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Article

Prognostic value of the location of submucosal uterine leiomyomas in infertility

  • Authors:
    • George-Alexandru Roșu
    • Crîngu Antoniu Ionescu
    • Florin Daniel Călin
    • Mihai Dimitriu
    • Liana Pleș
    • Alexandra Matei
    • Dan-Bogdan Navolan
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 050474 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Victor Babes’ University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania
  • Article Number: 1482
    |
    Published online on: October 25, 2021
       https://doi.org/10.3892/etm.2021.10917
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Abstract

Submucosal fibroid location and size are predictive factors of impaired fertility. Submucosal fibroids cause infertility through several mechanisms including distortion of the endometrial cavity, increased uterine contractility, local inflammation and remodeling of the endometrial blood supply. This is a monocentric, retrospective, cross‑sectional study, conducted in the Department of Obstetrics and Gynecology of ‘Sf. Pantelimon’ Clinical Emergency Hospital, analyzing patients from a 5‑year period (January 2015‑December 2019). In the present study, the relationship between different characteristics of the submucosal fibroids (among others, location and dimensions) and fertility (birth rates, early pregnancy loss rates) were investigated. This study identified that submucosal and intramural fibroids are risk factors for reduced birth rate compared with subserosal fibroids (P=0.02, RR=2.58, 95% CI 1.03‑6.47; P=0.005, RR=1.18, 95% CI 1.02‑1.35, respectively). In addition, G2 leiomyomas are risk factors for low birth rate compared with G0 and G1 fibroids (P=0.01, RR=1.95, 95% CI 1.05‑3.60). Moreover, the presence of a subserosal fibroid was associated with an increased early pregnancy loss rate (P=0.01, RR=2.14, 95% CI 1.05‑4.35). In conclusion, the location and degree of uterine cavity distortion are important factors that alter the normal development of a pregnancy and the birth rate.
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Copy and paste a formatted citation
Spandidos Publications style
Roșu G, Ionescu CA, Călin FD, Dimitriu M, Pleș L, Matei A and Navolan D: Prognostic value of the location of submucosal uterine leiomyomas in infertility. Exp Ther Med 22: 1482, 2021.
APA
Roșu, G., Ionescu, C.A., Călin, F.D., Dimitriu, M., Pleș, L., Matei, A., & Navolan, D. (2021). Prognostic value of the location of submucosal uterine leiomyomas in infertility. Experimental and Therapeutic Medicine, 22, 1482. https://doi.org/10.3892/etm.2021.10917
MLA
Roșu, G., Ionescu, C. A., Călin, F. D., Dimitriu, M., Pleș, L., Matei, A., Navolan, D."Prognostic value of the location of submucosal uterine leiomyomas in infertility". Experimental and Therapeutic Medicine 22.6 (2021): 1482.
Chicago
Roșu, G., Ionescu, C. A., Călin, F. D., Dimitriu, M., Pleș, L., Matei, A., Navolan, D."Prognostic value of the location of submucosal uterine leiomyomas in infertility". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1482. https://doi.org/10.3892/etm.2021.10917
Copy and paste a formatted citation
x
Spandidos Publications style
Roșu G, Ionescu CA, Călin FD, Dimitriu M, Pleș L, Matei A and Navolan D: Prognostic value of the location of submucosal uterine leiomyomas in infertility. Exp Ther Med 22: 1482, 2021.
APA
Roșu, G., Ionescu, C.A., Călin, F.D., Dimitriu, M., Pleș, L., Matei, A., & Navolan, D. (2021). Prognostic value of the location of submucosal uterine leiomyomas in infertility. Experimental and Therapeutic Medicine, 22, 1482. https://doi.org/10.3892/etm.2021.10917
MLA
Roșu, G., Ionescu, C. A., Călin, F. D., Dimitriu, M., Pleș, L., Matei, A., Navolan, D."Prognostic value of the location of submucosal uterine leiomyomas in infertility". Experimental and Therapeutic Medicine 22.6 (2021): 1482.
Chicago
Roșu, G., Ionescu, C. A., Călin, F. D., Dimitriu, M., Pleș, L., Matei, A., Navolan, D."Prognostic value of the location of submucosal uterine leiomyomas in infertility". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1482. https://doi.org/10.3892/etm.2021.10917
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