Exacerbation of bronchiectasis by <em>Pseudomonas putida</em> complicating COVID‑19 disease: A case report

Georgakopoulou,Vasiliki Epameinondas; Avramopoulos,Pantelis; Papalexis,Petros; Bitsani,Aikaterini; Damaskos,Christos; Garmpi,Anna; Gkoufa,Aikaterini; Garmpis,Nikolaos; Mantzouranis,Konstantinos; Chlapoutakis,Serafeim; Sklapani,Pagona; Trakas,Nikolaos; Spandidos,Demetrios A.

doi:10.3892/etm.2021.10887

Exacerbation of bronchiectasis by Pseudomonas putida complicating COVID‑19 disease: A case report

Authors:
- Vasiliki Epameinondas Georgakopoulou
- Pantelis Avramopoulos
- Petros Papalexis
- Aikaterini Bitsani
- Christos Damaskos
- Anna Garmpi
- Aikaterini Gkoufa
- Nikolaos Garmpis
- Konstantinos Mantzouranis
- Serafeim Chlapoutakis
- Pagona Sklapani
- Nikolaos Trakas
- Demetrios A. Spandidos
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Affiliations: Pulmonology Department, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, First Department of Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, First Department of Propedeutic Internal Medicine, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, Renal Transplantation Unit, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, N.S. Christeas Laboratory of Experimental Surgery and Surgical Research, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece, 1st Pulmonology Department Sismanogleio Hospital, 15126 Athens, Greece, Department of Thoracic Surgery, Agios Savvas Hospital, 11522 Athens, Greece, Department of Cytology, Mitera Hospital, 15123 Athens, Greece, Department of Biochemistry, Sismanogleio Hospital, Athens 15126, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece
Published online on: October 15, 2021 https://doi.org/10.3892/etm.2021.10887
Article Number: 1452
Copyright: © Georgakopoulou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Novel coronavirus infection presents with greater severity in individuals with comorbid chronic lung diseases. Bronchiectasis is an illness characterized by permanent enlargement of the airways, presenting with chronic cough and sputum production and vulnerability to lung infections. Bronchiectasis is not a common comorbid disease in patients with COVID‑19 disease and bronchiectasis exacerbation rates were decreased during the pandemic. However, COVID‑19 disease is associated with worse outcomes in patients with bronchiectasis and patients with bronchiectasis are more susceptible to SARS‑CoV‑2 infection development. Pseudomonas putida is an opportunistic pathogen, causing infections mostly in immunocompromised hosts and is not a frequent bacterial colonizer in patients with bronchiectasis. This present study reports a rare case of exacerbation of bronchiectasis by Pseudomonas putida complicating COVID‑19 disease in an immunocompetent 70‑year‑old woman. Clinicians should be aware that SARS‑CoV‑2 infection is probably a precipitating factor of bronchiectasis exacerbation while bronchiectasis is a risk factor for greater severity of SARS‑CoV‑2 infection.

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1	Cole PJ: Inflammation: A two-edged sword - the model of bronchiectasis. Eur J Respir Dis Suppl. 147:6–15. 1986.PubMed/NCBI
2	O'Donnell AE: Bronchiectasis update. Curr Opin Infect Dis. 31:194–198. 2018.PubMed/NCBI View Article : Google Scholar
3	Lonni S, Chalmers JD, Goeminne PC, McDonnell MJ, Dimakou K, De Soyza A, Polverino E, Van de Kerkhove C, Rutherford R, Davison J, et al: Etiology of non-cystic fibrosis bronchiectasis in adults and its correlation to disease severity. Ann Am Thorac Soc. 12:1764–1770. 2015.PubMed/NCBI View Article : Google Scholar
4	Georgakopoulou VE, Trakas N, Damaskos C, Garmpis N, Karakou E, Chatzikyriakou R, Lambrou P and Tsiafaki X: Neutrophils to lymphocyte ratio as a biomarker in bronchiectasis exacerbation: A retrospective study. Cureus. 12(e9728)2020.PubMed/NCBI View Article : Google Scholar
5	Wilson R, Aksamit T, Aliberti S, De Soyza A, Elborn JS, Goeminne P, Hill AT, Menendez R and Polverino E: Challenges in managing Pseudomonas aeruginosa in non-cystic fibrosis bronchiectasis. Respir Med. 117:179–189. 2016.PubMed/NCBI View Article : Google Scholar
6	Li X, Yin D, Yang Y, Bi C, Wang Z, Ma G, Fu X, Ji S, Jiang F and Yu T: Eosinophil: A nonnegligible predictor in COVID-19 re-positive patients. Front Immunol. 12(690653)2021.PubMed/NCBI View Article : Google Scholar
7	Lansbury L, Lim B, Baskaran V and Lim WS: Co-infections in people with COVID-19: A systematic review and meta-analysis. J Infect. 81:266–275. 2020.PubMed/NCBI View Article : Google Scholar
8	Langford BJ, So M, Raybardhan S, Leung V, Westwood D, MacFadden DR, Soucy JR and Daneman N: Bacterial co-infection and secondary infection in patients with COVID-19: A living rapid review and meta-analysis. Clin Microbiol Infect. 26:1622–1629. 2020.PubMed/NCBI View Article : Google Scholar
9	Crichton ML, Shoemark A and Chalmers JD: The impact of the COVID-19 pandemic on exacerbations and symptoms in bronchiectasis: A prospective study. Am J Respir Crit Care Med. 204:857–859. 2021.PubMed/NCBI View Article : Google Scholar
10	Volke DC, Calero P and Nikel PI: Pseudomonas putida . Trends Microbiol. 28:512–513. 2020.PubMed/NCBI View Article : Google Scholar
11	Yang CH, Young T, Peng MY and Weng MC: Clinical spectrum of Pseudomonas putida infection. J Formos Med Assoc. 95:754–761. 1996.PubMed/NCBI
12	Neulier C, Breton N, Pangon B, Le Monnier A, Henry-Lagarrigue M, Dujon C and Merrer J: Pseudo-outbreak of Pseudomonas putida respiratory infection caused by laboratory contamination. Infect Control Hosp Epidemiol. 32:523–525. 2011.PubMed/NCBI View Article : Google Scholar
13	Fujita J, Negayama K, Ohara M, Hojo S, Obayashi Y, Miyawaki H, Yamaji Y and Takahara J: Pneumonia caused by Pseudomonas putida with a mucoid phenotype. Respir Med. 92:693–695. 1998.PubMed/NCBI View Article : Google Scholar
14	Peter S, Oberhettinger P, Schuele L, Dinkelacker A, Vogel W, Dörfel D, Bezdan D, Ossowski S, Marschal M, Liese J, et al: Genomic characterisation of clinical and environmental Pseudomonas putida group strains and determination of their role in the transfer of antimicrobial resistance genes to Pseudomonas aeruginosa. BMC Genomics. 18(859)2017.PubMed/NCBI View Article : Google Scholar
15	Metersky ML: Fewer bronchiectasis exacerbations during the ‘Lockdown’ for COVID-19: Can we convert knowledge into action? Am J Respir Crit Care Med. 204:759–760. 2021.PubMed/NCBI View Article : Google Scholar
16	Lopinto J, Teulier M, Milon A, Voiriot G and Fartoukh M: Severe hemoptysis in post-tuberculosis bronchiectasis precipitated by SARS-CoV-2 infection. BMC Pulm Med. 20(244)2020.PubMed/NCBI View Article : Google Scholar
17	Faqihi F, Alharthy A, Pirompanich P, Noor A, Shahzad A, Nasim N, Balhamar A, Memish ZA and Karakitsos D: Co-infection of SARS-CoV-2 and Bordetella bronchiseptica in a young man with idiopathic non-cystic bronchiectasis and vitamin D3 deficiency. Respir Med Case Rep. 31(101203)2020.PubMed/NCBI View Article : Google Scholar
18	Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y and Zhou Y: Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: A systematic review and meta-analysis. Int J Infect Dis. 94:91–95. 2020.PubMed/NCBI View Article : Google Scholar
19	Wu Z and McGoogan JM: Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China: Summary of a report of 72,314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 323:1239–1242. 2020.PubMed/NCBI View Article : Google Scholar
20	Choi H, Lee H, Lee SK, Yang B, Chung SJ, Yeo Y, Park TS, Park DW, Moon JY, Kim TH, et al: Impact of bronchiectasis on susceptibility to and severity of COVID-19: A nationwide cohort study. Ther Adv Respir Dis: Feb 14, 2021 (Epub ahead of print). doi: 10.1177/1753466621995043.