Serous otitis media: Clinical and therapeutic considerations, including dexamethasone (C22H29FO5) intratympanic injection

Mârțu,Cristian; Cozma,Sebastian; Cobzeanu,Bogdan; Vesa,Doina; Butnaru,Corina; Bularda,Dragoș; Cumpătă,Adeline; Rădulescu,Luminița

doi:10.3892/etm.2021.11048

February-2022 Volume 23 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2022 Volume 23 Issue 2

Full Size Image

Article Open Access

Serous otitis media: Clinical and therapeutic considerations, including dexamethasone (C₂₂H₂₉FO₅) intratympanic injection

Authors:
- Cristian Mârțu
- Sebastian Cozma
- Bogdan Cobzeanu
- Doina Vesa
- Corina Butnaru
- Dragoș Bularda
- Adeline Cumpătă
- Luminița Rădulescu
View Affiliations / Copyright

Affiliations: ENT Department, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania, Clinical Surgical Department, Faculty of Medicine and Pharmacy, ‘Dunarea de Jos’ University of Galati, 800008 Galati, Romania, ENT Clinic, Clinical Rehabilitation Hospital, 700613 Iasi, Romania

Copyright: © Mârțu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Article Number: 125
|
Published online on: December 7, 2021

https://doi.org/10.3892/etm.2021.11048
Expand metrics +

Abstract

Serous otitis media (SOM) occurs in children and constitutes one of the most significant causes of hearing loss in young age, posing as an important risk factor for long‑term hearing loss. SOM is underdiagnosed, most frequently in infants, or the appointment to the ENT doctor is delayed due to non‑acute symptomatology. The aim of the present study was to assess 285 patients with SOM diagnosed within a two‑year span. The etiology and pathology of hearing loss in patients with different age groups were examined. The importance of a clinical examination and tympanometry was emphasized as absolutely necessary for a correct diagnosis. Treatment targeted Eustachian Tube permeabilization for satisfactory long‑term middle ear aeration. Nasal drops with vasoconstrictor drugs (phenylephrine) and disinfectant (colloidal silver 1%) were commonly used, but some patients also benefitted from dexamethasone intratympanic injection. Patients were evaluated at the end of the treatment and follow‑up occurred at one month, one year and three years later.

View Figures

View References

1	Kocygit M, Ortekin SG, Cakabay T, Ozkaya G, Bezgin SU and Adali MK: Frequency of serous otitis media in children without otolaryngological symptoms. Int Arch Otorhinolaryngol. 21:161–164. 2017.PubMed/NCBI View Article : Google Scholar
2	Stool SE, Berg AO, Berman S, Carney CJ, Cooley JR, Culpepper L, Eavey RD, Feagans LV, Finitzo T, Friedman E, et al: Managing otitis media with effusion in young children. American Academy of Pediatrics the Otitis Media Guideline Panel. Pediatrics. 94:766–773. 1994.PubMed/NCBI
3	Shekelle P, Takata G, Chan LS, Mangione-Smith R, Corley PM, Morphew T and Morton S: Diagnosis, natural history, and late effects of otitis media with effusion. Evid Rep Technol Assess (Summ). 55:1–5. 2002.PubMed/NCBI View Article : Google Scholar
4	Gates GA, Avery CA, Prihoda TJ and Cooper JC Jr: Effectiveness of adenoidectomy and tympanostomy tubes in the treatment of chronic otitis media with effusion. N Engl J Med. 317:1444–1451. 1987.PubMed/NCBI View Article : Google Scholar
5	Tos M: Epidemiology and natural history of secretory otitis. Am J Otol. 5:459–62. 1984.PubMed/NCBI
6	Mandel EM, Doyle WJ, Winther B and Alper CM: The incidence, prevalence and burden of OM in unselected children aged 1-8 years followed by weekly otoscopy through the ‘common cold’ season. Int J Pediatr Otorhinolaryngol. 72:491–499. 2008.PubMed/NCBI View Article : Google Scholar
7	Casselbrant M and Mandel EM: Epidemiology. In: Rosenfeld RM, Bluestone CD, Eds: Evdence-based otitis media, cd 2, Hamilton, Ontario, BC Decker, 147-162, 2003.
8	Martines F, Bentivegna D, Di Piazza F, Martinciglio G, Sciacca V and Martines E: The point prevalence of otitis media with effusion among primary school children in Western Sicily. Eur Arch Otorhinolaryngol. 267:709–714. 2010.PubMed/NCBI View Article : Google Scholar
9	Williamson IG, Dunleavey J, Bain J and Robinson D: The natural history of otitis media with effusion--a three-year study of the incidence and prevalence of abnormal tympanograms in four South West Hampshire infant and first schools. J Laryngol Otol. 108:930–934. 1994.PubMed/NCBI View Article : Google Scholar
10	Bhutta MF, Thornton RB, Kirkham LS, Kerschner JE and Cheeseman MT: Understanding the aetiology and resolution of chronic otitis media from animal and human studies. Dis Model Mech. 10:1289–1300. 2017.PubMed/NCBI View Article : Google Scholar
11	Rosenfeld RM, Schwartz SR, Cannon CR, Roland PS, Simon GR, Kumar KA, Huang WW, Haskell HW and Robertson PJ: Clinical practice guideline: Acute otitis externa. Otolaryngol Head Neck Surg. 150 (Suppl 1):S1–S24. 2014.PubMed/NCBI View Article : Google Scholar
12	Butnaru C, Serban R, Martu C, Lungu A, Doroftei EA, Cobzeanu B and Cozma S: Otitis media complications proceedings of national Ent. Head and Neck Surgery Conference. 102–106. 2019.
13	Serban R, Butnaru C, Stefanescu H, Martu C, Cozma S and Radulescu L: Complications of otomastoiditis in children. Conference: National ENT, head and neck surgery national ent. Head And Neck Surgery Conference. 312–315. 2017.
14	Vanneste P and Page C: Otitis media with effusion in children: Pathophysiology, diagnosis, and treatment. A review. J Otol. 14:33–39. 2019.PubMed/NCBI View Article : Google Scholar
15	Norman G, Llewellyn A, Harden M, Coatesworth A, Kimberling D, Schilder A and McDaid C: Systematic review of the limited evidence base for treatments of Eustachian tube dysfunction: A health technology assessment. Clin Otolaryngol. 39:6–21. 2014.PubMed/NCBI View Article : Google Scholar
16	Ma Y, Liang M, Tian P, Liu X, Dang H, Chen Q, Zou H and Zheng Y: Eustachian tube dysfunction in patients with house dust mite-allergic rhinitis. Clin Transl Allergy. 10(30)2020.PubMed/NCBI View Article : Google Scholar
17	Paksoy M, Altin G, Eken M and Hardal U: Effectiveness of intratympanic dexamethasone in otitis media with effusion resistant to conventional therapy. Indian J Otolaryngol Head Neck Surg. 65 (Suppl 3):S461–S467. 2013.PubMed/NCBI View Article : Google Scholar