Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2021 Volume 22 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis

  • Authors:
    • Dong-Sik Chae
    • Mi Eun Kim
    • Kyung-Yil Kang
    • Nae Yoon Lee
    • Woo-Suk Lee
    • Jun Sik Lee
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, International St. Mary's Hospital, College of Medicine, Catholic Kwandong University, Incheon 22711, Republic of Korea, Department of Life Science, Immunology Research Lab, BK21‑Four Education Research Group, College of Natural Sciences, Chosun University, Gwangju 61452, Republic of Korea, Department of Bionano Technology, Gachon University, Seongnam, Gyeonggi‑do 13120, Republic of Korea, Department of Orthopedic Surgery, Yonsei University College of Medicine, Gangnam Severence Hospital, Seoul 135720, Republic of Korea
  • Article Number: 1470
    |
    Published online on: October 21, 2021
       https://doi.org/10.3892/etm.2021.10905
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Osteoarthritis (OA), which is caused by joint damage, is the most common form of arthritis, affecting millions of people worldwide. This damage can accumulate over time, which is why aging is one of the main contributors to joint damage associated with OA. The OA‑related proteins that have been reported to date have been identified by the comparative analysis of OA patients with normal controls, following surgical or pharmacological treatment. For the first time, the present study analyzed OA‑related proteins in patients with OA according to the International Cartilage Repair Society (ICRS) scale. Changes in protein expression can be observed during the OA process. The present study demonstrated differential protein expression patterns in articular cartilage from ICRS1‑ and ICRS3‑graded OA patients. ICRS grade‑matched OA knee samples from 12 OA patients, 6 ICRS grade 1 patients and 6 ICRS3 patients were subjected to proteomic analysis using the LTQ‑Orbitrap mass spectrometry system. A total of 231 unique proteins were identified as expressed across the ICRS1 and ICRS3 OA patient groups. Relative differences in protein expression associated with the following classifications were observed: Biological adhesion, cell killing, cellular process, development process and molecular function. Although some of these proteins have been previously reported to be associated with rheumatoid arthritis, including cartilage oligomeric matrix protein, collagen types, angiogenin, complement C5 and CD59 glycoprotein, numerous additional proteins were newly identified, which may further help our understanding of disease pathogenesis. These findings suggested that these proteins may be used to develop novel therapeutic targets for OA.
View Figures

Figure 1

Figure 2

View References

1 

Martel-Pelletier J, Barr AJ, Cicuttini FM, Conaghan PG, Cooper C, Goldring MB, Goldring SR, Jones G, Teichtahl AJ and Pelletier JP: Osteoarthritis. Nat Rev Dis Primers. 2(16072)2016.PubMed/NCBI View Article : Google Scholar

2 

Disease GBD, Injury I and Prevalence C: GBD 2015 Disease and Injury Incidence and Prevalence Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. Lancet. 388:1545–1602. 2016.PubMed/NCBI View Article : Google Scholar

3 

Sokolove J and Lepus CM: Role of inflammation in the pathogenesis of osteoarthritis: Latest findings and interpretations. Ther Adv Musculoskelet Dis. 5:77–94. 2013.PubMed/NCBI View Article : Google Scholar

4 

Swagerty DL Jr and Hellinger D: Radiographic assessment of osteoarthritis. Am Fam Physician. 64:279–286. 2001.PubMed/NCBI

5 

Kohn MD, Sassoon AA and Fernando ND: Classifications in Brief: Kellgren-Lawrence classification of osteoarthritis. Clin Orthop Relat Res. 474:1886–1893. 2016.PubMed/NCBI View Article : Google Scholar

6 

Hurley M, Dickson K, Hallett R, Grant R, Hauari H, Walsh N, Stansfield C and Oliver S: Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: A mixed methods review. Cochrane Database Syst Rev. 4(CD010842)2018.PubMed/NCBI View Article : Google Scholar

7 

Bultink IE and Lems WF: Osteoarthritis and osteoporosis: What is the overlap? Curr Rheumatol Rep. 15(328)2013.PubMed/NCBI View Article : Google Scholar

8 

Pouresmaeili F, Kamalidehghan B, Kamarehei M and Goh YM: A comprehensive overview on osteoporosis and its risk factors. Ther Clin Risk Manag. 14:2029–2049. 2018.PubMed/NCBI View Article : Google Scholar

9 

Sözen T, Özışık L and Başaran NC: An overview and management of osteoporosis. Eur J Rheumatol. 4:46–56. 2017.PubMed/NCBI View Article : Google Scholar

10 

Nazrun AS, Tzar MN, Mokhtar SA and Mohamed IN: A systematic review of the outcomes of osteoporotic fracture patients after hospital discharge: Morbidity, subsequent fractures, and mortality. Ther Clin Risk Manag. 10:937–948. 2014.PubMed/NCBI View Article : Google Scholar

11 

Dhital R, Lynn T, Tachamo N and Poudel DR: The trend of osteoporosis and osteoporotic fragility fractures in inpatients: Results from a national database. J Community Hosp Intern Med Perspect. 9:211–214. 2019.PubMed/NCBI View Article : Google Scholar

12 

Loeser RF: The role of aging in the development of osteoarthritis. Trans Am Clin Climatol Assoc. 128:44–54. 2017.PubMed/NCBI

13 

Palo N, Chandel SS, Dash SK, Arora G, Kumar M and Biswal MR: Effects of osteoarthritis on quality of life in elderly population of Bhubaneswar, India: A prospective multicenter screening and therapeutic study of 2854 patients. Geriatr Orthop Surg Rehabil. 6:269–275. 2015.PubMed/NCBI View Article : Google Scholar

14 

Lorenzo P, Aspberg A, Saxne T and Önnerfjord P: Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays. Osteoarthritis Cartilage. 25:1436–1442. 2017.PubMed/NCBI View Article : Google Scholar

15 

Fernández-Puente P, Calamia V, González-Rodríguez L, Lourido L, Camacho-Encina M, Oreiro N, Ruiz-Romero C and Blanco FJ: Multiplexed mass spectrometry monitoring of biomarker candidates for osteoarthritis. J Proteomics. 152:216–225. 2017.PubMed/NCBI View Article : Google Scholar

16 

van der Meijden OA, Gaskill TR and Millett PJ: Glenohumeral joint preservation: A review of management options for young, active patients with osteoarthritis. Adv Orthop. 2012(160923)2012.PubMed/NCBI View Article : Google Scholar

17 

Sergé A: The molecular architecture of cell adhesion: Dynamic remodeling revealed by videonanoscopy. Front Cell Dev Biol. 4(36)2016.PubMed/NCBI View Article : Google Scholar

18 

Liu F, Wang X, Zhang X, Ren C and Xin J: Role of serum cartilage oligomeric matrix protein (COMP) in the diagnosis of rheumatoid arthritis (RA): A case-control study. J Int Med Res. 44:940–949. 2016.PubMed/NCBI View Article : Google Scholar

19 

Samali A, Fulda S, Gorman AM, Hori O and Srinivasula SM: Cell stress and cell death. Int J Cell Biol. 2010(245803)2010.PubMed/NCBI View Article : Google Scholar

20 

Green DR and Llambi F: Cell death signaling. Cold Spring Harb Perspect Biol. 7(a006080)2015.PubMed/NCBI View Article : Google Scholar

21 

Kim YL, Im YJ, Ha NC and Im DS: Albumin inhibits cytotoxic activity of lysophosphatidylcholine by direct binding. Prostaglandins Other Lipid Mediat. 83:130–138. 2007.PubMed/NCBI View Article : Google Scholar

22 

Kothari P, Johnson C, Sandone C, Iglesias PA and Robinson DN: How the mechanobiome drives cell behavior, viewed through the lens of control theory. J Cell Sci. 132(jcs234476)2019.PubMed/NCBI View Article : Google Scholar

23 

Mateos J, De la Fuente A, Lesende-Rodriguez I, Fernández-Pernas P, Arufe MC and Blanco FJ: Lamin A deregulation in human mesenchymal stem cells promotes an impairment in their chondrogenic potential and imbalance in their response to oxidative stress. Stem Cell Res (Amst). 11:1137–1148. 2013.PubMed/NCBI View Article : Google Scholar

24 

Attur M, Ben-Artzi A, Yang Q, Al-Mussawir HE, Worman HJ, Palmer G and Abramson SB: Perturbation of nuclear lamin A causes cell death in chondrocytes. Arthritis Rheum. 64:1940–1949. 2012.PubMed/NCBI View Article : Google Scholar

25 

Stephan JP, Roberts PE, Bald L, Lee J, Gu Q, Devaux B and Mather JP: Selective cloning of cell surface proteins involved in organ development: Epithelial glycoprotein is involved in normal epithelial differentiation. Endocrinology. 140:5841–5854. 1999.PubMed/NCBI View Article : Google Scholar

26 

Huang Z, Wang X and Chen D: Signal proteins involved in myogenic stem cells differentiation. Curr Protein Pept Sci. 18:571–578. 2017.PubMed/NCBI View Article : Google Scholar

27 

Oh JE, Freilinger A, Gelpi E, Pollak A, Hengstschläger M and Lubec G: Proteins involved in neuronal differentiation of neuroblastoma cell line N1E-115. Electrophoresis. 28:2009–2017. 2007.PubMed/NCBI View Article : Google Scholar

28 

Grassel S and Aszodi A: Osteoarthritis and cartilage regeneration: Focus on pathophysiology and molecular mechanisms. Int J Mol Sci. 20(6156)2019.PubMed/NCBI View Article : Google Scholar

29 

Akkiraju H and Nohe A: Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J Dev Biol. 3:177–192. 2015.PubMed/NCBI View Article : Google Scholar

30 

Hornum L, Hansen AJ, Tornehave D, Fjording MS, Colmenero P, Wätjen IF, Søe Nielsen NH, Bliddal H and Bartels EM: C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid. PLoS One. 12(e0189017)2017.PubMed/NCBI View Article : Google Scholar

31 

Xiang Y, Sekine T, Nakamura H, Imajoh-Ohmi S, Fukuda H, Nishioka K and Kato T: Proteomic surveillance of autoimmunity in osteoarthritis: Identification of triosephosphate isomerase as an autoantigen in patients with osteoarthritis. Arthritis Rheum. 50:1511–1521. 2004.PubMed/NCBI View Article : Google Scholar

32 

Takinami Y, Yoshimatsu S, Uchiumi T, Toyosaki-Maeda T, Morita A, Ishihara T, Yamane S, Fukuda I, Okamoto H, Numata Y, et al: Identification of potential prognostic markers for knee osteoarthritis by serum proteomic analysis. Biomark Insights. 8:85–95. 2013.PubMed/NCBI View Article : Google Scholar

33 

Park YJ, Chung MK, Hwang D and Kim WU: Proteomics in Rheumatoid Arthritis Research. Immune Netw. 15:177–185. 2015.PubMed/NCBI View Article : Google Scholar

34 

Camafeita E, Lamas JR, Calvo E, López JA and Fernández-Gutiérrez B: Proteomics: New insights into rheumatic diseases. Proteomics Clin Appl. 3:226–241. 2009.PubMed/NCBI View Article : Google Scholar

35 

Mun S, Lee J, Lim MK, Lee YR, Ihm C, Lee SH and Kang HG: Development of a novel diagnostic biomarker set for rheumatoid arthritis using a proteomics approach. BioMed Res Int. 2018(7490723)2018.PubMed/NCBI View Article : Google Scholar

36 

Lee J, Mun S, Kim D, Lee YR, Sheen DH, Ihm C, Lee SH and Kang HG: Proteomics Analysis for Verification of Rheumatoid Arthritis Biomarker Candidates Using Multiple Reaction Monitoring. Proteomics Clin Appl. 13(e1800011)2019.PubMed/NCBI View Article : Google Scholar

37 

Tan K and Lawler J: The interaction of Thrombospondins with extracellular matrix proteins. J Cell Commun Signal. 3:177–187. 2009.PubMed/NCBI View Article : Google Scholar

38 

Isenberg JS, Romeo MJ, Yu C, Yu CK, Nghiem K, Monsale J, Rick ME, Wink DA, Frazier WA and Roberts DD: Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling. Blood. 111:613–623. 2008.PubMed/NCBI View Article : Google Scholar

39 

Rouanne M, Adam J, Goubar A, Robin A, Ohana C, Louvet E, Cormier J, Mercier O, Dorfmüller P, Fattal S, et al: Osteopontin and thrombospondin-1 play opposite roles in promoting tumor aggressiveness of primary resected non-small cell lung cancer. BMC Cancer. 16(483)2016.PubMed/NCBI View Article : Google Scholar

40 

Pinessi D, Ostano P, Borsotti P, Bello E, Guffanti F, Bizzaro F, Frapolli R, Bani MR, Chiorino G, Taraboletti G, et al: Expression of thrombospondin-1 by tumor cells in patient-derived ovarian carcinoma xenografts. Connect Tissue Res. 56:355–363. 2015.PubMed/NCBI View Article : Google Scholar

41 

Bender HR, Campbell GE, Aytoda P, Mathiesen AH and Duffy DM: Thrombospondin 1 (THBS1) promotes follicular angiogenesis, luteinization, and ovulation in primates. Front Endocrinol (Lausanne). 10(727)2019.PubMed/NCBI View Article : Google Scholar

42 

Ernens I, Bousquenaud M, Lenoir B, Devaux Y and Wagner DR: Adenosine stimulates angiogenesis by up-regulating production of thrombospondin-1 by macrophages. J Leukoc Biol. 97:9–18. 2015.PubMed/NCBI View Article : Google Scholar

43 

Tolsma SS, Volpert OV, Good DJ, Frazier WA, Polverini PJ and Bouck N: Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity. J Cell Biol. 122:497–511. 1993.PubMed/NCBI View Article : Google Scholar

44 

Foulsham W, Dohlman TH, Mittal SK, Taketani Y, Singh RB, Masli S and Dana R: Thrombospondin-1 in ocular surface health and disease. Ocul Surf. 17:374–383. 2019.PubMed/NCBI View Article : Google Scholar

45 

Lee T, Esemuede N, Sumpio BE and Gahtan V: Thrombospondin-1 induces matrix metalloproteinase-2 activation in vascular smooth muscle cells. J Vasc Surg. 38:147–154. 2003.PubMed/NCBI View Article : Google Scholar

46 

Maumus M, Manferdini C, Toupet K, Chuchana P, Casteilla L, Gachet M, Jorgensen C, Lisignoli G and Noël D: Thrombospondin-1 partly mediates the cartilage protective effect of adipose-derived mesenchymal stem cells in osteoarthritis. Front Immunol. 8(1638)2017.PubMed/NCBI View Article : Google Scholar

47 

McMorrow JP, Crean D, Gogarty M, Smyth A, Connolly M, Cummins E, Veale D, Fearon U, Tak PP, Fitzgerald O, et al: Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered NR4A2 activity. Am J Pathol. 183:1243–1257. 2013.PubMed/NCBI View Article : Google Scholar

48 

Luo S, Li W, Wu W and Shi Q: Elevated expression of MMP8 and MMP9 contributes to diabetic osteoarthritis progression in a rat model. J Orthop Surg Res. 16(64)2021.PubMed/NCBI View Article : Google Scholar

49 

Lioté F, Champy R, Moenner M, Boval-Boizard B and Badet J: Elevated angiogenin levels in synovial fluid from patients with inflammatory arthritis and secretion of angiogenin by cultured synovial fibroblasts. Clin Exp Immunol. 132:163–168. 2003.PubMed/NCBI View Article : Google Scholar

50 

Iba K, Chiba H, Yamashita T, Ishii S and Sawada N: Phase-independent inhibition by retinoic acid of mineralization correlated with loss of tetranectin expression in a human osteoblastic cell line. Cell Struct Funct. 26:227–233. 2001.PubMed/NCBI View Article : Google Scholar

51 

Wewer UM, Ibaraki K, Schjørring P, Durkin ME, Young MF and Albrechtsen R: A potential role for tetranectin in mineralization during osteogenesis. J Cell Biol. 127:1767–1775. 1994.PubMed/NCBI View Article : Google Scholar

52 

Kamper EF, Kopeikina LT, Koutsoukos V and Stavridis J: Plasma tetranectin levels and disease activity in patients with rheumatoid arthritis. J Rheumatol. 24:262–268. 1997.PubMed/NCBI

53 

Kamper EF, Kopeikina LT, Trontzas P, Kyriazis NC, Vaiopoulos G and Stavridis J: Comparative study of tetranectin levels in serum and synovial fluid of patients with rheumatoid arthritis, seronegative spondylarthritis and osteoarthritis. Clin Rheumatol. 17:318–324. 1998.PubMed/NCBI View Article : Google Scholar

54 

Vincenti MP and Brinckerhoff CE: Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta. Arthritis Res. 3:381–388. 2001.PubMed/NCBI View Article : Google Scholar

55 

Sommaggio R, Pérez-Cruz M, Brokaw JL, Máñez R and Costa C: Inhibition of complement component C5 protects porcine chondrocytes from xenogeneic rejection. Osteoarthritis Cartilage. 21:1958–1967. 2013.PubMed/NCBI View Article : Google Scholar

56 

Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, et al: Identification of a central role for complement in osteoarthritis. Nat Med. 17:1674–1679. 2011.PubMed/NCBI View Article : Google Scholar

57 

Silawal S, Triebel J, Bertsch T and Schulze-Tanzil G: Osteoarthritis and the complement cascade. Clin Med Insights Arthritis Musculoskelet Disord: Jan 3, 2018 (Epub ahead of print). doi: 10.1177/1179544117751430.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chae D, Kim ME, Kang K, Lee NY, Lee W and Lee JS: Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis. Exp Ther Med 22: 1470, 2021.
APA
Chae, D., Kim, M.E., Kang, K., Lee, N.Y., Lee, W., & Lee, J.S. (2021). Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis. Experimental and Therapeutic Medicine, 22, 1470. https://doi.org/10.3892/etm.2021.10905
MLA
Chae, D., Kim, M. E., Kang, K., Lee, N. Y., Lee, W., Lee, J. S."Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis". Experimental and Therapeutic Medicine 22.6 (2021): 1470.
Chicago
Chae, D., Kim, M. E., Kang, K., Lee, N. Y., Lee, W., Lee, J. S."Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1470. https://doi.org/10.3892/etm.2021.10905
Copy and paste a formatted citation
x
Spandidos Publications style
Chae D, Kim ME, Kang K, Lee NY, Lee W and Lee JS: Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis. Exp Ther Med 22: 1470, 2021.
APA
Chae, D., Kim, M.E., Kang, K., Lee, N.Y., Lee, W., & Lee, J.S. (2021). Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis. Experimental and Therapeutic Medicine, 22, 1470. https://doi.org/10.3892/etm.2021.10905
MLA
Chae, D., Kim, M. E., Kang, K., Lee, N. Y., Lee, W., Lee, J. S."Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis". Experimental and Therapeutic Medicine 22.6 (2021): 1470.
Chicago
Chae, D., Kim, M. E., Kang, K., Lee, N. Y., Lee, W., Lee, J. S."Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1470. https://doi.org/10.3892/etm.2021.10905
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team