Open Access

Low‑activity 125I implantation into VX2 tumor rabbits and quantitative evaluation of the precise therapeutic effect

  • Authors:
    • Zheng Wang
    • Juan Wang
    • Yongyi Yao
    • Feng Wang
    • Qiang Fan
    • Ruifeng Zhao
  • View Affiliations

  • Published online on: October 12, 2021     https://doi.org/10.3892/etm.2021.10873
  • Article Number: 1438
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is still controversy about quantitatively evaluating the therapeutic effect of radioactive low‑activity iodine‑125 seeds (125I seeds). In the present study, a paired VX2 tumor model in a rabbit hind leg muscle was established, which is virus‑induced anaplastic squamous cell carcinoma characterized by hypervascularity, rapid growth and easy propagation in the skeletal muscle. 125I seeds with 0.4 and 0.7 mCi activity were implanted into the left and right legs, respectively, using a radiation treatment planning system under positron emission tomography (PET)/computed tomography (CT) guidance. PET/CT scans and hematoxylin and eosin staining were observed at 72 h and 2 and 4 weeks after implantation to assess the therapeutic effect. The results showed that the average tumor length and standard uptake value (SUV) decreased over time, and both 125I seed groups achieved therapeutic effects at 4 weeks post‑implantation. Quantitative evaluation of tumor inhibition rate, SUV variation and tumor marker ratio (Bcl‑2/Bax) suggested that 0.7 mCi 125I seeds were more suitable than 0.4 mCi seeds in a clinical setting.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Wang Z, Wang J, Yao Y, Wang F, Fan Q and Zhao R: Low‑activity <sup>125</sup>I implantation into VX<sub>2</sub> tumor rabbits and quantitative evaluation of the precise therapeutic effect. Exp Ther Med 22: 1438, 2021
APA
Wang, Z., Wang, J., Yao, Y., Wang, F., Fan, Q., & Zhao, R. (2021). Low‑activity <sup>125</sup>I implantation into VX<sub>2</sub> tumor rabbits and quantitative evaluation of the precise therapeutic effect. Experimental and Therapeutic Medicine, 22, 1438. https://doi.org/10.3892/etm.2021.10873
MLA
Wang, Z., Wang, J., Yao, Y., Wang, F., Fan, Q., Zhao, R."Low‑activity <sup>125</sup>I implantation into VX<sub>2</sub> tumor rabbits and quantitative evaluation of the precise therapeutic effect". Experimental and Therapeutic Medicine 22.6 (2021): 1438.
Chicago
Wang, Z., Wang, J., Yao, Y., Wang, F., Fan, Q., Zhao, R."Low‑activity <sup>125</sup>I implantation into VX<sub>2</sub> tumor rabbits and quantitative evaluation of the precise therapeutic effect". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1438. https://doi.org/10.3892/etm.2021.10873