Influence of extracellular nanovesicles derived from adipose‑derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration

  • Authors:
    • Zhiqiang Zhang
    • Liang Zhang
    • Jiandong Yang
    • Jijun Huang
    • Jun Cai
    • Shengfei Zhang
    • Xinmin Feng
    • Qiang Wang
  • View Affiliations

  • Published online on: October 11, 2021     https://doi.org/10.3892/etm.2021.10866
  • Article Number: 1431
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Abstract

An increasing number of individuals are suffering from lower back and neck pain caused by intervertebral disc degeneration each year. Although the application of mesenchymal stem cells (MSCs) has provided desirable results in the treatment of intervertebral disc degeneration, there are multiple risks associated with the directed application of MSCs. An increasing number of studies have suggested that stem cells, through the release of extracellular nanovesicles, have vital functions in tissue regeneration and repair with low risk. The present study investigated the effect of extracellular nanovesicles derived from adipose‑derived stem cells (ADSCs) on nucleus pulposus (NP) cells from patients with intervertebral disc degeneration. Human NP cells were obtained from patients with intervertebral disc degeneration undergoing surgical procedures in addition to ADSCs from liposuction patients. ADSC‑derived extracellular nanovesicles were isolated and characterized. The differentiation and biological activity of NP cells cultured with or without ADSC‑derived extracellular nanovesicles were assessed and inflammatory factors and intervertebral disc degeneration‑associated markers were also measured. The results indicated that extracellular nanovesicles derived from ADSCs increased the migration and proliferation of NP cells and inhibited inflammatory activity, suggesting their utility for the treatment of intervertebral disc degeneration.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Zhang Z, Zhang L, Yang J, Huang J, Cai J, Zhang S, Feng X and Wang Q: Influence of extracellular nanovesicles derived from adipose‑derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration. Exp Ther Med 22: 1431, 2021.
APA
Zhang, Z., Zhang, L., Yang, J., Huang, J., Cai, J., Zhang, S. ... Wang, Q. (2021). Influence of extracellular nanovesicles derived from adipose‑derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration. Experimental and Therapeutic Medicine, 22, 1431. https://doi.org/10.3892/etm.2021.10866
MLA
Zhang, Z., Zhang, L., Yang, J., Huang, J., Cai, J., Zhang, S., Feng, X., Wang, Q."Influence of extracellular nanovesicles derived from adipose‑derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration". Experimental and Therapeutic Medicine 22.6 (2021): 1431.
Chicago
Zhang, Z., Zhang, L., Yang, J., Huang, J., Cai, J., Zhang, S., Feng, X., Wang, Q."Influence of extracellular nanovesicles derived from adipose‑derived stem cells on nucleus pulposus cell from patients with intervertebral disc degeneration". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1431. https://doi.org/10.3892/etm.2021.10866