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Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis

  • Authors:
    • Qinwei Zhu
    • Shuanghong Li
    • Kui Ji
    • Hongyuan Zhou
    • Chuanchao Luo
    • Yana Sui
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Weifang Hospital of Traditional Chinese Medicine, Weifang, Shandong 261041, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1362
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    Published online on: September 27, 2021
       https://doi.org/10.3892/etm.2021.10796
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Abstract

Long non‑coding RNAs (lncRNAs) and microRNAs (miRs) have critical roles in the progression of various diseases. The present study aimed to investigate the levels and clinical significance of lncRNA taurine upregulated gene 1 (TUG1) and miR‑145‑5p in patients with chronic heart failure (CHF) and explore their indicative value regarding disease severity. TUG1 and miR‑145‑5p levels were detected by reverse‑transcription quantitative PCR. Correlations were examined using Pearson's correlation analysis. Receiver operating characteristic analysis was used to evaluate the diagnostic value of TUG1, miR‑145‑5p and brain natriuretic peptide (BNP). Survival analysis was performed by the Kaplan‑Meier method. Cox regression analysis was used to evaluate the prognostic value of TUG1 and miR‑145‑5p. The levels of interleukin‑6 and tumor necrosis factor‑α in serum were detected by ELISA. The results indicated that TUG1 was upregulated and miR‑145‑5p was downregulated in patients with CHF and they were negatively correlated. TUG1 and miR‑145‑5p were associated with the left ventricle ejection fraction and were able to indicate the severity of CHF. Serum TUG1 and miR‑145‑5p had a certain diagnostic value and the combination of BNP, TUG1 and miR‑145‑5p had high diagnostic accuracy. TUG1 and miR‑145‑5p were closely associated with overall survival and may function as independent prognostic biomarkers for patients with CHF. In addition, TUG1 and miR‑145‑5p levels were markedly correlated with inflammation in CHF. Upregulated TUG1 and downregulated miR‑145‑5p may indicate the severity of CHF, may serve as diagnostic and prognostic biomarkers and may be involved in CHF progression by regulating inflammatory responses.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu Q, Li S, Ji K, Zhou H, Luo C and Sui Y: Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis. Exp Ther Med 22: 1362, 2021.
APA
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., & Sui, Y. (2021). Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis. Experimental and Therapeutic Medicine, 22, 1362. https://doi.org/10.3892/etm.2021.10796
MLA
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., Sui, Y."Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis". Experimental and Therapeutic Medicine 22.6 (2021): 1362.
Chicago
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., Sui, Y."Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1362. https://doi.org/10.3892/etm.2021.10796
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Q, Li S, Ji K, Zhou H, Luo C and Sui Y: Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis. Exp Ther Med 22: 1362, 2021.
APA
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., & Sui, Y. (2021). Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis. Experimental and Therapeutic Medicine, 22, 1362. https://doi.org/10.3892/etm.2021.10796
MLA
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., Sui, Y."Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis". Experimental and Therapeutic Medicine 22.6 (2021): 1362.
Chicago
Zhu, Q., Li, S., Ji, K., Zhou, H., Luo, C., Sui, Y."Differentially expressed TUG1 and miR‑145‑5p indicate different severity of chronic heart failure and predict 2‑year survival prognosis". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1362. https://doi.org/10.3892/etm.2021.10796
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