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Ginger‑derived compounds exert in vivo and in vitro anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response

  • Authors:
    • Eungyung Kim
    • Soyoung Jang
    • Jun Koo Yi
    • Hyeonjin Kim
    • Hong Ju Kwon
    • Hobin Im
    • Hai Huang
    • Haibo Zhang
    • Na Eun Cho
    • Yonghun Sung
    • Sung-Hyun Kim
    • Yeon Shik Choi
    • Shengqing Li
    • Zae Young Ryoo
    • Myoung Ok Kim
  • View Affiliations / Copyright

    Affiliations: Department of Animal Science and Biotechnology, Kyungpook National University, Sangju, Gyeongsangbuk 37224, Republic of Korea, School of Life Science, BK21 Plus KNU Creative Bioresearch Group, Kyungpook National University, Daegu 41566, Republic of Korea, Gyeongsangbukdo Livestock Research Institute, Yeongju, Gyeongsang 36052, Republic of Korea, Laboratory Animal Center, Daegu‑Gyeongbuk Medical Innovation Foundation, Daegu 41061, Republic of Korea, Department of Bio‑Medical Analysis, Korea Polytechnic College, Nonsan, Chungcheongnam 32943, Republic of Korea, Department of Pulmonary and Critical Care Medicine, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 49
    |
    Published online on: November 15, 2021
       https://doi.org/10.3892/etm.2021.10971
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Abstract

6‑Shogaol (SHO) and 6‑gingerol (GIN), naturally derived compounds of ginger (Zingiber officinale Roscoe), have been found to have anti‑allergic effects on dermatitis‑like skin lesions and rhinitis. Although SHO and GIN have demonstrated a potential in various inflammatory diseases, their efficacy and mechanism in asthma have not been largely examined. Therefore, the present study demonstrated the anti‑asthmatic effects of SHO and GIN on the T‑helper (Th) 2 cell‑mediated allergic response pathway in an ovalbumin (OVA)‑induced asthma mouse model. The asthma mouse model was established with an intraperitoneal (i.p.) injection of 50 µg OVA and 1 mg aluminum hydroxide with or without an i.p. injection of SHO and GIN (10 mg/kg) before treatment with OVA. In addition, the current study assessed mast cell degranulation in antigen‑stimulated RBL‑2H3 cells under different treatment conditions (SHO or GIN at 0, 10, 25, 50 and 100 nM) and determined the mRNA and protein levels of anti‑oxidative enzymes [superoxide dismutase (SOD)1, SOD2, glutathione peroxidase‑1/2, catalase] in lung tissues. SHO and GIN inhibited eosinophilia in the bronchoalveolar lavage fluids and H&E‑stained lung tissues. Both factors also decreased mucus production in periodic acid‑Schiff‑stained lung tissues and the levels of Th2 cytokines in these tissues. GIN attenuated oxidative stress by upregulating the expression levels of anti‑oxidative proteins. In an in vitro experiment, the degranulation of RBL‑2H3 rat mast cells was significantly decreased. It was found that SHO and GIN effectively suppressed the allergic response in the mouse model by inhibiting eosinophilia and Th2 cytokine production. Collectively, it was suggested that SHO can inhibit lung inflammation by attenuating the Th2 cell‑mediated allergic response signals, and that GIN can inhibit lung inflammation and epithelial cell remodeling by repressing oxidative stress. Therefore, SHO and GIN could be used therapeutically for allergic and eosinophilic asthma.
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Spandidos Publications style
Kim E, Jang S, Yi JK, Kim H, Kwon HJ, Im H, Huang H, Zhang H, Cho NE, Sung Y, Sung Y, et al: Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response. Exp Ther Med 23: 49, 2022.
APA
Kim, E., Jang, S., Yi, J.K., Kim, H., Kwon, H.J., Im, H. ... Kim, M.O. (2022). Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response. Experimental and Therapeutic Medicine, 23, 49. https://doi.org/10.3892/etm.2021.10971
MLA
Kim, E., Jang, S., Yi, J. K., Kim, H., Kwon, H. J., Im, H., Huang, H., Zhang, H., Cho, N. E., Sung, Y., Kim, S., Choi, Y. S., Li, S., Ryoo, Z. Y., Kim, M. O."Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response". Experimental and Therapeutic Medicine 23.1 (2022): 49.
Chicago
Kim, E., Jang, S., Yi, J. K., Kim, H., Kwon, H. J., Im, H., Huang, H., Zhang, H., Cho, N. E., Sung, Y., Kim, S., Choi, Y. S., Li, S., Ryoo, Z. Y., Kim, M. O."Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response". Experimental and Therapeutic Medicine 23, no. 1 (2022): 49. https://doi.org/10.3892/etm.2021.10971
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Spandidos Publications style
Kim E, Jang S, Yi JK, Kim H, Kwon HJ, Im H, Huang H, Zhang H, Cho NE, Sung Y, Sung Y, et al: Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response. Exp Ther Med 23: 49, 2022.
APA
Kim, E., Jang, S., Yi, J.K., Kim, H., Kwon, H.J., Im, H. ... Kim, M.O. (2022). Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response. Experimental and Therapeutic Medicine, 23, 49. https://doi.org/10.3892/etm.2021.10971
MLA
Kim, E., Jang, S., Yi, J. K., Kim, H., Kwon, H. J., Im, H., Huang, H., Zhang, H., Cho, N. E., Sung, Y., Kim, S., Choi, Y. S., Li, S., Ryoo, Z. Y., Kim, M. O."Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response". Experimental and Therapeutic Medicine 23.1 (2022): 49.
Chicago
Kim, E., Jang, S., Yi, J. K., Kim, H., Kwon, H. J., Im, H., Huang, H., Zhang, H., Cho, N. E., Sung, Y., Kim, S., Choi, Y. S., Li, S., Ryoo, Z. Y., Kim, M. O."Ginger‑derived compounds exert <em>in vivo</em> and <em>in vitro</em> anti‑asthmatic effects by inhibiting the T‑helper 2 cell‑mediated allergic response". Experimental and Therapeutic Medicine 23, no. 1 (2022): 49. https://doi.org/10.3892/etm.2021.10971
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