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A systematic review of euthyroid Graves' disease (Review)

  • Authors:
    • Mioara-Laura Macovei
    • Űnal Azis
    • Alina Gabriela Gheorghe
    • Marian Burcea
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
    Copyright: © Macovei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1346
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    Published online on: September 22, 2021
       https://doi.org/10.3892/etm.2021.10781
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Abstract

Euthyroid Graves' Disease (EGD) is a challenging pathology, due to its atypical clinical manifestations and the absence of abnormal thyroid function. Typically, thyroid ophthalmopathy is associated with elevated thyroid hormone levels and with the presence of thyrotropin receptor antibodies (TRAb) but a low percentage of patients remain euthyroid without developing hyperthyroidism during long‑term follow‑up periods. Although it is considered a different pathology, it shares a lot of similarities with Graves' disease, rendering the diagnosis more difficult. It is also important to note that ophthalmopathy may be the first clinical manifestation of Graves' disease and that thyroid function examinations do not present abnormalities over a long period. Treatment choices for euthyroid disease do not differ from those described in Graves' ophthalmopathy. However, it is considered that since euthyroid patients develop milder ophthalmic symptoms and their clinical activity score is lower, they tend to have better responses to treatment. Moreover, atypical sight‑threatening cases such as exposure keratopathy and dysthyroid optic neuropathy with variable responses to therapy also exist. Disease management consists of a favorable collaboration between ophthalmologists and endocrinologists because patients with EGD can develop thyroid abnormalities over time. In conclusion, the diagnosis of EGD is difficult, clinical manifestations and evolution are variables depending on several factors, including the heterogeneity of TRAb. This review aimed to identify the characteristics of this disease by reviewing the clinical studies and case reports published in previous years.
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Copy and paste a formatted citation
Spandidos Publications style
Macovei M, Azis Ű, Gheorghe AG and Burcea M: A systematic review of euthyroid Graves' disease (Review). Exp Ther Med 22: 1346, 2021.
APA
Macovei, M., Azis, Ű., Gheorghe, A.G., & Burcea, M. (2021). A systematic review of euthyroid Graves' disease (Review). Experimental and Therapeutic Medicine, 22, 1346. https://doi.org/10.3892/etm.2021.10781
MLA
Macovei, M., Azis, Ű., Gheorghe, A. G., Burcea, M."A systematic review of euthyroid Graves' disease (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1346.
Chicago
Macovei, M., Azis, Ű., Gheorghe, A. G., Burcea, M."A systematic review of euthyroid Graves' disease (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1346. https://doi.org/10.3892/etm.2021.10781
Copy and paste a formatted citation
x
Spandidos Publications style
Macovei M, Azis Ű, Gheorghe AG and Burcea M: A systematic review of euthyroid Graves' disease (Review). Exp Ther Med 22: 1346, 2021.
APA
Macovei, M., Azis, Ű., Gheorghe, A.G., & Burcea, M. (2021). A systematic review of euthyroid Graves' disease (Review). Experimental and Therapeutic Medicine, 22, 1346. https://doi.org/10.3892/etm.2021.10781
MLA
Macovei, M., Azis, Ű., Gheorghe, A. G., Burcea, M."A systematic review of euthyroid Graves' disease (Review)". Experimental and Therapeutic Medicine 22.5 (2021): 1346.
Chicago
Macovei, M., Azis, Ű., Gheorghe, A. G., Burcea, M."A systematic review of euthyroid Graves' disease (Review)". Experimental and Therapeutic Medicine 22, no. 5 (2021): 1346. https://doi.org/10.3892/etm.2021.10781
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