Electrochemical monitoring of bronchial inflammation in pediatric athletes: A prospective study

Diaconu,Radu; Dumitrescu,Florentina; Stoica,Loredana; Diaconu,Carmen; Dobrescu,Mihaela-Amelia; Glodeanu,Adina-Dorina; Ionescu,Mihaela; Mavritsakis,Nikolaos; Stoica,Doru

doi:10.3892/etm.2021.11103

Electrochemical monitoring of bronchial inflammation in pediatric athletes: A prospective study

Authors:
- Radu Diaconu
- Florentina Dumitrescu
- Loredana Stoica
- Carmen Diaconu
- Mihaela-Amelia Dobrescu
- Adina-Dorina Glodeanu
- Mihaela Ionescu
- Nikolaos Mavritsakis
- Doru Stoica
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Affiliations: Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania, Department of Infectious Diseases, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania, Department of Dermatology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania, Department of Sports Medicine, Emergency Clinical Hospital Craiova, 200642 Craiova, Romania, Department of Medical Genetics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania, Department of Physical Education and Sport, ‘1 Decembrie 1918’ University, 510009 Alba Iulia, Romania, Physical Education and Sport Faculty, University of Craiova, 200177 Craiova, Romania
Published online on: December 28, 2021 https://doi.org/10.3892/etm.2021.11103
Article Number: 180
Copyright: © Diaconu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The assessment of inflammation by accessible, reproducible and especially non‑invasive methods is one of the main goals for numerous medical specialties. One variable for assessment is the fraction of nitric oxide in exhaled air (FeNO), which correlates with the inflammatory syndrome of the airways. The objective of the present study was the biochemical evaluation of FeNO in children practicing sports in Oltenia, Romania. Between January and December 2018, children practicing sports (football, track and field, judo, fencing, handball, volleyball and basketball) were enrolled in the study. The FeNO values were compared with the asthma history and with the spirometric evaluation. A total of 23 children without a previous asthma diagnosis exhibited positive spirometry results. The prevalence of the disease was 3.6% in the cohort, and FeNO dosing showed higher values in the group at risk in children diagnosed with asthma, compared with that in children without this diagnosis. The children who performed outdoor sports (soccer, and track and field) had higher electrochemical levels of nitric oxide compared with those who performed indoor sports (mean, 29.70 vs. 20.56; P<0.0005), which led to the hypothesis that these children had an increased risk of developing bronchospasm. FeNO dosing can thus be a useful and easy‑to‑use tool in practice for assessing bronchial inflammation in children practicing various types of sports. The spirometric data of undiagnosed asthma patients from the present study may indicate that the disease is still underdiagnosed within Romania.

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