Open Access

Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review)

  • Authors:
    • He Cai
    • Hongbo Men
    • Pengyu Cao
    • Yang Zheng
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  • Published online on: October 20, 2021     https://doi.org/10.3892/etm.2021.10898
  • Article Number: 1463
  • Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The relationship between cancer and heart failure has been extensively studied in the last decade. These studies have focused on describing heart injury caused by certain cancer treatments, including radiotherapy, chemotherapy and targeted therapy. Previous studies have demonstrated a higher incidence of cancer in patients with heart failure. Heart failure enhances an over‑activation of the sympathetic nervous system and the renin‑angiotensin‑aldosterone system, and subsequently promotes cancer development. Other studies have found that heart failure and cancer both have a common pathological origin, flanked by chronic inflammation in certain organs. The present review aims to summarize and describe the recent discoveries, suggested mechanisms and relationships between heart failure and cancer. The current review provides more ideas on clinical prevention strategies according to the pathological mechanism involved.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Copy and paste a formatted citation
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Spandidos Publications style
Cai H, Men H, Cao P and Zheng Y: Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review). Exp Ther Med 22: 1463, 2021
APA
Cai, H., Men, H., Cao, P., & Zheng, Y. (2021). Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review). Experimental and Therapeutic Medicine, 22, 1463. https://doi.org/10.3892/etm.2021.10898
MLA
Cai, H., Men, H., Cao, P., Zheng, Y."Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review)". Experimental and Therapeutic Medicine 22.6 (2021): 1463.
Chicago
Cai, H., Men, H., Cao, P., Zheng, Y."Mechanism and prevention strategy of a bidirectional relationship between heart failure and cancer (Review)". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1463. https://doi.org/10.3892/etm.2021.10898