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Article Open Access

Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks

  • Authors:
    • Tan Li
    • Tianlong Wang
    • Lirong Yan
    • Chunyan Ma
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, The First Clinical College of China Medical University, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 1468
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    Published online on: October 21, 2021
       https://doi.org/10.3892/etm.2021.10903
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Abstract

Abdominal aortic aneurysm (AAA) is a life‑threatening disorder and, therefore, investigation into its underlying mechanisms in light of the competing endogenous RNAs (ceRNAs) hypothesis has gradually increased. However, there is still lacking systematic analysis on AAA‑associated circular RNA (circRNA)‑microRNA (miRNA/miR)‑messenger RNA (mRNA) interaction networks based on bioinformatics methods. The present study attempted to identify novel molecular biomarkers for AAA by profiling circRNA‑miRNA‑mRNA networks using three public microarray datasets (GSE7084, GSE57691 and GSE144431). A total of 135 differentially expressed genes (DEGs) and 142 differentially expressed circRNAs were detected using the limma R package with the statistical threshold of P<0.05 and |log2fold change (FC)| >1.5. In addition, 12 circRNA‑miRNA‑mRNA axes were identified to construct upregulated and downregulated ceRNA networks using Cytoscape. Based on molecular complex detection algorithm, (hsa_circ_0057691/0092108/0006845/0082182)‑ miR‑330‑5p‑calponin 1 (CNN1) and (hsa_circ_0061482/0011450/0008351/0004121)‑miR‑326‑CD8a molecule (CD8A) were recognized as the center axes in ceRNA networks. Reverse transcription‑quantitative PCR results verified the significant downregulation of CNN1 and upregulation of CD8A in human AAA tissues (P<0.05). In addition, four upregulated circRNA/mRNA axes, and five downregulated circRNA/mRNA axes were revealed to have possible biological functions in the pathogenesis of AAA using the Cytoscape software. Receiver operating characteristic analysis demonstrated the accuracy of these nine DEGs involved in these axes for AAA diagnosis with area under the curves >0.80. The present study revealed novel circRNA‑miRNA‑mRNA networks associated with AAA, especially for CNN1 and CD8A axes with the potential function of ‘focal adhesion’ and ‘immune response’, respectively. Overall, the present findings may provide evidence to explore the implicated ceRNAs in the molecular mechanisms and as novel biomarkers for AAA.
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1 

Sakalihasan N, Michel JB, Katsargyris A, Kuivaniemi H, Defraigne JO, Nchimi A, Powell JT, Yoshimura K and Hultgren R: Abdominal aortic aneurysms. Nat Rev Dis Primers. 4(34)2018.PubMed/NCBI View Article : Google Scholar

2 

Chen S, Yang D, Lei C, Li Y, Sun X, Chen M, Wu X and Zheng Y: Identification of crucial genes in abdominal aortic aneurysm by WGCNA. PeerJ. 7(e7873)2019.PubMed/NCBI View Article : Google Scholar

3 

Wu QY, Cheng Z, Zhou YZ, Zhao Y, Li JM, Zhou XM, Peng HL, Zhang GS, Liao XB and Fu XM: A novel STAT3 inhibitor attenuates angiotensin II-induced abdominal aortic aneurysm progression in mice through modulating vascular inflammation and autophagy. Cell Death Dis. 11(131)2020.PubMed/NCBI View Article : Google Scholar

4 

Li W, Xu C, Guo J, Liu K, Hu Y, Wu D, Fang H, Zou Y, Wei Z, Wang Z, et al: Cis- and Trans-Acting Expression Quantitative Trait Loci of Long Non-Coding RNA in 2,549 Cancers With Potential Clinical and Therapeutic Implications. Front Oncol. 10(602104)2020.PubMed/NCBI View Article : Google Scholar

5 

Vishnoi A and Rani S: miRNA Biogenesis and Regulation of Diseases: An Overview. Methods Mol Biol. 1509:1–10. 2017.PubMed/NCBI View Article : Google Scholar

6 

Zhang S, Shen S, Yang Z, Kong X, Liu F and Zhen Z: Coding and Non-coding RNAs: Molecular Basis of Forest-Insect Outbreaks. Front Cell Dev Biol. 8(369)2020.PubMed/NCBI View Article : Google Scholar

7 

Ala U: Competing Endogenous RNAs, Non-Coding RNAs and Diseases: An Intertwined Story. Cells. 9(9)2020.PubMed/NCBI View Article : Google Scholar

8 

Sun Y, Zhong L, He X, Wang S, Lai Y, Wu W, Song H, Chen Y, Yang Y, Liao W, et al: lncRNA H19 promotes vascular inflammation and abdominal aortic aneurysm formation by functioning as a competing endogenous RNA. J Mol Cell Cardiol. 131:66–81. 2019.PubMed/NCBI View Article : Google Scholar

9 

Lin H, You B, Lin X, Wang X, Zhou D, Chen Z, Chen Y and Wang R: Silencing of long non-coding RNA Sox2ot inhibits oxidative stress and inflammation of vascular smooth muscle cells in abdominal aortic aneurysm via microRNA-145-mediated Egr1 inhibition. Aging (Albany NY). 12:12684–12702. 2020.PubMed/NCBI View Article : Google Scholar

10 

Tian Z, Sun Y, Sun X, Wang J and Jiang T: LINC00473 inhibits vascular smooth muscle cell viability to promote aneurysm formation via miR-212-5p/BASP1 axis. Eur J Pharmacol. 873(172935)2020.PubMed/NCBI View Article : Google Scholar

11 

Xia Q, Zhang L, Yan H, Yu L, Shan W and Jiang H: LUCAT1 contributes to MYRF-dependent smooth muscle cell apoptosis and may facilitate aneurysm formation via the sequestration of miR-199a-5p. Cell Biol Int. 44:755–763. 2020.PubMed/NCBI View Article : Google Scholar

12 

Yang B, Wang X, Ying C, Peng F, Xu M, Chen F and Cai B: Long Noncoding RNA SNHG16 Facilitates Abdominal Aortic Aneurysm Progression through the miR-106b-5p/STAT3 Feedback Loop. J Atheroscler Thromb. 28:66–78. 2021.PubMed/NCBI View Article : Google Scholar

13 

Tian L, Hu X, He Y, Wu Z, Li D and Zhang H: Construction of lncRNA-miRNA-mRNA networks reveals functional lncRNAs in abdominal aortic aneurysm. Exp Ther Med. 16:3978–3986. 2018.PubMed/NCBI View Article : Google Scholar

14 

Han Y, Zhang H, Bian C, Chen C, Tu S, Guo J, Wu Y, Böckler D and Zhang J: Circular RNA Expression: Its Potential Regulation and Function in Abdominal Aortic Aneurysms. Oxid Med Cell Longev. 2021(9934951)2021.PubMed/NCBI View Article : Google Scholar

15 

Zhao F, Chen T and Jiang N: CDR1as/miR-7/CKAP4 axis contributes to the pathogenesis of abdominal aortic aneurysm by regulating the proliferation and apoptosis of primary vascular smooth muscle cells. Exp Ther Med. 19:3760–3766. 2020.PubMed/NCBI View Article : Google Scholar

16 

Yue J, Zhu T, Yang J, Si Y, Xu X, Fang Y and Fu W: circCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4. Life Sci. 253(117533)2020.PubMed/NCBI View Article : Google Scholar

17 

Lenk GM, Tromp G, Weinsheimer S, Gatalica Z, Berguer R and Kuivaniemi H: Whole genome expression profiling reveals a significant role for immune function in human abdominal aortic aneurysms. BMC Genomics. 8(237)2007.PubMed/NCBI View Article : Google Scholar

18 

Biros E, Gäbel G, Moran CS, Schreurs C, Lindeman JH, Walker PJ, Nataatmadja M, West M, Holdt LM, Hinterseher I, et al: Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease. Oncotarget. 6:12984–12996. 2015.PubMed/NCBI View Article : Google Scholar

19 

Zhou M, Shi Z, Cai L, Li X, Ding Y, Xie T and Fu W: Circular RNA expression profile and its potential regulative role in human abdominal aortic aneurysm. BMC Cardiovasc Disord. 20(70)2020.PubMed/NCBI View Article : Google Scholar

20 

Jolliffe IT and Cadima J: Principal component analysis: A review and recent developments. Philos Trans A Math Phys Eng Sci. 374(20150202)2016.PubMed/NCBI View Article : Google Scholar

21 

RStudio Team: RStudio: Integrated Development for R. RStudio, Inc. Boston, MA, 2015. http://www.rstudio.com/. Accessed June 1, 2021.

22 

Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009.PubMed/NCBI View Article : Google Scholar

23 

Dudekula DB, Panda AC, Grammatikakis I, De S, Abdelmohsen K and Gorospe M: CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs. RNA Biol. 13:34–42. 2016.PubMed/NCBI View Article : Google Scholar

24 

Sticht C, De La Torre C, Parveen A and Gretz N: miRWalk: An online resource for prediction of microRNA binding sites. PLoS One. 13(e0206239)2018.PubMed/NCBI View Article : Google Scholar

25 

Agarwal V, Bell GW, Nam JW and Bartel DP: Predicting effective microRNA target sites in mammalian mRNAs. eLife. 4(4)2015.PubMed/NCBI View Article : Google Scholar

26 

Kohl M, Wiese S and Warscheid B: Cytoscape: Software for visualization and analysis of biological networks. Methods Mol Biol. 696:291–303. 2011.PubMed/NCBI View Article : Google Scholar

27 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4(2)2003.PubMed/NCBI View Article : Google Scholar

28 

World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. JAMA. 310:2191–2194. 2013.PubMed/NCBI View Article : Google Scholar

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Δ Δ C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

30 

Walter W, Sánchez-Cabo F and Ricote M: GOplot: An R package for visually combining expression data with functional analysis. Bioinformatics. 31:2912–2914. 2015.PubMed/NCBI View Article : Google Scholar

31 

Liu Y, Wang X, Wang H and Hu T: Identification of key genes and pathways in abdominal aortic aneurysm by integrated bioinformatics analysis. J Int Med Res. 48(300060519894437)2020.PubMed/NCBI View Article : Google Scholar

32 

Oh CK, Ko Y, Park JJ, Heo HJ, Kang J, Kwon EJ, Kang JW, Lee Y, Myung K, Kang JM, et al: FRZB as a key molecule in abdominal aortic aneurysm progression affecting vascular integrity. Biosci Rep. 41(41)2021.PubMed/NCBI View Article : Google Scholar

33 

Luo Y and Huang C: CircSFMBT2 facilitates vascular smooth muscle cell proliferation by targeting miR-331-3p/HDAC5. Life Sci. 264(118691)2021.PubMed/NCBI View Article : Google Scholar

34 

Guo X, Li D, Chen M, Chen L, Zhang B, Wu T and Guo R: miRNA-145 inhibits VSMC proliferation by targeting CD40. Sci Rep. 6(35302)2016.PubMed/NCBI View Article : Google Scholar

35 

Liu R and Jin JP: Calponin isoforms CNN1, CNN2 and CNN3: Regulators for actin cytoskeleton functions in smooth muscle and non-muscle cells. Gene. 585:143–153. 2016.PubMed/NCBI View Article : Google Scholar

36 

Gong J, Zhou D, Jiang L, Qiu P, Milewicz DM, Chen YE and Yang B: In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency: Implications for SMAD3-Related Thoracic Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 40:1651–1663. 2020.PubMed/NCBI View Article : Google Scholar

37 

Cheng Q, Li Z, Wang R, Zhang H, Cao H, Chen F, Li H, Xia Z, Feng S, Zhang H, et al: Genetic Profiles Related to Pathogenesis in Sporadic Intracranial Aneurysm Patients. World Neurosurg. 131:e23–e31. 2019.PubMed/NCBI View Article : Google Scholar

38 

Feng HZ, Wang H, Takahashi K and Jin JP: Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. J Mol Cell Cardiol. 129:49–57. 2019.PubMed/NCBI View Article : Google Scholar

39 

Lesiak M, Augusciak-Duma A, Stepien KL, Fus-Kujawa A, Botor M and Sieron AL: Searching for new molecular markers for cells obtained from abdominal aortic aneurysm. J Appl Genet. 62:487–497. 2021.PubMed/NCBI View Article : Google Scholar

40 

Ma K, Qiao Y, Wang H and Wang S: Comparative expression analysis of PD-1, PD-L1, and CD8A in lung adenocarcinoma. Ann Transl Med. 8(1478)2020.PubMed/NCBI View Article : Google Scholar

41 

Sagan A, Mikolajczyk TP, Mrowiecki W, MacRitchie N, Daly K, Meldrum A, Migliarino S, Delles C, Urbanski K, Filip G, et al: T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity. Front Immunol. 10(1979)2019.PubMed/NCBI View Article : Google Scholar

42 

Li G, Zhou H, He Y, Sun S, Wu X and Yuan H: Ulinastatin Inhibits the Formation and Progression of Experimental Abdominal Aortic Aneurysms. J Vasc Res. 57:58–64. 2020.PubMed/NCBI View Article : Google Scholar

43 

Chen J, Lin M and Zhang S: Identification of key miRNA mRNA pairs in septic mice by bioinformatics analysis. Mol Med Rep. 20:3858–3866. 2019.PubMed/NCBI View Article : Google Scholar

44 

Xue Q, Wang X, Deng X, Huang Y and Tian W: CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT-beta-catenin signaling pathway. Biochem Cell Biol. 98:249–257. 2020.PubMed/NCBI View Article : Google Scholar

45 

Chen Y, Li L and Zhang J: Cell migration inducing hyaluronidase 1 (CEMIP) activates STAT3 pathway to facilitate cell proliferation and migration in breast cancer. J Recept Signal Transduct Res. 41:145–152. 2021.PubMed/NCBI View Article : Google Scholar

46 

Cui S and Zhang L: circ_001653 Silencing Promotes the Proliferation and ECM Synthesis of NPCs in IDD by Downregulating miR-486-3p-Mediated CEMIP. Mol Ther Nucleic Acids. 20:385–399. 2020.PubMed/NCBI View Article : Google Scholar

47 

Ito D and Kumanogoh A: The role of Sema4A in angiogenesis, immune responses, carcinogenesis, and retinal systems. Cell Adhes Migr. 10:692–699. 2016.PubMed/NCBI View Article : Google Scholar

48 

Duijvis NW, Moerland PD, Kunne C, Slaman MMW, van Dooren FH, Vogels EW, de Jonge WJ, Meijer SL, Fluiter K and Te Velde AA: Inhibition of miR-142-5P ameliorates disease in mouse models of experimental colitis. PLoS One. 12(e0185097)2017.PubMed/NCBI View Article : Google Scholar

49 

Krishna SM, Seto SW, Jose RJ, Li J, Morton SK, Biros E, Wang Y, Nsengiyumva V, Lindeman JH, Loots GG, et al: Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis. Arterioscler Thromb Vasc Biol. 37:553–566. 2017.PubMed/NCBI View Article : Google Scholar

50 

Ma S, Wang DD, Ma CY and Zhang YD: MicroRNA-96 promotes osteoblast differentiation and bone formation in ankylosing spondylitis mice through activating the Wnt signaling pathway by binding to SOST. J Cell Biochem. 120:15429–15442. 2019.PubMed/NCBI View Article : Google Scholar

51 

Wei S, Zhang M, Zheng Y and Yan P: ZBTB16 Overexpression Enhances White Adipogenesis and Induces Brown-Like Adipocyte Formation of Bovine White Intramuscular Preadipocytes. Cell Physiol Biochem. 48:2528–2538. 2018.PubMed/NCBI View Article : Google Scholar

52 

Gerlinger-Romero F, Yonamine CY, Junior DC, Esteves JV and Machado UF: Dysregulation between TRIM63/FBXO32 expression and soleus muscle wasting in diabetic rats: Potential role of miR-1-3p, -29a/b-3p, and -133a/b-3p. Mol Cell Biochem. 427:187–199. 2017.PubMed/NCBI View Article : Google Scholar

53 

Dong Y and Simske JS: Vertebrate Claudin/PMP22/EMP22/MP20 family protein TMEM47 regulates epithelial cell junction maturation and morphogenesis. Dev Dyn. 245:653–666. 2016.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Li T, Wang T, Yan L and Ma C: Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks. Exp Ther Med 22: 1468, 2021.
APA
Li, T., Wang, T., Yan, L., & Ma, C. (2021). Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks. Experimental and Therapeutic Medicine, 22, 1468. https://doi.org/10.3892/etm.2021.10903
MLA
Li, T., Wang, T., Yan, L., Ma, C."Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks". Experimental and Therapeutic Medicine 22.6 (2021): 1468.
Chicago
Li, T., Wang, T., Yan, L., Ma, C."Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1468. https://doi.org/10.3892/etm.2021.10903
Copy and paste a formatted citation
x
Spandidos Publications style
Li T, Wang T, Yan L and Ma C: Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks. Exp Ther Med 22: 1468, 2021.
APA
Li, T., Wang, T., Yan, L., & Ma, C. (2021). Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks. Experimental and Therapeutic Medicine, 22, 1468. https://doi.org/10.3892/etm.2021.10903
MLA
Li, T., Wang, T., Yan, L., Ma, C."Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks". Experimental and Therapeutic Medicine 22.6 (2021): 1468.
Chicago
Li, T., Wang, T., Yan, L., Ma, C."Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA‑miRNA‑mRNA networks". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1468. https://doi.org/10.3892/etm.2021.10903
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