Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data
- Bianling Xu
- Nan Wang
- Xuegong Xu
- Yongmin Cai
Affiliations: Institute of Chinese Medicine Literature, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China, Laboratory of Zhengzhou Hospital of Traditional Chinese Medicine, Zhengzhou, Henan 450007, P.R. China
- Published online on: December 20, 2021 https://doi.org/10.3892/etm.2021.11083
Copyright: © Xu
et al. This is an open access article distributed under the
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Commons Attribution License.
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Long non‑coding RNAs (lncRNAs) have key roles in various diseases; however, their functions in hyperlipidemia (HLP) have remained elusive. In the present study, microarray technology was utilized to analyze the differential expression of lncRNAs and mRNAs in liver tissues of apolipoprotein E‑/‑ mice as a model of HLP compared with control mice. A total of 104 and 96 differentially expressed lncRNAs and mRNAs, respectively, were identified. Differentially expressed genes were significantly enriched in biological processes such as nitric oxide biosynthesis, innate immune response and inflammatory response. Finally, two pairs of target genes and 38 transcription factors with regulatory functions in HLP were predicted based on the lncRNA and mRNA co‑expression network. The lncRNA expression profile was significantly altered in liver tissues of the mouse model of HLP and may provide novel targets for research into treatments.