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circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis

Retraction in: /10.3892/etm.2025.13033
  • Authors:
    • Yanlin Jin
    • Yi Zhang
    • Xiaoming Luo
  • View Affiliations / Copyright

    Affiliations: First Ward of General Surgery, Railway Hospital, Shaoguan, Guangdong 512000, P.R. China, Public Health Guidance Section, Hongshan Centre for Diseases Control and Prevention, Wuhan, Hubei 430070, P.R. China, Department of Hepatobiliary Gastrointestinal Surgery, Hubei No. 3 People's Hospital of Jianghan University, Wuhan, Hubei 430033, P.R. China
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1276
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    Published online on: September 8, 2021
       https://doi.org/10.3892/etm.2021.10711
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Abstract

Hepatocellular carcinoma (HCC) is a lethal disease and one of the most common types of cancer. HCC is associated with exponentially increasing morbidity and mortality rates. Accumulating evidence has identified circular RNAs (circRNAs) to be regulators of cancer progression. However, to the best of our knowledge, the potential effect of circRNA protein tyrosine phosphatase receptor type A (circRNA_PTPRA) in HCC and its mechanism remain unknown. The present study aimed to assess the effects and underlying mechanism of circRNA_PTPRA in a HCC Huh‑7 cells model. The sites of interaction between circRNA_PTPRA and microRNA (miR)‑582‑3p were predicted using the StarBase software and verified using dual luciferase reporter and RNA immunoprecipitation (RIP) assays in Huh‑7 cells. HCC cell viability, apoptosis, migration and invasion were measured using MTT, flow cytometry and Transwell assays, respectively. The expression levels of circRNA_PTPRA, miR‑582‑3p, cyclin D1, MMP‑9, Bcl‑2 and Bax were analyzed using reverse transcription‑quantitative PCR and western blotting. The results of the dual luciferase reporter and RIP assays demonstrated that miR‑582‑3p directly targeted circRNA_PTPRA. Compared with the human normal hepatocyte cell line, THLE‑2, the expression levels of circRNA_PTPRA were upregulated, which were found to be inversely correlated with those of miR‑582‑3p expression in Huh‑7 and HCCLM3 cells. miR‑582‑3p overexpression using mimics suppressed cell proliferation, migration and invasion, whilst downregulating cyclin D1 and MMP‑9 expression in Huh‑7 cells. In addition, transfection of HCC cells with the miR‑582‑3p mimic promoted apoptosis by downregulating Bcl‑2 expression and upregulating Bax expression in Huh‑7 cells. Knocking down circRNA_PTPRA expression using small interfering RNA (siRNA) markedly downregulated circRNA_PTPRA expression levels and upregulated miR‑582‑3p expression, but was reversed by co‑transfection with the miR‑582‑3p inhibitor. Furthermore, reduced HCC cell proliferation, migration and invasion, increased levels of cell apoptosis, upregulated Bax expression and downregulated cyclin D1, MMP‑9 and Bcl‑2 expression were all observed after knocking down circRNA_PTPRA. All these effects aforementioned were reversed by co‑transfection with the miR‑582‑3p inhibitor. In conclusion, findings from the present study suggested that circRNA_PTPRA may regulate HCC cell proliferation, invasion, apoptosis and migration by sponging miR‑582‑3p. This indicates that the circRNA_PTPRA/miR‑582‑3p axis may represent a potential target for HCC diagnosis and treatment.
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View References

1 

Njei B, Rotman Y, Ditah I and Lim JK: Emerging trends in hepatocellular carcinoma incidence and mortality. Hepatology. 61:191–199. 2015.PubMed/NCBI View Article : Google Scholar

2 

Global Burden of Disease Liver Cancer Collaboration. Akinyemiju T, Abera S, Ahmed M, Alam N, Alemayohu MA, Allen C, Al-Raddadi R, Alvis-Guzman N, Amoako Y, et al: The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: Results from the Global Burden of Disease Study. JAMA Oncol. 3:1683–1691. 2015.PubMed/NCBI View Article : Google Scholar

3 

Qian X, Yan X, Zhai X, Li N, Qu C and Lu F: Hepatocellular carcinoma surveillance and treatment: A way to reduce cancer-related mortality in cirrhotic patients. J Clin Transl Hepatol. 7:1–2. 2019.PubMed/NCBI View Article : Google Scholar

4 

Berkel C and Cacan E: DYNLL1 is hypomethylated and up-regulated in a tumor stage- and grade-dependent manner and associated with increased mortality in hepatocellular carcinoma. Exp Mol Pathol. 117(104567)2020.PubMed/NCBI View Article : Google Scholar

5 

Wang M, Gu B, Yao G, Li P and Wang K: Circular RNA expression profiles and the Pro-tumorigenic function of CircRNA_10156 in Hepatitis B Virus-related liver cancer. Int J Med Sci. 17:1351–1365. 2020.PubMed/NCBI View Article : Google Scholar

6 

Banaudha KK and Verma M: Epigenetic biomarkers in liver cancer. Methods Mol Biol. 1238:65–76. 2015.PubMed/NCBI View Article : Google Scholar

7 

Ren Z, Ma X, Duan Z and Chen X: Diagnosis, therapy, and prognosis for hepatocellular carcinoma. Anal Cell Pathol (Amst). 2020(8157406)2020.PubMed/NCBI View Article : Google Scholar

8 

Ronot M, Purcell Y and Vilgrain V: Hepatocellular carcinoma: Current imaging modalities for diagnosis and prognosis. Dig Dis Sci. 64:934–950. 2019.PubMed/NCBI View Article : Google Scholar

9 

Altesha MA, Ni T, Khan A, Liu K and Zheng X: Circular RNA in cardiovascular disease. J Cell Physiol. 234:5588–5600. 2019.PubMed/NCBI View Article : Google Scholar

10 

Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J and Xu Z: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 18(20)2019.PubMed/NCBI View Article : Google Scholar

11 

Liu Z, Zhou Y, Liang G, Ling Y, Tan W, Tan L, Andrews R, Zhong W, Zhang X, Song E and Gong C: Circ_001783 regulates breast cancer progression via sponging miR-200c-3p. Cell Death Dis. 10(55)2019.PubMed/NCBI View Article : Google Scholar

12 

Hansen TB, Kjems J and Damgaard CK: Circular RNA and miR-7 in cancer. Cancer Res. 73:5609–5612. 2013.PubMed/NCBI View Article : Google Scholar

13 

Patop IL and Kadener S: circRNAs in cancer. Curr Opin Genet Dev. 48:121–127. 2018.PubMed/NCBI View Article : Google Scholar

14 

Yu T, Wang Y, Fan Y, Fang N, Wang T, Xu T and Shu Y: CircRNAs in cancer metabolism: A review. J Hematol Oncol. 12(90)2019.PubMed/NCBI View Article : Google Scholar

15 

Wei S, Zheng Y, Jiang Y, Li X, Geng J, Shen Y, Li Q, Wang X, Zhao C, Chen Y, et al: The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p. EBioMedicine. 44:182–193. 2019.PubMed/NCBI View Article : Google Scholar

16 

Zhong Z, Lv M and Chen J: Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma. Sci Rep. 6(30919)2016.PubMed/NCBI View Article : Google Scholar

17 

Daoud AZ, Mulholland EJ, Cole G and McCarthy HO: MicroRNAs in pancreatic cancer: Biomarkers, prognostic, and therapeutic modulators. BMC Cancer. 19(1130)2019.PubMed/NCBI View Article : Google Scholar

18 

Peng H, Dong JY, Zhao YN, Wu WB, Yang XL, Chen D, Hu KF, Chen LH and Liu J: The effect of methylation level of microRNA promoter on the expression of microRNAs and on the proliferation, migration and invasion of lung cancer cells. Sichuan Da Xue Xue Bao Yi Xue Ban. 50:182–187. 2019.PubMed/NCBI(In Chinese).

19 

Lu H, Hao L, Yang H, Chen J and Liu J: miRNA-34a suppresses colon carcinoma proliferation and induces cell apoptosis by targeting SYT1. Int J Clin Exp Pathol. 12:2887–2897. 2019.PubMed/NCBI

20 

Fang L, Cai J, Chen B, Wu S, Li R, Xu X, Yang Y, Guan H, Zhu X, Zhang L, et al: Aberrantly expressed miR-582-3p maintains lung cancer stem cell-like traits by: Activating Wnt/β-catenin signalling. Nat Commun. 6(8640)2015.PubMed/NCBI View Article : Google Scholar

21 

Huang S, Zou C, Tang Y, Wa Q, Peng X, Chen X, Yang C, Ren D, Huang Y, Liao Z, et al: miR-582-3p and miR-582-5p suppress prostate cancer metastasis to bone by repressing TGF-β signaling. Mol Ther Nucleic Acids. 16:91–104. 2019.PubMed/NCBI View Article : Google Scholar

22 

Zhang H, Dai Q, Zheng L, Yuan X, Pan S and Deng J: Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis. Biochem Biophys Res Commun. 533:501–509. 2020.PubMed/NCBI View Article : Google Scholar

23 

Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013.PubMed/NCBI View Article : Google Scholar

24 

Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, et al: Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs. Nat Commun. 7(11215)2016.PubMed/NCBI View Article : Google Scholar

25 

Li Y, Chen B and Huang S: Identification of circRNAs for miRNA targets by Argonaute2 RNA immunoprecipitation and luciferase screening assays. Methods Mol Biol. 1724:209–218. 2018.PubMed/NCBI View Article : Google Scholar

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

27 

Tchakarska G and Sola B: The double dealing of cyclin D1. Cell Cycle. 19:163–178. 2020.PubMed/NCBI View Article : Google Scholar

28 

Huang H: Matrix Metalloproteinase-9 (MMP-9) as a cancer biomarker and MMP-9 biosensors: Recent Advances. Sensors (Basel). 18(3249)2018.PubMed/NCBI View Article : Google Scholar

29 

Couri T and Pillai A: Goals and targets for personalized therapy for HCC. Hepatol Int. 13:125–137. 2019.PubMed/NCBI View Article : Google Scholar

30 

Vogl TJ and Gruber-Rouh T: HCC: Transarterial therapies-what the interventional radiologist can offer. Dig Dis Sci. 64:959–967. 2019.PubMed/NCBI View Article : Google Scholar

31 

Rimassa L, Pressiani T and Merle P: Systemic treatment options in hepatocellular carcinoma. Liver Cancer. 8:427–446. 2019.PubMed/NCBI View Article : Google Scholar

32 

Grandhi MS, Kim AK, Ronnekleiv-Kelly SM, Kamel IR, Ghasebeh MA and Pawlik TM: Hepatocellular carcinoma: From diagnosis to treatment. Surg Oncol. 25:74–85. 2016.PubMed/NCBI View Article : Google Scholar

33 

De Stefano F, Chacon E, Turcios L, Marti F and Gedaly R: Novel biomarkers in hepatocellular carcinoma. Dig Liver Dis. 50:1115–1123. 2018.PubMed/NCBI View Article : Google Scholar

34 

Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y and Nakatsura T: Biomarkers for the early diagnosis of hepatocellular carcinoma. World J Gastroenterol. 21:10573–10583. 2015.PubMed/NCBI View Article : Google Scholar

35 

Lei M, Zheng G, Ning Q, Zheng J and Dong D: Translation and functional roles of circular RNAs in human cancer. Mol Cancer. 19(30)2020.PubMed/NCBI View Article : Google Scholar

36 

Qiu L, Xu H, Ji M, Shang D, Lu Z, Wu Y, Tu Z and Liu H: Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms. Life Sci. 31(116660)2019.PubMed/NCBI View Article : Google Scholar

37 

Liu X, Zhong Y, Li J and Shan A: Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448. Oncotarget. 8:114829–114838. 2017.PubMed/NCBI View Article : Google Scholar

38 

He Q, Huang L, Yan D, Bi J, Yang M, Huang J and Lin T: CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and up-regulating KLF9. Aging (Albany NY). 11:11314–11328. 2019.PubMed/NCBI View Article : Google Scholar

39 

Lee YS and Dutta A: MicroRNAs in cancer. Annu Rev Pathol. 4:199–227. 2009.PubMed/NCBI View Article : Google Scholar

40 

Acunzo M, Romano G, Wernicke D and Croce CM: MicroRNA and cancer-a brief overview. Adv Biol Regul. 57:1–9. 2015.PubMed/NCBI View Article : Google Scholar

41 

Yuan W, Peng S, Wang J, Wei C, Ye Z, Wang Y, Wang M, Xu H, Jiang S, Sun D, et al: Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer. PeerJ. 7(e7602)2019.PubMed/NCBI View Article : Google Scholar

42 

He J, Su X and Xie W: MiR-582-3p alleviates osteoarthritis progression by targeting YAP1. Mol Immunol. 128:258–267. 2020.PubMed/NCBI View Article : Google Scholar

43 

Xu J, Zhang Y, Huang Y, Dong X, Xiang Z, Zou J, Wu L and Lu W: circEYA1 functions as a sponge of miR-582-3p to suppress cervical adenocarcinoma tumorigenesis via up-regulating CXCL14. Mol Ther Nucleic Acids. 22:1176–1190. 2020.PubMed/NCBI View Article : Google Scholar

44 

Di Leva G, Garofalo M and Croce CM: MicroRNAs in cancer. Annu Rev Pathol. 9:287–314. 2014.PubMed/NCBI View Article : Google Scholar

45 

Wang J, He H, Jiang Q, Wang Y and Jia S: CBX6 promotes HCC metastasis via transcription factors snail/zeb1-mediated EMT mechanism. Onco Targets Ther. 13:12489–12500. 2020.PubMed/NCBI View Article : Google Scholar

46 

Goldar S, Khaniani MS, Derakhshan SM and Baradaran B: Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 16:2129–2144. 2015.PubMed/NCBI View Article : Google Scholar

47 

Amidfar M, Karami Z, Kheirabadi GR, Afshar H and Esmaeili A: Expression of Bcl-2 and Bax genes in peripheral blood lymphocytes of depressed and nondepressed individuals. J Res Med Sci. 24(41)2019.PubMed/NCBI View Article : Google Scholar

48 

Kristensen LS, Hansen TB, Venø MT and Kjems J: Circular RNAs in cancer: Opportunities and challenges in the field. Oncogene. 37:555–565. 2018.PubMed/NCBI View Article : Google Scholar

49 

Huang M, He YR, Liang LC, Huang Q and Zhu ZQ: Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 23:6330–6338. 2017.PubMed/NCBI View Article : Google Scholar

50 

Jiao J, Zhang T, Jiao X, Huang T, Zhao L, Ma D and Cui B: hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion. J Cell Physiol. 235:1287–1295. 2020.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jin Y, Zhang Y and Luo X: circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033. Exp Ther Med 22: 1276, 2021.
APA
Jin, Y., Zhang, Y., & Luo, X. (2021). circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033. Experimental and Therapeutic Medicine, 22, 1276. https://doi.org/10.3892/etm.2021.10711
MLA
Jin, Y., Zhang, Y., Luo, X."circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033". Experimental and Therapeutic Medicine 22.5 (2021): 1276.
Chicago
Jin, Y., Zhang, Y., Luo, X."circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1276. https://doi.org/10.3892/etm.2021.10711
Copy and paste a formatted citation
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Spandidos Publications style
Jin Y, Zhang Y and Luo X: circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033. Exp Ther Med 22: 1276, 2021.
APA
Jin, Y., Zhang, Y., & Luo, X. (2021). circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033. Experimental and Therapeutic Medicine, 22, 1276. https://doi.org/10.3892/etm.2021.10711
MLA
Jin, Y., Zhang, Y., Luo, X."circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033". Experimental and Therapeutic Medicine 22.5 (2021): 1276.
Chicago
Jin, Y., Zhang, Y., Luo, X."circRNA_PTPRA functions as a sponge of miR‑582‑3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis Retraction in /10.3892/etm.2025.13033". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1276. https://doi.org/10.3892/etm.2021.10711
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