Feibi decoction‑medicated serum inhibits lipopolysaccharide‑induced inflammation in RAW264.7 cells and BMDMs

  • Authors:
    • Wan Wei
    • Guodong Li
    • Zhaoheng Liu
    • Haojie Yang
    • Shuo Liu
    • Xinxin Zou
    • Yang Jiao
  • View Affiliations

  • Published online on: December 2, 2021     https://doi.org/10.3892/etm.2021.11033
  • Article Number: 110
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Feibi decoction (FBD) is a traditional Chinese herbal medicine and has been clinically used in the treatment of pulmonary fibrosis (PF), which is characterized by diffuse interstitial inflammation and exaggerated collagen accumulation. However, the potential mechanisms remain to be elucidated. The present study aimed to investigate the effect of FBD‑medicated serum (FBDS) on lipopolysaccharide (LPS)‑induced inflammation in macrophages. In RAW264.7 macrophages and bone marrow‑derived macrophages (BMDMs), FBDS treatment significantly inhibited the production of pro‑inflammatory cytokines induced by LPS. In addition, it was indicated that FBDS treatment suppressed the activation of NF‑κB and Smad2/Smad3 following LPS treatment. Furthermore, FBDS treatment decreased the expression of transforming growth factor‑β1 and chitinase‑3‑like protein 1. In conclusion, the results demonstrated that treatment with FBDS inhibited LPS‑induced inflammation in RAW264.7 and BMDM cells. These data may improve understanding of the effect of FBD on anti‑inflammation and help determine the mechanisms underlying the alleviation of PF via FBD.
View Figures
View References

Related Articles

Journal Cover

January-2022
Volume 23 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wei W, Li G, Liu Z, Yang H, Liu S, Zou X and Jiao Y: Feibi decoction‑medicated serum inhibits lipopolysaccharide‑induced inflammation in RAW264.7 cells and BMDMs. Exp Ther Med 23: 110, 2022
APA
Wei, W., Li, G., Liu, Z., Yang, H., Liu, S., Zou, X., & Jiao, Y. (2022). Feibi decoction‑medicated serum inhibits lipopolysaccharide‑induced inflammation in RAW264.7 cells and BMDMs. Experimental and Therapeutic Medicine, 23, 110. https://doi.org/10.3892/etm.2021.11033
MLA
Wei, W., Li, G., Liu, Z., Yang, H., Liu, S., Zou, X., Jiao, Y."Feibi decoction‑medicated serum inhibits lipopolysaccharide‑induced inflammation in RAW264.7 cells and BMDMs". Experimental and Therapeutic Medicine 23.1 (2022): 110.
Chicago
Wei, W., Li, G., Liu, Z., Yang, H., Liu, S., Zou, X., Jiao, Y."Feibi decoction‑medicated serum inhibits lipopolysaccharide‑induced inflammation in RAW264.7 cells and BMDMs". Experimental and Therapeutic Medicine 23, no. 1 (2022): 110. https://doi.org/10.3892/etm.2021.11033