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Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR

  • Authors:
    • Young-Min Song
    • Hyun-Jin Lee
    • Sae-Kyung Min
    • Yoon-Hee Park
    • Jae-Kwen Oh
    • Ji-Youn Kim
    • Jun-Beom Park
  • View Affiliations / Copyright

    Affiliations: Department of Periodontics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea, Ebiogen, Seoul 04785, Republic of Korea, Merden Dental Hospital, Bucheon‑si, Gyeonggi 14544, Republic of Korea, Division of Oral and Maxillofacial Surgery, Department of Dentistry, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul 06591, Republic of Korea
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 32
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    Published online on: November 8, 2021
       https://doi.org/10.3892/etm.2021.10954
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Abstract

Noni fruit (Morinda citrifolia) has been widely used in traditional medicine across tropical and subtropical regions, and is now being paid more attention in Western medicine. The present study aimed to investigate the effects of noni extract on the change in the cellular morphology, maintenance of cellular viability and enhancement of osteogenic differentiation of stem cells. Stem cells obtained from gingiva were cultured where noni extracts existed at concentrations ranging from 10‑200 ng/ml. Evaluations of cell morphology and cellular viability were performed. Alkaline phosphatase activity assays were performed to assess the osteogenic differentiation. Alizarin Red S staining was performed to evaluate the calcium deposits in the culture, with the addition of noni extract. Global gene expression was analyzed via next‑generation mRNA sequencing. Gene ontology and pathway analyses were performed to determine the associated mechanisms. Validation procedures were performed via quantitative (q)PCR analysis. The addition of noni at concentrations ranging from 10‑200 ng/ml did not produce significant morphological changes. There were significantly higher values of cellular viability, with the highest value at 100 ng/ml compared with the control (P<0.05). Furthermore, significantly higher values of alkaline phosphatase activity was noted in the 10 and 100 ng/ml groups compared with the 0 ng/ml group on day 7 (P<0.05). Alizarin Red S staining revealed calcium deposits in each group. In addition, the highest value for Alizarin Red S staining was observed at 100 ng/ml compared with the unloaded control (P<0.05). qPCR analysis demonstrated that the mRNA expression levels of RUNX2, BSP, OCN and COL1A1 increased following treatment with noni. Taken together, the results of the present study suggest that noni extract has enhancing effects on gingiva‑derived mesenchymal stem cells, by enhancing cellular viability and osteogenic differentiation.
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View References

1 

Wall MM, Miller S and Siderhurst MS: Volatile changes in Hawaiian noni fruit, Morinda citrifolia L., during ripening and fermentation. J Sci Food Agric. 98:3391–3399. 2018.PubMed/NCBI View Article : Google Scholar

2 

Palu A, Su C, Zhou BN, West B and Jensen J: Wound healing effects of noni (Morinda citrifolia L.) leaves: A mechanism involving its PDGF/A2A receptor ligand binding and promotion of wound closure. Phytother Res. 24:1437–1441. 2010.PubMed/NCBI View Article : Google Scholar

3 

Hussain S, Tamizhselvi R, George L and Manickam V: Assessment of the role of Noni (Morinda citrifolia) juice for inducing osteoblast differentiation in isolated rat bone marrow derived mesenchymal stem cells. Int J Stem Cells. 9:221–229. 2016.PubMed/NCBI View Article : Google Scholar

4 

Sharma K, Pachauri SD, Khandelwal K, Ahmad H, Arya A, Biala P, Agrawal S, Pandey RR, Srivastava A, Srivastav A, et al: Anticancer effects of extracts from the fruit of Morinda Citrifolia (Noni) in breast cancer cell lines. Drug Res (Stuttg). 66:141–147. 2016.PubMed/NCBI View Article : Google Scholar

5 

Kumarasamy B, Manipal S, Duraisamy P, Ahmed A, Mohanaganesh S and Jeevika C: Role of aqueous extract of Morinda citrifolia (Indian noni) ripe fruits in inhibiting dental caries-causing Streptococcus mutans and Streptococcus mitis. J Dent (Tehran). 11:703–710. 2014.PubMed/NCBI

6 

Glang J, Falk W and Westendorf J: Effect of Morinda citrifolia L. fruit juice on gingivitis/periodontitis. Mod Res Inflamm. 2:21–27. 2013.

7 

Choudhary E, Indushekar KR, Saraf BG, Sheoran N, Sardana D and Shekhar A: Exploring the role of Morinda citrifolia and Triphala juice in root canal irrigation: An ex vivo study. J Conserv Dent. 21:443–449. 2018.PubMed/NCBI View Article : Google Scholar

8 

Needleman I, Worthington H, Giedrys-Leeper E and Tucker R: Guided tissue regeneration for periodontal infra-bony defects. Cochrane Database Syst Rev: Apr 19, 2006 (Epub ahead of print). doi: 10.1002/14651858.CD001724.pub2.

9 

Kim YT, Jeong SN and Lee JH: Effectiveness of porcine-derived xenograft with enamel matrix derivative for periodontal regenerative treatment of intrabony defects associated with a fixed dental prosthesis: A 2-year follow-up retrospective study. J Periodontal Implant Sci. 51:179–188. 2021.PubMed/NCBI View Article : Google Scholar

10 

Langford J, Doughty A, Wang M, Clayton L and Babich M: Effects of Morinda citrifolia on quality of life and auditory function in postmenopausal women. J Altern Complement Med. 10:737–739. 2004.PubMed/NCBI View Article : Google Scholar

11 

Wang X, Wang Y, Gou W, Lu Q, Peng J and Lu S: Role of mesenchymal stem cells in bone regeneration and fracture repair: A review. Int Orthop. 37:2491–2498. 2013.PubMed/NCBI View Article : Google Scholar

12 

Lee SI, Ko Y and Park JB: Evaluation of the maintenance of stemness, viability, and differentiation potential of gingiva-derived stem-cell spheroids. Exp Ther Med. 13:1757–1764. 2017.PubMed/NCBI View Article : Google Scholar

13 

Jin SH, Lee JE, Yun JH, Kim I, Ko Y and Park JB: Isolation and characterization of human mesenchymal stem cells from gingival connective tissue. J Periodontal Res. 50:461–467. 2015.PubMed/NCBI View Article : Google Scholar

14 

Min SK, Oh J and Park JB: The effects of Morinda citrifolia (Noni) on the cellular viability and osteogenesis of stem cell spheroids. Medicina (Kaunas). 56(56)2020.PubMed/NCBI View Article : Google Scholar

15 

Kang SH, Park JB, Kim I, Lee W and Kim H: Assessment of stem cell viability in the initial healing period in rabbits with a cranial bone defect according to the type and form of scaffold. J Periodontal Implant Sci. 49:258–267. 2019.PubMed/NCBI View Article : Google Scholar

16 

Kim BB, Tae JY, Ko Y and Park JB: Lovastatin increases the proliferation and osteoblastic differentiation of human gingiva-derived stem cells in three-dimensional cultures. Exp Ther Med. 18:3425–3430. 2019.PubMed/NCBI View Article : Google Scholar

17 

Lee H, Lee H, Na CB and Park JB: The effects of simvastatin on cellular viability, stemness and osteogenic differentiation using 3-dimensional cultures of stem cells and osteoblast-like cells. Adv Clin Exp Med. 28:699–706. 2019.PubMed/NCBI View Article : Google Scholar

18 

Tae JY, Park YH, Ko Y and Park JB: The effects of bone morphogenetic protein-4 on cellular viability, osteogenic potential, and global gene expression on gingiva-derived stem cell spheroids. Coatings. 10(1055)2020.

19 

Trapnell C, Pachter L and Salzberg SL: TopHat: Discovering splice junctions with RNA-Seq. Bioinformatics. 25:1105–1111. 2009.PubMed/NCBI View Article : Google Scholar

20 

Roberts A, Trapnell C, Donaghey J, Rinn JL and Pachter L: Improving RNA-Seq expression estimates by correcting for fragment bias. Genome Biol. 12(R22)2011.PubMed/NCBI View Article : Google Scholar

21 

Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017.PubMed/NCBI View Article : Google Scholar

22 

Lee HJ, Min SK, Park YH and Park JB: Application of bone morphogenetic protein 7 enhanced the osteogenic differentiation and mineralization of bone marrow-derived stem cells cultured on deproteinized bovine bone. Coatings. 11(642)2021.

23 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

24 

Huang HL, Liu CT, Chou MC, Ko CH and Wang CK: Noni (Morinda citrifolia L.) fruit extracts improve colon microflora and exert anti-inflammatory activities in Caco-2 cells. J Med Food. 18:663–676. 2015.PubMed/NCBI View Article : Google Scholar

25 

Chan-Blanco Y, Vaillant F, Pérez AM, Belleville M-P, Zúñiga C and Brat P: The ripening and aging of noni fruits (Morinda citrifolia L.): Microbiological flora and antioxidant compounds. J Sci Food Agric. 87:1710–1716. 2007.

26 

Singh B and Sharma RA: Indian Morinda species: A review. Phytother Res. 34:924–1007. 2020.PubMed/NCBI View Article : Google Scholar

27 

Wang M, Wang Q, Yang Q, Yan X, Feng S and Wang Z: Comparison of anthraquinones, iridoid glycosides and triterpenoids in Morinda officinalis and Morinda citrifolia using UPLC/Q-TOF-MS and multivariate statistical analysis. Molecules. 25(25)2019.PubMed/NCBI View Article : Google Scholar

28 

Gu H, Boonanantanasarn K, Kang M, Kim I, Woo KM, Ryoo HM and Baek JH: Morinda citrifolia Leaf extract enhances osteogenic differentiation through activation of Wnt/β-catenin signaling. J Med Food. 21:57–69. 2018.PubMed/NCBI View Article : Google Scholar

29 

Pratap UP, Priyanka HP, Ramanathan KR, Raman V, Hima L and Thyagarajan S: Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. J Integr Med. 16:199–207. 2018.PubMed/NCBI View Article : Google Scholar

30 

Osman WNW and Mohamed S: Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism. Phytother Res. 32:2078–2085. 2018.PubMed/NCBI View Article : Google Scholar

31 

Pandy V, Wai YC, Amira Roslan NF, Sajat A, Abdulla Jallb AH and Vijeepallam K: Methanolic extract of Morinda citrifolia Linn. unripe fruit attenuates methamphetamine-induced conditioned place preferences in mice. Biomed Pharmacother. 107:368–373. 2018.PubMed/NCBI View Article : Google Scholar

32 

Algenstaedt P, Stumpenhagen A and Westendorf J: The effect of Morinda citrifolia L. fruit juice on the blood sugar level and other serum parameters in patients with diabetes type 2. Evid Based Complement Alternat Med. 2018(3565427)2018.PubMed/NCBI View Article : Google Scholar

33 

Park JB, Jeong JH, Lee M, Lee DY and Byun Y: Xenotransplantation of exendin-4 gene transduced pancreatic islets using multi-component (alginate, poly-L-lysine, and polyethylene glycol) microcapsules for the treatment of type 1 diabetes mellitus. J Biomater Sci Polym Ed. 24:2045–2057. 2013.PubMed/NCBI View Article : Google Scholar

34 

Lee H, Min SK, Park YH and Park JB: The role of insulin-like growth factor-2 on the cellular viability and differentiation to the osteogenic lineage and mineralization of stem cells cultured on deproteinized bovine bone mineral. Appl Sci (Basel). 10(5471)2020.

35 

Gupta RK, Bajpai D and Singh N: Influence of Morinda citrifolia (Noni) on expression of DNA repair genes in cervical cancer cells. Asian Pac J Cancer Prev. 16:3457–3461. 2015.PubMed/NCBI View Article : Google Scholar

36 

Pratap UP, Anand K, Yasmine F, Hima L, Priyanka HP and Thyagarajan S: Phytochemicals in Morinda citrifolia fruit selectively modulate age-associated immunity and antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats. J Recept Signal Transduct Res. 36:139–151. 2015.PubMed/NCBI View Article : Google Scholar

37 

García-Vilas JA, Quesada AR and Medina MA: Damnacanthal, a noni anthraquinone, inhibits c-Met and is a potent antitumor compound against Hep G2 human hepatocellular carcinoma cells. Sci Rep. 5(8021)2015.PubMed/NCBI View Article : Google Scholar

38 

Garcia-Vilas JA, Medina MA, Melo FR, Pejler G and Garcia-Faroldi G: Damnacanthal inhibits IgE receptor-mediated activation of mast cells. Mol Immunol. 65:86–93. 2015.PubMed/NCBI View Article : Google Scholar

39 

West BJ, Deng S, Isami F, Uwaya A and Jensen CJ: The potential health benefits of noni juice: A review of human intervention studies. Foods. 7(7)2018.PubMed/NCBI View Article : Google Scholar

40 

Whittle AJ, Carobbio S, Martins L, Slawik M, Hondares E, Vázquez MJ, Morgan D, Csikasz RI, Gallego R, Rodriguez-Cuenca S, et al: BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell. 149:871–885. 2012.PubMed/NCBI View Article : Google Scholar

41 

Pieles O, Reck A and Morsczeck C: High endogenous expression of parathyroid hormone-related protein (PTHrP) supports osteogenic differentiation in human dental follicle cells. Histochem Cell Biol. 154:397–403. 2020.PubMed/NCBI View Article : Google Scholar

42 

Stuss M, Migdalska-Sek M, Brzezianska-Lasota E, Michalska-Kasiczak M, Bazela P and Sewerynek E: Assessment of Wnt pathway selected gene expression levels in peripheral blood mononuclear cells (PBMCs) of postmenopausal patients with low bone mass. Bosn J Basic Med Sci. 21:461–470. 2021.PubMed/NCBI View Article : Google Scholar

43 

Kim BB, Kim M, Park YH, Ko Y and Park JB: Short-term application of dexamethasone on stem cells derived from human gingiva reduces the expression of RUNX2 and β-catenin. J Int Med Res. 45:993–1006. 2017.PubMed/NCBI View Article : Google Scholar

44 

Komori T: Regulation of osteoblast differentiation by Runx2. Adv Exp Med Biol. 658:43–49. 2010.PubMed/NCBI View Article : Google Scholar

45 

Liu Y, Wang Y, Sun X, Zhang X, Wang X, Zhang C and Zheng S: RUNX2 mutation reduces osteogenic differentiation of dental follicle cells in cleidocranial dysplasia. Mutagenesis. 33:203–214. 2018.PubMed/NCBI View Article : Google Scholar

46 

Xia B, Wang J, Guo L and Jiang Z: Effect of bone sialoprotein on proliferation and osteodifferentiation of human bone marrow-derived mesenchymal stem cells in vitro. Biologicals. 39:217–223. 2011.PubMed/NCBI View Article : Google Scholar

47 

Lee H, Song Y, Park YH, Uddin MS and Park JB: Evaluation of the effects of Cuminum cyminum on cellular viability, osteogenic differentiation and mineralization of human bone marrow-derived stem cells. Medicina (Kaunas). 57(57)2021.PubMed/NCBI View Article : Google Scholar

48 

Kannan S, Ghosh J and Dhara SK: Osteogenic differentiation potential of porcine bone marrow mesenchymal stem cell subpopulations selected in different basal media. Biol Open. 9(9)2020.PubMed/NCBI View Article : Google Scholar

49 

Kang YC, Chen MH and Lai SL: Potentially unsafe herb-drug interactions between a commercial product of noni juice and phenytoin - a case report. Acta Neurol Taiwan. 24:43–46. 2015.PubMed/NCBI

50 

Garrido-Gallego F, Muñoz-Gómez R, Muñoz-Codoceo C, Delgado-Álvarez P, Fernández-Vázquez I and Castellano G: Acute liver failure in a patient consuming Herbalife products and Noni juice. Rev Esp Enferm Dig. 107:247–248. 2015.PubMed/NCBI

51 

Panditrao MM, Panditrao MM, Edghill F and Lockhart HF: Can Chronic consumption of noni (Morinda citrifolia) juice lead to changes in the coagulation profile, deranged liver function and excessive intraoperative haemorrhage? West Indian Med J. 63:814–815. 2014.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Song Y, Lee H, Min S, Park Y, Oh J, Kim J and Park J: Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR. Exp Ther Med 23: 32, 2022.
APA
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., & Park, J. (2022). Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR. Experimental and Therapeutic Medicine, 23, 32. https://doi.org/10.3892/etm.2021.10954
MLA
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., Park, J."Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR". Experimental and Therapeutic Medicine 23.1 (2022): 32.
Chicago
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., Park, J."Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR". Experimental and Therapeutic Medicine 23, no. 1 (2022): 32. https://doi.org/10.3892/etm.2021.10954
Copy and paste a formatted citation
x
Spandidos Publications style
Song Y, Lee H, Min S, Park Y, Oh J, Kim J and Park J: Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR. Exp Ther Med 23: 32, 2022.
APA
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., & Park, J. (2022). Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR. Experimental and Therapeutic Medicine, 23, 32. https://doi.org/10.3892/etm.2021.10954
MLA
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., Park, J."Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR". Experimental and Therapeutic Medicine 23.1 (2022): 32.
Chicago
Song, Y., Lee, H., Min, S., Park, Y., Oh, J., Kim, J., Park, J."Effects of noni on cellular viability and osteogenic differentiation of gingiva‑derived stem cells demonstrated by RNA sequencing and quantitative PCR". Experimental and Therapeutic Medicine 23, no. 1 (2022): 32. https://doi.org/10.3892/etm.2021.10954
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