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Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons

  • Authors:
    • Tian Zhang
    • Tan Wang
    • Xinxu Chen
    • Zhenqiang Zhao
    • Zhibin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Neurology, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan 570102, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: November 16, 2021
       https://doi.org/10.3892/etm.2021.10974
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Abstract

The composition of the intestinal flora of patients with Parkinson's disease (PD) can change. However, whether reshaping the gut microbial composition can treat PD remains to be seen. The present study evaluated the effect of intestinal flora in the treatment of PD in a C57BL/6 mouse PD model induced by 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine (MPTP). Chronic, low‑dose, MPTP‑treated mice exhibited upregulated gene expression levels of TNF‑α and IL‑1β in the substantia nigra (SN) of the mice, and induced intestinal microbial disorders. This indicated that the chronic low‑dose MPTP model could be used to evaluate the progress of early intestinal pathology and intestinal flora imbalance in PD. After transplantation of faecal bacteria to MPTP‑induced PD mice, the level of inflammation in the SN of the mice was reduced, and motor dysfunction was alleviated. Notably, faecal microbiota transplantation (FMT) upregulated the abundance of Blautia but downregulated Anaerostipes, Bifidobacterium, ASF356 and Ruminococcus in the gut of PD mice. In addition, FMT reduced the activation of microglia and astrocytes in the SN and reduced the expression levels of GSK3β, IL‑1β, inducible nitric oxide synthase and phosphorylated PTEN in the SN. Overall, the present study demonstrated that gut microbial dysfunction is associated with the pathogenesis of PD, and that FMT can protect PD mice by inhibiting neuroinflammation.
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View References

1 

Takahashi J: Clinical trial for Parkinson's disease gets a green light in the US. Cell Stem Cell. 28:182–183. 2021.PubMed/NCBI View Article : Google Scholar

2 

Ding XB, Wang XX, Xia DH, Liu H, Tian HY, Fu Y, Chen YK, Qin C, Wang JQ, Xiang Z, et al: Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson's disease. Nat Med. 27:411–418. 2021.PubMed/NCBI View Article : Google Scholar

3 

Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG and Montine TJ: Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol. 154:1423–1429. 1999.PubMed/NCBI View Article : Google Scholar

4 

Waters CM, Peck R, Rossor M, Reynolds GP and Hunt SP: Immunocytochemical studies on the basal ganglia and substantia nigra in Parkinson's disease and Huntington's chorea. Neuroscience. 25:419–438. 1988.PubMed/NCBI View Article : Google Scholar

5 

Crowther RA, Daniel SE and Goedert M: Characterisation of isolated α-synuclein filaments from substantia nigra of Parkinson's disease brain. Neurosci Lett. 292:128–130. 2000.PubMed/NCBI View Article : Google Scholar

6 

Bhattarai Y, Si J, Pu M, Ross OA, McLean PJ, Till L, Moor W, Grover M, Kandimalla KK, Margolis KG, et al: Role of gut microbiota in regulating gastrointestinal dysfunction and motor symptoms in a mouse model of Parkinson's disease. Gut Microbes. 13(1866974)2021.PubMed/NCBI View Article : Google Scholar

7 

Zhong XH, Haycock JW, Shannak K, Robitaille Y, Fratkin J, Koeppen AH, Hornykiewicz O and Kish SJ: Striatal dihydroxyphenylalanine decarboxylase and tyrosine hydroxylase protein in idiopathic Parkinson's disease and dominantly inherited olivopontocerebellar atrophy. Mov Disord. 10:10–17. 1995.PubMed/NCBI View Article : Google Scholar

8 

Zhong R, Chen Q, Zhang X, Li M and Lin W: Helicobacter pylori infection is associated with a poor response to levodopa in patients with Parkinson's disease: A systematic review and meta-analysis. J Neurol: Feb 22, 2021 (Epub ahead of print).

9 

Schaeffer E, Vaterrodt T, Zaunbrecher L, Liepelt-Scarfone I, Emmert K, Roeben B, Elshehabi M, Hansen C, Becker S, Nussbaum S, et al: Effects of Levodopa on quality of sleep and nocturnal movements in Parkinson's Disease. J Neurol. 268:2506–2514. 2021.PubMed/NCBI View Article : Google Scholar

10 

Anwer S, Branchard E, Dan Q, Dan A and Szaszi K: Tumor necrosis factor-α induces claudin-3 upregulation in kidney tubular epithelial cells through NFκB and CREB1. Am J Physiol Cell Physiol. 320:C495–C508. 2021.PubMed/NCBI View Article : Google Scholar

11 

Corbo RM, Businaro R and Scarabino D: Leukocyte telomere length and plasma interleukin-1β and interleukin-18 levels in mild cognitive impairment and Alzheimer's disease: New biomarkers for diagnosis and disease progression? Neural Regen Res. 16:1397–1398. 2021.PubMed/NCBI View Article : Google Scholar

12 

Carabotti M, Scirocco A, Maselli MA and Severi C: The gut-brain axis: Interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 28:203–209. 2015.PubMed/NCBI

13 

Cryan JF, O'Riordan KJ, Sandhu K, Peterson V and Dinan TG: The gut microbiome in neurological disorders. Lancet Neurol. 19:179–194. 2020.PubMed/NCBI View Article : Google Scholar

14 

Shen L: Gut, oral and nasal microbiota and Parkinson's disease. Microb Cell Fact. 19(50)2020.PubMed/NCBI View Article : Google Scholar

15 

Moustafa SA, Mohamed S, Dawood A, Azar J, Elmorsy E, Rizk NAM and Salama M: Gut brain axis: An insight into microbiota role in Parkinson's disease. Metab Brain Dis. 36:1545–1557. 2021.PubMed/NCBI View Article : Google Scholar

16 

Heintz-Buschart A, Pandey U, Wicke T, Sixel-Döring F, Janzen A, Sittig-Wiegand E, Trenkwalder C, Oertel WH, Mollenhauer B and Wilmes P: The nasal and gut microbiome in Parkinson's disease and idiopathic rapid eye movement sleep behavior disorder. Mov Disord. 33:88–98. 2018.PubMed/NCBI View Article : Google Scholar

17 

Cirstea MS, Yu AC, Golz E, Sundvick K, Kliger D, Radisavljevic N, Foulger LH, Mackenzie M, Huan T, Finlay BB, et al: Microbiota composition and metabolism are associated with gut function in Parkinson's disease. Movement Disord. 35:1208–1217. 2020.PubMed/NCBI View Article : Google Scholar

18 

Zhang F, Cui B, He X, Nie Y, Wu K and Fan D: FMT-standardization Study Group. Microbiota transplantation: concept, methodology and strategy for its modernization. Protein Cell. 9:462–473. 2018.PubMed/NCBI View Article : Google Scholar

19 

Xue LJ, Yang XZ, Tong Q, Shen P, Ma SJ, Wu SN, Zheng JL and Wang HG: Fecal microbiota transplantation therapy for Parkinson's disease: A preliminary study. Medicine (Baltimore). 99(e22035)2020.PubMed/NCBI View Article : Google Scholar

20 

Zha Z, Lv Y, Tang H, Li T, Miao Y, Cheng J, Wang G, Tan Y, Zhu Y, Xing X, et al: An orally administered butyrate-releasing xylan derivative reduces inflammation in dextran sulphate sodium-induced murine colitis. Int J Biol Macromol. 156:1217–1233. 2020.PubMed/NCBI View Article : Google Scholar

21 

Wang Y, Wei N and Li X: Preclinical evidence and possible mechanisms of baicalein for rats and mice with Parkinson's disease: A systematic review and meta-analysis. Front Aging Neurosci. 12(277)2020.PubMed/NCBI View Article : Google Scholar

22 

Guo HM, Zhou ZY, Huang YQ, Li X and Wang XJ: Investigation of the roles of dysbindin-1 and SATB2 in the progression of Parkinson's disease. Eur Rev Med Pharmacol Sci. 23:7510–7516. 2019.PubMed/NCBI View Article : Google Scholar

23 

Li L, Chen Y, Tang J and Yuan L: Evaluation of efficiency omega 3 fatty acid improves the behavioural phenotype and protects against oxidative stress against MPP+ induces Parkinson's disease in mice. Pak J Pharm Sci. 34:861–867. 2021.PubMed/NCBI

24 

Koentjoro B, Park J-S and Sue CM: Parkin western blotting is useful for identification of patients with Parkin-related Parkinson's disease. J Neurol Neurosurg Psychiatry. 85:1436–1437. 2014.PubMed/NCBI View Article : Google Scholar

25 

Oluwole OG, Kuivaniemi H, Abrahams S, Haylett WL, Vorster AA, van Heerden CJ, Kenyon CP, Tabb DL, Fawale MB, Sunmonu TA, et al: Targeted next-generation sequencing identifies novel variants in candidate genes for Parkinson’s disease in Black South African and Nigerian patients. BMC Med Genet. 21(23)2020.PubMed/NCBI View Article : Google Scholar

26 

Illumina Inc: 16S Metagenomic Sequencing Library Preparation, 2013. https://support.illumina.com/content/dam/illumina-support/documents/documentation/chemistry_documentation/16s/16s-metagenomic-library-prep-guide-15044223-b.pdf. Accessed, April 15, 2020.

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.PubMed/NCBI View Article : Google Scholar

28 

Hamilton MJ, Weingarden AR, Sadowsky MJ and Khoruts A: Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol. 107:761–767. 2012.PubMed/NCBI View Article : Google Scholar

29 

Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, et al: NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 156:1045–1059. 2014.PubMed/NCBI View Article : Google Scholar

30 

Zhang L, Zhang L, Li Y, Li L, Melchiorsen JU, Rosenkilde M and Hölscher C: The novel dual GLP-1/GIP receptor agonist DA-CH5 is superior to single GLP-1 receptor agonists in the MPTP model of Parkinson's disease. J Parkinsons Dis. 10:523–542. 2020.PubMed/NCBI View Article : Google Scholar

31 

Li W, Wu X, Hu X, Wang T, Liang S, Duan Y, Jin F and Qin B: Structural changes of gut microbiota in Parkinson's disease and its correlation with clinical features. Sci China Life Sci. 60:1223–1233. 2017.PubMed/NCBI View Article : Google Scholar

32 

Bedarf JR, Hildebrand F, Coelho LP, Sunagawa S, Bahram M, Goeser F, Bork P and Wüllner U: Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-nave Parkinson's disease patients. Genome Med. 9(39)2017.PubMed/NCBI View Article : Google Scholar

33 

Hill-Burns EM, Debelius JW, Morton JT, Wissemann WT, Lewis MR, Wallen ZD, Peddada SD, Factor SA, Molho E, Zabetian CP, et al: Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome. Mov Disord. 32:739–749. 2017.PubMed/NCBI View Article : Google Scholar

34 

Zhou ZL, Jia XB, Sun MF, Zhu YL, Qiao CM, Zhang BP, Zhao LP, Yang Q, Cui C, Chen X, et al: Neuroprotection of fasting mimicking diet on MPTP-induced Parkinson's disease mice via gut microbiota and metabolites. Neurotherapeutics. 16:741–760. 2019.PubMed/NCBI View Article : Google Scholar

35 

Sun B-L, Li W-W, Wang J, Xu YL, Sun HL, Tian DY, Wang YJ and Yao XQ: Gut microbiota alteration and its time course in a tauopathy mouse model. J Alzheimers Dis. 70:399–412. 2019.PubMed/NCBI View Article : Google Scholar

36 

Nagalingam NA, Kao JY and Young VB: Microbial ecology of the murine gut associated with the development of dextran sodium sulfate-induced colitis. Inflamm Bowel Dis. 17:917–926. 2011.PubMed/NCBI View Article : Google Scholar

37 

Scheperjans F, Aho V, Pereira PAB, Koskinen K, Paulin L, Pekkonen E, Haapaniemi E, Kaakkola S, Eerola-Rautio J, Pohja M, et al: Gut microbiota are related to Parkinson's disease and clinical phenotype. Mov Disord. 30:350–358. 2015.PubMed/NCBI View Article : Google Scholar

38 

Huang H, Xu H, Luo Q, He J, Li M, Chen H, Tang W, Nie Y and Zhou Y: Fecal microbiota transplantation to treat Parkinson's disease with constipation: A case report. Medicine (Baltimore). 98(e16163)2019.PubMed/NCBI View Article : Google Scholar

39 

Dutta SK, Verma S, Jain V, Surapaneni BK, Vinayek R, Phillips L and Nair PP: Parkinson's disease: The emerging role of gut dysbiosis, antibiotics, probiotics, and fecal microbiota transplantation. J Neurogastroenterol Motil. 25:363–376. 2019.PubMed/NCBI View Article : Google Scholar

40 

Lubomski M, Tan AH, Lim SY, Holmes AJ, Davis RL and Sue CM: Parkinson's disease and the gastrointestinal microbiome. J Neurol. 267:2507–2523. 2020.PubMed/NCBI View Article : Google Scholar

41 

Haavik J and Toska K: Tyrosine hydroxylase and Parkinson's disease. Mol Neurobiol. 16:285–309. 1998.PubMed/NCBI View Article : Google Scholar

42 

Kitamura Y, Sakanashi M, Ozawa A, Saeki Y, Nakamura A, Hara Y, Saeki KI and Arimoto-Kobayashi S: Protective effect of Actinidia arguta in MPTP-induced Parkinson's disease model mice. Biochem Biophys Res Commun. 555:154–159. 2021.PubMed/NCBI View Article : Google Scholar

43 

da Silva WAB, Ferreira Oliveira K, Caroline Vitorino L, Ferreira Romão L, Allodi S and Lourenço Correa C: Physical exercise increases the production of tyrosine hydroxylase and CDNF in the spinal cord of a Parkinson's disease mouse model. Neurosci Lett. 760(136089)2021.PubMed/NCBI View Article : Google Scholar

44 

Wang Y, Li M, Song M, Xu X, Xiong J, Yang X, Tan J and Bai Y: Expression of OX40 ligand in microglia activated by IFN-gamma sustains a protective CD4+ T-cell response in vitro. Cell Immunol. 251:86–92. 2008.PubMed/NCBI View Article : Google Scholar

45 

Utz SG, See P, Mildenberger W, Thion MS, Silvin A, Lutz M, Ingelfinger F, Rayan NA, Lelios I, Buttgereit A, et al: Early fate defines microglia and non-parenchymal brain macrophage development. Cell. 181:557–573.e18. 2020.PubMed/NCBI View Article : Google Scholar

46 

Kam TI, Hinkle JT, Dawson TM and Dawson VL: Microglia and astrocyte dysfunction in parkinson's disease. Neurobiol Dis. 144(105028)2020.PubMed/NCBI View Article : Google Scholar

47 

Joers V, Masilamoni G, Kempf D, Weiss AR, Rotterman TM, Murray B, Yalcin-Cakmakli G, Voll RJ, Goodman MM, Howell L, et al: Microglia, inflammation and gut microbiota responses in a progressive monkey model of Parkinson's disease: A case series. Neurobiol Dis. 144(105027)2020.PubMed/NCBI View Article : Google Scholar

48 

Hefazi M, Patnaik MM, Hogan WJ, Litzow MR, Pardi DS and Khanna S: Safety and efficacy of fecal microbiota transplant for recurrent clostridium difficile infection in patients with cancer treated with cytotoxic chemotherapy: A single-institution retrospective case series. Mayo Clin Proc. 92:1617–1624. 2017.PubMed/NCBI View Article : Google Scholar

49 

Porcu F, Rubio A, Pérez-Hernández M and Gutiérrez-López MD: Effect of intensive and repeated use of ethanol on the integrity of blood-brain barrier in mouse brain. Role of toll-like receptor 4 (TLR4). Basic Clin Pharmacol Toxicol. 115(41)2014.PubMed/NCBI View Article : Google Scholar

50 

Cao L, Liu C, Wang F and Wang H: SIRT1 negatively regulates amyloid-beta-induced inflammation via the NF-κB pathway. Braz J Med Biol Res. 46:659–669. 2013.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhang T, Wang T, Chen X, Zhao Z and Chen Z: Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Exp Ther Med 23: 52, 2022.
APA
Zhang, T., Wang, T., Chen, X., Zhao, Z., & Chen, Z. (2022). Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and Therapeutic Medicine, 23, 52. https://doi.org/10.3892/etm.2021.10974
MLA
Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z."Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons". Experimental and Therapeutic Medicine 23.1 (2022): 52.
Chicago
Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z."Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons". Experimental and Therapeutic Medicine 23, no. 1 (2022): 52. https://doi.org/10.3892/etm.2021.10974
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang T, Wang T, Chen X, Zhao Z and Chen Z: Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Exp Ther Med 23: 52, 2022.
APA
Zhang, T., Wang, T., Chen, X., Zhao, Z., & Chen, Z. (2022). Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and Therapeutic Medicine, 23, 52. https://doi.org/10.3892/etm.2021.10974
MLA
Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z."Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons". Experimental and Therapeutic Medicine 23.1 (2022): 52.
Chicago
Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z."Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons". Experimental and Therapeutic Medicine 23, no. 1 (2022): 52. https://doi.org/10.3892/etm.2021.10974
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