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Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)

  • Authors:
    • Bogdan Huzum
    • Bogdan Puha
    • Riana Maria Necoara
    • Stefan Gheorghevici
    • Gabriela Puha
    • Alexandru Filip
    • Paul Dan Sirbu
    • Ovidiu Alexa
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania, Orthopaedic and Traumatology Clinic, ‘Sf. Spiridon’ Clinical Emergency Hospital, 700111 Iasi, Romania, Radiology‑Imaging Clinic, ‘Sf. Spiridon’ Clinical Emergency Hospital, 700111 Iasi, Romania, Department of Orthopaedic and Traumatology, Faculty of Medicine, ‘Grigore T. Popa’ University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania
    Copyright: © Huzum et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1315
    |
    Published online on: September 17, 2021
       https://doi.org/10.3892/etm.2021.10750
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Abstract

Biocompatibility is one of the mandatory requirements for the clinical use of biomaterials in orthopedics. It refers to the ability of a biomaterial to perform its function without eliciting toxic or injurious effects on biological systems but producing an appropriate host response in a specific case. Today, the biocompatibility concept includes not only bio‑inertia, but also biofunctionality and biostability. High biocompatibility and functional properties are highly desirable for new biomaterials. The chemical, mechanical, structural properties of biomaterials, their interaction with biological environment or even the methodology of assessment can influence the biocompatibility. The biological evaluation of biomaterials includes a broad spectrum of in vitro and in vivo tests related to the cytocompatibility, genotoxicity, sensitization, irritation, acute and chronic toxicity, hemocompatibility, reproductive and developmental toxicitity, carcinogenicity, implantation and degradation as specified in different international standards. A brief review of the main assays used in the biocompatibility testing of orthopedic biomaterials is presented. In addition, their main biocompatibility issues are overviewed.
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Copy and paste a formatted citation
Spandidos Publications style
Huzum B, Puha B, Necoara RM, Gheorghevici S, Puha G, Filip A, Sirbu PD and Alexa O: Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review). Exp Ther Med 22: 1315, 2021.
APA
Huzum, B., Puha, B., Necoara, R.M., Gheorghevici, S., Puha, G., Filip, A. ... Alexa, O. (2021). Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review). Experimental and Therapeutic Medicine, 22, 1315. https://doi.org/10.3892/etm.2021.10750
MLA
Huzum, B., Puha, B., Necoara, R. M., Gheorghevici, S., Puha, G., Filip, A., Sirbu, P. D., Alexa, O."Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1315.
Chicago
Huzum, B., Puha, B., Necoara, R. M., Gheorghevici, S., Puha, G., Filip, A., Sirbu, P. D., Alexa, O."Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1315. https://doi.org/10.3892/etm.2021.10750
Copy and paste a formatted citation
x
Spandidos Publications style
Huzum B, Puha B, Necoara RM, Gheorghevici S, Puha G, Filip A, Sirbu PD and Alexa O: Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review). Exp Ther Med 22: 1315, 2021.
APA
Huzum, B., Puha, B., Necoara, R.M., Gheorghevici, S., Puha, G., Filip, A. ... Alexa, O. (2021). Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review). Experimental and Therapeutic Medicine, 22, 1315. https://doi.org/10.3892/etm.2021.10750
MLA
Huzum, B., Puha, B., Necoara, R. M., Gheorghevici, S., Puha, G., Filip, A., Sirbu, P. D., Alexa, O."Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1315.
Chicago
Huzum, B., Puha, B., Necoara, R. M., Gheorghevici, S., Puha, G., Filip, A., Sirbu, P. D., Alexa, O."Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1315. https://doi.org/10.3892/etm.2021.10750
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