Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration

  • Authors:
    • Jing Xu
    • Chunyang Wang
    • Pengjuan Xu
  • View Affiliations

  • Published online on: October 26, 2021     https://doi.org/10.3892/etm.2021.10921
  • Article Number: 1486
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Abstract

Hydroxyapatite (HA) has been extensively used as a reconstructive and prosthetic material for osseous tissue. The present study aimed to determine whether HA extract exerted effects on central nervous system injury following transient cerebral ischemia/reperfusion in rats. Male Wistar rats were treated with HA following bilateral common carotid artery clamping (two‑vessel occlusion). The results demonstrated that treatment with HA extract attenuated the inhibition of long‑term potential in a rat model of transient cerebral ischemia/reperfusion. Furthermore, HA extract improved axon regeneration, which was confirmed via the immunohistochemical analysis of growth associated protein 43 and glial fibrillary acidic protein. Taken together, the results of the present study provided preliminary evidence of the protective effect of HA on neuronal damage.
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December-2021
Volume 22 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

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Spandidos Publications style
Xu J, Wang C and Xu P: Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Exp Ther Med 22: 1486, 2021
APA
Xu, J., Wang, C., & Xu, P. (2021). Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration. Experimental and Therapeutic Medicine, 22, 1486. https://doi.org/10.3892/etm.2021.10921
MLA
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22.6 (2021): 1486.
Chicago
Xu, J., Wang, C., Xu, P."Effects of hydroxyapatite extract on rats with transient ischemia: Long‑term potentiation and axon regeneration". Experimental and Therapeutic Medicine 22, no. 6 (2021): 1486. https://doi.org/10.3892/etm.2021.10921