Inhibitors of apoptosis (IAPs) are a family of cell death inhibitors found in viruses and metazoans that physically interact with a variety of pro‑apoptotic proteins and inhibit apoptosis induced by diverse stimuli. Melanoma IAP (ML‑IAP) is a potent anti‑apoptotic protein that is strongly upregulated in melanoma and confers protection against a variety of pro‑apoptotic stimuli. In the present study, it was revealed that ML‑IAP was expressed at high levels in testicular teratoma. Deletion and mutational analysis demonstrated that ML‑IAP silencing significantly decreased P19 cell proliferation while inducing cell cycle arrest and apoptosis. ML‑IAP knockdown significantly induced caspase‑3/8/9‑mediated apoptosis in P19 cells. In addition, metabolism and stemness maintenance in P19 cells were suppressed by ML‑IAP knockdown. These results indicated that ML‑IAP silencing is a powerful inducer of apoptosis mediated by cell death receptors and may function as a direct activator of downstream effector caspases.
Something has gone wrong
HTTP Error 400
Well this is embarrassing. Something has gone wrong. Hopefully it is a transient error that will go away if you retry.
If the problem persists if you email our System Administrators letting them know what you were doing and telling them it was because:
Exception evaluating SpringEL expression: "dispArt?.images" (template: "article" - line 384, col 9)