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Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology

  • Authors:
    • Ioana Binișor
    • Ileana Monica Baniță
    • Dragoș Alexandru
    • Mihaela Cezarina Mehedinți
    • Sanda Jurja
    • Ana-Marina Andrei
    • Cătălina Gabriela Pisoschi
  • View Affiliations / Copyright

    Affiliations: Department of Histology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Histology, ‘Dunărea de Jos’ University of Galați, 80010 Galați, Romania, Department of Ophthalmology, ‘Ovidius’ University of Constanta, 900470 Constanta, Romania, Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
    Copyright: © Binișor et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1337
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    Published online on: September 22, 2021
       https://doi.org/10.3892/etm.2021.10772
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Abstract

The connection between central obesity and the development and metastasis of various visceral tumors is largely accepted and one of the main causes seems to be the local synthesis of proangiogenic molecules. Progranulin (PRG), recently identified as an adipokine, is a novel pleiotropic growth factor acting on the proliferation and development of fast‑growing epithelial cells, cancer cells, and also a proangiogenic factor whose expression is induced in activated endothelial cells. One of the molecules that seems to trigger the angiogenic activity of PRG is vascular endothelial growth factor (VEGF). Two groups of human subjects were considered and adipose tissue was processed for an immunohistochemical and morphometric study after surgery for abdominal tumoral or non‑tumoral pathology. The presence of PRG in adipose pads of the omentum was analyzed and its association with VEGF, CD34 and collagen IV in tumoral and non‑tumoral visceral pathology was examined. The results showed that PRG but not VEGF expression was upregulated in adipose tissue in tumoral visceral pathology. In conclusion, the involvement of the proangiogenic activity of PRG and VEGF in adipose tissue under tumor conditions may be dependent on the visceral tumor type.
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Binișor I, Baniță IM, Alexandru D, Mehedinți MC, Jurja S, Andrei A and Pisoschi CG: Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology. Exp Ther Med 22: 1337, 2021.
APA
Binișor, I., Baniță, I.M., Alexandru, D., Mehedinți, M.C., Jurja, S., Andrei, A., & Pisoschi, C.G. (2021). Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology. Experimental and Therapeutic Medicine, 22, 1337. https://doi.org/10.3892/etm.2021.10772
MLA
Binișor, I., Baniță, I. M., Alexandru, D., Mehedinți, M. C., Jurja, S., Andrei, A., Pisoschi, C. G."Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology". Experimental and Therapeutic Medicine 22.5 (2021): 1337.
Chicago
Binișor, I., Baniță, I. M., Alexandru, D., Mehedinți, M. C., Jurja, S., Andrei, A., Pisoschi, C. G."Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1337. https://doi.org/10.3892/etm.2021.10772
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Spandidos Publications style
Binișor I, Baniță IM, Alexandru D, Mehedinți MC, Jurja S, Andrei A and Pisoschi CG: Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology. Exp Ther Med 22: 1337, 2021.
APA
Binișor, I., Baniță, I.M., Alexandru, D., Mehedinți, M.C., Jurja, S., Andrei, A., & Pisoschi, C.G. (2021). Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology. Experimental and Therapeutic Medicine, 22, 1337. https://doi.org/10.3892/etm.2021.10772
MLA
Binișor, I., Baniță, I. M., Alexandru, D., Mehedinți, M. C., Jurja, S., Andrei, A., Pisoschi, C. G."Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology". Experimental and Therapeutic Medicine 22.5 (2021): 1337.
Chicago
Binișor, I., Baniță, I. M., Alexandru, D., Mehedinți, M. C., Jurja, S., Andrei, A., Pisoschi, C. G."Progranulin: A proangiogenic factor in visceral adipose tissue in tumoral and non‑tumoral visceral pathology". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1337. https://doi.org/10.3892/etm.2021.10772
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