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Article

Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration

  • Authors:
    • Jing Xu
    • Chunyang Wang
    • Pengjuan Xu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China
  • Article Number: 1486
    |
    Published online on: October 26, 2021
       https://doi.org/10.3892/etm.2021.10921
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Abstract

Hydroxyapatite (HA) has been extensively used as a reconstructive and prosthetic material for osseous tissue. The present study aimed to determine whether HA extract exerted effects on central nervous system injury following transient cerebral ischemia/reperfusion in rats. Male Wistar rats were treated with HA following bilateral common carotid artery clamping (two‑vessel occlusion). The results demonstrated that treatment with HA extract attenuated the inhibition of long‑term potential in a rat model of transient cerebral ischemia/reperfusion. Furthermore, HA extract improved axon regeneration, which was confirmed via the immunohistochemical analysis of growth associated protein 43 and glial fibrillary acidic protein. Taken together, the results of the present study provided preliminary evidence of the protective effect of HA on neuronal damage.
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Copy and paste a formatted citation
Spandidos Publications style
Xu J, Wang C and Xu P: Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Exp Ther Med 22: 1486, 2021.
APA
Xu, J., Wang, C., & Xu, P. (2021). Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Experimental and Therapeutic Medicine, 22, 1486. https://doi.org/10.3892/etm.2021.10921
MLA
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22.6 (2021): 1486.
Chicago
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1486. https://doi.org/10.3892/etm.2021.10921
Copy and paste a formatted citation
x
Spandidos Publications style
Xu J, Wang C and Xu P: Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Exp Ther Med 22: 1486, 2021.
APA
Xu, J., Wang, C., & Xu, P. (2021). Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Experimental and Therapeutic Medicine, 22, 1486. https://doi.org/10.3892/etm.2021.10921
MLA
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22.6 (2021): 1486.
Chicago
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1486. https://doi.org/10.3892/etm.2021.10921
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