Diagnostic challenges, management, and outcome of infants born to mothers with COVID 19 during the first wave of the pandemic

Zaharie,Gabriela; Hasmasanu,Monica; Muresan,Daniel; Kovacs,Tunde; Matyas,Melinda

doi:10.3892/etm.2021.11025

Diagnostic challenges, management, and outcome of infants born to mothers with COVID 19 during the first wave of the pandemic

Authors:
- Gabriela Zaharie
- Monica Hasmasanu
- Daniel Muresan
- Tunde Kovacs
- Melinda Matyas
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Affiliations: Department of Neonatology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania, Department of Obstetrics and Gynecology, ‘Iuliu Hatieganu’ University of Medicine and Pharmacy, 400006 Cluj Napoca, Romania
Published online on: December 1, 2021 https://doi.org/10.3892/etm.2021.11025
Article Number: 102
Copyright: © Zaharie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Severe acute respiratory distress syndrome with coronavirus 2 (SARS‑CoV‑2) infection affected pregnant women during the pandemic. Immunological particularity of this population and the increased need for medical assistance placed this population in a high‑risk category for SARS‑Cov‑2 infection. Owing to high contamination risk and limited studies regarding vertical transmission, the labor and delivery of positive women required particular conditions. Cesarean section probably proved to be the optimal option for delivery of infants to reduce the risk of infection during birth. The aim of the present study was to present the management and outcome of infants born to mothers confirmed with coronavirus disease 2019 (COVID 19) prior to delivery. This is a longitudinal, retrospective study, analyzing demographics, laboratory data and management of neonates born to mothers with diagnosis of SARS‑Cov‑2 infection. The results showed that 5 neonates were born to SARS‑Cov‑2‑positive mothers, all by Cesarean section and had a negative reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) test. None of the women breastfed during the hospital stay. The negative RT‑qPCR test allowed us to reduce the hospital stay of infants and care in non‑isolated areas. In summary, in the present study, vertical or perinatal transmission of the infection was not present. The testing of the pregnant women, their isolation and delivery in safe conditions for the medical staff were possible, with the latter using adequate protection equipment to limit their infection and the risk for the newborns.

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1	Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, et al: A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 382:727–733. 2020.PubMed/NCBI View Article : Google Scholar
2	Sutton D, Fuchs K, D'Alton M and Goffman D: Universal screening for SARS-CoV-2 in women admitted for delivery. N Engl J Med. 382:2163–2164. 2020.PubMed/NCBI View Article : Google Scholar
3	Vintzileos WS, Muscat J, Hoffmann E, John NS, Vertichio R, Vintzileos AM and Vo D: Screening all pregnant women admitted to labor and delivery for the virus responsible for coronavirus disease 2019. Am J Obstet Gynecol. 223:284–286. 2020.PubMed/NCBI View Article : Google Scholar
4	Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, Li J, Zhao D, Xu D, Gong Q, et al: Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: A retrospective review of medical records. Lancet. 395:809–815. 2020.PubMed/NCBI View Article : Google Scholar
5	Panahi L, Amiri M and Pouy S: Risks of novel coronavirus disease (COVID-19) in pregnancy; a narrative review. Arch Acad Emerg Med. 8(e34)2020.PubMed/NCBI
6	Sohrabi C, Alsafi Z, O'Neill N, Khan M, Kerwan A, Al-Jabir A, Iosifidis C and Agha R: World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). Int J Surg. 76:71–76. 2020.PubMed/NCBI View Article : Google Scholar
7	Zhang N, Wang L, Deng X, Liang R, Su M, He C, Hu L, Su Y, Ren J, Yu F, et al: Recent advances in the detection of respiratory virus infection in humans. J Med Virol. 92:408–417. 2020.PubMed/NCBI View Article : Google Scholar
8	National Center for Immunization and Respiratory Diseases (NCIRD) Division of Viral Diseases: Interim clinical guidance for management of patients with confirmed 2019 novel coronavirus (2019-nCoV) infection. CDC, 2020.
9	Lu Q and Shi Y: Coronavirus disease (COVID-19) and neonate: What neonatologist need to know. J Med Virol. 92:564–567. 2020.PubMed/NCBI View Article : Google Scholar
10	Yu N, Li W, Kang Q, Xiong Z, Wang S, Lin X, Liu Y, Xiao J, Liu H, Deng D, et al: Clinical features and obstetric and neonatal outcomes of pregnant patients with COVID-19 in Wuhan, China: A retrospective, single-centre, descriptive study. Lancet Infect Dis. 20:559–564. 2020.PubMed/NCBI View Article : Google Scholar
11	Dong L, Tian J, He S, Zhu C, Wang J, Liu C and Yang J: Possible vertical transmission of SARS-CoV-2 from an infected mother to her newborn. JAMA. 323:1846–1848. 2020.PubMed/NCBI View Article : Google Scholar
12	Liu W, Wang Q, Zhang Q, Chen L, Chen J, Zhang B, Lu Y, Wang S, Xia L, Huang L, et al: Coronavirus disease 2019 (COVID-19) during pregnancy: A case series. Preprints: 2020020373, 2020.
13	Zhu H, Wang L, Fang C, Peng S, Zhang L, Chang G, Xia S and Zhou W: Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Transl Pediatr. 9:51–60. 2020.PubMed/NCBI View Article : Google Scholar
14	Zhang L, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, Tian JH, Dong L and Hu RH: Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 55:166–171. 2020.PubMed/NCBI View Article : Google Scholar : (In Chinese).
15	Zeng L, Xia S, Yuan W, Yan K, Xiao F, Shao J and Zhou W: Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China. JAMA Pediatr. 174:722–725. 2020.PubMed/NCBI View Article : Google Scholar
16	Wang X, Zhou Z, Zhang J, Zhu F, Tang Y and Shen X: A case of 2019 novel coronavirus in a pregnant woman with preterm delivery. Clin Infect Dis. 71:844–846. 2020.PubMed/NCBI View Article : Google Scholar
17	Chen S, Liao E, Cao D, Gao Y, Sun G and Shao Y: Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia. J Med Virol. 92:1556–1561. 2020.PubMed/NCBI View Article : Google Scholar
18	Fornari F: Vertical transmission of Covid-19-A systematic review. J Pediatr Perinatol Child Heal. 4:7–13. 2020.
19	Boelig RC, Manuck T, Oliver EA, Di Mascio D, Saccone G, Bellussi F and Berghella V: Labor and delivery guidance for COVID-19. Am J Obstet Gynecol MFM. 2(100110)2020.PubMed/NCBI View Article : Google Scholar
20	Calina D, Docea AO, Petrakis D, Egorov AM, Ishmukhametov AA, Gabibov AG, Shtilman MI, Kostoff R, Carvalho F, Vinceti M, et al: Towards effective COVID-19 vaccines: Updates, perspectives and challenges (review). Int J Mol Med. 46:3–16. 2020.PubMed/NCBI View Article : Google Scholar
21	Docea AO, Tsatsakis A, Albulescu D, Cristea O, Zlatian O, Vinceti M, Moschos SA, Tsoukalas D, Goumenou M, Drakoulis N, et al: A new threat from an old enemy: Re-emergence of coronavirus (Review). Int J Mol Med. 45:1631–1643. 2020.PubMed/NCBI View Article : Google Scholar