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Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)

  • Authors:
    • Ionut Serban Fanfaret
    • Daniel Boda
    • Laura Mihaela Ion
    • Daniela Hosseyni
    • Poliana Leru
    • Selda Ali
    • Sabina Corcea
    • Roxana Bumbacea
  • View Affiliations / Copyright

    Affiliations: Pediatrics Department, Béziers Hospital Center, 34500 Béziers, France, Dermatology Department, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Pediatrics Department, ‘Ponderas’ Academic Hospital, 014142 Bucharest, Romania, Public Health Department, Harvard T.H. Chan School of Public Health, ECPE, PPCR Program, Boston, MA 02115, USA, Internal Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Allergy Department, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania
    Copyright: © Fanfaret et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1376
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    Published online on: September 28, 2021
       https://doi.org/10.3892/etm.2021.10811
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Abstract

Atopic dermatitis (AD) represents a chronic inflammatory skin condition in which the skin barrier is impaired; thus, the permeability is increased. Hence, there is a greater risk of allergic sensitization, as well as a higher pH and lower protection against resident microbes. Since this condition is currently increasing among children, it requires further study, as little is known regarding the pathogenesis that makes the skin prone to chronic relapsing inflammation. Trying to standardize the data regarding the use of prebiotics and probiotics in AD, we encountered tremendous variability in the literature data. Literature abounds in conflicting data: studies regarding prophylactic and therapeutic applications, different types of strains and dosages, applications in young children up to 5 years of age and above, usage of probiotics alone, prebiotics alone or synbiotics combined. There are also conflicting data regarding the outcome of these studies; some confirming a positive effect of prebiotics, probiotics or synbiotics and some showing no efficacy at all. The articles were divided into those assessing probiotics or prebiotics alone and a combination of the two, with studies showing a positive effect and studies proving no efficacy at all. We tried to critically analyze those articles showing weak and strong points. In summary, the most studied probiotics were the strains of Lactobacilli and Bifidobacteria. The Severity Scoring of Atopic Dermatitis (SCORAD) index was used to measure the efficacy of the treatment. Most studies compared their results with a placebo group and the efficacy when seen in moderate to severe forms of AD in patients with other allergic diseases present. However, the results are difficult to interpret, as in many studies the authors suggest that the disease may have a tendency to improve in time in some groups of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Fanfaret IS, Boda D, Ion LM, Hosseyni D, Leru P, Ali S, Corcea S and Bumbacea R: Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review). Exp Ther Med 22: 1376, 2021.
APA
Fanfaret, I.S., Boda, D., Ion, L.M., Hosseyni, D., Leru, P., Ali, S. ... Bumbacea, R. (2021). Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review). Experimental and Therapeutic Medicine, 22, 1376. https://doi.org/10.3892/etm.2021.10811
MLA
Fanfaret, I. S., Boda, D., Ion, L. M., Hosseyni, D., Leru, P., Ali, S., Corcea, S., Bumbacea, R."Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)". Experimental and Therapeutic Medicine 22.6 (2021): 1376.
Chicago
Fanfaret, I. S., Boda, D., Ion, L. M., Hosseyni, D., Leru, P., Ali, S., Corcea, S., Bumbacea, R."Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1376. https://doi.org/10.3892/etm.2021.10811
Copy and paste a formatted citation
x
Spandidos Publications style
Fanfaret IS, Boda D, Ion LM, Hosseyni D, Leru P, Ali S, Corcea S and Bumbacea R: Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review). Exp Ther Med 22: 1376, 2021.
APA
Fanfaret, I.S., Boda, D., Ion, L.M., Hosseyni, D., Leru, P., Ali, S. ... Bumbacea, R. (2021). Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review). Experimental and Therapeutic Medicine, 22, 1376. https://doi.org/10.3892/etm.2021.10811
MLA
Fanfaret, I. S., Boda, D., Ion, L. M., Hosseyni, D., Leru, P., Ali, S., Corcea, S., Bumbacea, R."Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)". Experimental and Therapeutic Medicine 22.6 (2021): 1376.
Chicago
Fanfaret, I. S., Boda, D., Ion, L. M., Hosseyni, D., Leru, P., Ali, S., Corcea, S., Bumbacea, R."Probiotics and prebiotics in atopic dermatitis: Pros and cons (Review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1376. https://doi.org/10.3892/etm.2021.10811
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