Postpartum assessment of fetal inflammatory response syndrome in a preterm population with premature rupture of membranes: A Romanian study

Zaharie,Gabriela Corina; Drugan,Tudor; Crivii,Carmen; Muresan,Daniel; Zaharie,Alexandru; Hășmășanu,Monica Gabriela; Zaharie,Flaviu; Matyas,Melinda

doi:10.3892/etm.2021.10862

Postpartum assessment of fetal inflammatory response syndrome in a preterm population with premature rupture of membranes: A Romanian study

Authors:
- Gabriela Corina Zaharie
- Tudor Drugan
- Carmen Crivii
- Daniel Muresan
- Alexandru Zaharie
- Monica Gabriela Hășmășanu
- Flaviu Zaharie
- Melinda Matyas
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Affiliations: Department of Neonatology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Anatomy and Embryology, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Medical Informatics and Biostatistics, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Obstetrics and Gynecology I, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania, Department of Radiation Oncology, Medical University of Vienna, 1090 Vienna, Austria, ‘Iuliu Haţieganu’ University of Medicine and Pharmacy, 400012 Cluj‑Napoca, Romania
Published online on: October 11, 2021 https://doi.org/10.3892/etm.2021.10862
Article Number: 1427
Copyright: © Zaharie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Fetal inflammatory response syndrome is associated with increased neonatal morbidity and mortality. The aim of the present study was to evaluate the dynamics of the plasmatic value of pro‑inflammatory cytokines: tumor necrosis factor‑α (TNF‑α), interleukin‑6 (IL‑6) and neutrophil activating peptide 78 (ENA‑78) and the anti‑inflammatory cytokine IL‑10 in the first and third day of life and the correlation with neonatal morbidities and mortality. The current research was designed as a prospective case control study included 80 neonates hospitalized at the 3rd level Neonatal Intensive Care Unit (NICU), 1st Gynecology Clinic, County Emergency Hospital, Cluj‑Napoca, Romania. For each patient, the following parameters were noted: pH at first hour of life, oxygen saturation, fraction of inspired oxygen (FiO₂) and duration of premature rupture of the membranes (PROM). Measurements of cytokines were determined from venous blood in the first and third day of life. The values of all cytokines were higher in the newborns from mothers with PROM. The value of IL‑6 in the study group was higher compared to the controls during the first day of life and met the highest value in necrotizing enterocolitis (NEC). ENA‑78 was higher in the study group (P=0.037) and decreased during the first 3 days of life. The highest value of ENA‑78 was found in the neonates with cerebral hemorrhage. IL‑10 also had values with a significant difference in the first day of life between both groups (P=0.02). IL‑10 had the highest value in sepsis cases. In conclusion, among the inflammatory parameters that were evaluated, the dynamics of ENA‑78 and IL‑10 were found to influence the neonatal prognosis of newborns with PROM. The decrease in ENA‑78 and IL‑10 during the third day of life could suggest the evolution towards the ending of the inflammatory process and an increase in the survival rate was noted.

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