Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke

  • Authors:
    • Hou-Wei Ren
    • Bin Gu
    • Yue-Zhan Zhang
    • Ting Guo
    • Qian Wang
    • Yue-Qin Shen
    • Jun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Taizhou People's Hospital Affiliated to Nantong University, Taizhou, Jiangsu 225300, P.R. China, Department of Emergency, The Fourth Affiliated Hospital of Zhejiang University, School of Medicine, Yiwu, Zhejiang 322000, P.R. China
    Copyright: © Ren et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1453
    |
    Published online on: October 15, 2021
       https://doi.org/10.3892/etm.2021.10888
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cerebral ischemic stroke is the primary cause of stroke‑associated mortality and disability, and current therapeutic options are limited and ineffective. The present study aimed to investigate the potential of apoptotic therapy and the role of microRNA (miR)‑424 in cerebral ischemic stroke. PC12 cells, a cloned cell line from rat adrenal pheochromocytoma, were treated with CoCl2 to construct a cellular ischemia model. mRNA and protein levels of programmed cell death protein 4 (PDCD4), Bcl‑2, Bax, caspase‑3, PI3K and AKT were evaluated using reverse transcription‑quantitative PCR and western blot analyses, respectively. Cell Counting Kit‑8 assays were performed to examine cell viability in the ischemia model. Flow cytometry was conducted to evaluate the apoptosis of ischemic cells. Furthermore, a luciferase assay was performed to verify the target gene of miR‑424. It was revealed that the expression level of miR‑424 was downregulated in the ischemia model, while the expression of PDCD4 was upregulated. Moreover, the expression of miR‑424 was increased after treatment with miR‑424 mimics. The mRNA and protein expression of PDCD4 was upregulated after transfection with pcDNA3.1‑PDCD4. PDCD4 was predicted and demonstrated to be a target of miR‑424. Notably, overexpression of miR‑424 increased cell viability and inhibited apoptosis in the ischemia model, which was reversed by co‑treatment with pcDNA3.1‑PDCD4. Furthermore, overexpression of miR‑424 regulated the expression of PDCD4, Bax, Bcl‑2, phosphorylated‑PI3K/AKT and caspase‑3, which was restored after co‑transfection with pcDNA3.1‑PDCD4. Collectively, the results indicated that miR‑424 regulated the progression of cerebral ischemic stroke in a cellular model by targeting PDCD4.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Johnston SC, Mendis S and Mathers CD: Global variation in stroke burden and mortality: Estimates from monitoring, surveillance, and modelling. Lancet Neurol. 8:345–354. 2009.PubMed/NCBI View Article : Google Scholar

2 

Zhao WJ, Zhang HF and Su JY: Downregulation of microRNA-195 promotes angiogenesis induced by cerebral infarction via targeting VEGFA. Mol Med Rep. 16:5434–5440. 2017.PubMed/NCBI View Article : Google Scholar

3 

Lo EH, Dalkara T and Moskowitz MA: Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 4:399–415. 2003.PubMed/NCBI View Article : Google Scholar

4 

Donnan GA, Fisher M, Macleod M and Davis SM: Stroke. Lancet. 371:1612–1623. 2008.PubMed/NCBI View Article : Google Scholar

5 

Xu G, Ma M, Liu X and Hankey GJ: Is there a stroke belt in China and why? Stroke. 44:1775–1783. 2013.PubMed/NCBI View Article : Google Scholar

6 

Kleindorfer D, de los Rios La Rosa F, Khatri P, Kissela B, Mackey J and Adeoye O: Temporal trends in acute stroke management. Stroke. 44 (Suppl 1):S129–S131. 2013.PubMed/NCBI View Article : Google Scholar

7 

Vemuganti R: All's well that transcribes well: Non-coding RNAs and post-stroke brain damage. Neurochem Int. 63:438–449. 2013.PubMed/NCBI View Article : Google Scholar

8 

Truelsen T and Bonita R: Epidemiological transition of stroke in China? Stroke. 39:1653–1654. 2008.PubMed/NCBI View Article : Google Scholar

9 

Wang W, Jiang B, Sun H, Ru X, Sun D, Wang L, Wang L, Jiang Y, Li Y, Wang Y, et al: NESS-China Investigators: Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480,687 Adults. Circulation. 135:759–771. 2017.PubMed/NCBI View Article : Google Scholar

10 

Xing B, Chen H, Zhang M, Zhao D, Jiang R, Liu X and Zhang S: Ischemic postconditioning inhibits apoptosis after focal cerebral ischemia/reperfusion injury in the rat. Stroke. 39:2362–2369. 2008.PubMed/NCBI View Article : Google Scholar

11 

Townsend PA, Scarabelli TM, Pasini E, Gitti G, Menegazzi M, Suzuki H, Knight RA, Latchman DS and Stephanou A: Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J. 18:1621–1623. 2004.PubMed/NCBI View Article : Google Scholar

12 

Li P, Shen M, Gao F, Wu J, Zhang J, Teng F and Zhang C: An Antagomir to MicroRNA-106b-5p Ameliorates Cerebral Ischemia and Reperfusion Injury in Rats Via Inhibiting Apoptosis and Oxidative Stress. Mol Neurobiol. 54:2901–2921. 2017.PubMed/NCBI View Article : Google Scholar

13 

Pasquinelli AE: MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship. Nat Rev Genet. 13:271–282. 2012.PubMed/NCBI View Article : Google Scholar

14 

Ghelani HS, Rachchh MA and Gokani RH: MicroRNAs as newer therapeutic targets: A big hope from a tiny player. J Pharmacol Pharmacother. 3:217–227. 2012.PubMed/NCBI View Article : Google Scholar

15 

Croce CM and Calin GA: miRNAs, cancer, and stem cell division. Cell. 122:6–7. 2005.PubMed/NCBI View Article : Google Scholar

16 

Zheng Y, Wang L, Chen M, Pei A, Xie L and Zhu S: Upregulation of miR-130b protects against cerebral ischemic injury by targeting water channel protein aquaporin 4 (AQP4). Am J Transl Res. 9:3452–3461. 2017.PubMed/NCBI

17 

Zheng L, Cheng W, Wang X, Yang Z, Zhou X and Pan C: Overexpression of MicroRNA-145 Ameliorates Astrocyte Injury by Targeting Aquaporin 4 in Cerebral Ischemic Stroke. BioMed Res Int. 2017(9530951)2017.PubMed/NCBI View Article : Google Scholar

18 

Yin KJ, Hamblin M and Chen YE: Non-coding RNAs in cerebral endothelial pathophysiology: Emerging roles in stroke. Neurochem Int. 77:9–16. 2014.PubMed/NCBI View Article : Google Scholar

19 

Zhao L, Hua C, Li Y, Sun Q and Wu W: miR-525-5p inhibits ADAMTS13 and is correlated with Ischemia/reperfusion injury-induced neuronal cell death. Int J Clin Exp Med. 8:18115–18122. 2015.PubMed/NCBI

20 

Wei N, Xiao L, Xue R, Zhang D, Zhou J, Ren H, Guo S and Xu J: MicroRNA-9 Mediates the Cell Apoptosis by Targeting Bcl2l11 in Ischemic Stroke. Mol Neurobiol. 53:6809–6817. 2016.PubMed/NCBI View Article : Google Scholar

21 

Zhang YZ, Wang J and Xu F: Circulating miR-29b and miR-424 as Prognostic Markers in Patients with Acute Cerebral Infarction. Clin Lab. 63:1667–1674. 2017.PubMed/NCBI View Article : Google Scholar

22 

Darbinian N: Cultured Cell Line Models of Neuronal Differentiation: NT2, PC12, and SK-N-MC. Methods Mol Biol. 2311:25–38. 2021.PubMed/NCBI View Article : Google Scholar

23 

Katarzyna B and Benita W: PC12 and THP-1 Cell Lines as Neuronal and Microglia Model in Neurobiological Research. Appl Sci (Basel). 11(3729)2021.

24 

Kudo TA, Tominami K, Izumi S, Hayashi Y, Noguchi T, Matsuzawa A, Hong G and Nakai J: Characterization of PC12 Cell Subclones with Different Sensitivities to Programmed Thermal Stimulation. Int J Mol Sci. 21(8356)2020.PubMed/NCBI View Article : Google Scholar

25 

Wiatrak B and Balon K: Protective Activity of Aβ on Cell Cultures (PC12 and THP-1 after Differentiation) Preincubated with Lipopolysaccharide (LPS). Mol Neurobiol. 58:1453–1464. 2021.PubMed/NCBI View Article : Google Scholar

26 

Amalia L, Sadeli HA, Parwati I, Rizal A and Panigoro R: Hypoxia-inducible factor-1α in acute ischemic stroke: Neuroprotection for better clinical outcome. Heliyon. 6(e04286)2020.PubMed/NCBI View Article : Google Scholar

27 

Tripathi VK, Subramaniyan SA and Hwang I: Molecular and Cellular Response of Co-cultured Cells toward Cobalt Chloride (CoCl2)-Induced Hypoxia. ACS Omega. 4:20882–20893. 2019.PubMed/NCBI View Article : Google Scholar

28 

Kim HB, Yoo JY, Yoo SY, Lee JH, Chang W, Kim HS, Baik TK and Woo RS: Neuregulin-1 inhibits CoCl2-induced upregulation of excitatory amino acid carrier 1 expression and oxidative stress in SH-SY5Y cells and the hippocampus of mice. Mol Brain. 13(153)2020.PubMed/NCBI View Article : Google Scholar

29 

Matsuhashi S, Manirujjaman M, Hamajima H and Ozaki I: Control mechanisms of the tumor suppressor PDCD4: Expression and functions. Int J Mol Sci. 20(2304)2019.PubMed/NCBI View Article : Google Scholar

30 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

31 

Saugstad JA: MicroRNAs as effectors of brain function. Stroke. 44 (Suppl 1):S17–S19. 2013.PubMed/NCBI View Article : Google Scholar

32 

Yan H, Fang M and Liu XY: Role of microRNAs in stroke and poststroke depression. ScientificWorldJournal. 2013(459692)2013.PubMed/NCBI View Article : Google Scholar

33 

Gui SH, Wang YM, Fan CY, Han LK, Wang TG, Di MQ and Gu JQ: miR-424 Inhibits neuronal apoptosis in rats with cerebral infarction through regulating TGF-β1/Smad3 signaling pathway. J Biol Regul Homeost Agents. 34:1285–1296. 2020.PubMed/NCBI View Article : Google Scholar

34 

Sun H, Zhong D, Wang C, Sun Y, Zhao J and Li G: MiR-298 Exacerbates Ischemia/Reperfusion Injury Following Ischemic Stroke by Targeting Act1. Cell Physiol Biochem. 48:528–539. 2018.PubMed/NCBI View Article : Google Scholar

35 

Baczyńska D, Michałowska D and Witkiewicz W: The role of microRNA in ischemic diseases - impact on the regulation of inflammatory, apoptosis and angiogenesis processes. Przegl Lek. 70:135–142. 2013.PubMed/NCBI(In Polish).

36 

Yao S, Tang B, Li G, Fan R and Cao F: miR-455 inhibits neuronal cell death by targeting TRAF3 in cerebral ischemic stroke. Neuropsychiatr Dis Treat. 12:3083–3092. 2016.PubMed/NCBI View Article : Google Scholar

37 

Xing G, Luo Z, Zhong C, Pan X and Xu X: Influence of miR-155 on Cell Apoptosis in Rats with Ischemic Stroke: Role of the Ras Homolog Enriched in Brain (Rheb)/mTOR Pathway. Med Sci Monit. 22:5141–5153. 2016.PubMed/NCBI View Article : Google Scholar

38 

Schwarzenbach H, Nishida N, Calin GA and Pantel K: Clinical relevance of circulating cell-free microRNAs in cancer. Nat Rev Clin Oncol. 11:145–156. 2014.PubMed/NCBI View Article : Google Scholar

39 

Guo YB, Ji TF, Zhou HW and Yu JL: Effects of microRNA-21 on Nerve Cell Regeneration and Neural Function Recovery in Diabetes Mellitus Combined with Cerebral Infarction Rats by Targeting PDCD4. Mol Neurobiol. 55:2494–2505. 2018.PubMed/NCBI View Article : Google Scholar

40 

Yan H, Rao J, Yuan J, Gao L, Huang W, Zhao L and Ren J: Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway. Cell Death Dis. 8(3211)2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ren H, Gu B, Zhang Y, Guo T, Wang Q, Shen Y and Wang J: MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke. Exp Ther Med 22: 1453, 2021.
APA
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., & Wang, J. (2021). MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke. Experimental and Therapeutic Medicine, 22, 1453. https://doi.org/10.3892/etm.2021.10888
MLA
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., Wang, J."MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke". Experimental and Therapeutic Medicine 22.6 (2021): 1453.
Chicago
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., Wang, J."MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1453. https://doi.org/10.3892/etm.2021.10888
Copy and paste a formatted citation
x
Spandidos Publications style
Ren H, Gu B, Zhang Y, Guo T, Wang Q, Shen Y and Wang J: MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke. Exp Ther Med 22: 1453, 2021.
APA
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., & Wang, J. (2021). MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke. Experimental and Therapeutic Medicine, 22, 1453. https://doi.org/10.3892/etm.2021.10888
MLA
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., Wang, J."MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke". Experimental and Therapeutic Medicine 22.6 (2021): 1453.
Chicago
Ren, H., Gu, B., Zhang, Y., Guo, T., Wang, Q., Shen, Y., Wang, J."MicroRNA‑424 alleviates neurocyte injury by targeting PDCD4 in a cellular model of cerebral ischemic stroke". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1453. https://doi.org/10.3892/etm.2021.10888
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team