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PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway

  • Authors:
    • Xuejun Wang
    • Jinwen Su
    • Zhikang Lin
    • Kangyong Liu
    • Yu Zhuang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, P.R. China, Department of Cardiology, Shanghai Ninth People's Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai 200011, P.R. China, Department of Neurology, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, P.R. China, Department of Cardiovascular Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 62
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    Published online on: November 22, 2021
       https://doi.org/10.3892/etm.2021.10984
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Abstract

Myocardial infarction (MI), the leading cause of death among patients with cardiovascular diseases, is characterized by acute cardiac muscle injury due to severe impairment of the coronary blood supply, which may lead to cardiogenic shock and cardiac arrest. Particularly interesting new cysteine histidine rich 1 (PINCH1) protein, a key component of the integrin signaling pathway, interacts with several proteins and serves a vital role in numerous cellular processes, including cytoskeleton remodeling, cell proliferation and cell migration. To investigate the role of PINCH1 in heart injury in the present study, PINCH1 was knocked out in the myocardial tissue of mice (age, 18 weeks) to induce MI. In addition, cell viability, migration and apoptosis, as well as the expression levels of NF‑κB‑associated proteins were determined in murine HL1 cardiomyocytes with a conditional PINCH1 shRNA using Cell Counting Kit‑8, Transwell, flow cytometry and western blot assays, respectively. Furthermore, the cardiac expansion and myocardial fibrosis in PINCH1 knockout mice was investigated in vivo by performing morphological and histological examinations. Additionally, the murine ventricular myocardial ultrastructure was evaluated using an electron microscope, and the cardiomyocyte apoptotic rate and expression levels of NF‑κB‑related proteins were determined using TUNEL and western blot assays, respectively. The results showed that the apoptotic rate in the in vivo PINCH1 knockdown group was significantly increased. In addition, the protein expression levels of NF‑κB signaling pathway‑related proteins, including NF‑κB, myeloid differentiation factor 88, TNF‑α and caspase‑3, were significantly increased in the in vivo PINCH1 knockdown group compared with the wild‑type group, but the protein expression of MMP2 and MMP9 were the opposite. Overall, the in vitro and in vivo results revealed that PINCH1 knockout in mice significantly aggravated MI via the NF‑κB signaling pathway.
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1 

Sopko N, Qin Y, Finan A, Dadabayev A, Chigurupati S, Qin J, Penn MS and Gupta S: Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy. PLoS One. 6(e20184)2011.PubMed/NCBI View Article : Google Scholar

2 

Zou L, Ma X, Lin S, Wu B, Chen Y and Peng C: Bone marrow mesenchymal stem cell-derived exosomes protect against myocardial infarction by promoting autophagy. Exp Ther Med. 18:2574–2582. 2019.PubMed/NCBI View Article : Google Scholar

3 

Zhang HR, Bai H, Yang E, Zhong ZH, Chen WY, Xiao Y, Gu YH and Lu SF: Effect of moxibustion preconditioning on autophagy-related proteins in rats with myocardial ischemia reperfusion injury. Ann Transl Med. 7(559)2019.PubMed/NCBI View Article : Google Scholar

4 

Wang R, Wang M, Zhou J, Ye T, Xie X, Ni D, Ye J, Han Q, Di C, Guo L, et al: Shuxuening injection protects against myocardial ischemia-reperfusion injury through reducing oxidative stress, inflammation and thrombosis. Ann Transl Med. 7(562)2019.PubMed/NCBI View Article : Google Scholar

5 

Jiang T, Zhang L, Ding M and Li M: Protective effect of vasicine against myocardial infarction in rats via modulation of oxidative stress, inflammation, and the PI3K/Akt pathway. Drug Des Devel Ther. 13:3773–3784. 2019.PubMed/NCBI View Article : Google Scholar

6 

Zhang C, Liang R, Gan X, Yang X, Chen L and Jian J: MicroRNA-384-5p/Beclin-1 as potential indicators for epigallocatechin gallate against cardiomyocytes ischemia reperfusion injury by inhibiting autophagy via PI3K/Akt pathway. Drug Des Devel Ther. 13:3607–3623. 2019.PubMed/NCBI View Article : Google Scholar

7 

Belete S, Punjabi K, Afoke J and Anderson J: Surgical management of post-infarction ventricular septal defect, mitral regurgitation and ventricular aneurysm. J Surg Case Rep. 2019(rjz256)2019.PubMed/NCBI View Article : Google Scholar

8 

Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Wang G, Rearden A, Wu C, Peterson KL, et al: Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation. 120:568–576. 2009.PubMed/NCBI View Article : Google Scholar

9 

Braun A, Bordoy R, Stanchi F, Moser M, Kostka GG, Ehler E, Brandau O and Fässler R: PINCH2 is a new five LIM domain protein, homologous to PINCH and localized to focal adhesions. Exp Cell Res. 284:239–250. 2003.PubMed/NCBI View Article : Google Scholar

10 

Liang X, Zhou Q, Li X, Sun Y, Lu M, Dalton N, Ross J Jr and Chen J: PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 25:3056–3062. 2005.PubMed/NCBI View Article : Google Scholar

11 

Pan SP, Pirker T, Kunert O, Kretschmer N, Hummelbrunner S, Latkolik SL, Rappai J, Dirsch VM, Bochkov V and Bauer R: C13 megastigmane derivatives from epipremnum pinnatum: β-Damascenone inhibits the expression of pro-inflammatory cytokines and leukocyte adhesion molecules as well as NF-κB signaling. Front Pharmacol. 10(1351)2019.PubMed/NCBI View Article : Google Scholar

12 

Zhang J, Lei JR, Yuan LL, Wen R and Yang J: Response gene to complement-32 promotes cell survival via the NF-κB pathway in non-small-cell lung cancer. Exp Ther Med. 19:107–114. 2020.PubMed/NCBI View Article : Google Scholar

13 

Ge ZW, Wang BC, Hu JL, Sun JJ, Wang S, Chen XJ, Meng SP, Liu L and Cheng ZY: IRAK3 gene silencing prevents cardiac rupture and ventricular remodeling through negative regulation of the NF-κB signaling pathway in a mouse model of acute myocardial infarction. J Cell Physiol. 234:11722–11733. 2019.PubMed/NCBI View Article : Google Scholar

14 

Han A, Lu Y, Zheng Q, Zhang J, Zhao Y, Zhao M and Cui X: Qiliqiangxin attenuates cardiac remodeling via inhibition of TGF-β1/Smad3 and NF-κB signaling pathways in a rat model of myocardial infarction. Cell Physiol Biochem. 45:1797–1806. 2018.PubMed/NCBI View Article : Google Scholar

15 

He Q, Zhou W, Xiong C, Tan G and Chen M: Lycopene attenuates inflammation and apoptosis in post-myocardial infarction remodeling by inhibiting the nuclear factor-κB signaling pathway. Mol Med Rep. 11:374–378. 2015.PubMed/NCBI View Article : Google Scholar

16 

Jin JL, Deng ZT, Lyu RG, Liu XH and Wei JR: Expression changes of Notch and nuclear factor-κB signaling pathways in the rat heart with myocardial infarction. Zhonghua Xin Xue Guan Bing Za Zhi. 45:507–512. 2017.PubMed/NCBI View Article : Google Scholar : (In Chinese).

17 

Gupta S, Kumar S, Sopko N, Qin Y, Wei C and Kim IK: Thymosin β4 and cardiac protection: Implication in inflammation and fibrosis. Ann N Y Acad Sci. 1269:84–91. 2012.PubMed/NCBI View Article : Google Scholar

18 

Qiu P, Wheater MK, Qiu Y and Sosne G: Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 25:1815–1826. 2011.PubMed/NCBI View Article : Google Scholar

19 

Chen J, Kubalak SW, Minamisawa S, Price RL, Becker KD, Hickey R, Ross J Jr and Chien KR: Selective requirement of myosin light chain 2v in embryonic heart function. J Biol Chem. 273:1252–1256. 1998.PubMed/NCBI View Article : Google Scholar

20 

Sandfort V, Eke I and Cordes N: The role of the focal adhesion protein PINCH1 for the radiosensitivity of adhesion and suspension cell cultures. PLoS One. 5(e13056)2010.PubMed/NCBI View Article : Google Scholar

21 

Zhang W, Tian Y, Gao Q, Li X, Li Y, Zhang J, Yao C, Wang Y, Wang H, Zhao Y, et al: Inhibition of apoptosis reduces diploidization of haploid mouse embryonic stem cells during differentiation. Stem Cell Reports. 15:185–197. 2020.PubMed/NCBI View Article : Google Scholar

22 

Yokokawa T, Yoshihisa A, Kanno Y, Abe S, Misaka T, Yamada S, Kaneshiro T, Sato T, Oikawa M, Kobayashi A, et al: Circulating acetoacetate is associated with poor prognosis in heart failure patients. Int J Cardiol Heart Vasc. 25(100432)2019.PubMed/NCBI View Article : Google Scholar

23 

Luo ZR, Li H, Xiao ZX, Shao SJ, Zhao TT, Zhao Y, Mou FF, Yu B and Guo HD: Taohong siwu decoction exerts a beneficial effect on cardiac function by possibly improving the microenvironment and decreasing mitochondrial fission after myocardial infarction. Cardiol Res Pract. 2019(5198278)2019.PubMed/NCBI View Article : Google Scholar

24 

Neyrinck K, Breuls N, Holvoet B, Oosterlinck W, Wolfs E, Vanbilloen H, Gheysens O, Duelen R, Gsell W, Lambrichts I, et al: The human somatostatin receptor type 2 as an imaging and suicide reporter gene for pluripotent stem cell-derived therapy of myocardial infarction. Theranostics. 8:2799–2813. 2018.PubMed/NCBI View Article : Google Scholar

25 

Puddighinu G, D'Amario D, Foglio E, Manchi M, Siracusano A, Pontemezzo E, Cordella M, Facchiano F, Pellegrini L, Mangoni A, et al: Molecular mechanisms of cardioprotective effects mediated by transplanted cardiac ckit+ cells through the activation of an inflammatory hypoxia-dependent reparative response. Oncotarget. 9:937–957. 2017.PubMed/NCBI View Article : Google Scholar

26 

Wang B, Zhang L, Cao H, Yang J, Wu M, Ma Y, Fan H, Zhan Z and Liu Z: Myoblast transplantation improves cardiac function after myocardial infarction through attenuating inflammatory responses. Oncotarget. 8:68780–68794. 2017.PubMed/NCBI View Article : Google Scholar

27 

Meder B, Huttner IG, Sedaghat-Hamedani F, Just S, Dahme T, Frese KS, Vogel B, Köhler D, Kloos W, Rudloff J, et al: PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling. Mol Cell Biol. 31:3424–3435. 2011.PubMed/NCBI View Article : Google Scholar

28 

Singh MV, Swaminathan PD, Luczak ED, Kutschke W, Weiss RM and Anderson ME: MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction. J Mol Cell Cardiol. 52:1135–1144. 2012.PubMed/NCBI View Article : Google Scholar

29 

Gu C, Wang F, Zhao Z, Wang H, Cong X and Chen X: Lysophosphatidic acid is associated with atherosclerotic plaque instability by regulating NF-κB dependent matrix metalloproteinase-9 expression via LPA2 in macrophages. Front Physiol. 8(266)2017.PubMed/NCBI View Article : Google Scholar

30 

Wang Q, Sui X, Sui DJ and Yang P: Flavonoid extract from propolis inhibits cardiac fibrosis triggered by myocardial infarction through upregulation of SIRT1. Evid Based Complement Alternat Med. 2018(4957573)2018.PubMed/NCBI View Article : Google Scholar

31 

Ibarra-Lara L, Sánchez-Aguilar M, Soria-Castro E, Vargas-Barrón J, Roldán FJ, Pavón N, Torres-Narváez JC, Cervantes-Pérez LG, Pastelín-Hernández G and Sánchez-Mendoza A: Clofibrate treatment decreases inflammation and reverses myocardial infarction-induced remodelation in a rodent experimental model. Molecules. 24(270)2019.PubMed/NCBI View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Su J, Lin Z, Liu K and Zhuang Y: PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway. Exp Ther Med 23: 62, 2022.
APA
Wang, X., Su, J., Lin, Z., Liu, K., & Zhuang, Y. (2022). PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 23, 62. https://doi.org/10.3892/etm.2021.10984
MLA
Wang, X., Su, J., Lin, Z., Liu, K., Zhuang, Y."PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 23.1 (2022): 62.
Chicago
Wang, X., Su, J., Lin, Z., Liu, K., Zhuang, Y."PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 23, no. 1 (2022): 62. https://doi.org/10.3892/etm.2021.10984
Copy and paste a formatted citation
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Spandidos Publications style
Wang X, Su J, Lin Z, Liu K and Zhuang Y: PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway. Exp Ther Med 23: 62, 2022.
APA
Wang, X., Su, J., Lin, Z., Liu, K., & Zhuang, Y. (2022). PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway. Experimental and Therapeutic Medicine, 23, 62. https://doi.org/10.3892/etm.2021.10984
MLA
Wang, X., Su, J., Lin, Z., Liu, K., Zhuang, Y."PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 23.1 (2022): 62.
Chicago
Wang, X., Su, J., Lin, Z., Liu, K., Zhuang, Y."PINCH1 knockout aggravates myocardial infarction in mice via mediating the NF‑κB signaling pathway". Experimental and Therapeutic Medicine 23, no. 1 (2022): 62. https://doi.org/10.3892/etm.2021.10984
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