Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Experimental and Therapeutic Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-0981 Online ISSN: 1792-1015
Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2022 Volume 23 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6

  • Authors:
    • Xuan Zhao
    • Limei Ren
    • Xiaoru Wang
    • Guangxin Han
    • Shuo Wang
    • Qingguo Yao
    • Yonghao Qi
  • View Affiliations / Copyright

    Affiliations: Department of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei 050035, P.R. China, Department of Chemical Engineering, Shijiazhuang University, Shijiazhuang, Hebei 050035, P.R. China, Department of Pathology and Key Laboratory of Kidney of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
    |
    Published online on: December 30, 2021
       https://doi.org/10.3892/etm.2021.11104
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

TNF receptor‑associated factor 6 (TRAF6) has been reported to be associated with the development of cancer. Nevertheless, the exact role of TRAF6 in cancer remains unclear. The purpose of the present study was to explore the mechanism of 2‑benzoyl‑3‑hydroxy‑4‑methyl‑9H‑xanthen‑9‑one leading to the inhibition of the activation of AKT and TGF‑β‑activated kinase 1 (TAK1), and to the apoptosis of MCF‑7 cells. Using a computational docking program and examination of AKT and TAK1 level changes, a new small molecule was identified, 2‑benzoyl‑3‑hydroxy‑4‑methyl‑9H‑xanthen‑9‑one, which competitively bound to TRAF6. Next, the effect of this new compound on MCF‑7 cells' biological behavior was studied in vitro. MTT assays were used to investigate cell viability; flow cytometry and invasion assays were performed to detect early apoptosis and invasion in MCF‑7 cells, respectively. Immunoprecipitation, western blotting and caspase‑3/9 activity assays were carried out to explore changes in protein expression. Briefly, the present data indicated that 2‑benzoyl‑3‑hydroxy‑4‑methyl‑9H‑xanthen‑9‑one could suppress proliferation, induce early apoptosis and inhibit invasion in MCF‑7 cells by suppressing the expression of Bcl‑2 and promoting the expression of Bax, caspase‑9, and caspase‑3. These findings indicated that 2‑benzoyl‑3‑hydroxy‑4‑methyl‑9H‑xanthen‑9‑one could induce apoptosis by inhibiting the activation of AKT and TAK1, and affecting the Bcl‑2/Bax‑caspase‑9‑caspase‑3 pathway by competitively binding with TRAF6.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Inoue JI, Ishida T, Tsukamoto N, Kobayashi N, Natio A, Azuma S and Yamamoto T: Tumor necrosis factor receptor-associated factor (TRAF) family: Adapter proteins that mediate cytokine signaling. Exp Cell Res. 254:14–24. 2000.PubMed/NCBI View Article : Google Scholar

2 

Han F, Zhang L, Qiu W and Yi X: TRAF6 promotes the invasion and metastasis and predicts a poor prognosis in gastric cancer. Pathol Res Pract. 212:31–37. 2016.PubMed/NCBI View Article : Google Scholar

3 

Tian X, Zhao H, Zhang Z, Guo Z and Li W: Intestinal mucosal injury induced by obstructive jaundice is associated with activation of TLR4/TRAF6/NF-κB pathways. PLoS One. 14(e0223651)2019.PubMed/NCBI View Article : Google Scholar

4 

Qi Y, Zhao X, Chen J, Pradipta AR, Wei J, Ruan H, Zhou L, Hsung RP and Tanaka K: In vitro and in vivo cancer cell apoptosis triggered by competitive binding of Cinchona alkaloids to the RING domain of TRAF6. Biosci Biotechnol Biochem. 83:1011–1026. 2019.PubMed/NCBI View Article : Google Scholar

5 

Frede S, Berchner-Pfannschmidt U and Fandrey J: Regulation of hypoxia-inducible factors during inflammation. Methods Enzymol. 435:405–419. 2007.PubMed/NCBI View Article : Google Scholar

6 

Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell. 140:883–899. 2010.PubMed/NCBI View Article : Google Scholar

7 

Zucchelli S, Codrich M, Marcuzzi F, Pinto M, Vilotti S, Biagioli M, Ferrer I and Gustincich S: TRAF6 promotes atypical ubiquitination of mutant DJ-1 and alpha-synuclein and is localized to Lewy bodies in sporadic Parkinson's disease brains. Hum Mol Genet. 19:3759–3770. 2010.PubMed/NCBI View Article : Google Scholar

8 

Lamothe B, Besse A, Campos AD, Webster WK, Wu H and Darnay BG: Site-specific Lys-63-linked tumor necrosis factor receptor-associated factor 6 auto-ubiquitination is a critical determinant of I kappa B kinase activation. J Biol Chem. 282:4102–4112. 2007.PubMed/NCBI View Article : Google Scholar

9 

Shi J, Liu Z and Xu Q: Tumor necrosis factor receptor-associated factor 6 contributes to malignant behavior of human cancers through promoting AKT ubiquitination and phosphorylation. Cancer Sci. 110:1909–1920. 2019.PubMed/NCBI View Article : Google Scholar

10 

Zhi X, Fang C, Gu Y, Chen H, Chen X, Cui J, Hu Y, Weng W, Zhou Q, Wang Y, et al: Guaiacol suppresses osteoclastogenesis by blocking interactions of RANK with TRAF6 and C-Src and inhibiting NF-κB, MAPK and AKT pathways. J Cell Mol Med. 24:5122–5134. 2020.PubMed/NCBI View Article : Google Scholar

11 

Jang JH, Kim H and Cho JH: Molecular cloning and functional characterization of TRAF6 and TAK1 in rainbow trout, Oncorhynchus mykiss. Fish Shellfish Immunol. 84:927–936. 2019.PubMed/NCBI View Article : Google Scholar

12 

Luo J, Manning BD and Cantley LC: Targeting the PI3K-Akt pathway in human cancer: Rationale and promise. Cancer Cell. 4:257–262. 2003.PubMed/NCBI View Article : Google Scholar

13 

Parsons R: Human cancer, PTEN and the PI-3 kinase pathway. Semin Cell Dev Biol. 15:171–176. 2004.PubMed/NCBI View Article : Google Scholar

14 

Scheid MP and Woodgett JR: Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett. 546:108–112. 2003.PubMed/NCBI View Article : Google Scholar

15 

Jeong SJ, Pise-Masison CA, Radonovich MF, Park HU and Brady JN: Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1-transformed cells. Oncogene. 24:6719–6728. 2005.PubMed/NCBI View Article : Google Scholar

16 

Landstrom M: The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol. 42:585–589. 2010.PubMed/NCBI View Article : Google Scholar

17 

Takeuchi O and Akira S: Pattern recognition receptors and inflammation. Cell. 140:805–820. 2010.PubMed/NCBI View Article : Google Scholar

18 

Wang C, Deng L, Hong M, Akkaraju GR, Inoue J and Chen ZJ: TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. 412:346–351. 2001.PubMed/NCBI View Article : Google Scholar

19 

Ouyang C, Nie L, Gu M, Wu A, Han X, Wang X, Shao J and Xia Z: Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and X-linked protein kinase (PRKX). J Biol Chem. 289:24226–24237. 2014.PubMed/NCBI View Article : Google Scholar

20 

Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE and Reusch JE: Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem. 275:10761–10766. 2000.PubMed/NCBI View Article : Google Scholar

21 

Wu R, Tang S, Wang M, Xu X, Yao C and Wang S: MicroRNA-497 induces apoptosis and suppresses proliferation via the Bcl-2/Bax-caspase9-caspase3 pathway and cyclin D2 protein in HUVECs. PLoS One. 11(e0167052)2016.PubMed/NCBI View Article : Google Scholar

22 

Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG and Lin HK: The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 325:1134–1138. 2009.PubMed/NCBI View Article : Google Scholar

23 

Avila M, Martinez-Juarez A, Ibarra-Sanchez A and Gonzalez-Espinosa C: Lyn kinase controls TLR4-dependent IKK and MAPK activation modulating the activity of TRAF-6/TAK-1 protein complex in mast cells. Innate Immun. 18:648–660. 2012.PubMed/NCBI View Article : Google Scholar

24 

Kim SY, Bae S, Choi KH and An S: Hydrogen peroxide controls Akt activity via ubiquitination/degradation pathways. Oncol Rep. 26:1561–1566. 2011.PubMed/NCBI View Article : Google Scholar

25 

Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov NI and Bourne PE: The protein data bank. Nucleic Acids Res. 28:235–242. 2000.PubMed/NCBI View Article : Google Scholar

26 

Schnetzke U, Fischer M, Kuhn AK, Spies-Weisshart B, Zirm E, Hochhaus A, Muller JP and Scholl S: The E3 ubiquitin ligase TRAF6 inhibits LPS-induced AKT activation in FLT3-ITD-positive MV4-11 AML cells. J Cancer Res Clin Oncol. 139:605–615. 2013.PubMed/NCBI View Article : Google Scholar

27 

Yoon K, Jung EJ, Lee SR, Kim J, Choi Y and Lee SY: TRAF6 deficiency promotes TNF-induced cell death through inactivation of GSK3beta. Cell Death Differ. 15:730–738. 2008.PubMed/NCBI View Article : Google Scholar

28 

Ling MT, Wang XH, Ouyang XS, Xu K, Tsao SW and Wong YC: Id-1 expression promotes cell survival through activation of NF-kappaB signaling pathway in prostate cancer cells. Oncogene. 22:4498–4508. 2013.PubMed/NCBI View Article : Google Scholar

29 

Wen J, Liu X, Qi Y, Niu F, Niu Z, Geng W, Zou Z, Huang R, Wang J and Zou H: BMP3 suppresses colon tumorigenesis via ActRIIB/SMAD2-dependent and TAK1/JNK signaling pathways. J Exp Clin Cancer Res. 38(428)2019.PubMed/NCBI View Article : Google Scholar

30 

Starczynowski DT, Lockwood WW, Delehouzee S, Chari R, Wegrzyn J, Fuller M, Tsao MS, Lam S, Gazdar AF, Lam WL and Karsan A: TRAF6 is an amplified oncogene bridging the RAS and NF-κB pathways in human lung cancer. J Clin Invest. 121:4095–4105. 2011.PubMed/NCBI View Article : Google Scholar

31 

Zhang J, Lei Z, Huang Z, Zhang X, Zhou Y, Luo Z, Zeng W, Su J, Peng C and Chen X: Epigallocatechin-3-gallate (EGCG) suppresses melanoma cell growth and metastasis by targeting TRAF6 activity. Oncotarget. 7:79557–79571. 2016.PubMed/NCBI View Article : Google Scholar

32 

Mercier P, Lewis MJ, Hau DD, Saltibus LF, Xiao W and Spyracopoulos L: Structure, interactions, and dynamics of the RING domain from human TRAF6. Protein Sci. 16:602–614. 2007.PubMed/NCBI View Article : Google Scholar

33 

Liu H, Tamashiro S, Baritaki S, Penichet M, Yu Y, Chen H, Berenson J and Bonavida B: TRAF6 activation in multiple myeloma: A potential therapeutic target. Clin Lymphoma Myeloma Leuk. 12:155–163. 2012.PubMed/NCBI View Article : Google Scholar

34 

Naito A, Azuma S, Tanaka S, Miyazaki T, Takaki S, Takatsu K, Nakao K, Nakamura K, Katsuki M, Yamamoto T and Inoue J: Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells. 4:353–362. 1999.PubMed/NCBI View Article : Google Scholar

35 

Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, et al: E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol. 16:658–666. 2009.PubMed/NCBI View Article : Google Scholar

36 

Chaudhry SI, Hooper S, Nye E, Williamson P, Harrington K and Sahai E: Autocrine IL-1β-TRAF6 signaling promotes squamous cell carcinoma invasion through paracrine TNFα signaling to carcinoma-associated fibroblasts. Oncogene. 32:747–758. 2013.PubMed/NCBI View Article : Google Scholar

37 

Ji YX, Zhang P, Zhang XJ, Zhao YC, Deng KQ, Jing X, Wang PX, Huang Z and Li H: The ubiquitin E3 ligase TRAF6 exacerbates pathological cardiac hypertrophy via TAK1-dependent signaling. Nat Commun. 7(11267)2016.PubMed/NCBI View Article : Google Scholar

38 

Li T, Qin JJ, Xia Y, Ji YX, Guo F, Cheng WL, Wu X, Gong FH, Hong Y, Zhu XY, et al: The ubiquitin E3 ligase TRAF6 exacerbates ischemic stroke by ubiquitinating and activating Rac1. J Neurosci. 37:12123–12140. 2017.PubMed/NCBI View Article : Google Scholar

39 

Paul PK, Bhatnagar S, Mishra V, Srivastava S, Darnay BG, Choi Y and Kumar A: The E3 ubiquitin ligase TRAF6 intercedes in starvation-induced skeletal muscle atrophy through multiple mechanisms. Mol Cell Biol. 32:1248–1259. 2012.PubMed/NCBI View Article : Google Scholar

40 

Dey N, Liu T, Garofalo RP and Casola A: TAK1 regulates NF-κB and AP-1 activation in airway epithelial cells following RSV infection. Virology. 418:93–101. 2011.PubMed/NCBI View Article : Google Scholar

41 

Yamashita M, Fatyol K, Jin C, Wang X, Liu Z and Zhang YE: TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell. 31:918–924. 2008.PubMed/NCBI View Article : Google Scholar

42 

Kim H, Chung H, Kim HJ, Lee JY, Oh MY, Kim Y and Kong G: Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells. Breast Cancer Res Treat. 112:287–296. 2008.PubMed/NCBI View Article : Google Scholar

43 

Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, et al: Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 419:634–637. 2002.PubMed/NCBI View Article : Google Scholar

44 

McNutt MC, Lagace TA and Horton JD: Catalytic activity is not required for secreted PCSK9 to reduce low density lipoprotein receptors in HepG2 cells. J Biol Chem. 282:20799–20803. 2007.PubMed/NCBI View Article : Google Scholar

45 

Rahman M, Chan AP, Tang M and Tai IT: A peptide of SPARC interferes with the interaction between caspase8 and Bcl2 to resensitize chemoresistant tumors and enhance their regression in vivo. PLoS One. 6(e26390)2011.PubMed/NCBI View Article : Google Scholar

46 

Vegran F, Boidot R, Solary E and Lizard-Nacol S: A short caspase-3 isoform inhibits chemotherapy-induced apoptosis by blocking apoptosome assembly. PLoS One. 6(e29058)2011.PubMed/NCBI View Article : Google Scholar

47 

Cain K, Bratton SB and Cohen GM: The Apaf-1 apoptosome: A large caspase-activating complex. Biochimie. 84:203–214. 2002.PubMed/NCBI View Article : Google Scholar

48 

Qi Y, Pradipta AR, Li M, Zhao X, Lu L, Fu X, Wei J, Hsung RP, Tanaka K and Zhou L: Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. J Exp Clin Cancer Res. 36(35)2017.PubMed/NCBI View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Ren L, Wang X, Han G, Wang S, Yao Q and Qi Y: Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6. Exp Ther Med 23: 181, 2022.
APA
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., & Qi, Y. (2022). Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6. Experimental and Therapeutic Medicine, 23, 181. https://doi.org/10.3892/etm.2021.11104
MLA
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., Qi, Y."Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6". Experimental and Therapeutic Medicine 23.2 (2022): 181.
Chicago
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., Qi, Y."Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6". Experimental and Therapeutic Medicine 23, no. 2 (2022): 181. https://doi.org/10.3892/etm.2021.11104
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Ren L, Wang X, Han G, Wang S, Yao Q and Qi Y: Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6. Exp Ther Med 23: 181, 2022.
APA
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., & Qi, Y. (2022). Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6. Experimental and Therapeutic Medicine, 23, 181. https://doi.org/10.3892/etm.2021.11104
MLA
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., Qi, Y."Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6". Experimental and Therapeutic Medicine 23.2 (2022): 181.
Chicago
Zhao, X., Ren, L., Wang, X., Han, G., Wang, S., Yao, Q., Qi, Y."Benzoyl‑xanthone derivative induces apoptosis in MCF‑7 cells by binding TRAF6". Experimental and Therapeutic Medicine 23, no. 2 (2022): 181. https://doi.org/10.3892/etm.2021.11104
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team