cytokines, such as interleukin (IL)‑4, IL‑6, TNF‑α, IL‑1β, IL‑13 and IFN‑γ were measured by flow cytometry. T cell proliferation was assessed by the carboxyfluorescein diacetate succinimidyl ester method. Finally, the functional role of EGCG in glaucoma was explored. The levels of the inflammation‑associated proteins p‑IκBα and p‑p65 were measured by western blot analysis. The results showed that optic nerve injury occurred, and elevated levels of the inflammatory cytokines IL‑4, IL‑6, TNF‑α, IL‑1β, IL‑13 and IFN‑γ were observed in the rat model of acute glaucoma. In addition, an increased T lymphocyte proliferation rate and imbalance of Th1/Th2 cytokines were present in the models. Importantly, treatment with EGCG significantly alleviated optic nerve injury. At the molecular level, EGCG decreased the levels of inflammation‑associated cytokines, decreased the proliferation rate of T lymphocyte cells, and repaired the imbalance of Th1/Th2 cytokines. Moreover, EGCG inhibited the increase in the phosphorylation of IκBα and p65 caused by modelling and thus suppressed the activation of the nuclear factor (NF)‑κB signalling pathway. The findings of the present study indicate that EGCG could attenuate the symptoms of glaucoma and inhibit inflammatory responses by suppressing the NF‑κB signalling pathway in a rat glaucoma model.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Lei X and Zhao Y: Neovascular glaucoma regulation by arylsulfonyl indoline-benzamide (ASIB) through targeting NF-κB signalling pathway. 3 Biotech. 9(211)2019.PubMed/NCBI View Article : Google Scholar

2 

Quigley HA: Neuronal death in glaucoma. Prog Retin Eye Res. 18:39–57. 1999.PubMed/NCBI View Article : Google Scholar

3 

Foster PJ: The epidemiology of primary angle closure and associated glaucomatous optic neuropathy. Semin Ophthalmol. 17:50–58. 2002.PubMed/NCBI View Article : Google Scholar

4 

Shen C, Chen L, Jiang L and Lai TY: Neuroprotective effect of epigallocatechin-3-gallate in a mouse model of chronic glaucoma. Neurosci Lett. 600:132–136. 2015.PubMed/NCBI View Article : Google Scholar

5 

Wong M, Huang P, Li W, Li Y, Zhang SS and Zhang C: T-helper1/T-helper2 cytokine imbalance in the iris of patients with glaucoma. PLoS One. 10(e0122184)2015.PubMed/NCBI View Article : Google Scholar

6 

Wang J and Zhao Q: Kaempferitrin inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes. Phytother Res. 33:1726–1735. 2019.PubMed/NCBI View Article : Google Scholar

7 

Niu Y, Dong Q and Li R: Matrine regulates Th1/Th2 cytokine responses in rheumatoid arthritis by attenuating the NF-kappaB signaling. Cell Biol Int. 41:611–621. 2017.PubMed/NCBI View Article : Google Scholar

8 

Liu B, Lu R, Li H, Zhou Y, Zhang P, Bai L, Chen D, Chen J, Li J, Yu P, et al: Zhen-wu-tang ameliorates membranous nephropathy rats through inhibiting NF-κB pathway and NLRP3 inflammasome. Phytomedicine. 59(152913)2019.PubMed/NCBI View Article : Google Scholar

9 

Wei HY, Zhang YJ and Zhao SZ: Puerarin regulates neovascular glaucoma through pigment epitheliumderived growth factorinduced NF-κB signaling pathway. Mol Med Rep. 17:7866–7874. 2018.PubMed/NCBI View Article : Google Scholar

10 

Kar AK, Singh A, Dhiman N, Purohit MP, Jagdale P, Kamthan M, Singh D, Kumar M, Ghosh D and Patnaik S: Polymer-assisted in situ synthesis of silver nanoparticles with epigallocatechin gallate (EGCG) impregnated wound patch potentiate controlled inflammatory responses for brisk wound healing. Int J Nanomedicine. 14:9837–9854. 2019.PubMed/NCBI View Article : Google Scholar

11 

Nguyen T, Payan B, Zambrano A, Du Y, Bondesson M and Mohan C: Epigallocatechin-3-gallate suppresses neutrophil migration speed in a transgenic zebrafish model accompanied by reduced inflammatory mediators. J Inflamm Res. 12:231–239. 2019.PubMed/NCBI View Article : Google Scholar

12 

Yelins'ka AM, Liashenko LI and Kostenko VO: Quercetin potentiates antiradical properties of epigallocatechin-3-gallate in periodontium of rats under systemic and local administration of lipopolisaccharide of salmonella typhi. Wiad Lek. 72:1499–1503. 2019.PubMed/NCBI

13 

Wang J, Jia R, Celi P, Ding X, Bai S, Zeng Q, Mao X, Xu S and Zhang K: Green tea polyphenol epigallocatechin-3-gallate improves the antioxidant capacity of eggs. Food Funct. 11:534–543. 2020.PubMed/NCBI View Article : Google Scholar

14 

Sharifi-Rad M, Pezzani R, Redaelli M, Zorzan M, Imran M, Ahmed Khalil A, Salehi B, Sharopov F, Cho WC and Sharifi-Rad J: preclinical pharmacological activities of epigallocatechin-3-gallate in signaling pathways: An update on cancer. Molecules. 25(467)2020.PubMed/NCBI View Article : Google Scholar

15 

Md Nesran ZN, Shafie NH, Ishak AH, Mohd Esa N, Ismail A and Md Tohid SF: Induction of endoplasmic reticulum stress pathway by green tea epigallocatechin-3-Gallate (EGCG) in colorectal cancer cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α. Biomed Res Int. 2019(3480569)2019.PubMed/NCBI View Article : Google Scholar

16 

Chen J, Chen L, Lu T, Xie Y, Li C, Jia Z and Cao J: ERα36 is an effective target of epigallocatechin-3-gallate in hepatocellular carcinoma. Int J Clin Exp Pathol. 12:3222–3234. 2019.PubMed/NCBI

17 

Mao L, Hochstetter D, Yao L, Zhao Y, Zhou J, Wang Y and Xu P: Green Tea Polyphenol (-)-Epigallocatechin Gallate (EGCG) attenuates neuroinflammation in palmitic acid-stimulated BV-2 microglia and high-fat diet-induced obese mice. Int J Mol Sci. 20(5081)2019.PubMed/NCBI View Article : Google Scholar

18 

Wang D, Gao Q, Wang T, Kan Z, Li X, Hu L, Peng CY, Qian F, Wang Y and Granato D: Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation. Food Res Int. 127(108628)2020.PubMed/NCBI View Article : Google Scholar

19 

Karatas A, Dagli AF, Orhan C, Gencoglu H, Ozgen M, Sahin N, Sahin K and Koca SS: Epigallocatechin 3-gallate attenuates arthritis by regulating Nrf2, HO-1, and cytokine levels in an experimental arthritis model. Biotechnol Appl Biochem. 67:317–322. 2020.PubMed/NCBI View Article : Google Scholar

20 

Chen J, Liu J, Lei Y and Liu M: Potential ameliorative effects of epigallocatechin-3-gallate against cigarette smoke exposure induced renal and hepatic deficits. Ecotoxicol Environ Saf. 191(110202)2020.PubMed/NCBI View Article : Google Scholar

21 

Singh BN, Shankar S and Srivastava RK: Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications. Biochem Pharmacol. 82:1807–1821. 2011.PubMed/NCBI View Article : Google Scholar

22 

Liang L, He L, Zhu M, Chen B and Xiao C: Protective effects of carnosic acid on retinal ganglion cells in acute ocular hypertension rats. Int Ophthalmol. 40:1869–1878. 2020.PubMed/NCBI View Article : Google Scholar

23 

Azarsiz E, Karaca N, Ergun B, Durmuscan M, Kutukculer N and Aksu G: In vitro T lymphocyte proliferation by carboxyfluorescein diacetate succinimidyl ester method is helpful in diagnosing and managing primary immunodeficiencies. J Clin Lab Anal. 32(e22216)2018.PubMed/NCBI View Article : Google Scholar

24 

Yin Y, Mitson-Salazar A and Prussin C: Detection of intracellular cytokines by flow cytometry. Curr Protoc Immunol. 110:6.24.1–6.24.18. 2015.PubMed/NCBI View Article : Google Scholar

25 

Foster B, Prussin C, Liu F, Whitmire JK and Whitton JL: Detection of intracellular cytokines by flow cytometry. Curr Protoc Immunol Chapter. 6(Unit 6 24)2007.PubMed/NCBI View Article : Google Scholar

26 

Li W, Ma N, Liu MX, Ye BJ, Li YJ, Hu HY and Tang YH: C1q/TNF-related protein-9 attenuates retinal inflammation and protects blood-retinal barrier in db/db mice. Eur J Pharmacol. 853:289–298. 2019.PubMed/NCBI View Article : Google Scholar

27 

Paula AP, Paula JS, Silva MJ, Rocha EM, De Moraes CG and Rodrigues ML: Effects of swimming goggles wearing on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude. J Glaucoma. 25:860–864. 2016.PubMed/NCBI View Article : Google Scholar

28 

Sanchez-Sanchez C, Puerto B, Lopez-Caballero C and Contreras I: Unilateral acute iris depigmentation and transillumination after glaucoma surgery with mitomycin application and intracameral moxifloxacin. Am J Ophthalmol Case Rep. 18(100639)2020.PubMed/NCBI View Article : Google Scholar

29 

Otarola F, Virgili G, Shah A, Hu K, Bunce C and Gazzard G: Ab interno trabecular bypass surgery with Schlemm s canal microstent (Hydrus) for open angle glaucoma. Cochrane Database Syst Rev. 3(CD012740)2020.PubMed/NCBI View Article : Google Scholar

30 

Dada T, Midha N, Shah P, Sidhu T, Angmo D and Sihota R: Innovations in glaucoma surgery from Dr. Rajendra Prasad Centre for Ophthalmic Sciences. Indian J Ophthalmol. 65:103–108. 2017.PubMed/NCBI View Article : Google Scholar

31 

Weinreb RN, Aung T and Medeiros FA: The pathophysiology and treatment of glaucoma: A review. JAMA. 311:1901–1911. 2014.PubMed/NCBI View Article : Google Scholar

32 

Hong S, Kim CY, Lee WS, Shim J, Yeom HY and Seong GJ: Ocular hypotensive effects of topically administered agmatine in a chronic ocular hypertensive rat model. Exp Eye Res. 90:97–103. 2010.PubMed/NCBI View Article : Google Scholar

33 

Yu S, Tanabe T and Yoshimura N: A rat model of glaucoma induced by episcleral vein ligation. Exp Eye Res. 83:758–770. 2006.PubMed/NCBI View Article : Google Scholar

34 

Zhong L: A modified chronic ocular hypertension rat model for retinal ganglion cell neuroprotection. Front Med. 7:367–377. 2013.PubMed/NCBI View Article : Google Scholar

35 

Morrison JC, Johnson EC and Cepurna WO: Hypertonic saline injection model of experimental glaucoma in rats. Methods Mol Biol. 1695:11–21. 2018.PubMed/NCBI View Article : Google Scholar

36 

Zhou J, Mao L, Xu P and Wang Y: Effects of (-)-Epigallocatechin Gallate (EGCG) on energy expenditure and microglia-mediated hypothalamic inflammation in mice fed a high-fat diet. Nutrients. 10(1681)2018.PubMed/NCBI View Article : Google Scholar

37 

Liu D, Perkins JT and Hennig B: EGCG prevents PCB-126-induced endothelial cell inflammation via epigenetic modifications of NF-κB target genes in human endothelial cells. J Nutr Biochem. 28:164–170. 2016.PubMed/NCBI View Article : Google Scholar

38 

Kian K, Khalatbary AR, Ahmadvand H, Karimpour Malekshah A and Shams Z: Neuroprotective effects of (-)-epigallocatechin-3-gallate (EGCG) against peripheral nerve transection-induced apoptosis. Nutr Neurosci. 22:578–586. 2019.PubMed/NCBI View Article : Google Scholar

39 

Husain S, Abdul Y, Webster C, Chatterjee S, Kesarwani P and Mehrotra S: Interferon-gamma (IFN-gamma)-mediated retinal ganglion cell death in human tyrosinase T cell receptor transgenic mouse. PLoS One. 9(e89392)2014.PubMed/NCBI View Article : Google Scholar

40 

Borkenstein A, Faschinger C, Maier R, Weger M, Theisl A, Demel U, Graninger W, Irene H and Mossböck G: Measurement of tumor necrosis factor-alpha, interleukin-6, Fas ligand, interleukin-1a, and interleukin-1β in the aqueous humor of patients with open angle glaucoma using multiplex bead analysis. Mol Vis. 19:2306–2311. 2013.PubMed/NCBI

41 

Gramlich OW, Ding QJ, Zhu W, Cook A, Anderson MG and Kuehn MH: Adoptive transfer of immune cells from glaucomatous mice provokes retinal ganglion cell loss in recipients. Acta Neuropathol Commun. 3(56)2015.PubMed/NCBI View Article : Google Scholar

42 

Wax MB, Tezel G, Yang J, Peng G, Patil RV, Agarwal N, Sappington RM and Calkins DJ: Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T-cell-derived fas-ligand. J Neurosci. 28:12085–12096. 2008.PubMed/NCBI View Article : Google Scholar

43 

Huang P, Zhang SS and Zhang C: The two sides of cytokine signaling and glaucomatous optic neuropathy. J Ocul Biol Dis Infor. 2:78–83. 2009.PubMed/NCBI View Article : Google Scholar

44 

Chen H, Cho KS, Vu THK, Shen CH, Kaur M, Chen G, Mathew R, McHam ML, Fazelat A, Lashkari K, et al: Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma. Nat Commun. 9(3209)2018.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang W, Chen Y, Gao L and Cao Y: Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway. Exp Ther Med 22: 1235, 2021.
APA
Zhang, W., Chen, Y., Gao, L., & Cao, Y. (2021). Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway. Experimental and Therapeutic Medicine, 22, 1235. https://doi.org/10.3892/etm.2021.10669
MLA
Zhang, W., Chen, Y., Gao, L., Cao, Y."Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway". Experimental and Therapeutic Medicine 22.5 (2021): 1235.
Chicago
Zhang, W., Chen, Y., Gao, L., Cao, Y."Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1235. https://doi.org/10.3892/etm.2021.10669
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang W, Chen Y, Gao L and Cao Y: Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway. Exp Ther Med 22: 1235, 2021.
APA
Zhang, W., Chen, Y., Gao, L., & Cao, Y. (2021). Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway. Experimental and Therapeutic Medicine, 22, 1235. https://doi.org/10.3892/etm.2021.10669
MLA
Zhang, W., Chen, Y., Gao, L., Cao, Y."Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway". Experimental and Therapeutic Medicine 22.5 (2021): 1235.
Chicago
Zhang, W., Chen, Y., Gao, L., Cao, Y."Neuroprotective role of epigallocatechin‑3‑gallate in acute glaucoma via the nuclear factor‑κB signalling pathway". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1235. https://doi.org/10.3892/etm.2021.10669
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team