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Article

Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures

  • Authors:
    • Irina Pacu
    • Nikolaos Zygouropoulos
    • Mihai Dimitriu
    • George Rosu
    • Cringu A. Ionescu
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Sf. Pantelimon’ Emergency Clinical Hospital, 021623 Bucharest, Romania
  • Article Number: 1412
    |
    Published online on: October 7, 2021
       https://doi.org/10.3892/etm.2021.10848
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Abstract

Couple infertility is a pathology with an absolute number of cases growing markedly over the last decade in connection mainly with the increased age of couples wishing to conceive. Platelet‑rich plasma (PRP) is an alternative treatment used for several years for experimental purposes. Yet, this method is not yet defined as a standard therapeutic option in the infertility protocol for poor responders in assisted human reproduction procedures. Thus, the present study is a retrospective study conducted between February 2019 and February 2020 to evaluate the effect of ovarian PRP injection in patients with a poor ovarian response (POR) to ovarian stimulation. Women (n=20; age 31‑44 years) diagnosed with POR based on the European Society of Human Reproduction and Embryology criteria underwent ovarian injection with autologous PRP injection. Markers of ovarian reserve before, during the following two menstrual cycles, and at six months after treatment were followed as well as stimulation and fertilisation parameters before and post‑treatment. PRP treatment resulted in increased antral follicle count and serum anti‑Mullerian hormone, while levels of serum follicle‑stimulating hormone and luteinising hormone were decreased. These changes were more pronounced during the 2nd menstrual cycle following treatment. By six months following the injection, their values return to pre‑treatment levels and any small differences were not considered statistically significant. The average dose of gonadotropin used and duration remained statistically unchanged, but a significant increase in estradiol achieved by the day of the human chorionic gonadotropin trigger day was achieved. The cancellation rate decreased following PRP treatment while the number of collected oocytes, number of oocytes in metaphase II rose. The number of embryos (of A and B quality) resulting also increased but fell short of the significance level set (α=0.073). Following the PRP injection, two singleton pregnancies were achieved, resulting in live births at term without complications during pregnancy. Another pregnancy was achieved spontaneously 45 months following the PRP and a failed assisted human reproduction procedure. Although the group included a small number of women, the results indicate the potential benefits of an ovarian autologous PRP injection in women with POR. Positive results appear to be short‑term for 2‑6 months after the procedure.
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Copy and paste a formatted citation
Spandidos Publications style
Pacu I, Zygouropoulos N, Dimitriu M, Rosu G and Ionescu CA: Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures. Exp Ther Med 22: 1412, 2021.
APA
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., & Ionescu, C.A. (2021). Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures. Experimental and Therapeutic Medicine, 22, 1412. https://doi.org/10.3892/etm.2021.10848
MLA
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., Ionescu, C. A."Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures". Experimental and Therapeutic Medicine 22.6 (2021): 1412.
Chicago
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., Ionescu, C. A."Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1412. https://doi.org/10.3892/etm.2021.10848
Copy and paste a formatted citation
x
Spandidos Publications style
Pacu I, Zygouropoulos N, Dimitriu M, Rosu G and Ionescu CA: Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures. Exp Ther Med 22: 1412, 2021.
APA
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., & Ionescu, C.A. (2021). Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures. Experimental and Therapeutic Medicine, 22, 1412. https://doi.org/10.3892/etm.2021.10848
MLA
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., Ionescu, C. A."Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures". Experimental and Therapeutic Medicine 22.6 (2021): 1412.
Chicago
Pacu, I., Zygouropoulos, N., Dimitriu, M., Rosu, G., Ionescu, C. A."Use of platelet‑rich plasma in the treatment of infertility in poor responders in assisted human reproduction procedures". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1412. https://doi.org/10.3892/etm.2021.10848
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