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Lung neuroendocrine tumors: A systematic literature review (Review)

  • Authors:
    • Cornel Savu
    • Alexandru Melinte
    • Camelia Diaconu
    • Ovidiu Stiru
    • Florentina  Gherghiceanu
    • Ștefan Dragoș Octavian Tudorica
    • Oana Clementina Dumitrașcu
    • Angelica Bratu
    • Irina Balescu
    • Nicolae Bacalbasa
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Internal Medicine, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Cardiovascular Surgery, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Marketing and Medical Technology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania, Department of Anesthesiology and Intensive Care, Emergency University Hospital, 050098 Bucharest, Romania, Department of Surgery, ‘Ponderas’ Academic Hospital, 021188 Bucharest, Romania, Department of Obstetrics and Gynecology, ‘Carol Davila’ University of Medicine and Pharmacy, 020021 Bucharest, Romania
  • Article Number: 176
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    Published online on: December 28, 2021
       https://doi.org/10.3892/etm.2021.11099
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Abstract

Neuroendocrine tumors (NETs) can have multiple localizations in the human body however, most often, it appears in the in thorax at tracheobronchial tree and the thymus. NETs are a group of tumors with heterogenous malignancy that evolve from neuroendocrine cells, with the lung being the second target organ after the gastrointestinal tract. These rare tumors are usually asymptomatic and non‑functional with little information regarding incidence in the specialty literature. The main purpose of this review, was the analysis of the available literature in all aspects while mainly focusing on molecular diagnosis data and secondly, by using this molecular landscape to establish a differentiation of lung neuroendocrine tumors (LNETs). By analyzing the literature, new data were revealed regarding histological evaluation, genetic aberrations, prognosis depending on the type of LNET and therapeutic options that derive from these. Efficient management of these tumors is essential in the handling of symptoms and increase in life expectancy, especially in patients with functional tumors. Histological differentiation of LNETs is important in establishing proper therapeutic options and prognosis. Combined types of LNETs remain a controversial topic of discussion regarding diagnosis and treatment, a topic on which further studies are required in order to improve diagnosis in this group of tumors with heterogenous malignancy.
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Copy and paste a formatted citation
Spandidos Publications style
Savu C, Melinte A, Diaconu C, Stiru O, Gherghiceanu F, Tudorica ȘD, Dumitrașcu OC, Bratu A, Balescu I, Bacalbasa N, Bacalbasa N, et al: Lung neuroendocrine tumors: A systematic literature review (Review). Exp Ther Med 23: 176, 2022.
APA
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș.D. ... Bacalbasa, N. (2022). Lung neuroendocrine tumors: A systematic literature review (Review). Experimental and Therapeutic Medicine, 23, 176. https://doi.org/10.3892/etm.2021.11099
MLA
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș. D., Dumitrașcu, O. C., Bratu, A., Balescu, I., Bacalbasa, N."Lung neuroendocrine tumors: A systematic literature review (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 176.
Chicago
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș. D., Dumitrașcu, O. C., Bratu, A., Balescu, I., Bacalbasa, N."Lung neuroendocrine tumors: A systematic literature review (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 176. https://doi.org/10.3892/etm.2021.11099
Copy and paste a formatted citation
x
Spandidos Publications style
Savu C, Melinte A, Diaconu C, Stiru O, Gherghiceanu F, Tudorica ȘD, Dumitrașcu OC, Bratu A, Balescu I, Bacalbasa N, Bacalbasa N, et al: Lung neuroendocrine tumors: A systematic literature review (Review). Exp Ther Med 23: 176, 2022.
APA
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș.D. ... Bacalbasa, N. (2022). Lung neuroendocrine tumors: A systematic literature review (Review). Experimental and Therapeutic Medicine, 23, 176. https://doi.org/10.3892/etm.2021.11099
MLA
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș. D., Dumitrașcu, O. C., Bratu, A., Balescu, I., Bacalbasa, N."Lung neuroendocrine tumors: A systematic literature review (Review)". Experimental and Therapeutic Medicine 23.2 (2022): 176.
Chicago
Savu, C., Melinte, A., Diaconu, C., Stiru, O., Gherghiceanu, F., Tudorica, Ș. D., Dumitrașcu, O. C., Bratu, A., Balescu, I., Bacalbasa, N."Lung neuroendocrine tumors: A systematic literature review (Review)". Experimental and Therapeutic Medicine 23, no. 2 (2022): 176. https://doi.org/10.3892/etm.2021.11099
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