Effects of long‑term soft contact lens wear on corneal epithelial thickness after small incision lenticule extraction

Wang,Yun; Zhang,Xiaofeng; Yang,Xiaolong; Xu,Yue; Luo,Baogen; Qian,Yifeng

doi:10.3892/etm.2021.10930

Effects of long‑term soft contact lens wear on corneal epithelial thickness after small incision lenticule extraction

Authors:
- Yun Wang
- Xiaofeng Zhang
- Xiaolong Yang
- Yue Xu
- Baogen Luo
- Yifeng Qian
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Affiliations: Department of Ophthalmology, Suzhou Dushu Lake Hospital (Dushu Lake Hospital Affiliated Soochow University, Medical Center of Soochow University), Suzhou, Jiangsu 215100, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
Published online on: October 28, 2021 https://doi.org/10.3892/etm.2021.10930
Article Number: 8
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study investigated changes in corneal epithelial thickness after small incision lenticule extraction (SMILE) in patients with long‑term preoperative soft contact lens (SCL) wear, the impact of SCL wear on the efficacy of surgical outcomes and the effects of long‑term SCL wear on postoperative corneal aberrations. Patients were assigned to three groups according to the duration of SCL wear: Group A, the non‑SCL‑wearing group; group B, those with SCL wear ≤1 year; and group C, those with SCL wear >1 year. Epithelial thickness was recorded in nine zones by anterior segment optical coherence tomography across a 5‑mm diameter before surgery and at 1 week, and 1, 3 and 6 months post‑surgery. Corneal epithelial thickness and corneal aberrations among the three groups were compared, as well as the effects of changes in corneal epithelial thickness on postoperative visual acuity and manifest refraction. No significant differences were noted with regard to age or preoperative spherical equivalent among groups A (22 eyes), B (17 eyes) and C (18 eyes). Preoperative corneal epithelial thickness in the inferonasal, inferior and inferotemporal zones was thinner in group B compared with that in group A, and corneal epithelial thickness was thinner in all nine zones in group C compared with that in group A (P<0.05). At all follow‑up time points, in the central, nasal, inferonasal, inferior, inferotemporal and temporal areas, the epithelial thickness was thinner in group C compared with that in group A (P<0.05). At 3 months postoperatively, the epithelial thickness was thinner in the inferonasal and inferior sectors in group C compared with that in group B (P<0.05), and at 6 months postoperatively, the epithelial thickness in the inferior region was thinner in group C compared with that in group B (P<0.05). There were no significant differences in visual acuity or manifest refraction among the three groups at all postoperative time points. The total higher‑order aberrations were greater in group C compared with those in group A for all time points (P<0.05) and were greater in group C at 1 and 3 months postoperatively compared with those in group B (P<0.05). The spherical aberrations at 3 and 6 months postoperatively were greater in group C compared with those in group A (P<0.05). The coma aberrations were greater in group C compared with those in groups A and B for all time points (P<0.05). In conclusion, long‑term SCL wear will result in corneal epithelial thinning, which does not impact visual acuity or manifest refraction after SMILE.

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1	Holden BA, Sweeney DF, Vannas A, Nilsson KT and Efron N: Effects of long-term extended contact lens wear on the human cornea. Invest Ophthalmol Vis Sci. 26:1489–1501. 1985.PubMed/NCBI
2	Liesegang TJ: Physiologic changes of the cornea with contact lens wear. CLAO J. 28:12–27. 2002.PubMed/NCBI
3	Zhang X, Marchetti C, Lee J, Sun Y, Debanne S, Jiang Y, Kern J, Harrod M, Benetz BA, Pearlman E and Szczotka-Flynn L: The impact of lens care solutions on corneal epithelial changes during daily silicone hydrogel contact lens wear as measured by in vivo confocal microscopy. Contact Lens Anterior Eye. 40:33–41. 2017.PubMed/NCBI View Article : Google Scholar
4	Yanai R, Ko JA, Morishige N, Chikama T, Ichijima H and Nishida T: Disruption of zonula occludens-1 localization in the rabbit corneal epithelium by contact lens-induced hypoxia. Invest Ophthalmol Vis Sci. 50:4605–4610. 2009.PubMed/NCBI View Article : Google Scholar
5	Bastion ML and Mohamad MH: Study of the factors associated with the presence of white dots in the corneas of regular soft contact lens users from an Asian Country. Eye Contact Lens. 32:223–227. 2006.PubMed/NCBI View Article : Google Scholar
6	Edelhauser HF: The resiliency of the corneal endothelium to refractive and intraocular surgery. Cornea. 19:263–273. 2000.PubMed/NCBI View Article : Google Scholar
7	Yamamoto K, Ladage PM, Ren DH, Li L, Petroll WM, Jester JV and Cavanagh HD: Effect of eyelid closure and overnight contact lens wear on viability of surface epithelial cells in rabbit cornea. Cornea. 21:85–90. 2002.PubMed/NCBI View Article : Google Scholar
8	Hong J, Qian T, Yang Y, Jiang C, Liu Z, Sun X, Deng SX and Xu J: Corneal epithelial thickness map in long-term contact lenses wearers. Optom Vis Sci. 91:1455–1461. 2014.PubMed/NCBI View Article : Google Scholar
9	Jalbert I, Sweeney DF and Stapleton F: The effect of long-term wear of soft lenses of low and high oxygen transmissibility on the corneal epithelium. Eye (Lond). 23:1282–1287. 2009.PubMed/NCBI View Article : Google Scholar
10	Stachura J, Mlyniuk P, Bloch W, Jimenez-Villar A, Grulkowski I and Kaluzny BJ: Shape of the anterior surface of the cornea after extended wear of silicone hydrogel soft contact lenses. Ophthalmic Physiol Opt. 41:683–690. 2021.PubMed/NCBI View Article : Google Scholar
11	Lei Y, Zheng X, Hou J, Xu B and Mu G: Effects of long-term soft contact lens wear on the corneal thickness and corneal epithelial thickness of myopic subjects. Mol Med Rep. 11:2020–2026. 2015.PubMed/NCBI View Article : Google Scholar
12	Shehadeh-Mashor R, Mimouni M, Shapira Y, Sela T, Munzer G and Kaiserman I: Duration of contact lens removal before myopic refractive surgery. Eur J Ophthalmol. 31:1695–1699. 2021.PubMed/NCBI View Article : Google Scholar
13	Sekundo W, Kunert KS and Blum M: Small incision corneal refractive surgery using the small incision lenticule extraction (SMILE) procedure for the correction of myopia and myopic astigmatism: Results of a 6 month prospective study. Br J Ophthalmol. 95:335–339. 2011.PubMed/NCBI View Article : Google Scholar
14	Reinstein DZ, Archer TJ and Randleman JB: Mathematical model to compare the relative tensile strength of the cornea after PRK, LASIK, and small incision lenticule extraction. J Refract Surg. 29:454–460. 2013.PubMed/NCBI View Article : Google Scholar
15	Denoyer A, Landman E, Trinh L, Faure JF, Auclin F and Baudouin C: Dry eye disease after refractive surgery: Comparative outcomes of small incision lenticule extraction versus LASIK. Ophthalmology. 122:669–676. 2015.PubMed/NCBI View Article : Google Scholar
16	Ishii R, Shimizu K, Igarashi A, Kobashi H and Kamiya K: Influence of femtosecond lenticule extraction and small incision lenticule extraction on corneal nerve density and ocular surface: A 1-year prospective, confocal, microscopic study. J Refract Surg. 31:10–15. 2015.PubMed/NCBI View Article : Google Scholar
17	Shah R, Shah S and Sengupta S: Results of small incision lenticule extraction: All-in-one femtosecond laser refractive surgery. J Cataract Refract Surg. 37:127–137. 2011.PubMed/NCBI View Article : Google Scholar
18	Reinstein DZ, Archer TJ and Gobbe M: Lenticule thickness readout for small incision lenticule extraction compared to artemis three-dimensional very high-frequency digital ultrasound stromal measurements. J Refract Surg. 30:304–309. 2014.PubMed/NCBI View Article : Google Scholar
19	Vestergaard AH, Grauslund J, Ivarsen AR and Hjortdal JØ: Central corneal sublayer pachymetry and biomechanical properties after refractive femtosecond lenticule extraction. J Refract Surg. 30:102–108. 2014.PubMed/NCBI View Article : Google Scholar
20	Reinstein DZ, Archer TJ, Gobbe M, Silverman RH and Coleman DJ: Epithelial thickness in the normal cornea: Three-dimensional display with very high frequency ultrasound. J Refract Surg. 24:571–581. 2008.PubMed/NCBI View Article : Google Scholar
21	Li Y, Tan O, Brass R, Weiss JL and Huang D: Corneal epithelial thickness mapping by Fourier-domain optical coherence tomography in normal and keratoconic eyes. Ophthalmology. 119:2425–2433. 2012.PubMed/NCBI View Article : Google Scholar
22	Pérez JG, Méijome JM, Jalbert I, Sweeney DF and Erickson P: Corneal epithelial thinning profile induced by long-term wear of hydrogel lenses. Cornea. 22:304–307. 2003.PubMed/NCBI View Article : Google Scholar
23	Chen Y, Thompson DC, Koppaka V, Jester JV and Vasiliou V: Ocular aldehyde dehydrogenases: Protection against ultraviolet damage and maintenance of transparency for vision. Prog Retin Eye Res. 33:28–39. 2013.PubMed/NCBI View Article : Google Scholar
24	Patel SV, McLaren JW, Hodge DO and Bourne WM: Confocal microscopy in vivo in corneas of long-term contact lens wearers. Invest Ophthalmol Vis Sci. 43:995–1003. 2002.PubMed/NCBI
25	Markoulli M, Papas E, Cole N and Holden B: Corneal erosions in contact lens wear. Cont Lens Anterior Eye. 35:2–8. 2012.PubMed/NCBI View Article : Google Scholar
26	Efron N: Contact lens-induced changes in the anterior eye as observed in vivo with the confocal microscope. Prog Retin Eye Res. 26:398–436. 2007.PubMed/NCBI View Article : Google Scholar
27	Luft N, Ring MH, Dirisamer M, Mursch-Edlmayr AS, Kreutzer TC, Pretzl J, Bolz M and Priglinger SG: Corneal epithelial remodeling induced by small incision lenticule extraction (SMILE). Invest Ophthalmol Vis Sci. 57:OCT176–OCT183. 2016.PubMed/NCBI View Article : Google Scholar
28	Ryu IH, Kim BJ, Lee JH and Kim SW: Comparison of corneal epithelial remodeling after femtosecond laser-assisted LASIK and small incision lenticule extraction (SMILE). J Refract Surg. 33:250–256. 2017.PubMed/NCBI View Article : Google Scholar
29	Reinstein DZ, Archer TJ and Gobbe M: Change in epithelial thickness profile 24 h and longitudinally for 1 year after myopic LASIK: Three-dimensional display with artemis very high-frequency digital ultrasound. J Refract Surg. 28:195–202. 2012.PubMed/NCBI View Article : Google Scholar
30	Nourouzi H, Rajavi J and Okhovatpour MA: Time to resolution of corneal edema after longt-term contact lens wear. Am J Ophthalmol. 142:671–673. 2006.PubMed/NCBI View Article : Google Scholar
31	Hashemi H, Firoozabadi MR, Mehravaran S and Gorouhi F: Corneal stability after discontinued soft contact lens wear. Cont Lens Anterior Eye. 31:122–125. 2008.PubMed/NCBI View Article : Google Scholar
32	Riau AK, Angunawela RI, Chaurasia SS, Lee WS, Tan DT and Mehta JS: Early corneal wound healing and inflammatory responses after refractive lenticule extraction (ReLEX). Invest Ophthalmol Vis Sci. 52:6213–6221. 2011.PubMed/NCBI View Article : Google Scholar
33	Lloyd-McKernan A, Simo Mannion L and O'Dwyer V: The effect of previous soft contact lens wear on corneal refractive surgery outcomes. Cont Lens Anterior Eye. 40:301–310. 2017.PubMed/NCBI View Article : Google Scholar
34	Fukui M, Yamada M, Akune Y, Shigeyasu C and Tsubota K: Fluorophotometric analysis of the ocular surface glycocalyx in soft contact lens wearers. Curr Eye Res. 41:9–14. 2016.PubMed/NCBI View Article : Google Scholar
35	Guillon M and Maissa C: Dry eye symptomatology of soft contact lens wearers and nonwearers. Optom Vis Sci. 82:829–834. 2005.PubMed/NCBI View Article : Google Scholar
36	Denoyer A, Rabut G and Baudouin C: Tear film aberration dynamics and vision-related quality of life in patients with dry eye disease. Ophthalmology. 119:1811–1818. 2012.PubMed/NCBI View Article : Google Scholar