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Article Open Access

lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p

Retraction in: /10.3892/etm.2024.12627
  • Authors:
    • Yang Zhang
    • Yan Yang
    • Yi Zhang
    • Zhisu Liu
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The General Hospital of The Central Military Theater of The People's Liberation Army, Wuhan, Hubei 430030, P.R. China, Department of Pediatric Hematology, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430031, P.R. China, Department of Hepatobiliary Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1348
    |
    Published online on: September 23, 2021
       https://doi.org/10.3892/etm.2021.10783
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Abstract

Long non‑coding RNA ST8 α‑N‑acetyl‑neuraminide α‑2,8‑sialyltransferase 6 antisense 1 (ST8SIA6‑AS1) has been identified as a novel oncogene in breast cancer. However, its involvement in liver cancer has remained elusive. In the present study, the expression of ST8SIA6‑AS1 and microRNA (miR)‑142‑3p in liver cancer tissues and cell lines was detected by reverse transcription‑quantitative PCR. Tumor cell proliferation, migration and invasion assays were performed to determine the biological functions of ST8SIA6‑AS1. The targeting interaction between ST8SIA6‑AS1 and miR‑142‑3p predicted by bioinformatics was verified by a luciferase reporter assay and a biotin pulldown assay. The results indicated that ST8SIA6‑AS1 was highly expressed in liver cancer tissues and cell lines, and the high expression of ST8SIA6‑AS1 in liver cancer tissues was associated with poor prognosis. Knockdown of ST8SIA6‑AS1 inhibited the proliferation, metastasis and invasion of liver cancer cells. Mechanistic investigation revealed that ST8SIA6‑AS1 sequesters miR‑142‑3p and negatively regulates miR‑142‑3p expression in liver cancer cells. Further investigation indicated that the tumor‑inhibitory effect of ST8SIA6‑AS1 silencing was reversed by miR‑142‑3p depletion. In conclusion, ST8SIA6‑AS1 was indicated to exert an oncogenic function in liver cancer by competitively sponging miR‑142‑3p.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Yang Y, Zhang Y and Liu Z: lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627. Exp Ther Med 22: 1348, 2021.
APA
Zhang, Y., Yang, Y., Zhang, Y., & Liu, Z. (2021). lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627. Experimental and Therapeutic Medicine, 22, 1348. https://doi.org/10.3892/etm.2021.10783
MLA
Zhang, Y., Yang, Y., Zhang, Y., Liu, Z."lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627". Experimental and Therapeutic Medicine 22.6 (2021): 1348.
Chicago
Zhang, Y., Yang, Y., Zhang, Y., Liu, Z."lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1348. https://doi.org/10.3892/etm.2021.10783
Copy and paste a formatted citation
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Spandidos Publications style
Zhang Y, Yang Y, Zhang Y and Liu Z: lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627. Exp Ther Med 22: 1348, 2021.
APA
Zhang, Y., Yang, Y., Zhang, Y., & Liu, Z. (2021). lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627. Experimental and Therapeutic Medicine, 22, 1348. https://doi.org/10.3892/etm.2021.10783
MLA
Zhang, Y., Yang, Y., Zhang, Y., Liu, Z."lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627". Experimental and Therapeutic Medicine 22.6 (2021): 1348.
Chicago
Zhang, Y., Yang, Y., Zhang, Y., Liu, Z."lncRNA ST8SIA6‑AS1 facilitates proliferation and invasion in liver cancer by regulating miR‑142‑3p Retraction in /10.3892/etm.2024.12627". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1348. https://doi.org/10.3892/etm.2021.10783
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