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Article

Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience

  • Authors:
    • Nadejda Cojocari
    • Gabriel Viorel Crihana
    • Nicolae Bacalbasa
    • Irina Balescu
    • Leonard David
  • View Affiliations / Copyright

    Affiliations: Department of Visceral Surgery, ‘Fundeni’ Clinical Institute, 022328 Bucharest, Romania, Department of Visceral Surgery, Ilfov County Emergency Clinical Hospital, 22113 Bucharest, Romania, Department of Visceral Surgery, ‘Ponderas’ Academic Hospital, 021188 Bucharest, Romania
  • Article Number: 1378
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    Published online on: September 28, 2021
       https://doi.org/10.3892/etm.2021.10813
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Abstract

Duodenal or pancreatic invasion in locally advanced right colon cancer (LARCC) is a challenging situation that can pose difficulties in its management. When the duodenum alone is invaded, the surgeon may undertake right hemicolectomy (RH) en bloc with the affected patch of duodenum. The duodenal defect can be reconstructed using several techniques. When invasion of the pancreas is present, RH en bloc with duodenopancreatectomy (DP) is the treatment of choice. We present our experience regarding the treatment and prognostic results of this rare colon cancer form. We retrospectively reviewed the data of patients who underwent surgery for right‑sided colon cancer with duodenal and/or pancreatic invasion between January 2004 and March 2020. Among the 110 patients with LARCC, pancreas and/or duodenum invasion was encountered in 22 patients, with a mean age of 49.5 years. From the 22 patients, 5 patients underwent palliative procedures, with a maximal survival of 15 months. Three patients underwent RH alone, with lethal outcome in the first year in 66% of the cases. RH en bloc with antrectomy was performed in 2 patients. Eight patients underwent RH with DP, with a 1‑year survival of 75% (6/8) and a 5‑year survival of 50% (3/6). Thirty‑day mortality post‑DP was noted in 25% (2/8) of the cases. Four patients underwent RH with limited duodenal resection, with no recurrence of disease at 11 to 39 months postoperatively. Among the duodenal defect restoration, simple duodenal suture was practiced in 2 patients, duodenojejunostomy in one patient and pedicled ileal flap in 1 case. In conclusion, although postoperative mortality can be significant, en bloc resection for LARCC invading the duodenum and/or pancreas offers prolonged survival in a considerable number of patients.
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Copy and paste a formatted citation
Spandidos Publications style
Cojocari N, Crihana GV, Bacalbasa N, Balescu I and David L: Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience. Exp Ther Med 22: 1378, 2021.
APA
Cojocari, N., Crihana, G.V., Bacalbasa, N., Balescu, I., & David, L. (2021). Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience. Experimental and Therapeutic Medicine, 22, 1378. https://doi.org/10.3892/etm.2021.10813
MLA
Cojocari, N., Crihana, G. V., Bacalbasa, N., Balescu, I., David, L."Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience". Experimental and Therapeutic Medicine 22.6 (2021): 1378.
Chicago
Cojocari, N., Crihana, G. V., Bacalbasa, N., Balescu, I., David, L."Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1378. https://doi.org/10.3892/etm.2021.10813
Copy and paste a formatted citation
x
Spandidos Publications style
Cojocari N, Crihana GV, Bacalbasa N, Balescu I and David L: Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience. Exp Ther Med 22: 1378, 2021.
APA
Cojocari, N., Crihana, G.V., Bacalbasa, N., Balescu, I., & David, L. (2021). Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience. Experimental and Therapeutic Medicine, 22, 1378. https://doi.org/10.3892/etm.2021.10813
MLA
Cojocari, N., Crihana, G. V., Bacalbasa, N., Balescu, I., David, L."Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience". Experimental and Therapeutic Medicine 22.6 (2021): 1378.
Chicago
Cojocari, N., Crihana, G. V., Bacalbasa, N., Balescu, I., David, L."Right‑sided colon cancer with invasion of the duodenum or pancreas: A glimpse into our experience". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1378. https://doi.org/10.3892/etm.2021.10813
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