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Review Open Access

Current trends in gene therapy for retinal diseases (Review)

  • Authors:
    • Andreea Dana Moraru
    • Dănuț Costin
    • Raluca Eugenia Iorga
    • Mihnea Munteanu
    • Radu Lucian Moraru
    • Daniel Constantin Branisteanu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iași, Romania, Department of Ophthalmology, ‘Victor Babeș’ University of Medicine and Pharmacy, 300041 Timișoara, Romania, Department of Otorhinolaryngology, ‘Transmed Expert’ Medical Center, 700011 Iași, Romania
    Copyright: © Moraru et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 26
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    Published online on: November 5, 2021
       https://doi.org/10.3892/etm.2021.10948
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Abstract

The eye is considered an effective target for genetic therapy, as it has a privileged immune status, it is easily accessed for medication delivery and it is affected by a number of inherited disorders. In particular, the retina is considered for gene therapy due to the fact that it can be visualized with ease, it does not have lymphatic vessels, nor a direct blood network for the outer layers and its cells do not divide after birth, and thus transgene expression is not affected. As gene therapy is currently on a continuously progressive development trend, this emerging field of gene manipulation techniques has yielded promising results. This involves the development of treatments for a number of debilitating and blinding diseases, which were to date considered intractable. However, numerous unanswered questions remain as regards the long‑term efficacy and safety profile of these treatments. The present review article discusses the current research status regarding genetic manipulation techniques aimed at addressing visual impairment related to retinal disorders, both inherited and degenerative.
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Copy and paste a formatted citation
Spandidos Publications style
Moraru AD, Costin D, Iorga RE, Munteanu M, Moraru RL and Branisteanu DC: Current trends in gene therapy for retinal diseases (Review). Exp Ther Med 23: 26, 2022.
APA
Moraru, A.D., Costin, D., Iorga, R.E., Munteanu, M., Moraru, R.L., & Branisteanu, D.C. (2022). Current trends in gene therapy for retinal diseases (Review). Experimental and Therapeutic Medicine, 23, 26. https://doi.org/10.3892/etm.2021.10948
MLA
Moraru, A. D., Costin, D., Iorga, R. E., Munteanu, M., Moraru, R. L., Branisteanu, D. C."Current trends in gene therapy for retinal diseases (Review)". Experimental and Therapeutic Medicine 23.1 (2022): 26.
Chicago
Moraru, A. D., Costin, D., Iorga, R. E., Munteanu, M., Moraru, R. L., Branisteanu, D. C."Current trends in gene therapy for retinal diseases (Review)". Experimental and Therapeutic Medicine 23, no. 1 (2022): 26. https://doi.org/10.3892/etm.2021.10948
Copy and paste a formatted citation
x
Spandidos Publications style
Moraru AD, Costin D, Iorga RE, Munteanu M, Moraru RL and Branisteanu DC: Current trends in gene therapy for retinal diseases (Review). Exp Ther Med 23: 26, 2022.
APA
Moraru, A.D., Costin, D., Iorga, R.E., Munteanu, M., Moraru, R.L., & Branisteanu, D.C. (2022). Current trends in gene therapy for retinal diseases (Review). Experimental and Therapeutic Medicine, 23, 26. https://doi.org/10.3892/etm.2021.10948
MLA
Moraru, A. D., Costin, D., Iorga, R. E., Munteanu, M., Moraru, R. L., Branisteanu, D. C."Current trends in gene therapy for retinal diseases (Review)". Experimental and Therapeutic Medicine 23.1 (2022): 26.
Chicago
Moraru, A. D., Costin, D., Iorga, R. E., Munteanu, M., Moraru, R. L., Branisteanu, D. C."Current trends in gene therapy for retinal diseases (Review)". Experimental and Therapeutic Medicine 23, no. 1 (2022): 26. https://doi.org/10.3892/etm.2021.10948
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